The role of the Mediterranean diet in reducing the risk of cognitive impairement, dementia, and Alzheimer’s disease: a meta-analysis

GeroScience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 11, 2025

Abstract Age-related cognitive impairment and dementia pose a significant global health, social, economic challenge. While Alzheimer’s disease (AD) has historically been viewed as the leading cause of dementia, recent evidence reveals considerable impact vascular (VCID), which now accounts for nearly half all cases. The Mediterranean diet—characterized by high consumption fruits, vegetables, whole grains, fish, olive oil—has widely recognized its cardiovascular benefits may also reduce risk decline dementia. To investigate protective effects diet on we conducted systematic literature review using PubMed, Web Science, Google Scholar, focusing studies published between 2000 2024. included in meta-nalysis examined adherence to incidence AD. We applied random-effects model calculate pooled hazard ratios (HRs) with 95% confidence intervals (CIs) assessed heterogeneity through I -square statistics. Forest plots, funnel Z -score plots were used visualize study outcomes. Of 324 full-text records reviewed, 23 met inclusion criteria. combined HR among those adhering was 0.82 (95% CI 0.75–0.89); 0.89 0.83–0.95); AD, 0.70 0.60–0.82), indicating substantial effects. Significant observed across studies, though suggested sufficient sample sizes support reliable conclusions each condition. In conclusion, this meta-analysis confirms that is associated an 11–30% reduction age-related disorders, including impairment, These findings underscore diet’s potential central element neuroprotective public health strategies mitigate promote healthier aging.

Язык: Английский

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Mediterranean Diet and Quality of Life in Adults: A Systematic Review

Nutrients, Год журнала: 2025, Номер 17(3), С. 577 - 577

Опубликована: Фев. 5, 2025

Background/Objectives: With the increasing life expectancy and, as a result, aging of global population, there has been rise in prevalence chronic conditions, which can significantly impact individuals’ health-related quality life, multidimensional concept that comprises an individual’s physical, mental, and social wellbeing. While balanced, nutrient-dense diet, such Mediterranean is widely recognized for its role disease prevention, particularly reducing risk cardiovascular diseases certain cancers, potential benefits extend beyond these well-known effects, showing promise improving physical mental wellbeing, promoting life. Methods: A systematic search scientific literature electronic databases (Pubmed/Medline) was performed to identify potentially eligible studies reporting on relation between adherence diet published up December 2024. Results: total 28 were included this review, comprising 13 conducted among general population 15 involving various types patients. Overall, most showed significant association HRQoL, with results retrieved domains suggesting seems play relevant both people affected by conditions inflammatory basis. Conclusions: Adherence provides preventing managing commonly associated populations. Furthermore, it enhances overall health individuals, ultimately supporting more effective less invasive treatment approaches diseases.

Язык: Английский

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Sleep and the Mediterranean diet: A systematic review and meta-analysis

Sleep Medicine Reviews, Год журнала: 2025, Номер 80, С. 102071 - 102071

Опубликована: Фев. 7, 2025

Язык: Английский

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Pain-Free Alpha-Synuclein Detection by Low-Cost Hierarchical Nanowire Based Electrode

Nanomaterials, Год журнала: 2024, Номер 14(2), С. 170 - 170

Опубликована: Янв. 12, 2024

Analytical methods for the early detection of neurodegenerative biomarker Parkinson’s disease (PD), α-synuclein, are time-consuming and invasive, require skilled personnel sophisticated expensive equipment. Thus, a pain-free, prompt simple α-synuclein biosensor in plasma is highly demanded. In this paper, an electrochemical based on hierarchical polyglutamic acid/ZnO nanowires decorated by gold nanoparticles, assembled as nanostars (NSs), determination human proposed. ZnO NSs were prepared chemical bath deposition (CBD) with electrodeposited Au nanoparticles (Au NPs). Then, electro-polymerized glutamic acid was grown functionalized anti-α-synuclein. A synergistic enhancement electrode sensitivity observed when NPs embedded into NSs. The analytical performance evaluated cyclic voltammetry (CV) impedance spectroscopy (EIS), using Fe(II)(CN)64−/Fe(III)(CN)63− probe. charge transfer resistance after recognition found to be linear, concentration range 0.5 pg·mL−1 10 pg·mL−1, limit 0.08 good reproducibility (5% variation) stability (90%). also shown reliably discriminate between healthy PD plasma. These results suggest that proposed provides rapid, quantitative high-sensitivity result content plasma, represents feasible tool capable accelerating non-invasive identification disease.

