Experimental and thermodynamic investigation of gemifloxacin solubility in supercritical CO2 for the production of nanoparticles

The Journal of Supercritical Fluids, Год журнала: 2024, Номер 206, С. 106165 - 106165

Опубликована: Янв. 4, 2024

Язык: Английский

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Determination of Regorafenib monohydrate (colorectal anticancer drug) solubility in supercritical CO2: Experimental and thermodynamic modeling

Heliyon, Год журнала: 2024, Номер 10(8), С. e29049 - e29049

Опубликована: Апрель 1, 2024

In this study, the solubilities of

Язык: Английский

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Binary and ternary approach of solubility of Rivaroxaban for preparation of developed nano drug using supercritical fluid

Arabian Journal of Chemistry, Год журнала: 2024, Номер 17(4), С. 105707 - 105707

Опубликована: Март 6, 2024

This study addressed the solubility of Rivaroxaban in supercritical carbon dioxide at a temperature range 308–338 K and pressure 12–30 MPa with without Co-solvent binary ternary systems. The impact ethanol was also examined. Furthermore, examined systems were modeled using semi-empirical approaches once tentative data determined. ranged based on mole fraction from 1.0×10-6 to 2.57×10-5 1.9×10-5 2.02×10-4, respectively. Based results, use can greatly boost Rivaroxaban. highest effect Rivaroxaban-Ethanol-CO2 mixture observed 18.73 (338 12 MPa). empirical models effectively fit values analyzed materials by AARD% Radj for approaches. Jouyban et al. (AARD%=7.40 = 0.993) model system Garlapati-Madras (AARD%=6.16 0.991) Sodeifian-Sajadian (AARD%=6.13 0.979) Soltani-Mazloumi (AARD%=6.89 0.987) are most accurate models.

Язык: Английский

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Solubility Measurement and Correlation of Alprazolam in Carbon Dioxide with/without Ethanol at Temperatures from 308 to 338 K and Pressures from 120 to 300 bar

Journal of Chemical & Engineering Data, Год журнала: 2024, Номер 69(4), С. 1718 - 1730

Опубликована: Март 28, 2024

This research investigated the solubility of alprazolam in supercritical carbon dioxide (scCO2) with addition ethanol as a cosolvent. The was examined at various pressures (ranging from 120 to 300 bar) and temperatures 308 338 K). scCO2 ranged 0.027 × 10–4 0.632 10–4. When used cosolvent, increased range 0.157 1.660 (with 1 mol % ethanol) 0.449 3.167 3 ethanol). Under specified operating parameters, highest achieved ternary system bar K. 16.63 times higher than when using pure under same circumstances. Several semiempirical correlations were compute dioxide. These models yielded similar average absolute relative deviations ranging 7.0 8.40%. findings demonstrated superiority Kumar–Johnston model binary systems an deviation 7.0%) Garlapati–Madras 6.19%) compared alternative models.

Язык: Английский

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Measurement and Modeling of the Solubility of Mebeverine Hydrochloride in Supercritical Carbon Dioxide

Chemical Engineering & Technology, Год журнала: 2024, Номер 47(5), С. 811 - 821

Опубликована: Апрель 1, 2024

Abstract Mebeverine hydrochloride is an important drug to treat irritable bowel syndrome. The solubility of this in supercritical carbon dioxide was measured at temperatures from 35 65 °C and pressures 12 30 MPa. Results were between 2.16 30.2 ppm by mole. data correlated with density‐based models (K‐J, MST, Chrastil, Garlapati Madras, Bartle et al., Sparks al.) equations state (Peng‐Robinson, Soave, Estévez al. models). mean relative deviation corrected correlation coefficient used assess the goodness models. Based on all ten models, performed best according average absolute (5.64 %), R adj (0.997). However, contribution's main merit reported experimental data.

