Cell Biochemistry and Function,
Год журнала:
2024,
Номер
42(2)
Опубликована: Март 1, 2024
Abstract
Over
the
past
decade,
prevalence
of
diabetes
has
increased
significantly
worldwide,
leading
to
an
increase
in
vascular
complications
(VCD),
such
as
diabetic
cardiomyopathy
(DCM),
nephropathy
(DN),
and
retinopathy
(DR).
Noncoding
RNAs
(ncRNAs),
microRNAs
(miRNAs),
long
(lncRNAs),
circular
(circRNAs),
play
a
key
role
cellular
processes,
including
pathophysiology
VCD
via
pyroptosis.
ncRNAs
(e.g.,
miR‐17,
lnc‐MEG3,
lnc‐KCNQ1OT1)
can
regulate
pyroptosis
pancreatic
β
cells.
Some
are
involved
progression.
For
example,
miR‐21,
lnc‐KCNQ1OT1,
lnc‐GAS5,
lnc‐MALAT1
were
reported
DN
DCM,
lnc‐MIAT
was
identified
DCM
DR.
Herein,
this
review
aimed
summarize
recent
research
findings
related
ncRNAs‐mediated
at
onset
progression
VCD.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Апрель 25, 2023
In
the
working-age
population
worldwide,
diabetic
retinopathy
(DR),
a
prevalent
complication
of
diabetes,
is
main
cause
vision
impairment.
Chronic
low-grade
inflammation
plays
an
essential
role
in
DR
development.
Recently,
concerning
pathogenesis
DR,
Nod-Like
Receptor
Family
Pyrin
Domain
Containing
3
(NLRP3)
inflammasome
retinal
cells
has
been
determined
as
causal
factor.
eye,
NLRP3
activated
by
several
pathways
(such
ROS
and
ATP).
The
activation
NPRP3
leads
to
secretion
inflammatory
cytokines
interleukin-1β
(IL-1β)
interleukin-18
(IL-18),
pyroptosis,
rapid
form
lytic
programmed
cell
death
(PCD).
Cells
that
undergo
pyroptosis
swell
rapture,
releasing
more
factors
accelerating
progression.
This
review
focuses
on
mechanisms
activate
leading
DR.
present
research
highlighted
some
inhibitors
NLRP3/pyroptosis
novel
therapeutic
measures
treatment.
Journal of Neuroinflammation,
Год журнала:
2022,
Номер
19(1)
Опубликована: Июль 14, 2022
Pyroptosis
is
a
programmed
cell
death
characterized
by
swift
plasma
membrane
disruption
and
subsequent
release
of
cellular
contents
pro-inflammatory
mediators
(cytokines),
including
IL-1β
IL-18.
It
differs
from
other
types
such
as
apoptosis,
autophagy,
necroptosis,
ferroptosis,
NETosis
in
terms
its
morphology
mechanism.
As
recently
discovered
form
death,
pyroptosis
has
been
demonstrated
to
be
involved
the
progression
multiple
diseases.
Recent
studies
have
also
suggested
that
linked
various
ocular
In
this
review,
we
systematically
summarized
discussed
recent
scientific
discoveries
involvement
common
diseases,
diabetic
retinopathy,
age-related
macular
degeneration,
AIDS-related
human
cytomegalovirus
retinitis,
glaucoma,
dry
eye
disease,
keratitis,
uveitis,
cataract.
We
organized
new
emerging
evidence
suggesting
signaling
pathways
may
potential
therapeutic
targets
hoping
provide
summary
overall
intervention
strategies
relevant
multi-dimensional
evaluations
for
well
offer
valuable
ideas
further
research
development
perspective
pyroptosis.
Frontiers in Cell and Developmental Biology,
Год журнала:
2023,
Номер
11
Опубликована: Май 12, 2023
Programmed
cell
death
has
crucial
roles
in
the
physiological
maturation
of
an
organism,
maintenance
metabolism,
and
disease
progression.
Pyroptosis,
a
form
programmed
which
recently
received
much
attention,
is
closely
related
to
inflammation
occurs
via
canonical,
non-canonical,
caspase-3-dependent,
unclassified
pathways.
The
pore-forming
gasdermin
proteins
mediate
pyroptosis
by
promoting
lysis,
contributing
outflow
large
amounts
inflammatory
cytokines
cellular
contents.
Although
response
critical
for
body’s
defense
against
pathogens,
uncontrolled
can
cause
tissue
damage
vital
factor
occurrence
progression
various
diseases.
In
this
review,
we
briefly
summarize
major
signaling
pathways
discuss
current
research
on
pathological
function
autoinflammatory
diseases
sterile
Theranostics,
Год журнала:
2023,
Номер
13(11), С. 3655 - 3674
Опубликована: Янв. 1, 2023
Diabetes
is
a
group
of
chronic
diseases
with
blood
glucose
imbalance,
and
long-term
hyperglycaemia
causes
sustained
damage
to
various
organs
the
body,
resulting
in
vascular
lesions,
neuropathy
impaired
wound
healing.Diabetic
formation
involves
variety
complex
mechanisms,
they
are
characterized
by
persistent
inflammatory
response,
degradation
angiogenesis
imbalance
extracellular
matrix
regulation,
all
which
related
oxidative
stress.Additionally,
repair
healing
diabetic
wounds
require
participation
cells,
cytokines,
genes,
other
factors,
together
constitute
biological
regulatory
network.Recent
studies
have
shown
that
long
noncoding
RNAs
(lncRNAs)
can
be
involved
regulation
several
key
pathways
cellular
functions
demonstrating
their
critical
role
healing.LncRNAs
major
family
limited
or
no
protein-coding
function.Numerous
recently
reported
strong
link
between
stress
lncRNAs.Given
both
lncRNAs
been
identified
as
potential
drivers
healing,
inferred.However,
specific
mechanism
still
unclear,
elucidating
these
processes
remains
challenge.This
article
reviews
mechanisms
stages
discusses
diagnostic
treatment
treat
improving
stress,
well
challenges
using
for
this
purpose.It
hoped
results
will
provide
new
targets
strategies
diagnosis
patients.
