Frontiers in Nutrition,
Год журнала:
2022,
Номер
9
Опубликована: Ноя. 22, 2022
Although
phthalates
are
common
environmental
pollutants,
few
studies
have
focused
on
the
relationship
of
exposure
with
non-alcoholic
fatty
liver
disease
(NAFLD)
or
fibrosis,
and
especially,
alternative
been
questioned
in
recent
years
about
whether
they
better
choices.
Thus,
this
study
aimed
to
explore
associations
major
NAFLD
fibrosis.Data
1450
adults
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2017-2018
were
collected.
The
urinary
metabolite
concentrations
di-2-ethylhexyl
phthalate
(DEHP),
diisononyl
(DINP)
diisodecyl
(DIDP)
detected.
Controlled
attenuation
parameter
(CAP)
median
stiffness
measurement
(LSM)
acquired
for
quantitative
diagnosis
fibrosis
by
vibration-controlled
transient
elastography.
Multivariate
logistic
regression
analysis
linear
performed
examine
between
fibrosis.After
adjustment
potential
factors,
prevalence
was
significantly
elevated
among
those
fourth
quartile
mono-(2-ethyl-5-carboxypentyl)
(OR,
95%CI
=
2.719,
1.296,
5.700,
P
0.016),
mono
(2-ethyl-5-hydroxyhexyl)
2.073,
1.111,
3.867,
0.037).
No
significant
association
found
NAFLD.
similar
result
gained
that
MECPP
still
associated
Ln
CAP
(Q4
vs.
Q1:
β,
0.067,
0.017,
0.118,
0.027).
After
same
covariates,
no
logistics
analysis.All
all,
higher
is
correlated
DEHP
but
not
DINP
DIDP
American
adults.
There
defined
as
LSM
≥
8
Kpa.
Nevertheless,
further
research
needed
provide
evidence
causality.
Redox Biology,
Год журнала:
2022,
Номер
59, С. 102584 - 102584
Опубликована: Дек. 22, 2022
The
global
rate
of
human
male
infertility
is
rising
at
an
alarming
owing
to
environmental
and
lifestyle
changes.
Phthalates
are
the
most
hazardous
chemical
additives
in
plastics
have
apparently
negative
impact
on
function
reproductive
system.
Ferroptosis
a
recently
described
form
iron-dependent
cell
death
has
been
linked
several
diseases.
Transferrin
receptor
(TfRC),
specific
ferroptosis
marker,
universal
iron
importer
for
all
cells
using
extracellular
transferrin.
We
aim
investigate
potential
involvement
during
toxicity,
provide
means
drawing
conclusions
effect
phthalates-induced
disease.
In
this
study,
we
found
that
di
(2-ethylhexyl)
phthalate
(DEHP)
triggered
blood-testis
barrier
(BTB)
dysfunction
mouse
testicular
tissues.
DEHP
also
induced
mitochondrial
morphological
changes
lipid
peroxidation,
which
manifestations
ferroptosis.
As
primary
metabolite
DEHP,
mono-2-ethylhexyl
(MEHP)
by
inhibiting
glutathione
defense
network
increasing
peroxidation.
TfRC
knockdown
blocked
MEHP-induced
decreasing
intracellular
levels
Fe2+.
Our
findings
indicate
can
regulate
Sertoli
therefore
novel
therapeutic
molecule
disorders
patients
with
infertility.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
72(27), С. 15334 - 15344
Опубликована: Июнь 25, 2024
Di-2-ethylhexyl
phthalate
(DEHP)
is
frequently
used
as
a
plasticizer
to
enhance
the
plasticity
and
durability
of
agricultural
products,
which
pose
adverse
effects
human
health
environment.
Aquaporin
1
(AQP1)
main
water
transport
channel
protein
involved
in
maintenance
intestinal
integrity.
However,
impact
DEHP
exposure
on
gut
its
potential
mechanisms
remain
elusive.
Here,
we
determined
that
induced
compromised
duodenum
structure,
was
concomitant
with
mitochondrial
structural
injury
epithelial
cells.
Importantly,
caused
inflammatory
cell
damage
strong
response
accompanied
by
activating
TLR4/MyD88/NF-κB
signaling
pathway.
Mechanistically,
directly
inhibits
expression
AQP1
thus
leads
an
response,
ultimately
disrupting
integrity
barrier
function.
Collectively,
our
findings
uncover
role
phthalate-induced
disorders,
could
be
promising
therapeutic
approach
for
treating
patients
disorders
or
diseases.