Язык: Английский

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Solubility of gemcitabine (an anticancer drug) in supercritical carbon dioxide green solvent: Experimental measurement and thermodynamic modeling

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 6, 2025

In order to develop supercritical fluid (SCF) processes for the micro or nanosizing of solid solute components, such as pharmaceuticals, it is essential assess their solubility in solvents including carbon dioxide (SC–CO2). This crucial step fundamental choosing and evaluating SCF technology. A statistical method was developed used determine gemcitabine SC-CO2. The measurements at various pressures temperatures were conducted using UV–vis analysis. Two model types correlate data: semi-empirical (with 3–6 parameters) equation state (EoS) models. SC-CO2 a static 308–338 K 120–270 bar measured modeled first time. Solubility ranged from 0.1274 × 10− 5 1.8128 mole fraction 0.00295 0.08489 kg/L. PR EoS performed best 308 with an AARD 12.58%, SRK excelled 318–338 AARDs between 12.93 15.68%. Application Joback (AARD 12.04–27.13%) COSMO-RS 18.68–31.28%) models also compared. Bian et al. showed fit among density-based 16.62%.

Язык: Английский

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Solubility of oxazepam in supercritical carbon dioxide: Experimental and modeling

Fluid Phase Equilibria, Год журнала: 2024, Номер 585, С. 114165 - 114165

Опубликована: Июнь 15, 2024

Язык: Английский

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Solubility measurement of Ceftriaxone sodium in SC-CO2 and thermodynamic modeling using PR-KM EoS and vdW mixing rules with semi-empirical models

Case Studies in Thermal Engineering, Год журнала: 2024, Номер 61, С. 105074 - 105074

Опубликована: Сен. 1, 2024

The complete investigation of the solubility Ceftriaxone sodium drug has not yet been conducted. This communication investigates in supercritical CO2 (SC-CO2) for first time. measurements were performed using utilizing UV-vis analysis under different operation conditions (at P (bar) = 120-270 and T (K) 308-338). results demonstrated that ranged from 0.90 × 10-6 to 8.01 10-6. mole fraction increases proportionally with an increase pressure, while maintaining a constant temperature. However, crossover was noted. behavior SC-CO2 modeled by Peng-Robinson equation state (PR EoS) Kwak-Mansoori van der Waals mixing rules seven semi-empirical correlations (Bian et al., Kumar-Johnston, Chrastil, Garlapati-Madras, Bartle Sung-Shim Sodeifian al.,). vaporization, total solvation enthalpies sodium/SC-carbon dioxide system obtained KJ, al. correlations. evaluation two methods absolute average relative deviation (AARD%). Both models exhibited satisfactory level agreement experimental data. Finally, PR/KM EoS Chrastil models, AARD% values 8.70% 8.10% respectively, showed superior precision accurately fitting

Язык: Английский

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Study of Baclofen Solubility in Supercritical CO₂ with and without Cosolvents: Experimental Analysis, Thermodynamic Evaluation, and Machine Learning Methods

Journal of Chemical & Engineering Data, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

This study investigates the solubility of Baclofen in supercritical CO2, which is essential for developing an efficient drug delivery system using processes. Solubility measurements were carried out both with and without presence various cosolvents (ethanol dimethyl sulfoxide (DMSO)), across a temperature range 308–338 K pressure 12–30 MPa. exhibited ranging from 1.62 × 10–5 to 2.30 mole fractions pure CO2. In cosolvents, increased 5.76 12.79 ethanol 3.50 7.02 DMSO. Indeed, addition DMSO by approximately 3.55–5.56 times 2.15–3.05 times, respectively. Several density-based empirical models thermodynamic (Soave–Redlich–Kwong (SRK) Peng–Robinson (PR) equations state) used correlate data. Jafari Nejad's model CO2–Baclofen Jouyban's CO2–ethanol/DMSO–Baclofen systems displayed higher consistency. Also, PR showed better accuracy correlating while SRK outperformed CO2–ethanol/DMSO cosolvents. Moreover, machine learning exceptional accuracy, over 99% predictions closely matching experimental data, emphasizing its outstanding performance.

Язык: Английский

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Thermodynamic assessment for Rivaroxaban nanoparticle production using GAS anti-solvent (GAS) Process: Synthesis and Characterization

Journal of Molecular Liquids, Год журнала: 2025, Номер unknown, С. 127125 - 127125

Опубликована: Фев. 1, 2025

Язык: Английский

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