Journal of Inflammation Research,
Год журнала:
2023,
Номер
Volume 16, С. 5145 - 5156
Опубликована: Ноя. 1, 2023
Abnormal
changes
in
body
composition
and
systemic
inflammation
response
have
been
associated
with
poor
survival
of
cancer
patients.
Our
study
was
to
explore
the
prognostic
value
association
between
indicators
markers
among
patients
locally
advanced
cervical
(LACC)
who
underwent
concurrent
chemoradiotherapy
(CCRT).We
retrospectively
reviewed
medical
records
LACC
treated
2016
2019.
Subcutaneous,
visceral
intra-muscular
adipose
index
(SAI,
VAI
IMAI)
skeletal
muscle
(SMI)
were
derived
from
computed
tomography
(CT).
Kaplan-Meier
analysis
Univariate
multivariate
Cox
analyses
used
evaluate
survival.
A
nomogram
constructed
assess
value.The
included
196
CCRT.
According
multivariable
analyses,
IIIC1r
(P
=
0.045),
high
immune-inflammation
(SII)
0.004),
sarcopenia
0.008),
SAI
0.016)
0.001)
significantly
risk
factors
for
overall
(OS).
showed
that
low
lymphocyte-to-monocyte
ratio
(LMR)
had
longer
OS
than
those
LMR
0.023).
The
neutrophil-to-lymphocyte
(NLR)
non-sarcopenic
better
0.022).
Low
0.019)
or
IMAI
combined
SII
a
favorable
OS.
calibration
plots
predicting
3-year
5-year
rates
close
ideal
models.Inflammation
closely
abnormal
fat
distribution.
reliable
Cells,
Год журнала:
2022,
Номер
11(15), С. 2359 - 2359
Опубликована: Авг. 1, 2022
Sarcopenia
is
generally
an
age-related
condition
that
directly
impacts
the
quality
of
life.
It
also
related
to
chronic
diseases
such
as
metabolic
dysfunction
associated
with
diabetes
and
obesity.
This
means
everyone
will
be
vulnerable
sarcopenia
at
some
point
in
their
Research
find
precise
molecular
mechanisms
implicated
this
can
increase
knowledge
for
better
prevention,
diagnosis,
treatment
sarcopenia.
Our
work
gathered
most
recent
research
regarding
inflammation
new
therapeutic
agents
proposed
target
its
consequences
pyroptosis
cellular
senescence.
Finally,
we
compared
dual
X-ray
absorptiometry
(DXA),
magnetic
resonance
imaging
(MRI),
ultrasound
(US)
techniques
diagnose
follow
up
on
sarcopenia,
indicating
respective
advantages
disadvantages.
goal
scientific
evidence
presented
here
help
guide
future
understand
involved
strategies,
translation
into
clinical
practice.
Diabetes Metabolic Syndrome and Obesity,
Год журнала:
2023,
Номер
Volume 16, С. 1541 - 1554
Опубликована: Май 1, 2023
Abstract:
Diabetes
and
sarcopenia
are
emerging
as
serious
public
health
issues.
Sarcopenia,
an
age-related
disorder
characterized
by
loss
of
skeletal
muscle
mass
function,
is
recognized
a
new
complication
in
elderly
patients
with
type
2
diabetes
mellitus
(T2DM).
Type
insulin
resistance,
chronic
inflammation,
accumulation
advanced
glycation
products
increased
oxidative
stress,
which
can
negatively
affect
mass,
strength
function
leading
to
sarcopenia.
There
mutual
interrelationship
between
T2DM
light
pathophysiology
mechanism
long-term
outcome.
will
accelerate
the
decline
turn
lead
glucose
metabolism
disorders,
reduced
physical
activity
risk
diabetes.
However,
specific
involved
has
not
been
thoroughly
studied.
Therefore,
this
review
aims
explore
therapeutic
strategy
related
provide
insight
for
future
investigations,
great
significance
improving
quality
life
concurrently
reducing
incidence
complications.
Keywords:
mellitus,
sarcopenia,
gut
microbiota,
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(3), С. 2415 - 2415
Опубликована: Янв. 26, 2023
The
progressive
loss
of
skeletal
muscle
mass
and
concomitant
reduction
in
contractile
strength
plays
a
central
role
frailty
syndrome.
Age-related
neuronal
impairments
are
closely
associated
with
sarcopenia
the
elderly,
which
is
characterized
by
severe
muscular
atrophy
that
can
considerably
lessen
overall
quality
life
at
old
age.
Mass-spectrometry-based
proteomic
surveys
senescent
human
muscles,
as
well
animal
models
sarcopenia,
have
decisively
improved
our
understanding
molecular
cellular
consequences
fiber-type
shifting
during
aging.
This
review
outlines
spectrometric
identification
proteome-wide
changes
atrophying
focus
on
proteins
potential
markers
distribution
patterns.
observed
trend
fast-to-slow
transitions
individual
muscles
aging
process
most
likely
linked
to
preferential
susceptibility
fast-twitching
fibers
atrophy.
