Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(2)
Published: Feb. 13, 2025
Language: Английский
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: April 25, 2023
In the working-age population worldwide, diabetic retinopathy (DR), a prevalent complication of diabetes, is main cause vision impairment. Chronic low-grade inflammation plays an essential role in DR development. Recently, concerning pathogenesis DR, Nod-Like Receptor Family Pyrin Domain Containing 3 (NLRP3) inflammasome retinal cells has been determined as causal factor. eye, NLRP3 activated by several pathways (such ROS and ATP). The activation NPRP3 leads to secretion inflammatory cytokines interleukin-1β (IL-1β) interleukin-18 (IL-18), pyroptosis, rapid form lytic programmed cell death (PCD). Cells that undergo pyroptosis swell rapture, releasing more factors accelerating progression. This review focuses on mechanisms activate leading DR. present research highlighted some inhibitors NLRP3/pyroptosis novel therapeutic measures treatment.
Language: Английский
Citations
58
APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 4, 2025
Language: Английский
Citations
3
Journal of Neuroinflammation, Journal Year: 2022, Volume and Issue: 19(1)
Published: July 14, 2022
Pyroptosis is a programmed cell death characterized by swift plasma membrane disruption and subsequent release of cellular contents pro-inflammatory mediators (cytokines), including IL-1β IL-18. It differs from other types such as apoptosis, autophagy, necroptosis, ferroptosis, NETosis in terms its morphology mechanism. As recently discovered form death, pyroptosis has been demonstrated to be involved the progression multiple diseases. Recent studies have also suggested that linked various ocular In this review, we systematically summarized discussed recent scientific discoveries involvement common diseases, diabetic retinopathy, age-related macular degeneration, AIDS-related human cytomegalovirus retinitis, glaucoma, dry eye disease, keratitis, uveitis, cataract. We organized new emerging evidence suggesting signaling pathways may potential therapeutic targets hoping provide summary overall intervention strategies relevant multi-dimensional evaluations for well offer valuable ideas further research development perspective pyroptosis.
Language: Английский
Citations
65
Theranostics, Journal Year: 2023, Volume and Issue: 13(11), P. 3655 - 3674
Published: Jan. 1, 2023
Diabetes is a group of chronic diseases with blood glucose imbalance, and long-term hyperglycaemia causes sustained damage to various organs the body, resulting in vascular lesions, neuropathy impaired wound healing.Diabetic formation involves variety complex mechanisms, they are characterized by persistent inflammatory response, degradation angiogenesis imbalance extracellular matrix regulation, all which related oxidative stress.Additionally, repair healing diabetic wounds require participation cells, cytokines, genes, other factors, together constitute biological regulatory network.Recent studies have shown that long noncoding RNAs (lncRNAs) can be involved regulation several key pathways cellular functions demonstrating their critical role healing.LncRNAs major family limited or no protein-coding function.Numerous recently reported strong link between stress lncRNAs.Given both lncRNAs been identified as potential drivers healing, inferred.However, specific mechanism still unclear, elucidating these processes remains challenge.This article reviews mechanisms stages discusses diagnostic treatment treat improving stress, well challenges using for this purpose.It hoped results will provide new targets strategies diagnosis patients.
