Electroacupuncture ameliorates gastrointestinal dysfunction by modulating DMV cholinergic efferent signals to drive the vagus nerve in p-MCAO rats

Heliyon, Journal Year: 2024, Volume and Issue: 10(8), P. e29426 - e29426

Published: April 1, 2024

The use of proton pump inhibitors in the acute phase cerebral infarction may lead to adverse long-term outcomes, this study aims explore potential electroacupuncture (EA) replacing omeprazole exerting post-stroke gastrointestinal protection.

Language: Английский

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α7nACh receptor, a promising target to reduce BBB damage by regulating inflammation and autophagy after ischemic stroke

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117337 - 117337

Published: Aug. 27, 2024

Increased blood-brain barrier (BBB) permeability can lead to cerebral vasogenic edema and hemorrhagic transformation (HT) after reperfusion with tissue plasminogen activator (tPA), the only United States Food Drug Administration (FDA)-approved treatment for acute ischemia stroke (AIS). The therapeutic benefits of tPA AIS are partially outweighed by a more than six-fold increase in risk symptomatic intracerebral hemorrhage. Therefore, strategies protect integrity BBB urgently needed reduce HT thrombolysis or endovascular thrombectomy. Interestingly, an NIH study showed that smokers treated had significantly lower prevalence brain hemorrhage nonsmokers, suggesting cigarette smoking may patients from side effects Importantly, we recently nicotine reduces AIS-induced damage modulating α7nAChR modulation could ischemia/reperfusion-induced damage, be potential target AIS. In this review, first provide overview impact activation on damage. Next, discuss features mechanism destruction We then effect as well underlying those effects. Finally,

Language: Английский

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The protective effect of the vagus nerve-α7nAChR-IL-22 pathway on acute liver injury

Cytokine, Journal Year: 2024, Volume and Issue: 186, P. 156840 - 156840

Published: Dec. 19, 2024

Language: Английский

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Neuroprotective Effects of Thymol and p-Cymene in Immobilized Male rats through Alterations in Molecular, Biochemical, Histological, and Behavioral Parameters

Neurochemical Research, Journal Year: 2024, Volume and Issue: 50(1)

Published: Nov. 14, 2024

Language: Английский

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Porphyromonas gingivalis protease Rgp induces M1-type polarization and pyroptosis in BV-2 cells by inhibiting SIRT1 expression

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 4, 2024

Background Periodontitis and Alzheimer's disease (AD) are age-related diseases that reciprocally act as risk factors. It has been reported periodontal pathogen Porphyromonas gingivalis its gingipains contribute to neuroinflammation mediated by microglial cells, playing a crucial role in the onset of AD. However, it remains unclear whether play pro-inflammatory inducing senescent phenotypic changes cells. Methods BV-2 cells were cultured stimulated with gingival protease (Rgp), combination or not SRT1720, an inhibitor SIRT1. SA-βgal staining was used observe altered cellular phenotype. Immunoprotein blotting real-time fluorescence quantitative polymerase chain reaction (RT-qPCR) confirm results SIRT1, NLRP3, Caspase-1 GSDMD expression. ELISA flow cytometry detect IL-1β IL-18 levels supernatants M1 polarization Results Rgp induced present phenotype downregulated expression senescence-related protein showed concentration-dependent upregulation NLRP3 upon stimulation, accompanied significant increase M1-type Simultaneously, pyroptosis-related proteins increased, analysis indicated pyroptosis Further restoration verification using SIRT1 activator SRT1720 that, compared stimulation group, intervention group exhibited increased decreased expression, reduction polarization. Additionally, decreased, cell significantly reduced. Conclusions promoted inhibiting thereby exacerbating inflammatory response.

Language: Английский

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α7 nicotinic receptor activation mitigates herpes simplex virus type 1 infection in microglia cells

Antiviral Research, Journal Year: 2024, Volume and Issue: 228, P. 105934 - 105934

Published: June 15, 2024

Language: Английский

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Protective effects of seed oil from Nicotiana tabacum L. On D-galactose induced liver and brain damages of mice by regulating PI3K/Akt/Nrf2 signaling pathway

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 124, P. 106628 - 106628

Published: Dec. 12, 2024

Language: Английский

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