Electroacupuncture ameliorates gastrointestinal dysfunction by modulating DMV cholinergic efferent signals to drive the vagus nerve in p-MCAO rats
Heliyon,
Год журнала:
2024,
Номер
10(8), С. e29426 - e29426
Опубликована: Апрель 1, 2024
The
use
of
proton
pump
inhibitors
in
the
acute
phase
cerebral
infarction
may
lead
to
adverse
long-term
outcomes,
this
study
aims
explore
potential
electroacupuncture
(EA)
replacing
omeprazole
exerting
post-stroke
gastrointestinal
protection.
Язык: Английский
α7nACh receptor, a promising target to reduce BBB damage by regulating inflammation and autophagy after ischemic stroke
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
179, С. 117337 - 117337
Опубликована: Авг. 27, 2024
Increased
blood-brain
barrier
(BBB)
permeability
can
lead
to
cerebral
vasogenic
edema
and
hemorrhagic
transformation
(HT)
after
reperfusion
with
tissue
plasminogen
activator
(tPA),
the
only
United
States
Food
Drug
Administration
(FDA)-approved
treatment
for
acute
ischemia
stroke
(AIS).
The
therapeutic
benefits
of
tPA
AIS
are
partially
outweighed
by
a
more
than
six-fold
increase
in
risk
symptomatic
intracerebral
hemorrhage.
Therefore,
strategies
protect
integrity
BBB
urgently
needed
reduce
HT
thrombolysis
or
endovascular
thrombectomy.
Interestingly,
an
NIH
study
showed
that
smokers
treated
had
significantly
lower
prevalence
brain
hemorrhage
nonsmokers,
suggesting
cigarette
smoking
may
patients
from
side
effects
Importantly,
we
recently
nicotine
reduces
AIS-induced
damage
modulating
α7nAChR
modulation
could
ischemia/reperfusion-induced
damage,
be
potential
target
AIS.
In
this
review,
first
provide
overview
impact
activation
on
damage.
Next,
discuss
features
mechanism
destruction
We
then
effect
as
well
underlying
those
effects.
Finally,
Язык: Английский
The protective effect of the vagus nerve-α7nAChR-IL-22 pathway on acute liver injury
Cytokine,
Год журнала:
2024,
Номер
186, С. 156840 - 156840
Опубликована: Дек. 19, 2024
Язык: Английский
Neuroprotective Effects of Thymol and p-Cymene in Immobilized Male rats through Alterations in Molecular, Biochemical, Histological, and Behavioral Parameters
Neurochemical Research,
Год журнала:
2024,
Номер
50(1)
Опубликована: Ноя. 14, 2024
Язык: Английский
Porphyromonas gingivalis protease Rgp induces M1-type polarization and pyroptosis in BV-2 cells by inhibiting SIRT1 expression
Hong-Xuan Cai,
TIAN Yaguang,
SI Weixing
и другие.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 4, 2024
Abstract
Background
Periodontitis
and
Alzheimer's
disease
(AD)
are
age-related
diseases
that
reciprocally
act
as
risk
factors.
It
has
been
reported
periodontal
pathogen
Porphyromonas
gingivalis
its
gingipains
contribute
to
neuroinflammation
mediated
by
microglial
cells,
playing
a
crucial
role
in
the
onset
of
AD.
However,
it
remains
unclear
whether
play
pro-inflammatory
inducing
senescent
phenotypic
changes
cells.
Methods
BV-2
cells
were
cultured
stimulated
with
gingival
protease
(Rgp),
combination
or
not
SRT1720,
an
inhibitor
SIRT1.
SA-βgal
staining
was
used
observe
altered
cellular
phenotype.
Immunoprotein
blotting
real-time
fluorescence
quantitative
polymerase
chain
reaction
(RT-qPCR)
confirm
results
SIRT1,
NLRP3,
Caspase-1
GSDMD
expression.
ELISA
flow
cytometry
detect
IL-1β
IL-18
levels
supernatants
M1
polarization
Results
Rgp
induced
present
phenotype
downregulated
expression
senescence-related
protein
showed
concentration-dependent
upregulation
NLRP3
upon
stimulation,
accompanied
significant
increase
M1-type
Simultaneously,
pyroptosis-related
proteins
increased,
analysis
indicated
pyroptosis
Further
restoration
verification
using
SIRT1
activator
SRT1720
that,
compared
stimulation
group,
intervention
group
exhibited
increased
decreased
expression,
reduction
polarization.
Additionally,
decreased,
cell
significantly
reduced.
Conclusions
promoted
inhibiting
thereby
exacerbating
inflammatory
response.
Язык: Английский
α7 nicotinic receptor activation mitigates herpes simplex virus type 1 infection in microglia cells
Antiviral Research,
Год журнала:
2024,
Номер
228, С. 105934 - 105934
Опубликована: Июнь 15, 2024
Язык: Английский
Protective effects of seed oil from Nicotiana tabacum L. On D-galactose induced liver and brain damages of mice by regulating PI3K/Akt/Nrf2 signaling pathway
Journal of Functional Foods,
Год журнала:
2024,
Номер
124, С. 106628 - 106628
Опубликована: Дек. 12, 2024
Язык: Английский