Language: Английский
Citations
31
Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11
Published: May 12, 2023
Programmed cell death has crucial roles in the physiological maturation of an organism, maintenance metabolism, and disease progression. Pyroptosis, a form programmed which recently received much attention, is closely related to inflammation occurs via canonical, non-canonical, caspase-3-dependent, unclassified pathways. The pore-forming gasdermin proteins mediate pyroptosis by promoting lysis, contributing outflow large amounts inflammatory cytokines cellular contents. Although response critical for body’s defense against pathogens, uncontrolled can cause tissue damage vital factor occurrence progression various diseases. In this review, we briefly summarize major signaling pathways discuss current research on pathological function autoinflammatory diseases sterile
Language: Английский
Citations
30
Experimental Eye Research, Journal Year: 2024, Volume and Issue: 245, P. 109955 - 109955
Published: June 5, 2024
Language: Английский
Citations
10
Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(2), P. 447 - 462
Published: Jan. 21, 2024
The discovery of non-coding RNAs (ncRNAs) has unveiled a wide range transcripts that do not encode proteins but play key roles in several cellular and molecular processes. Long noncoding (lncRNAs) are specific class ncRNAs longer than 200 nucleotides have gained significant attention due to their diverse mechanisms action potential involvement various pathological conditions. In the current review article, authors focus on role lncRNAs, specifically highlighting Myocardial Infarction Associated Transcript (MIAT), non-oncological context. MIAT is nuclear lncRNA been directly linked myocardial infarction reported control post-transcriptional processes as competitive endogenous RNA (ceRNA) molecule. It interacts with microRNAs (miRNAs), thereby limiting translation expression target messenger (mRNA) regulating protein expression. Yet, implicated other numerous conditions infarction, including cardiovascular diseases, autoimmune disease, neurodegenerative metabolic many others. this review, emphasize exhibits distinct patterns functions across different emerging diagnostic, prognostic, therapeutic agent. Additionally, highlight regulatory function shed light lncRNAs diseases.
Language: Английский
Citations
9
Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12
Published: Oct. 19, 2021
Diabetic retinopathy (DR) is prevalent among people with long-term diabetes mellitus (DM) and remains the leading cause of visual impairment in working-aged people. DR related to chronic low-level inflammatory reactions. Pyroptosis an emerging type cell death mediated by gasdermin D (GSDMD), NOD-like receptors caspases that promote interleukin-1β (IL-1β) IL-18 release. In addition, retinal neurovascular unit (NVU) functional basis retina. Recent studies have shown pyroptosis may participate destruction NVU cells simulated hyperglycemic environments. this review, we will clarify importance during development DR.
Language: Английский
Citations
46
Frontiers in Endocrinology, Journal Year: 2022, Volume and Issue: 13
Published: July 25, 2022
Background Diabetic retinopathy is a diabetic microvascular complication. Pyroptosis, as way of inflammatory death, plays an important role in the occurrence and development retinopathy, but its underlying mechanism has not been fully elucidated. The purpose this study to identify potential pyroptosis-related genes by bioinformatics analysis validation model predict microRNAs (miRNAs) long non-coding RNAs (lncRNAs) interacting with them. Subsequently, competing endogenous RNA (ceRNA) regulatory network structured explore their molecular mechanism. Methods We obtained mRNA expression profile dataset GSE60436 from Gene Expression Omnibus (GEO) database collected 51 PubMmed database. differentially expressed were R software, then eight key interest identified correlation analysis, Ontology (GO) enrichment Kyoto Encyclopedia Genes Genomes (KEGG) pathway protein–protein interaction (PPI) analysis. Then, levels these validated quantitative real-time polymerase chain reaction (qRT-PCR) human retinal endothelial cells high glucose incubation, which was used vitro retinopathy. Western blot performed measure protein gasdermin D (GSDMD), dasdermin E (GSDME) cleaved caspase-3 cells. Moreover, aforementioned further confirmed set. Finally, ceRNA structured, miRNAs lncRNAs interacted CASP3, TLR4, GBP2 predicted. Results A total 13 screened six proliferative patients three samples retinas, including one downregulated gene 12 upregulated genes. showed that there among KEGG GO analyses functional roles results mainly related inflammasome complex, interleukin-1 beta production, NOD-like receptor signaling pathway. In addition, hub genes—CASP3, NLRP3, GBP2, CASP1, CASP4, PYCARD, GBP1—were PPI using Cytoscape software. High increased level GSDMD GSDME, critical effectors pyroptosis, vascular Verified qRT-PCR, all consistent chip. Among them, GBP1, GSE179568 dataset. 20 predicted target 22 potentially bind miRNAs. we constructed expected mediate cellular pyroptosis Conclusion Through data GEO software verification qRT-PCR set, successfully involved associated structured. These findings might improve understanding mechanisms
Language: Английский
Citations
32
The Journal of Nutritional Biochemistry, Journal Year: 2022, Volume and Issue: 105, P. 109001 - 109001
Published: March 26, 2022
Language: Английский
Citations
31