Transdermal delivery of resveratrol loaded solid lipid nanoparticle as a microneedle patch: a novel approach for the treatment of Parkinson’s disease

Drug Delivery and Translational Research, Год журнала: 2024, Номер unknown

Опубликована: Июнь 29, 2024

Язык: Английский

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Investigating the Interplay Between the Nrf2/Keap1/HO-1/SIRT-1 Pathway and the p75NTR/PI3K/Akt/MAPK Cascade in Neurological Disorders: Mechanistic Insights and Therapeutic Innovations

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 7, 2025

Язык: Английский

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Role of manganese in brain health and disease: focus on oxidative stress

Free Radical Biology and Medicine, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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Resveratrol-like Compounds as SIRT1 Activators

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(23), С. 15105 - 15105

Опубликована: Дек. 1, 2022

The sirtuin 1 (SIRT1) activator resveratrol has emerged as a promising candidate for the prevention of vascular oxidative stress, which is trigger endothelial dysfunction. However, its clinical use limited by low oral bioavailability. In this work, we have applied previously developed computational protocol to identify most derivatives from our in-house chemical library derivatives. compounds in terms SIRT1 activation and bioavailability, predicted silico, were evaluated their ability activate isolated enzyme. Then, assessed antioxidant effects effective derivative, compound 3d, human umbilical vein cells (HUVECs) injured with H2O2 100 µM. 3d significantly preserved cell viability prevented an intracellular reactive oxygen species increase HUVECs exposed stimulus. Such partially reduced presence inhibitor, sirtinol, confirming potential role sirtuins activity Although appeared less than activating enzyme, exhibited both almost superimposable, suggesting higher cross membranes target SIRT1.

Язык: Английский

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SIRT1/PGC-1α is involved in arsenic-induced male reproductive damage through mitochondrial dysfunction, which is blocked by the antioxidative effect of zinc

Environmental Pollution, Год журнала: 2023, Номер 320, С. 121084 - 121084

Опубликована: Янв. 18, 2023

Язык: Английский

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Formononetin promotes fatty acid β-oxidation to treat non-alcoholic steatohepatitis through SIRT1/PGC-1α/PPARα pathway

Phytomedicine, Год журнала: 2023, Номер 124, С. 155285 - 155285

Опубликована: Дек. 16, 2023

Язык: Английский

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Manganese overexposure induces Parkinson-like symptoms, altered lipid signature and oxidative stress in C57BL/6 J mouse

Ecotoxicology and Environmental Safety, Год журнала: 2023, Номер 263, С. 115238 - 115238

Опубликована: Июль 11, 2023

Although adequate intake of manganese (Mn) is essential to humans, Mn in excess neurotoxic. Exposure extremely high doses results "manganism", a condition that exhibits Parkinson-like symptoms. However, the mechanisms underlying its neurotoxic effects Mn-induced parkinsonism pathogenesis are unclear. In this study, 8-week-old male C57BL/6 J mice were injected intraperitoneally with saline and 50 mg/kg MnCl2 respectively once daily for 14 days produce an acute neurotoxicity model. Accumulation midbrain, motor dysfunction loss dopaminergic neurons substantia nigra evidenced neurotoxicity. Untargeted lipidomic analysis demonstrated overexposure altered lipidome profiles. A significant modulation 12 lipid subclasses belonging 5 different categories found midbrain among most abundant lipids sphingolipids, glycerophospholipids, glycerides. The levels sphingomyelin (SM) significantly decreased after treatment. expression SM biosynthesis genes was dramatically while sphingomyelinase up-regulated. addition, we observed oxidative stress both MN9D cells, indicated by increase MDA level, decrease reduced GSH level inhibition SOD GPx enzyme activities. There correlation between these changes dysfunctions. Overall, our study first use lipidomics techniques explore mice. induced molecular events such as metabolism disorders, injury, may mechanistically play important roles Moreover, findings emphasize necessity reducing health risk environmental pollutants relation parkinsonism.

