Deleted Journal, Год журнала: 2025, Номер 2(1)
Опубликована: Март 11, 2025
Язык: Английский
Frontiers in Microbiology, Год журнала: 2024, Номер 14
Опубликована: Янв. 5, 2024
The imbalance of microbial composition and diversity in favor pathogenic microorganisms combined with a loss beneficial gut microbiota taxa results from factors such as age, diet, antimicrobial administration for different infections, other underlying medical conditions, etc. Probiotics are known their capacity to improve health by stimulating the indigenous microbiota, enhancing host immunity resistance infection, helping digestion, carrying out various functions. Concurrently, metabolites produced these microorganisms, termed postbiotics, which include compounds like bacteriocins, lactic acid, hydrogen peroxide, contribute inhibiting wide range bacteria. This review presents an update on using probiotics managing treating human diseases, including complications that may emerge during or after COVID-19 infection.
Язык: Английский
Процитировано
46
Food Hydrocolloids, Год журнала: 2024, Номер 153, С. 109956 - 109956
Опубликована: Фев. 29, 2024
Язык: Английский
Процитировано
15
Antibiotics, Год журнала: 2024, Номер 13(1), С. 53 - 53
Опубликована: Янв. 4, 2024
Bacteria of the genus
Язык: Английский
Процитировано
10
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Янв. 30, 2024
Rheumatoid arthritis (RA) and postmenopausal osteoporosis (PMOP) are common bone-immune diseases. The imbalance between helper (Th17) regulatory T cells (Tregs) produced during differentiation of CD4 + plays a key role in bone remodelling disorders RA PMOP. However, the specific mechanism this PMOP has not been clarified. Identifying underlying Th17/Treg represents factor research development new drugs for immune In review, potential roles Th17, Treg, regulating have summarised, mechanisms by which probiotics, traditional Chinese medicine compounds, monomers maintain balance expounded. maintenance could be considered as an therapeutic alternative treatment This study also summarizes advantages disadvantages conventional treatments quality life rehabilitation patients with findings presented her will provide better understanding close relationship immunity chronic diseases ideas future research, prevention,
Язык: Английский
Процитировано
9
PLoS ONE, Год журнала: 2024, Номер 19(2), С. e0297858 - e0297858
Опубликована: Фев. 21, 2024
The influence of human gut microbiota on health and disease is now commonly appreciated. Therefore, it not surprising that microbiome research has found interest in the sports community, hoping to improve optimize performance. Comparative studies new species or pathways were more enriched elites than sedentary controls. In addition, sport-specific performance-level-specific features have been identified. However, results remain inconclusive indicate need for further assessment. this case-control study, we tested two athletic populations (i.e. strength athletes, endurance athletes) a non-athletic, but physically active, control group across acute exercise bouts, separated by 2-week period, measured explosive high intensity fitness level (repeated 30-s all-out Wingate test (WT)) cardiorespiratory (Bruce Treadmill Test). While did identify any differences alpha beta diversity significant differential abundance components at baseline, one-third identified unique each group. Longitudinal sample (pre- post-exercise) analysis revealed an Alistipes communis during WT 88 with notable between-group Bruce Test. SparCC recognized Bifidobacterium longum adolescentis , short-chain fatty acid producers probiotic properties, strongly associated VO 2 max. Ultimately, several taxa different baseline abundances longitudinal changes when comparing individuals based their max, average power, maximal power parameters. Our confirmed status are consistent assumptions about health. Furthermore, our findings better performance previously elite athletes.
Язык: Английский
Процитировано
8
Cells, Год журнала: 2024, Номер 13(17), С. 1437 - 1437
Опубликована: Авг. 27, 2024
The gut microbiota plays an essential role in maintaining immune homeostasis and influencing the landscape within tumor microenvironment. This review aims to elucidate interactions between dynamics, with a focus on colorectal cancer (CRC). spans foundational concepts of immuno-microbial interplay, factors microbiome composition, evidence linking immunotherapy outcomes. Gut modulates anti-cancer immunity through several mechanisms, including enhancement surveillance modulation inflammatory responses. Specific microbial species their metabolic byproducts can significantly influence efficacy immunotherapies. Furthermore, diversity correlates clinical outcomes CRC, suggesting potential as valuable biomarker for predicting response immunotherapy. Conclusions: Understanding relationship responses offers novel therapeutic strategies development. not only influences natural history treatment CRC but also serves critical modulator activity. Further exploration into microbiome's could enhance effectiveness existing treatments guide development new modalities.