Язык: Английский

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Impact of adherence to the Mediterranean diet on stroke risk

GeroScience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

Abstract Stroke is a leading cause of morbidity and mortality worldwide, dietary patterns have emerged as significant modifiable factor in stroke prevention. The Mediterranean diet, characterized by high intake fruits, vegetables, whole grains, nuts, olive oil, fish, has been widely recognized for its cardiovascular benefits. However, specific impact on risk requires further elucidation. We conducted comprehensive meta-analysis 30 studies, including both cohort case–control designs, to evaluate the relationship between adherence diet stroke. A systematic search was performed across multiple databases, random-effects model used estimate pooled hazard ratios (HRs) with 95% confidence intervals (CIs). Heterogeneity assessed using I 2 statistic, publication bias examined through funnel plots Egger’s regression test. Additionally, trial sequential analysis determine adequacy sample size. revealed reduction among individuals adhering HR 0.88 (95% CI: 0.84–0.91). Notably, heterogeneity detected ( = 34%). Z-score plot from confirmed that sizes were sufficient draw definitive conclusions. potential identified. studies highly effect (HR 0.54, 0.4–0.73). settings hinted at presence bias, supported Our findings provide robust evidence supporting protective against Despite some cumulative suggests promoting could serve an effective public health strategy Further research recommended explore underlying mechanisms assess diet’s diverse populations.

Язык: Английский

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Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications

Nutrients, Год журнала: 2025, Номер 17(8), С. 1351 - 1351

Опубликована: Апрель 15, 2025

Vitamin D plays a crucial role in the regulation of immune system, with immunomodulatory effects that are key prevention colorectal cancer (CRC). Over past decades, research has shown this steroid hormone impacts much more than bone health, significantly influencing responses. enhances organ functions such as spleen and lymph nodes, boosts T-cell activity, which is essential defending body against tumors. Additionally, vitamin mitigates inflammatory responses closely linked to development, reducing inflammation contributes CRC. It acts via receptors (VDRs) expressed on cells, modulating Adequate levels influence gene expression related cell proliferation, inhibiting tumor development. also activates mechanisms suppress survival, migration, metastasis. Low have been associated an increased risk CRC, deficiency correlating higher disease incidence. Lifestyle factors, diet high red meat calories but low fiber, fruits, vegetables, well physical inactivity, contribute CRC risk. Insufficient calcium intake occurrence poorer clinical outcomes. Maintaining optimal adequate dietary preventing improving patient prognosis. This review explores summarizes findings from randomized trials assessing supplementation

Язык: Английский

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Adherence to the Mediterranean diet and its protective effects against colorectal cancer: a meta-analysis of 26 studies with 2,217,404 participants

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Авг. 1, 2024

Abstract Colorectal cancer (CRC) is a major global health concern and represents significant public challenge in Hungary, where it exhibits some of the highest morbidity mortality rates European Union. The Mediterranean diet has been suggested to reduce incidence CRC, but comprehensive evidence from diverse study designs needed substantiate this effect. A systematic literature search was conducted PubMed, ClinicalTrials.gov, CENTRAL, Web Science identify randomized controlled trials human clinical 2008 2024 relevant studies. Statistical analysis performed using https://metaanalysisonline.com web application random effects model estimate pooled hazard (HRs). Forest plots, funnel Z -score plots were utilized visualize results. We identified 15 9 case–control studies, encompassing total 2,217,404 subjects. indicated that adherence significantly reduced prevalence CRC (HR = 0.84, 95% CI 0.78–0.91, p < 0.01). This protective effect consistent across sexes, with HRs 0.85 (95% 0.75–0.97, 0.01) for males 0.88 0.79–0.99, 0.03) females. Case–control studies specifically showed substantial 0.51, 0.38–0.68, Notable heterogeneity observed yet priori information size substantially below cumulative sample size, ensuring sufficient data reliable conclusions. findings meta-analysis reinforce role against CRC. results will inform dietary interventions designed mitigate risk, which are within framework Semmelweis Study, an ongoing cohort at University, explore multifaceted causes unhealthy aging Hungary. These aim practical patterns reducing among Hungarian population.