Язык: Английский

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Di(2‐ethylhexyl) phthalate and microplastics cause necroptosis and apoptosis in hepatocytes of mice by inducing oxidative stress

Environmental Toxicology, Год журнала: 2023, Номер 38(6), С. 1226 - 1238

Опубликована: Март 8, 2023

Abstract Di(2‐ethylhexyl) phthalate (DEHP) is a plasticizer and an endocrine disruptor. Microplastics (MPs) are pathogenic small plastic particles abundant in the aqueous environment. The problem of residual hazards products worthy study, especially joint exposure variety plastic‐related to toxic effect. We used 200 mg/kg DEHP 10 mg/L MPs establish model vivo 2 mM μg/L AML12 cell vitro. In study results showed that compared with control group (NC) group, significantly increased contents malondialdehyde hydrogen peroxide, decreased glutathione activity superoxide dismutase, total antioxidant capacity, catalase peroxidase. level oxidative stress was further aggravated after combined exposure. reactive oxygen species exposed vitro higher than NC single also confirmed could increase mRNA protein levels apoptosis markers necroptosis there additive After N‐acetylcysteine treatment vitro, above‐mentioned damage significantly. This provided reference for advocating reduction mixed use products, basis preventing harm residues.

Язык: Английский

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Manganese in autism spectrum disorder and attention deficit hyperactivity disorder: The state of the art

Current Research in Toxicology, Год журнала: 2024, Номер 6, С. 100170 - 100170

Опубликована: Янв. 1, 2024

The objective of the present narrative review was to synthesize existing clinical and epidemiological findings linking manganese (Mn) exposure biomarkers autism spectrum disorder (ASD) attention deficit hyperactivity (ADHD), discuss key pathophysiological mechanisms neurodevelopmental disorders that may be affected by this metal. Existing data demonstrated both direct inverse association between Mn body burden ASD, or lack any relationship. In contrast, majority studies revealed significantly higher levels in subjects with ADHD, as well relationship inattention scores children, although several reported contradictory results. laboratory impaired animals following associated dopaminergic dysfunction neuroinflammation. Despite evidence on Mn-induced neurobiological alterations patients ASD a plethora neurotoxic effects overexposure interfere pathogenesis inherent these disorders. Specifically, overload shown impair not only neurotransmission, but also affect metabolism glutamine/glutamate, GABA, serotonin, noradrenaline, thus affecting neuronal signaling. turn, its ability induce oxidative stress, apoptosis, neuroinflammation, and/or neurogenesis. Nonetheless, additional detailed are required evaluate environmental at wide range concentrations estimate potential dose-dependent effects, genetic factors association.

Язык: Английский

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Differential Protective Effect of Resveratrol and Its Microbial Metabolites on Intestinal Barrier Dysfunction is Mediated by the AMPK Pathway

Journal of Agricultural and Food Chemistry, Год журнала: 2022, Номер 70(36), С. 11301 - 11313

Опубликована: Сен. 6, 2022

The effectiveness of resveratrol (RES) on intestinal barrier dysfunction and colitis has been extensively studied. However, the specific effects its microbial metabolites gut function remain unclear. Hence, we compared protective RES dihydroresveratrol (DHR) 3-(4-hydroxyphenyl)-propionic acid (4HPP) against injury colitis. Only 4HPP significantly reduced paracellular permeability secretion proinflammatory cytokines in lipopolysaccharides (LPS)-treated Caco-2 cells, which was consistent with upregulation tight junction (TJ) proteins. Furthermore, ameliorated colonic inflammation mice, while DHR did not. In particular, expressions TJ proteins Muc2 were restored by 4HPP. molecular mechanism involved adenosine monophosphate-activated protein kinase (AMPK)-mediated activation CDX2 regulation SIRT1/NF-κB pathway. These findings provide new insights into understanding damage

Язык: Английский

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