Studies
models,
including
mostly
aged
rodent
confirmed
shifting.
analysis
fast
versus
slow
isoforms
key
proteins,
such
myosin
heavy
chains,
light
actins,
troponins
tropomyosins,
suggests
them
suitable
bioanalytical
tools
Frontiers in Immunology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 8, 2024
Neutrophils
are
the
most
abundant
innate
immune
cells.
Multiple
mechanisms
allow
them
to
engage
a
wide
range
of
metabolic
pathways
for
biosynthesis
and
bioenergetics
mediating
biological
processes
such
as
development
in
bone
marrow
antimicrobial
activity
ROS
production
NET
formation,
inflammation
tissue
repair.
We
first
discuss
recent
work
on
neutrophil
functions
regulate
granulopoiesis,
migration
trafficking
well
effector
functions.
then
syndromes
with
impaired
that
influenced
by
genetic
environmental
factors
nutrient
availability
usage.
Here,
we
particularly
focus
role
specific
macronutrients,
glucose,
fatty
acids,
protein,
micronutrients
vitamin
B3,
regulating
biology
how
this
regulation
impacts
host
health.
A
special
section
review
primarily
discusses
ways
deficiencies
could
impact
increase
infection
susceptibility.
emphasize
biochemical
approaches
explore
metabolism
relation
Lastly,
opportunities
challenges
neutrophil-centered
therapeutic
immune-driven
diseases
highlight
unanswered
questions
guide
future
discoveries.
The journal of nutrition health & aging,
Год журнала:
2024,
Номер
28(4), С. 100184 - 100184
Опубликована: Фев. 12, 2024
The
aim
of
the
study
was
to
comprehensively
analyze
effects
whey
protein
(WP)-enriched
supplement
intake
with
or
without
resistance
training
(RT)
in
older
patients,
either
from
community
hospital,
who
were
diagnosed
sarcopenia
according
EWGSOP
AWGS
criteria.
Clinical Science,
Год журнала:
2023,
Номер
137(22), С. 1721 - 1751
Опубликована: Ноя. 1, 2023
Abstract
Ageing
is
a
complex
biological
process
associated
with
increased
morbidity
and
mortality.
Nine
classic,
interdependent
hallmarks
of
ageing
have
been
proposed
involving
genetic
biochemical
pathways
that
collectively
influence
trajectories
susceptibility
to
pathology
in
humans.
skeletal
muscle
undergoes
profound
morphological
physiological
changes
loss
strength,
mass,
function,
condition
known
as
sarcopenia.
The
aetiology
sarcopenia
whilst
research
this
area
growing
rapidly,
there
relative
paucity
human
studies,
particularly
older
women.
Here,
we
evaluate
how
the
nine
classic
ageing:
genomic
instability,
telomere
attrition,
epigenetic
alterations,
proteostasis,
deregulated
nutrient
sensing,
mitochondrial
dysfunction,
cellular
senescence,
stem
cell
exhaustion,
altered
intercellular
communication
contribute
pathophysiology
We
also
highlight
five
novel
particular
significance
inflammation,
neural
extracellular
matrix
reduced
vascular
perfusion,
ionic
dyshomeostasis,
discuss
are
interconnected.
Their
clinical
relevance
translational
potential
considered.
Abstract
Background
It
has
been
proposed
that
inflammation
plays
a
role
in
the
development
of
sarcopenia.
This
study
aimed
to
investigate
links
complete
blood
cell
count
(CBC)
parameters
and
CBC-derived
inflammatory
indicators
with
sarcopenia
mortality.
Methods
Data
pertaining
were
extracted
from
1999–2006
National
Health
Nutrition
Examination
Survey
(NHANES),
mortality
events
ascertained
through
Death
Index
up
December
31,
2019.
The
assessed
this
included
neutrophil-to-lymphocyte
ratio
(NLR),
derived
(dNLR),
monocyte-to-lymphocyte
(MLR),
neutrophil-monocyte
lymphocyte
(NMLR),
systemic
response
index
(SIRI),
immune-inflammation
(SII).
prognostic
significance
these
was
evaluated
using
random
survival
forests
(RSF)
analysis.
Results
encompassed
cohort
12,689
individuals,
among
whom
1,725
diagnosed
Among
individuals
sarcopenia,
782
experienced
all-cause
mortality,
195
succumbed
cardiovascular
causes.
Following
adjustment
for
confounding
variables,
it
observed
elevated
levels
NLR,
dNLR,
NMLR,
SIRI,
SII
associated
an
increased
prevalence
participants
those
highest
quartile
NLR
(HR
=
1.336
[1.095–1.631]),
dNLR
1.274
[1.046–1.550]),
MLR
1.619
[1.290–2.032]),
NMLR
1.390
[1.132–1.707]),
SIRI
1.501
[1.210–1.862])
exhibited
risk
compared
lowest
inflammation-derived
indicators.
These
associations
similarly
1.874
[1.169–3.003]
MLR,
HR
1.838
[1.175–2.878]
SIRI).
RSF
analysis
indicated
predictive
power
both
Conclusions
Our
findings
underscore
association
between
adults
Of
note,
emerged
as
most
robust
predictor
population.
