Pharmaceuticals,
Год журнала:
2024,
Номер
17(10), С. 1305 - 1305
Опубликована: Сен. 30, 2024
Non-healing
diabetic
wounds
represent
a
significant
clinical
challenge
globally,
necessitating
innovative
approaches
in
drug
delivery
to
enhance
wound
healing.
Understanding
the
pathogenesis
of
these
is
crucial
for
developing
effective
treatments.
Bioactive
dressings
and
polymeric
nanofibers
have
emerged
as
promising
modalities,
with
silk
biomaterials
gaining
attention
their
unique
properties
Nano-Micro Letters,
Год журнала:
2024,
Номер
16(1)
Опубликована: Фев. 6, 2024
Inflammatory
skin
disorders
can
cause
chronic
scarring
and
functional
impairments,
posing
a
significant
burden
on
patients
the
healthcare
system.
Conventional
therapies,
such
as
corticosteroids
nonsteroidal
anti-inflammatory
drugs,
are
limited
in
efficacy
associated
with
adverse
effects.
Recently,
nanozyme
(NZ)-based
hydrogels
have
shown
great
promise
addressing
these
challenges.
NZ-based
possess
unique
therapeutic
abilities
by
combining
benefits
of
redox
nanomaterials
enzymatic
activity
water-retaining
capacity
hydrogels.
The
multifaceted
effects
include
scavenging
reactive
oxygen
species
other
inflammatory
mediators
modulating
immune
responses
toward
pro-regenerative
environment
enhancing
regenerative
potential
triggering
cell
migration
differentiation.
This
review
highlights
current
state
art
NZ-engineered
(NZ@hydrogels)
for
regeneration
applications.
It
also
discusses
underlying
chemo-mechano-biological
mechanisms
behind
their
effectiveness.
Additionally,
challenges
future
directions
this
ground,
particularly
clinical
translation,
addressed.
insights
provided
aid
design
engineering
novel
hydrogels,
offering
new
possibilities
targeted
personalized
skin-care
therapies.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Март 27, 2024
Skin,
the
largest
biological
organ,
consists
of
three
main
parts:
epidermis,
dermis,
and
subcutaneous
tissue.
Wounds
are
abnormal
wounds
in
various
forms,
such
as
lacerations,
burns,
chronic
wounds,
diabetic
acute
fractures.
The
wound
healing
process
is
dynamic,
complex,
lengthy
four
stages
involving
cells,
macrophages,
growth
factors.
Wound
dressing
refers
to
a
substance
that
covers
surface
prevent
infection
secondary
damage.
Biomaterials
applied
management
have
advanced
significantly.
Natural
biomaterials
increasingly
used
due
their
advantages
including
biomimicry
ECM,
convenient
accessibility,
involvement
native
healing.
However,
there
still
limitations
low
mechanical
properties
expensive
extraction
methods.
Therefore,
combination
with
synthetic
and/or
adding
bioactive
agents
has
become
an
option
for
researchers
this
field.
In
present
study,
natural
effect
on
its
direction,
type,
level
will
be
investigated.
Then,
different
types
polysaccharides
proteins
were
selected
desirable
biomaterials,
polymers
variable
suitable
properties,
effective
additives.
following,
structure
production
methods,
participation
healing,
quality
control
techniques
biomaterials-based
dressings
discussed.
Journal of Composites Science,
Год журнала:
2025,
Номер
9(3), С. 133 - 133
Опубликована: Март 13, 2025
Severe
skin
injuries
such
as
burns
and
chronic
wounds
are
a
subject
of
interest
in
the
medical
field,
they
require
much
attention.
These
types
susceptible
to
serious
complications,
which
can
worsen
health
patients
reduce
their
quality
life.
Hydrogels
have
emerged
innovative
wound
dressings
for
treating
acute
wounds,
including
burns,
diabetic
foot
ulcers,
venous
leg
pressure
ulcers.
polymeric
networks
provide
moist
environment,
promote
cellular
migration,
offer
antimicrobial
properties,
being
recognized
superior
conventional
dressings.
This
review
aims
explore
recent
advancements
hydrogel-based
dressings,
emphasizing
state-of-the-art
technologies
used
this
purpose
trend
achieving
personalized
therapeutic
approaches.
Despite
promising
vitro
vivo
findings
described
review,
further
clinical
validation
large-scale
manufacturing
optimizations
required
widespread
adoption.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(2), С. 1304 - 1304
Опубликована: Янв. 21, 2024
Cutaneous
wound
healing
consists
of
four
stages:
hemostasis,
inflammation,
proliferation/repair,
and
remodeling.
