Gut microbiome and human health: Exploring how the probiotic genus Lactobacillus modulate immune responses

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Окт. 24, 2022

The highest density of microbes resides in human gastrointestinal tract, known as “Gut microbiome”. Of note, the members genus Lactobacillus that belong to phyla Firmicutes are most important probiotic bacteria gut microbiome. These gut-residing species not only communicate with each other but also epithelial lining balance barrier integrity, mucosal defence and ameliorate host immune responses. body suffers from several inflammatory diseases affecting gut, lungs, heart, bone or neural tissues. Mounting evidence supports significant role spp. their components (such metabolites, peptidoglycans, and/or surface proteins) modulatingimmune responses, primarily through exchange immunological signals between tract distant organs. This bidirectional crosstalk which is mediated by promotes anti-inflammatory response, thereby supporting improvement symptoms pertaining asthma, chronic obstructive pulmonary disease (COPD), neuroinflammatory multiple sclerosis, alzheimer’s disease, parkinson’s disease), cardiovascular diseases, bowel (IBD) infections patients. metabolic disorders, obesity diabetes characterized a low-grade inflammation. Genus alleviates disorders regulating oxidative stress response pathways. Osteoporosis associated inflammation resorption. metabolites act powerful cell controllers exhibit regulatory resorption formation, health. Thus, this review demonstrated mechanisms summarized benefit alleviating different organs animal clinical trials. present narrative explores detail complex interactions gut-dwelling promote host’s

Язык: Английский

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Therapeutic and Improving Function of Lactobacilli in the Prevention and Treatment of Cardiovascular-Related Diseases: A Novel Perspective From Gut Microbiota

Frontiers in Nutrition, Год журнала: 2021, Номер 8

Опубликована: Июнь 7, 2021

The occurrence and development of cardiovascular-related diseases are associated with structural functional changes in gut microbiota (GM). accumulation beneficial commensals contributes to the improvement diseases. that can be relieved by Lactobacillus supplementation, including hypercholesterolemia, atherosclerosis, myocardial infarction, heart failure, type 2 diabetes mellitus, obesity, have expanded. As probiotics, lactobacilli occupy a substantial part GM play important roles through various GM-derived metabolites. Lactobacilli ultimately impact on lipid metabolism, inflammatory factors, oxidative stress relieve symptoms However, axis cellular process commensal improving not been fully elucidated. Additionally, strains produce diverse antimicrobial peptides, which help maintain intestinal homeostasis ameliorate These field needs further investigated immediately. Thus, this review demonstrated mechanisms summarized evidence benefit strain supplementation from animal studies human clinical trials. We also highlighted broad range candidates therapeutic capability mining their Our study provides instruction as food improve

Язык: Английский

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Lactobacillus paracasei 24 Attenuates Lipid Accumulation in High-Fat Diet-Induced Obese Mice by Regulating the Gut Microbiota

Journal of Agricultural and Food Chemistry, Год журнала: 2022, Номер 70(15), С. 4631 - 4643

Опубликована: Апрель 4, 2022

Obesity has become a worldwide public health problem. Lactic acid bacteria have attracted extensive attention for alleviating obesity and fat accumulation. This study aimed to evaluate the effects of Lactobacillus paracasei 24 (LP24) on lipid accumulation in an obese mouse model induced by high-fat diet (HFD). The results showed that LP24 treatment significantly reduced body weight deposition HFD mice, improved blood levels liver steatosis, oxidative stress injury inflammatory response, regulated metabolism-related factors. Moreover, abundance diversity gut microbiota, Firmicutes ratio Firmicutes/Bacteroidetes (F/B), increased Akkermansia. In summary, regulates metabolism activating expression level related genes regulating microbiota through gut-liver axis attenuate development obesity. provides theoretical basis probiotics regulate reduce

Язык: Английский

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Lactobacillus plantarum 23-1 improves intestinal inflammation and barrier function through the TLR4/NF-κB signaling pathway in obese mice

Food & Function, Год журнала: 2022, Номер 13(11), С. 5971 - 5986

Опубликована: Янв. 1, 2022

As a natural active ingredient, lactic acid bacteria have potential anti-inflammatory effects. In this study, male C57BL/6J mice were given high-fat diet (HFD) to establish an obese mouse model. Lactobacillus plantarum 23-1 (LP23-1) with prebiotic characteristics was intervened for 8 weeks evaluate its remission effect on animals and related mechanisms. The effects of LP23-1 lipid accumulation intestinal inflammation in HFD-fed systematically evaluated by detecting accumulation, blood level, pathological changes the liver small intestine, oxidative stress inflammatory cell transport-related gene expression, signaling pathway, tight junction (TJ) mRNA protein expression. results showed that could significantly reduce body weight fat index mice, improve levels serum liver, histopathological damage alleviate response caused obesity. addition, reverse transcription-polymerase chain reaction western blot analysis regulate expression genes; activate TLR4/NF-κB pathway; inflammation; TJ proteins zona occludens-1 (ZO-1), occludin, claudin-1, Muc2; repair mucosal injury; enhance barrier function. aforementioned through pathway function reduced obesity symptoms. This study provided new insights into mechanism reducing theoretical basis developing functional foods.