Язык: Английский

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Mediterranean Diet and Mental Health in Children and Adolescents: A Systematic Review

Nutrition Reviews, Год журнала: 2024, Номер unknown

Опубликована: Май 17, 2024

Abstract Context Childhood and adolescence are periods of critical importance in the development mental health disorders. The Mediterranean diet (MD) has been linked to multiple positive outcomes, including reduced incidence disorders fewer psychiatric symptoms. Objective This study aimed investigate association between adherence an MD outcomes children adolescents. Methods A systematic literature review was conducted original research that explored relationship symptoms or MD. search on PubMed, Scopus, Web Science, MEDES, Dialnet, Latindex from inception November 2022, Newcastle-Ottawa Scale used evaluate quality studies. Results total 13 studies (6 cross-sectional, 4 case-control, 2 randomized clinical trials, 1 longitudinal cohort) out 450 met inclusion criteria. 3058 adolescents with a mean age range 8.6 16.2 years were included. Among reviewed studies, 5 (71.42%) those looking at attention-deficit/hyperactivity disorder, (80%) examining depression, (50%) assessing anxiety found significant protective association. Seven articles (53.84%) be high 6 (46.15%) moderate quality. Conclusion Adherence could factor for child adolescent populations. suggests promoting help prevent onset symptoms, reduce symptom severity, improve prognosis young patients. Systematic Review Registration PROSPERO registration no. CRD42021276316.

Язык: Английский

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Adherence and Sociodemographic Determinants of Adherence to the Mediterranean Diet among Slovenian Adults and the Elderly

Nutrients, Год журнала: 2023, Номер 15(14), С. 3219 - 3219

Опубликована: Июль 20, 2023

The Mediterranean diet (MD) is considered a model for good health, and promoted worldwide as one of the healthiest dietary patterns. Despite MD’s health benefits, literature suggests that adherence to MD tends be in decline most populations worldwide, including those region. aim this study was investigate MD, its main sociodemographic lifestyle factors, Slovenian population. Using nationwide cross-sectional food consumption survey (SI.Menu), data were collected from general questionnaire, 14-item screener (14-MEDAS score), questionnaire on habits 850 adults elderly people. mean MEDAS score total sample 5.6 (SD 2.1), indicating low among higher women (OR = 1.534; 95% Cl 1.156–2.034), with university degree 1.527; 1.098–2.125; compared no degree), who lived suburb or city 1.511; 1.016–2.249; OR 1.568; 1.122–2.191; village), non-smokers 1.561; 1.380–1.830; smokers), western part Slovenia 1.558; 1.170–2.074; eastern Slovenia). Adherence population low, strongly related educational level, gender, geographic region, place residence, smoking status. frequency different groups also closely related.

Язык: Английский

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Effects of repetitive transcranial magnetic stimulation combined with cognitive training on cognitive function in patients with Alzheimer’s disease: a systematic review and meta-analysis

Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 15

Опубликована: Янв. 25, 2024

Purpose To evaluate the effect of repetitive transcranial magnetic stimulation (rTMS) paired with cognitive training on function in Alzheimer’s Disease (AD) patients. Methods PubMed, The Cochrane Library, Embase, CINAHL Complete (EBSCO), China National Knowledge Infrastructure (CNKI) and WanFang Database were searched. risk bias was appraised through collaboration tool. A meta-analysis conducted, including an assessment heterogeneity. Results Ten studies comprising 408 participants included. addition rTMS significantly improved overall cognition patients compared intervention alone ( p &lt; 0.05 for all tests). treatment also had some continuity, significant improvements within weeks after ended Conclusion Repetitive combined (rTMS-CT) is a valuable technique rehabilitation AD It beneficial to improve ability restore their functional state. results study may provide basis clinical providers implement interventions that facilitate design more rigorous high-quality interventions. Limitations number sample size our small. We did not explore possible interactions between medications mood improvement due inadequate data. Systematic review registration This registered PROSPERO CRD42023405615.

Язык: Английский

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