While
healthy
wounds
normally
heal
in
to
six
weeks,
a
variety
underlying
medical
conditions
can
impair
the
progression
through
stages
healing,
resulting
development
chronic,
non-healing
wounds.
Great
progress
has
been
made
developing
dressings
improving
surgical
techniques,
yet
challenges
remain
finding
effective
therapeutics
that
directly
promote
healing.
This
review
examines
current
understanding
pro-healing
effects
targeted
pharmaceuticals,
re-purposed
drugs,
natural
products,
cell-based
therapies
on
various
cell
types
present
normal
chronic
Overall,
despite
several
promising
studies,
there
remains
only
one
therapeutic
approved
by
United
States
Food
Drug
Administration
(FDA),
Becaplermin,
shown
significantly
improve
closure
clinic.
highlights
need
for
new
approaches
aimed
at
targeting
mechanisms
impeding
moving
field
from
management
towards
resolving
Exploration of Immunology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 11, 2025
Wound
healing
is
an
area
of
growing
importance
in
the
healthcare
field,
especially
chronic
wounds
associated
with
comorbidities
like
diabetes
mellitus
(DM),
hypoxic
stress,
obesity,
and
malnutrition.
Chronic
significantly
increase
costs
reduce
patients’
quality
life.
Cytokines
are
a
promising
therapeutic
target,
as
they
regulate
all
stages
wound
healing,
dysfunction
cytokine
production
can
cause
inflammatory
non-healing
wounds.
Interleukin-1
(IL-1),
IL-2,
IL-6,
IL-8,
tumour
necrosis
factor-α
(TNF-α)
facilitate
leukocyte
recruitment
clear
dead
cells
during
initial
inflammation
stage
while
transforming
growth
factor-β
(TGF-β),
IL-4,
IL-13
inhibit
stimulate
proliferation
fibroblasts
to
begin
extracellular
matrix
(ECM)
deposition.
Given
complexity
interactions
their
diverse
cellular
targets,
comprehensive
understanding
these
signaling
pathways
crucial.
This
review
examines
multifaceted
roles
cytokines
discusses
recent
advancements
application
modulation
for
improved
care
outcomes.
Despite
significant
improving
specificity
therapies,
further
research
needed
focus
on
targeting
downstream
or
specific
receptors
minimize
adverse
effects
treatments.
Materials Today Bio,
Год журнала:
2024,
Номер
25, С. 100975 - 100975
Опубликована: Янв. 26, 2024
Diabetic
wound
healing
is
delayed
due
to
persistent
inflammation,
and
macrophage-immunomodulating
biomaterials
can
control
the
inflammatory
phase
shorten
time.
In
this
study,
acellular
embryoid
bodies
(aEBs)
were
prepared
mixed
with
thermosensitive
hydroxybutyl
chitosan
(HBC)
hydrogels
produce
aEB/HBC
composite
hydrogels.
The
exhibited
reversible
temperature-sensitive
transition
behavior
a
hybrid
porous
network.
vitro
analysis
showed
that
better
antimicrobial
activity
than
PBS
control,
aEBs
or
HBC
promoted
M0
M2
polarization
but
not
M1
macrophage
repolarization
in
culture.
vivo
results
accelerated
cutaneous
closure,
re-epithelialization,
ingrowth
of
new
blood
vessels,
collagen
deposition
reduced
scar
width
during
diabetic
mice
over
Macrophage
phenotype
induce
reactions
continually,
upregulate
M2-related
mRNA
protein
expression
downregulate
M1-related
expression.
Therefore,
have
excellent
activity,
promote
accelerate
functional
structural
wounds.
ACS Omega,
Год журнала:
2024,
Номер
9(31), С. 33751 - 33764
Опубликована: Июль 9, 2024
Infectious
diseases
are
acknowledged
as
one
of
the
leading
causes
death
worldwide.
Statistics
show
that
annual
toll
caused
by
bacterial
infections
has
reached
14
million,
most
which
drug-resistant
strains.
Bacterial
antibiotic
resistance
is
currently
regarded
a
compelling
problem
with
dire
consequences,
motivates
urgent
identification
alternative
ways
fighting
bacteria.
Various
types
nanomaterials
have
been
reported
to
date
efficient
antibacterial
solutions.
Among
these,
carbon-based
nanomaterials,
such
carbon
nanodots,
graphene
oxide,
and
nanotubes
(CNTs),
shown
be
effective
in
killing
wide
panel
pathogenic
With
this
study,
we
aim
provide
additional
insights
into
topic
research
investigating
activity
specific
type
multiwalled
CNTs,
diameters
from
50
150
nm,
against
two
representative
opportunistic
pathogens,
i.e.,
Gram-positive
bacterium