Язык: Английский

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Green tea catechin epigallocatechin gallate alleviates high‐fat diet‐induced obesity in mice by regulating the gut–brain axis

Food Frontiers, Год журнала: 2023, Номер 4(3), С. 1413 - 1425

Опубликована: Май 14, 2023

Abstract Plant polyphenols have gained attention in recent years because of their potential to alleviate obesity and metabolic syndrome, protect neurological function, maintain intestinal function. Here, we evaluated the effect green tea catechin epigallocatechin gallate (EGCG) suppress obesity, inflammation, regulate hypothalamic neurotransmitters high‐fat diet mice. Obese male C57BL/6J mice were gavaged with 25, 50, or 100 mg/kg·body weight (bw) EGCG water per day for 6 weeks. The results demonstrated that significantly reduced bw, fat accumulation, liver steatosis. also modulated such as dopamine 5‐HTP. Besides, attenuated expression colonic inflammatory factors barrier damage, increased gut microbial abundance genus Alloprevotella , short‐chain fatty acids, downregulated transcription factors. suggest may related disorders through gut–brain interaction.

Язык: Английский

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Effects of Pomegranate Peel Polyphenols Combined with Inulin on Gut Microbiota and Serum Metabolites of High-Fat-Induced Obesity Rats

Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(14), С. 5733 - 5744

Опубликована: Март 30, 2023

Pomegranate peel polyphenols (PPPs) and inulin have been reported to lipid-lowering effects. Here, the effects of PPPs combined with on obesity traits change gut microbiota, short-chain fatty acids (SCFAs), serum metabolomics profiles in rats a high-fat diet (HFD) were investigated. According experimental results, most effective reducing body weight liver lipid levels. Besides, ameliorated disorder particular, enrichment SCFA producers, such as Lactobacillus, Roseburia, Christensenellaceae_R-7_group, Ruminococcaceae_UCG-005, Bacteroides, Allobaculum, depletion Blautia unclassified Lachnospiraceae population. also regulated levels metabolites changed by HFD feeding via tryptophan metabolism, valine, leucine, isoleucine biosynthesis, arachidonic acid metabolism pathways. The correlation analysis showed that remitted HFD-induced elevation triglycerides (TGs), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) lowered high-density lipoprotein (HDL) through regulating SCFAs, related metabolites. These findings elucidated good anti-obesity effect. This study extends understanding PPP high-fat-induced obesity, which includes relationship among metabolites, TG-, IL-6- TNF-α- lowering HDL-elevating functions.

Язык: Английский

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Potential Probiotic Properties of Blautia producta Against Lipopolysaccharide-Induced Acute Liver Injury

Probiotics and Antimicrobial Proteins, Год журнала: 2023, Номер 15(3), С. 785 - 796

Опубликована: Фев. 15, 2023

Язык: Английский

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Ginsenoside Rb1, Compound K and 20(S)-Protopanaxadiol Attenuate High-Fat Diet-Induced Hyperlipidemia in Rats via Modulation of Gut Microbiota and Bile Acid Metabolism

Molecules, Год журнала: 2024, Номер 29(5), С. 1108 - 1108

Опубликована: Март 1, 2024

Hyperlipidemia, characterized by elevated serum lipid concentrations resulting from metabolism dysfunction, represents a prevalent global health concern. Ginsenoside Rb1, compound K (CK), and 20(S)-protopanaxadiol (PPD), bioactive constituents derived Panax ginseng, have shown promise in mitigating disorders. However, the comparative efficacy underlying mechanisms of these compounds hyperlipidemia prevention remain inadequately explored. This study investigates impact ginsenoside CK, PPD supplementation on rats induced high-fat diet. Our findings demonstrate that Rb1 significantly decreased body weight gain, ameliorated hepatic steatosis, improved dyslipidemia HFD-fed rats, outperforming CK PPD. Moreover, distinctly modified gut microbiota composition function. increased relative abundance Blautia Eubacterium, while Akkermansia levels. Both Prevotella Bacteroides, whereas Clostridium-sensu-stricto Lactobacillus were reduced following treatment with all three compounds. Notably, only enhanced modulating PPARγ/ACC/FAS signaling pathway promoting fatty acid β-oxidation. Additionally, ginsenosides markedly bile enterohepatic circulation via FXR/CYP7A1 pathway, reducing total acids pool decreasing primary/unconjugated (CA, CDCA, β-MCA) increasing conjugated (TCDCA, GCDCA, GDCA, TUDCA), correlated changes. In conclusion, our results suggest offer promising prebiotic interventions for managing HFD-induced demonstrating superior efficacy.

Язык: Английский

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Application of metabolomics for revealing the interventional effects of functional foods on metabolic diseases

Food Chemistry, Год журнала: 2021, Номер 367, С. 130697 - 130697

Опубликована: Июль 28, 2021

Язык: Английский

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Health-Promoting Properties of Lacticaseibacillus paracasei: A Focus on Kefir Isolates and Exopolysaccharide-Producing Strains

Foods, Год журнала: 2021, Номер 10(10), С. 2239 - 2239

Опубликована: Сен. 22, 2021

Among artisanal fermented beverages, kefir (fermented milk drink) and water nondairy beverage) are of special interest because their grains can be considered natural reservoirs safe potentially probiotic strains. In the last years, several reports on Lacticaseibacillus paracasei (formerly Lactobacillus paracasei) isolated from both beverages were published focusing health-promoting properties. Although this is not predominant species in or kefir, it may contribute to health benefits associated consumption beverage. Since classification L. has been a difficult task, selection an adequate method for identification, which essential avoid mislabeling products, publications, some publicly available DNA sequences, discussed present work. The findings promoting properties bioactive compounds described compared strains providing focus exopolysaccharides as effector molecules. knowledge state art help understand contribution these microorganisms well discover new applications food industry.

Язык: Английский

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