Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 14, 2024
AbstractEleutherococcus
senticosus
essential
oil
(ESEO)
has
the
function
of
clearing
heat
and
detoxifying,
delaying
aging.
The
ESEO
yield
obtained
by
traditional
extraction
methods
is
low
because
oils
are
encased
in
plant
cell
structures
difficult
to
extract.
In
this
study,
we
adopted
method
glucose
oxidase
promoting
cellulase
assisted
hydrogenation
distillation(GCAHD),
utilized
interaction
promote
full
destruction
cellulose
cells,
resulting
a
large
amount
internal
flowing
out
improving
ESEO.
By
optimizing
main
factors
enzymatic
hydrolysis,
optimal
conditions
for
E.
were
determined
through
BBD
experiments.
ratio
1:20,
concentration
enzyme
1.02%,
temperature
hydrolysis
40.0
℃,
pH
value
3.44.
was
0.14%.
extracted
from
increased
49.9%
compared
single
method.
process
used
work
milder,
more
environmentally
friendly,
efficient,
which
important
reference
industrial
utilization
medicinal
plants.
Plants,
Год журнала:
2024,
Номер
13(2), С. 184 - 184
Опубликована: Янв. 10, 2024
Stilbenes
are
a
group
of
plant
phenolic
secondary
metabolites,
with
trans-resveratrol
(3,5,4'-trihydroxy-trans-stilbene)
being
recognized
as
the
most
prominent
and
studied
member.
have
great
potential
for
use
in
agriculture
medicine,
they
significant
activities
against
pathogens
valuable
beneficial
effects
on
human
health.
In
this
study,
we
analyzed
direct
application
stilbenes,
stilbene
precursor,
stilbene-rich
extract
solutions
to
foliar
surface
increasing
resistance
Arabidopsis
thaliana
various
abiotic
stresses
(heat,
cold,
drought,
soil
salinity).
Exogenous
treatment
A.
stilbenes
(trans-resveratrol,
piceid,
spruce
bark
extract)
precursor
(p-coumaric
acid
or
CA)
during
germination
resulted
considerable
growth
retardation
plants:
strong
delay
root
stem
length
1-week-old
seedlings
(in
1.3-4.5
fold)
rosette
diameter
1-month-old
plants
1.2-1.8
fold),
while
2-month-old
treated
were
not
significantly
different
size
from
control.
Plant
treatments
CA
increased
heat
and,
lesser
extent,
salinity
(only
t-resveratrol
drought
CA),
cold
was
affected.
increase
survival
rates
under
heat,
showing
1.5-2.3
times
higher
compared
untreated
plants.
Thus,
exogenous
able
improve
certain
via
specific
activation
genes
involved
biosynthesis
auxins,
gibberellins,
abscisic
acid,
some
stress-related
genes.
The
present
work
provides
new
insights
into
stress
tolerance.
Chemistry & Biodiversity,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 11, 2025
ABSTRACT
Eleutherococcus
senticosus
essential
oil
(ESEO)
has
the
function
of
clearing
heat
and
detoxifying,
delaying
aging.
The
ESEO
yield
obtained
by
traditional
extraction
methods
is
low
because
oils
are
encased
in
plant
cell
structures
difficult
to
extract.
In
this
work,
we
adopted
method
glucose
oxidase
promoting
cellulase‐assisted
hydrodistillation,
utilized
interaction
cellulase
promote
full
destruction
cellulose
cells,
resulting
a
large
amount
internal
flowing
out
improving
ESEO.
By
optimizing
main
factors
enzymatic
hydrolysis,
optimal
conditions
for
were
determined
through
Box–Behnken
design
experiments.
ratio
1:20,
concentration
enzyme
1.02%,
temperature
hydrolysis
40.0°C,
pH
value
3.44.
was
0.140%.
extracted
from
E.
increased
49.9%
compared
single
method.
process
used
work
milder,
more
environmentally
friendly,
efficient,
which
important
reference
industrial
utilization
medicinal
plants.
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 27, 2025
This
study
investigated
the
effects
of
2,4-epibrassinolide
(EBR)
residues
on
Dendrobium
officinale
quality.
The
decreased
from
0.164
to
0.238
mg/kg
(2
h)
0.014–0.071
(35
d)
in
stems
with
0.02–0.05
mg/L
EBR
applications.
Polysaccharide,
mannose,
and
glucose
content
were
increased
leaves,
reaching
a
maximum
61%
dried
35
d.
increase
may
result
significant
upregulation
enzyme
activities,
including
UGP,
SUS,
SPS.
