Modulation of the Microbiome–Fat–Liver Axis by Lactic Acid Bacteria: A Potential Alleviated Role in High-Fat-Diet-Induced Obese Mice DOI

Benliang Wei,

Zhen Peng,

Muyan Xiao

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2023, Номер 71(27), С. 10361 - 10374

Опубликована: Июнь 30, 2023

The major characteristics of obesity are abnormal lipid metabolism, chronic inflammation, and imbalanced gut microbiota. It has been reported that lactic acid bacteria (LAB) possess potential for alleviating obesity, considering which the strain-specific functions diverse mechanisms roles various LAB worthy investigation. This study aimed to validate investigate effects underlying three strains, Lactiplantibacillus plantarum NCUH001046 (LP), Limosilactobacillus reuteri NCUH064003, fermentum NCUH003068 (LF), in high-fat-diet-induced obese mice. findings demonstrated particularly LP, suppressed body weight gain fat deposition; ameliorated disorders, liver adipocyte morphology, low-grade inflammation; reduced synthesis via activating adenosine 5'-monophosphate-activated protein kinase (AMPK) signaling pathway. In addition, LP LF decreased enrichment positively correlated with like Mucispirillum, Olsenella, Streptococcus, but facilitated growth beneficial negatively Roseburia, Coprococcus, Bacteroides, along increasing short-chain fatty levels. is deduced mechanism was modulate hepatic AMPK pathway microbiota by microbiome-fat-liver axis alleviate development. conclusion, as a diet supplement, promising prevention treatment.

Язык: Английский

Exploration of the Muribaculaceae Family in the Gut Microbiota: Diversity, Metabolism, and Function DOI Open Access

Yiqing Zhu,

Borui Chen,

Xinyu Zhang

и другие.

Nutrients, Год журнала: 2024, Номер 16(16), С. 2660 - 2660

Опубликована: Авг. 12, 2024

The gut microbiota are mainly composed of

Язык: Английский

Процитировано

53
Brain targeted peptide-functionalized chitosan nanoparticles for resveratrol delivery: Impact on insulin resistance and gut microbiota in obesity-related Alzheimer's disease DOI
Licong Yang, Yabin Wang, Zhiwei Li

и другие.

Carbohydrate Polymers, Год журнала: 2023, Номер 310, С. 120714 - 120714

Опубликована: Фев. 18, 2023

Язык: Английский

Процитировано

48
Tea Polyphenol Epigallocatechin Gallate Protects Against Nonalcoholic Fatty Liver Disease and Associated Endotoxemia in Rats via Modulating Gut Microbiota Dysbiosis and Alleviating Intestinal Barrier Dysfunction and Related Inflammation DOI

Gaolong Zuo,

Meiyan Chen,

Yingpeng Zuo

и другие.

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Апрель 12, 2024

Nonalcoholic fatty liver disease (NAFLD) is characterized by fat accumulation and inflammation. Epigallocatechin gallate (EGCG) has been proven to be effective against NAFLD, but its hepatoprotective mechanisms based on the "gut microbiota-barrier-liver axis" are still not fully understood. Herein, results demonstrated that EGCG effectively ameliorated NAFLD phenotypes metabolic disorders in rats fed a high-fat diet (HFD), inhibited intestinal barrier dysfunction inflammation, which also supported experiment of Caco-2 cells. Moreover, could restore gut microbiota diversity composition, particularly promoting beneficial microbes, including short-chain acids (SCFAs) producers, such as Lactobacillus, suppressing Gram-negative bacteria, Desulfovibrio. The microbial modulation raised SCFA levels, decreased lipopolysaccharide TLR4/NF-κB pathway, strengthened function via Nrf2 pathway activation, thereby alleviating steatosis Spearman's correlation analysis showed 24 key OTUs, negatively or positively associated with disorders, were reshaped EGCG. Our suggested combinative improvement dysbiosis, dysfunction, inflammation might potential therapeutic target for NAFLD.