Non-coding RNA Research,
Год журнала:
2024,
Номер
9(2), С. 447 - 462
Опубликована: Янв. 21, 2024
The
discovery
of
non-coding
RNAs
(ncRNAs)
has
unveiled
a
wide
range
transcripts
that
do
not
encode
proteins
but
play
key
roles
in
several
cellular
and
molecular
processes.
Long
noncoding
(lncRNAs)
are
specific
class
ncRNAs
longer
than
200
nucleotides
have
gained
significant
attention
due
to
their
diverse
mechanisms
action
potential
involvement
various
pathological
conditions.
In
the
current
review
article,
authors
focus
on
role
lncRNAs,
specifically
highlighting
Myocardial
Infarction
Associated
Transcript
(MIAT),
non-oncological
context.
MIAT
is
nuclear
lncRNA
been
directly
linked
myocardial
infarction
reported
control
post-transcriptional
processes
as
competitive
endogenous
RNA
(ceRNA)
molecule.
It
interacts
with
microRNAs
(miRNAs),
thereby
limiting
translation
expression
target
messenger
(mRNA)
regulating
protein
expression.
Yet,
implicated
other
numerous
conditions
infarction,
including
cardiovascular
diseases,
autoimmune
disease,
neurodegenerative
metabolic
many
others.
this
review,
emphasize
exhibits
distinct
patterns
functions
across
different
emerging
diagnostic,
prognostic,
therapeutic
agent.
Additionally,
highlight
regulatory
function
shed
light
lncRNAs
diseases.
Frontiers in Immunology,
Год журнала:
2021,
Номер
12
Опубликована: Окт. 19, 2021
Diabetic
retinopathy
(DR)
is
prevalent
among
people
with
long-term
diabetes
mellitus
(DM)
and
remains
the
leading
cause
of
visual
impairment
in
working-aged
people.
DR
related
to
chronic
low-level
inflammatory
reactions.
Pyroptosis
an
emerging
type
cell
death
mediated
by
gasdermin
D
(GSDMD),
NOD-like
receptors
caspases
that
promote
interleukin-1β
(IL-1β)
IL-18
release.
In
addition,
retinal
neurovascular
unit
(NVU)
functional
basis
retina.
Recent
studies
have
shown
pyroptosis
may
participate
destruction
NVU
cells
simulated
hyperglycemic
environments.
this
review,
we
will
clarify
importance
during
development
DR.
Frontiers in Endocrinology,
Год журнала:
2022,
Номер
13
Опубликована: Июль 25, 2022
Background
Diabetic
retinopathy
is
a
diabetic
microvascular
complication.
Pyroptosis,
as
way
of
inflammatory
death,
plays
an
important
role
in
the
occurrence
and
development
retinopathy,
but
its
underlying
mechanism
has
not
been
fully
elucidated.
The
purpose
this
study
to
identify
potential
pyroptosis-related
genes
by
bioinformatics
analysis
validation
model
predict
microRNAs
(miRNAs)
long
non-coding
RNAs
(lncRNAs)
interacting
with
them.
Subsequently,
competing
endogenous
RNA
(ceRNA)
regulatory
network
structured
explore
their
molecular
mechanism.
Methods
We
obtained
mRNA
expression
profile
dataset
GSE60436
from
Gene
Expression
Omnibus
(GEO)
database
collected
51
PubMmed
database.
differentially
expressed
were
R
software,
then
eight
key
interest
identified
correlation
analysis,
Ontology
(GO)
enrichment
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
pathway
protein–protein
interaction
(PPI)
analysis.
Then,
levels
these
validated
quantitative
real-time
polymerase
chain
reaction
(qRT-PCR)
human
retinal
endothelial
cells
high
glucose
incubation,
which
was
used
vitro
retinopathy.
Western
blot
performed
measure
protein
gasdermin
D
(GSDMD),
dasdermin
E
(GSDME)
cleaved
caspase-3
cells.
Moreover,
aforementioned
further
confirmed
set.
Finally,
ceRNA
structured,
miRNAs
lncRNAs
interacted
CASP3,
TLR4,
GBP2
predicted.
Results
A
total
13
screened
six
proliferative
patients
three
samples
retinas,
including
one
downregulated
gene
12
upregulated
genes.
showed
that
there
among
KEGG
GO
analyses
functional
roles
results
mainly
related
inflammasome
complex,
interleukin-1
beta
production,
NOD-like
receptor
signaling
pathway.
In
addition,
hub
genes—CASP3,
NLRP3,
GBP2,
CASP1,
CASP4,
PYCARD,
GBP1—were
PPI
using
Cytoscape
software.
High
increased
level
GSDMD
GSDME,
critical
effectors
pyroptosis,
vascular
Verified
qRT-PCR,
all
consistent
chip.
Among
them,
GBP1,
GSE179568
dataset.
20
predicted
target
22
potentially
bind
miRNAs.
we
constructed
expected
mediate
cellular
pyroptosis
Conclusion
Through
data
GEO
software
verification
qRT-PCR
set,
successfully
involved
associated
structured.
These
findings
might
improve
understanding
mechanisms