Further
analysis
by
nontargeted
metabolomics
revealed
5
upregulated
(UDP-l-rhamnose,
mannose-6-phosphate,
GDP-mannose,
chitobiose,
N-acetyl-galactosamine-6-phosphate)
13
downregulated
metabolites
associated
polysaccharide
monosaccharide
growth
treatments.
These
differential
regulate
biosynthesis
polysaccharides
mainly
through
key
metabolic
pathways,
such
as
fructose
metabolism.
results
provide
reference
for
regulatory
mechanisms
governing
quality
indicators
after
application.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 2121 - 2121
Опубликована: Фев. 27, 2025
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder
characterized
by
gradual
decline
in
cognitive
function.
Currently,
there
are
no
effective
treatments
for
this
condition.
Medicine
food
homology
plants
have
gained
increasing
attention
as
potential
natural
AD
because
of
their
nutritional
value
and
therapeutic
benefits.
In
work,
we
aimed
to
provide
deeper
understanding
how
medicine
may
help
alleviate
or
potentially
treat
identifying
key
targets,
pathways,
small
molecule
compounds
from
10
that
play
an
important
role
process.
Using
network
pharmacology,
identified
623
common
targets
between
the
selected
plants,
including
crucial
proteins
such
STAT3,
IL6,
TNF,
IL1B.
Additionally,
molecules
were
grouped
into
four
clusters
using
hierarchical
clustering.
The
ConPlex
algorithm
was
then
applied
predict
binding
capabilities
these
protein
targets.
Cluster
3
showed
superior
predicted
IL1B,
which
further
validated
molecular
docking.
Scaffold
analysis
revealed
those
with
steroid-like
core-comprising
three
fused
six-membered
rings
one
five-membered
ring
carbon-carbon
double
bond-exhibited
better
affinities
triple-target
inhibitors.
Among
them,
MOL005439,
MOL000953,
MOL005438
top-performing
compounds.
This
study
highlights
source
active
could
be
developed
new
drugs
treatment.
However,
pharmacokinetic
studies
essential
assess
efficacy
minimize
side
effects.
Food Chemistry X,
Год журнала:
2024,
Номер
23, С. 101742 - 101742
Опубликована: Авг. 14, 2024
Merging
traditional
Chinese
medicine's
(TCM)
principles
of
medicine-food
homology
with
modern
flavor
chemistry,
this
research
unveils
PungentDB
(http://www.pungentdb.org.cn/home),
a
database
documenting
205
unique
pungent
compounds
from
231
TCMs.
It
provides
detailed
insights
into
their
chemical
attributes,
biological
targets
(including
IC50/EC50
values),
and
molecular
structures
(2D/3D),
enriched
visualizations
target
organ
distribution
protein
structures,
exploring
the
space
help
feature-rich
visual
interface.
This
collection,
derived
over
3249
sources
highlighting
9129
targets,
delves
compounds'
flavors-taste,
aroma,
thermal
sensations-and
interaction
taste
olfactory
receptors.
bridges
ancient
wisdom
culinary
innovation,
offering
nuanced
exploration
flavors'
role
in
enhancing
food
quality,
safety,
sensory
experiences.
initiative
propels
chemistry
forward,
serving
as
pivotal
resource
for
science
advancement
innovative
application
flavors.
Chemistry & Biodiversity,
Год журнала:
2024,
Номер
21(5)
Опубликована: Апрель 11, 2024
Abstract
Garlic
oil
has
a
wide
range
of
biological
activities,
and
its
broad‐spectrum
activity
against
phytopathogenic
fungi
still
the
potential
to
be
explored.
In
this
study,
enzymatic
treatment
garlic
resulted
in
an
increase
approximately
50
%
yield
essential
oil,
feasible
GC‐MS
analytical
program
for
was
provided.
Vacuum
fractionation
volatile
determination
inhibitory
10
demonstrated
that
good
antifungal
activity.
The
levels
were
ranked
as
diallyl
trisulfide
(
S‐3
)>diallyl
disulfide
S‐2
monosulfide
S‐1
),
with
EC
value
Botrytis
cinerea
reached
8.16
mg/L.
Following
structural
modification
compound
,
series
derivatives,
including
compounds
S‐4~7
synthesized
screened
their
findings
unequivocally
dimethyl
S‐4
)
exhibited
exceptional
Sclerotinia
sclerotiorum
6.83
SEM,
vivo
experiments,
changes
mycelial
nucleic
acids,
soluble
proteins
sugar
leakage
further
confirmed
study
indicated
bond
structure
key
activity,
which
can
developed
into
new
type
green
plant‐derived
fungicide
plant
protection.