Язык: Английский

Процитировано

20
Adzuki Bean Alleviates Obesity and Insulin Resistance Induced by a High-Fat Diet and Modulates Gut Microbiota in Mice DOI Open Access
Qingyu Zhao, Dianzhi Hou,

Yongxia Fu

и другие.

Nutrients, Год журнала: 2021, Номер 13(9), С. 3240 - 3240

Опубликована: Сен. 17, 2021

Adzuki bean consumption has many health benefits, but its effects on obesity and regulating gut microbiota imbalances induced by a high-fat diet (HFD) have not been thoroughly studied. Mice were fed low-fat diet, HFD, HFD supplemented with 15% adzuki (HFD-AB) for 12 weeks. supplementation significantly reduced obesity, lipid accumulation, serum lipopolysaccharide (LPS) levels HFD. It also mitigated liver function damage hepatic steatosis. In particular, improved glucose homeostasis increasing insulin sensitivity. addition, it reversed HFD-induced imbalances. the ratio of Firmicutes/Bacteroidetes (F/B); enriched occurrence Bifidobacterium, Prevotellaceae, Ruminococcus_1, norank_f_Muribaculaceae, Alloprevotella, Muribaculum, Turicibacter, Lachnospiraceae_NK4A136_group, Lachnoclostridium; returned HFD-dependent taxa (Desulfovibrionaceae, Bilophila, Ruminiclostridium_9, Blautia, Ruminiclostridium) back to normal status. PICRUSt2 analysis showed that changes in may be associated metabolism carbohydrates, lipids, sulfur, cysteine methionine; LPS biosynthesis; valine, leucine, isoleucine degradation.

Язык: Английский

Процитировано

85
Chemical constituents and biological properties of Pu-erh tea DOI

Sunan Wang,

Yi Qiu, Ren‐You Gan

и другие.

Food Research International, Год журнала: 2021, Номер 154, С. 110899 - 110899

Опубликована: Дек. 15, 2021

Язык: Английский

Процитировано

80
Protective Effects of a Novel Probiotic Bifidobacterium pseudolongum on the Intestinal Barrier of Colitis Mice via Modulating the Pparγ/STAT3 Pathway and Intestinal Microbiota DOI Creative Commons

Weiling Guo,

Bingyong Mao, Shumao Cui

и другие.

Foods, Год журнала: 2022, Номер 11(11), С. 1551 - 1551

Опубликована: Май 25, 2022

Colitis has become a major health concern worldwide. The objective of the present study was to determine probiotic influence different strains B. pseudolongum (Bp7 and Bp8) on alleviating colitis explore its possible potential mechanisms. Our results displayed that Bp7 Bp8 intervention effectively reduced dextran sodium sulfate (DSS)-caused body weight loss release several pro-inflammatory factors (interleukin (IL)-6, IL-1β, tumor necrosis factor-α (TNF-α)) increased activities antioxidant enzymes (T-AOC, SOD, GSH) concentrations tight junction proteins (occludin, claudin-1, ZO-1). Moreover, drastically down-regulated expression colonic MyD88, NF-κB, iNOS COX2 elevated STAT3, Nrf2, PPARγ. Gas chromatography-mass spectrometry revealed cecal levels isobutyric, butyric, isovaleric acids were in mice intervened with Bp8. 16S rRNA sequencing modulated intestinal microbiota structure, particularly by enhancing proportion Eubacterium coprostanoligenes group, Marvinbryantia, Enterorhabdus, Faecalibaculum, Coriobacteriaceae UCG 002, Alistipes, Bifidobacterium, which are relevant isobutyric acid, butyric inflammatory cytokines. Collectively, these findings suggest alleviates barrier function, possibly blocking secretion proinflammatory cytokines, maintaining physical integrity, activating PPARγ/STAT3 pathway, modulating composition. also suggested is promising for treatment.

Язык: Английский

Процитировано

61
Insoluble yeast β-glucan attenuates high-fat diet-induced obesity by regulating gut microbiota and its metabolites DOI
Xiaoxing Mo,

Yunhong Sun,

Xiaoling Liang

и другие.

