Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Янв. 27, 2023
Diabetes
mellitus
is
a
global
public
health
problem
with
both
macrovascular
and
microvascular
complications,
such
as
diabetic
corneal
neuropathy
(DCN).
Using
in-vivo
confocal
microscopy,
nerve
changes
in
DCN
patients
can
be
examined.
Additionally,
the
morphology
quantity
of
dendritic
cells
(DCs)
corneas
have
also
been
observed.
DCs
are
bone
marrow-derived
antigen-presenting
that
serve
immunological
non-immunological
roles
human
corneas.
However,
role
pathogenesis
DC
not
well
understood.
In
this
article,
we
provide
comprehensive
review
animal
clinical
studies
report
DCs,
including
density,
maturation
stages,
relationships
between
nerves,
epithelium,
We
discussed
associations
various
or
imaging
parameters,
age,
status,
blood
metabolic
parameters.
Such
information
would
valuable
insight
into
development
diagnostic,
preventive,
therapeutic
strategies
for
DM-associated
ocular
surface
complications.
Antioxidants,
Год журнала:
2021,
Номер
10(9), С. 1479 - 1479
Опубликована: Сен. 16, 2021
The
pathogenesis
of
Alzheimer's
disease
involves
β
amyloid
(Aβ)
accumulation
known
to
induce
synaptic
dysfunction
and
neurodegeneration.
brain's
vulnerability
oxidative
stress
(OS)
is
considered
a
crucial
detrimental
factor
in
disease.
OS
Aβ
are
linked
each
other
because
induces
OS,
increases
the
deposition.
Thus,
answer
question
"which
comes
first:
chicken
or
egg?"
remains
extremely
difficult.
In
any
case,
evidence
for
primary
occurrence
AD
attractive.
indicates
that
long
period
gradual
damage
precedes
results
appearance
clinical
pathological
symptoms,
including
deposition,
neurofibrillary
tangle
formation,
metabolic
dysfunction,
cognitive
decline.
Moreover,
plays
role
many
risk
factors
AD.
begins
years
before
its
antioxidant
treatment
can
be
an
important
therapeutic
target
attacking
Cell Proliferation,
Год журнала:
2023,
Номер
56(9)
Опубликована: Март 13, 2023
Abstract
Low
back
pain
(LBP)
is
a
leading
cause
of
labour
loss
and
disability
worldwide,
it
also
imposes
severe
economic
burden
on
patients
society.
Among
symptomatic
LBP,
approximately
40%
caused
by
intervertebral
disc
degeneration
(IDD).
IDD
the
pathological
basis
many
spinal
degenerative
diseases
such
as
herniation
stenosis.
Currently,
therapeutic
approaches
for
mainly
include
conservative
treatment
surgical
treatment,
neither
which
can
solve
problem
from
root
terminating
process
(IVD).
Therefore,
further
exploring
pathogenic
mechanisms
adopting
targeted
strategies
one
current
research
hotspots.
complex
pathophysiological
processes
IDD,
oxidative
stress
considered
main
factor.
The
delicate
balance
between
reactive
oxygen
species
(ROS)
antioxidants
essential
maintaining
normal
function
survival
IVD
cells.
Excessive
ROS
levels
damage
to
macromolecules
nucleic
acids,
lipids,
proteins
cells,
affect
cellular
activities
functions,
ultimately
lead
cell
senescence
or
death.
This
review
discusses
potential
role
in
understand
provides
IDD.
Frontiers in Endocrinology,
Год журнала:
2022,
Номер
13
Опубликована: Март 29, 2022
The
global
diabetes
epidemic
and
its
complications
are
increasing,
thereby
posing
a
major
threat
to
public
health.
A
comprehensive
understanding
of
mellitus
(DM)
is
necessary
for
the
development
effective
treatments.
Ferroptosis
newly
identified
form
programmed
cell
death
caused
by
production
reactive
oxygen
species
an
imbalance
in
iron
homeostasis.
Increasing
evidence
suggests
that
ferroptosis
plays
pivotal
role
pathogenesis
diabetes-related
complications.
In
this
review,
we
summarize
potential
impact
regulatory
mechanisms
on
complications,
as
well
inhibitors
diabetic
Therefore,
developing
drugs
or
agents
target
may
provide
new
treatment
strategies
patients
with
diabetes.
Phytomedicine,
Год журнала:
2023,
Номер
111, С. 154658 - 154658
Опубликована: Янв. 12, 2023
Wumei
Wan
(WMW)
has
been
used
to
address
digestive
disorder
for
centuries
in
traditional
Chinese
medicine.