Язык: Английский
Процитировано
8
Frontiers in Immunology, Год журнала: 2025, Номер 16
Опубликована: Фев. 18, 2025
Natural food-derived bioactive compounds have garnered increasing attention for their potential to modulate immune responses and promote gut health. In particular, like mulberry-derived postbiotics (MDP) may offer novel therapeutic strategies address inflammation, a key driver of many metabolic disorders. This study examines the protective effects MDP against inflammation in LPS-induced mice, using transcriptomic microbiome analyses explore underlying mechanisms. pretreatment alleviates LPSinduced villous atrophy intestinal barrier damage, promoting recovery morphology. Transcriptomic profiling revealed significant changes gene expression, with 983 upregulated 1220 downregulated genes NC vs LPS comparison, 380 204 LPS+MDP comparison. Enrichment analysis GO KEGG pathways associations transcriptional regulatory activity, NOD-like receptor signaling pathway among differentially expressed genes. Protein-protein interaction identified involved regulation, hub IL6, CXCL10, MYD88 group CD74, CIITA, H2-AB1 MDP-treated group. Microbiome suggested also influence microbiota composition, supporting systemic regulation. These findings highlight MDP's as food additive modulation
Язык: Английский
Процитировано
1
Cell Death Discovery, Год журнала: 2025, Номер 11(1)
Опубликована: Фев. 26, 2025
Abstract Colorectal cancer (CRC) is the third most common malignancy globally and second leading cause of cancer-related mortality. Its development a multifactorial multistage process influenced by dynamic interplay between gut microbiota, environmental factors, fatty acid metabolism. Dysbiosis intestinal microbiota abnormalities in microbiota-associated metabolites have been implicated colorectal carcinogenesis, highlighting pivotal role microbial metabolic interactions. Fatty metabolism serves as critical nexus linking dietary patterns with activity, significantly impacting health. In CRC patients, reduced levels short-chain acids (SCFAs) SCFA-producing bacteria consistently observed. Supplementation probiotics has demonstrated tumor-suppressive effects, while therapeutic strategies aimed at modulating SCFA shown potential enhancing efficacy radiation therapy immunotherapy both preclinical clinical settings. This review explores intricate relationship metabolism, CRC, offering insights into underlying mechanisms their translational applications. Understanding this could pave way for novel diagnostic, therapeutic, preventive management CRC.
Язык: Английский
Процитировано
1
Biomedicines, Год журнала: 2023, Номер 11(3), С. 865 - 865
Опубликована: Март 12, 2023
Background: The integrity of the intestinal barrier is fundamental to gut health and homeostasis; its damage can increase permeability, with translocation bacteria and/or endotoxins from gut, onset various diseases. Lactobacillus spp. one most common probiotics normally found in fermented foods dairy products known for anti-inflammatory immunomodulatory properties ability protect enhance functions. aim this work was evaluate different strains improve vitro barrier, exert activity prevent Salmonella Typhimurium enteroinvasive Escherichia coli (EIEC) infections. Methods: We analyzed cellular expression tight junctions, antimicrobial peptide HBD-2, pro-inflammatory cytokines inhibition pathogens adhesion invasion a model co-cultured epithelial cells treated Results: L. brevis, reuteri rhamnosus proved be more effective protecting epithelium. Conclusions: These studies help select particularly active their intended use obtain consortia formulations that have as much maximum yield possible terms patient benefit.
Язык: Английский
Процитировано
20
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Июнь 1, 2023
Chronic low-grade inflammation affects health and is associated with aging age-related diseases. Dysregulation of the gut flora an important trigger for chronic inflammation. Changes in composition exposure to related metabolites have effect on inflammatory system host. This results development crosstalk between barrier immune system, contributing impairment health. Probiotics can increase diversity microbiota, protect barrier, regulate immunity, thereby reducing Therefore, use probiotics a promising strategy beneficial immunomodulation protection through microbiota. These processes might positively influence diseases, which are common elderly.
Язык: Английский
Процитировано
19