Carbohydrate Polymers, Год журнала: 2022, Номер 281, С. 119046 - 119046

Опубликована: Янв. 4, 2022

Язык: Английский

Процитировано

47
Biological potential and mechanisms of Tea’s bioactive compounds: An Updated review DOI Creative Commons

Qiaoxian Luo,

Longbiao Luo,

Jinmin Zhao

и другие.

Journal of Advanced Research, Год журнала: 2023, Номер 65, С. 345 - 363

Опубликована: Дек. 5, 2023

Tea (Camellia sinensis) has a rich history and is widely consumed across many countries, categorized into green tea, white oolong yellow black dark tea based on the level of fermentation. Based review previous literature, commonly recognized bioactive substances in include polyphenols, amino acids, polysaccharides, alkaloids, terpenoids, macro minerals, trace elements, vitamins, which have been known to various potential health benefits, such as anticancer, antioxidant, anti-inflammatory, anti-diabetes, anti-obesity properties, cardiovascular protection, immune regulation, control intestinal microbiota. Most studies only pointed out characteristics tea's bioactivities, so comprehensive summary pharmacological mechanisms bioactivities their use risks are vital. Review The aim this paper summarize mechanisms, providing scientific basis for application outlining future research directions study tea. Key Scientific Concepts This summarizes main biologically active substances, effects, discusses risks. It may help researchers grasp more progress further promote natural substance medical field.

Язык: Английский

Процитировано

41
Green tea catechin epigallocatechin gallate alleviates high‐fat diet‐induced obesity in mice by regulating the gut–brain axis DOI Creative Commons
Jihong Zhou,

Lejia Ding,

Wei Chen

и другие.

Food Frontiers, Год журнала: 2023, Номер 4(3), С. 1413 - 1425

Опубликована: Май 14, 2023

Abstract Plant polyphenols have gained attention in recent years because of their potential to alleviate obesity and metabolic syndrome, protect neurological function, maintain intestinal function. Here, we evaluated the effect green tea catechin epigallocatechin gallate (EGCG) suppress obesity, inflammation, regulate hypothalamic neurotransmitters high‐fat diet mice. Obese male C57BL/6J mice were gavaged with 25, 50, or 100 mg/kg·body weight (bw) EGCG water per day for 6 weeks. The results demonstrated that significantly reduced bw, fat accumulation, liver steatosis. also modulated such as dopamine 5‐HTP. Besides, attenuated expression colonic inflammatory factors barrier damage, increased gut microbial abundance genus Alloprevotella , short‐chain fatty acids, downregulated transcription factors. suggest may related disorders through gut–brain interaction.

Язык: Английский

Процитировано

30
DHA-enriched phosphatidylserine alleviates high fat diet-induced jejunum injury in mice by modulating gut microbiota DOI
Shanshan Tian, Yanfeng Zhao, Qian Li

и другие.

Food & Function, Год журнала: 2023, Номер 14(3), С. 1415 - 1429

Опубликована: Янв. 1, 2023

A long-term high-fat diet (HFD) is one of the high-risk factors for intestinal barrier damage. Docosahexaenoic acid-enriched phosphatidylserine (DHA-PS) has multiple biological activities, while its protective effect on HFD-caused jejunum injury remains unknown. Thus, present study investigated DHA-PS HFD-induced in mice. Our results showed that (100 mg per kg d) could protect against by decreasing levels inflammatory such as interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α) serum tissues, with histological analysis confirming this amelioration. Additionally, alleviated oxidative stress malondialdehyde (MDA) increasing total antioxidant capacity (T-AOC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) catalase (CAT) jejunum. Moreover, significantly increased expression tight junction proteins (ZO-1, occludin, claudin-4) jejunum, modulated gut microbiota disorder Firmicutes Bacteroidetes ratio, reducing relative abundance Lachnoclostridium, Coriobacteriaceae, Desulfovibrionaceae, Helicobacter, Lachnospiraceae_NK4A136_group, Alistipes, norank_f__Muribaculaceae, Bacteroides. Overall, these support can alleviate injury.

Язык: Английский

Процитировано

29