Previous
studies
have
demonstrated
its
anti-colitis
efficacy,
but
the
underlying
mechanism
of
action
remains
be
further
clarified.To
investigate
mechanisms
WMW
treatment
chronic
ulcerative
colitis
(UC)
through
network
pharmacology
and
experimental
validation.Traditional
Medicine
Systems
Pharmacology
(TCMSP)
platform
were
identify
ingredients
potential
targets
WMW.
The
microarray
gene
data
GSE75214
datasets
from
GEO
database
was
define
UC-associated
targets.
Cytoscape3.7.2
employed
construct
protein-protein
interaction
(PPI)
compounds-disease
network.
GO
enrichment
analysis
KEGG
pathway
performed
by
R
software
functional
annotation.
UPLC-TOF-MS/MS
method
quantitatively
analyze
active
For
validation,
three
cycles
2%
dextran
sulfate
sodium
salt
(DSS)
model.
hub
signal
detected
qPCR,
ELISA,
western
blotting
,
immunohistochemical
immunofluorescence.Through
analysis,
104
obtained
WMW,
47
these
had
UC.
A
total
41
13
identified.
showed
that
involved
advanced
glycation
end
products-receptor
products
(AGE-RAGE)
signaling
pathway.
Taxifolin,
rutaecarpine,
kaempferol,
quercetin,
luteolin
more
highly
predictive
components
related
AGE-RAGE
In
vivo
improved
DSS-induced
colitis,
reduced
expression
inflammatory
cytokines
chemokines.
Notably,
it
significantly
decreased
mRNA
Spp1,
Serpine1,
Mmp2,
Mmp9,
Ptgs2,
Nos2,
Kdr
Icam1,
which
associated
with
angiogenesis.
addition,
we
confirmed
inhibited
RAGE
diminished
epithelial
barrier
alterations
CONCLUSION:
Our
results
initially
effective
strong
anti-angiogenic
activity
colitis.
Sufficient
evidence
satisfactory
verified
this
study,
suggesting
as
a
quite
prospective
agent
therapy
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(15), С. 12378 - 12378
Опубликована: Авг. 3, 2023
Diabetes
mellitus
(DM)
belongs
to
the
category
of
socially
significant
diseases
with
epidemic
rates
increases
in
prevalence.
Diabetic
nephropathy
(DN)
is
a
specific
kind
kidney
damage
that
occurs
40%
patients
DM
and
considered
serious
complication
DM.
Most
modern
methods
for
treatments
aimed
at
slowing
down
progression
DN
have
side
effects
do
not
produce
unambiguous
positive
results
long
term.
This
fact
has
encouraged
researchers
search
additional
or
alternative
treatment
methods.
Hyperglycemia
negative
effect
on
renal
structures
due
number
factors,
including
activation
polyol
hexosamine
glucose
metabolism
pathways,
renin-angiotensin-aldosterone
sympathetic
nervous
systems,
accumulation
advanced
glycation
end
products
insulin
resistance
endothelial
dysfunction
tissues.
The
above
mechanisms
cause
development
oxidative
stress
(OS)
reactions
mitochondrial
dysfunction,
which
turn
contribute
DN.
Modern
antioxidant
therapies
involve
various
phytochemicals
(food
antioxidants,
resveratrol,
curcumin,
alpha-lipoic
acid
preparations,
etc.),
are
widely
used
only
diabetes
but
also
other
systemic
diseases.
It
been
suggested
therapeutic
approaches
target
source
reactive
oxygen
species
may
certain
advantages
terms
nephroprotection
from
OS.
review
describes
significance
studies
OS
biomarkers
pathogenesis
analyzes
reducing
intensity
prevention
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3086 - 3086
Опубликована: Март 7, 2024
Diabetic
kidney
disease
(DKD)
is
a
major
cause
of
chronic
(CKD),
and
it
heightens
the
risk
cardiovascular
incidents.
The
pathogenesis
DKD
thought
to
involve
hemodynamic,
inflammatory,
metabolic
factors
that
converge
on
fibrotic
pathway.
Genetic
predisposition
unhealthy
lifestyle
practices
both
play
significant
role
in
development
progression
DKD.
In
spite
recent
emergence
angiotensin
receptors
blockers
(ARBs)/angiotensin
converting
enzyme
inhibitor
(ACEI),
sodium-glucose
cotransporter
2
(SGLT2)
inhibitors,
nonsteroidal
mineralocorticoid
antagonists
(NS-MRAs),
current
therapies
still
fail
effectively
arrest
Glucagon-like
peptide
1
receptor
agonists
(GLP-1RAs),
promising
class
agents,
possess
potential
act
as
renal
protectors,
slowing
Other
including
pentoxifylline
(PTF),
selonsertib,
baricitinib
hold
great
promise
for
due
their
anti-inflammatory
antifibrotic
properties.
Multidisciplinary
treatment,
encompassing
modifications
drug
therapy,
can
decelerate
Based
treatment
heart
failure,
recommended
use
multiple
drugs
combination
rather
than
single-use
Unearthing
mechanisms
underlying
urgent
optimize
management
Inflammatory
(including
IL-1,
MCP-1,
MMP-9,
CTGF,
TNF-a
TGF-β1),
along
with
lncRNAs,
not
only
serve
diagnostic
biomarkers,
but
also
therapeutic
targets.
this
review,
we
delve
into
We
explore
additional
value
combing
these
develop
novel
strategies.
Drawing
from
understanding
pathogenesis,
propose
HIF
AGE
epigenetic
targets
future.
Frontiers in Pharmacology,
Год журнала:
2021,
Номер
12
Опубликована: Авг. 16, 2021
The
Wnt/β-catenin
signaling
pathway
plays
important
roles
in
embryonic
development
and
tissue
homeostasis.
Wnt
is
induced,
β-catenin
activated,
associated
with
the
progression
of
renal
fibrosis.
controls
expression
various
downstream
mediators
such
as
snail1,
twist,
matrix
metalloproteinase-7,
plasminogen
activator
inhibitor-1,
transient
receptor
potential
canonical
6,
renin-angiotensin
system
components
epithelial
cells,
fibroblast,
macrophages.
In
addition,
usually
intertwined
other
pathways
to
promote
interstitial
Actually,
given
crucial
fibrogenesis,
blocking
this
may
benefit
There
are
several
antagonists
that
negatively
control
activation,
these
include
soluble
Fzd-related
proteins,
family
Dickkopf
1
Klotho
inhibitory
factor-1.
Furthermore,
numerous
emerging
small-molecule
inhibitors
cannot
be
ignored
prevent
treat
Moreover,
we
reviewed
knowledge
focusing
on
anti-fibrotic
effects
natural
products
commonly
used
kidney
disease
by
inhibiting
pathway.
Therefore,
review,
summarize
recent
advances
regulation,
targets,
role,
mechanisms
fibrosis
pathogenesis.
We
also
discuss
therapeutic
targeting
fibrosis;
shed
new
insights
into
effective
treatment
strategies
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
24(1), С. 570 - 570
Опубликована: Дек. 29, 2022
Diabetic
kidney
disease
(DKD)
is
the
leading
cause
of
chronic
disease,
including
end-stage
and
increases
risk
cardiovascular
mortality.
Although
treatment
options
for
DKD,
angiotensin-converting
enzyme
inhibitors,
angiotensin
II
receptor
blockers,
sodium-glucose
cotransporter
2
mineralocorticoid
antagonists,
have
advanced,
their
efficacy
still
limited.
Thus,
a
deeper
understanding
molecular
mechanisms
DKD
onset
progression
necessary
development
new
innovative
treatments
DKD.
The
complex
pathogenesis
includes
various
different
pathways,
can
be
broadly
classified
into
inflammatory,
fibrotic,
metabolic,
hemodynamic
factors.
Here,
we
summarize
recent
findings
in
basic
research,
focusing
on
each
factor
advances
Collective
evidence
from
clinical
research
studies
helpful
definitive
regulatory
systems.
Further
comprehensive
exploration
warranted
to
advance
our
knowledge
establish
novel
preventive
strategies.
Cells,
Год журнала:
2022,
Номер
11(21), С. 3345 - 3345
Опубликована: Окт. 24, 2022
Periodontal
diseases
include
periodontitis
and
gingival
overgrowth.
Periodontitis
is
a
bacterial
infectious
disease,
its
pathological
cascade
regulated
by
many
inflammatory
cytokines
secreted
immune
or
tissue
cells,
such
as
interleukin-6.
In
contrast,
overgrowth
develops
side
effect
of
specific
drugs,
immunosuppressants,
anticonvulsants,
calcium
channel
blockers.
Human
fibroblasts
(HGFs)
are
the
most
abundant
cells
in
connective
tissue,
human
periodontal
ligament
(HPLFs)
located
between
teeth
alveolar
bone.
HGFs
HPLFs
both
crucial
for
remodeling
homeostasis
their
roles
pathogenesis
have
been
examined
25
years.
Various
responses
contribute
to
progression
diseases.
This
review
summarizes
biological
effects
on
