Baicalin regulates Treg/Th17 cell imbalance by inhibiting autophagy in allergic rhinitis

Molecular Immunology, Год журнала: 2020, Номер 125, С. 162 - 171

Опубликована: Июль 17, 2020

Язык: Английский

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Effects of Probiotics on Allergic Rhinitis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

American Journal of Rhinology and Allergy, Год журнала: 2022, Номер 36(4), С. 440 - 450

Опубликована: Янв. 31, 2022

Background The prevalence of allergic rhinitis has been estimated to range from 10 30% in adults and up 40% children. Probiotics have tested as for this condition, but no census on which probiotic types are most effective. Objective Our aim study was provide strain-specific evaluation the treatment rhinitis. Methods Databases (PubMed, Google Scholar, ScienceDirect) were searched (from inception October 2020) identify randomized controlled trials (RCTs) treatments patients. A systematic review done comparing reported outcomes, clinical immunological parameters safety data. meta-analysis probiotics with at least two RCTs per strain(s) sharing a common outcome. Results total 13 randomized, double-blind, placebo-controlled (N = 1591 participants) included review. Overall, 8 9 alleviated one symptom results showed that, neither L. paracasei Lp33 (SMD −1.61, 95% CI −4.67, 1.45) nor rhamnosus GG −1.00, −3.01, 1.00) had significant efficacy reducing nasal scores. Conclusions analysis produced slight improvement some measurements Due diversity outcome lack sufficient each strain, future needed similar design uniform outcomes better compare effect

Язык: Английский

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Opportunities for correction of individual links of the pathogenesis of allergic rhinitis and bronchial asthma with assessment of the quality of life of patients

Meditsinskiy sovet = Medical Council, Год журнала: 2022, Номер 4, С. 24 - 34

Опубликована: Апрель 5, 2022

Introduction . One of the antileukotriene drugs for treatment bronchial asthma and allergic rhinitis with without polyposis is montelukast. The presented article presents results analysis effectiveness, safety impact on quality life patients, use singular, in various forms associated comorbid conditions. Aim study To assess effectiveness montelukast complex therapy patients diseases. Materials methods. A simple, blind, randomized, controlled clinical trial involved 97 divided into 4 groups: moderate rhinitis; severity asthma; severe rhinitis, polypous rhinosinusitis. In parallel comparison drug tolerability, symptoms (rhinorrhea, nasal congestion, itching, sneezing, bronchopulmonary manifestations), was assessed using a special SNOT-22 questionnaire. Results related conditions significantly improved over entire period all groups. There an increase suppression leukotriene-mediated effects when montelukast, more group people asthma, such as triad, mucus hypersecretion, bronchospasm, eosinophilia, increased vascular permeability, etc. Conclusion morbid conditions, Singular has demonstrated inhibitory effect cysteinyl leukotrienes, high bioavailability, good tolerability safety.

Язык: Английский

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Potential of Lactoferrin in the Treatment of Lung Diseases

Pharmaceuticals, Год журнала: 2023, Номер 16(2), С. 192 - 192

Опубликована: Янв. 28, 2023

Lactoferrin (LF) is a multifunctional iron-binding glycoprotein that exhibits variety of properties, such as immunomodulatory, anti-inflammatory, antimicrobial, and anticancer, can be used to treat numerous diseases. Lung diseases continue the leading cause death disability worldwide. Many therapies currently these have limited efficacy or are associated with side effects. Therefore, there constant pursuit for new drugs therapies, LF frequently considered therapeutic agent and/or adjunct drug-based treatment lung This article focuses on review existing most up-to-date literature contribution beneficial effects diseases, including asthma, viral infections, cystic fibrosis, cancer, among others. Although in vitro vivo studies indicate significant potency listed only case respiratory tract infections do human seem confirm them by demonstrating effectiveness reducing episodes illness shortening recovery period. For COVID-19 sepsis, reports conflicting, other paucity conclusively confirming LF.

Язык: Английский

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Polydatin inhibits mitochondrial damage and mitochondrial ROS by promoting PINK1‐Parkin‐mediated mitophagy in allergic rhinitis

The FASEB Journal, Год журнала: 2023, Номер 37(4)

Опубликована: Март 11, 2023

Polydatin (PD), a natural product derived from Polygonum cuspidatum, has anti-inflammatory and antioxidant effects significant benefits in treating allergic diseases. However, its role mechanism rhinitis (AR) have not been fully elucidated. Herein, we investigated the effect of PD AR. AR model was established mice with OVA. Human nasal epithelial cells (HNEpCs) were stimulated IL-13. HNEpCs also treated an inhibitor mitochondrial division or transfected siRNA. The levels IgE cellular inflammatory factors examined by enzyme linked immunosorbent assay flow cytometry. expressions PINK1, Parkin, P62, LC3B, NLRP3 inflammasome proteins, apoptosis proteins tissues measured Western blot. We found that suppressed OVA-induced thickening eosinophil accumulation mucosa, reduced IL-4 production NALF, regulated Th1/Th2 balance. In addition, mitophagy induced after OVA challenge IL-13 stimulation. Meanwhile, enhanced PINK1-Parkin-mediated but decreased reactive oxygen species (mtROS) production, activation, apoptosis. PD-induced abrogated PINK1 knockdown Mdivi-1 treatment, indicating key PINK1-Parkin mitophagy. Moreover, damage, mtROS under exposure more severe treatment. Conclusively, may exert protective on promoting mitophagy, which further suppresses tissue damage through decreasing activation.

Язык: Английский

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Common Allergens and Immune Responses Associated with Allergic Rhinitis in China

Journal of Asthma and Allergy, Год журнала: 2023, Номер Volume 16, С. 851 - 861

Опубликована: Авг. 1, 2023

Abstract: Allergic rhinitis (AR) is a chronic allergic disease of the upper respiratory system that affects approximately 10– 40% global population. Due to large number plant pollen allergens with obvious seasonal variations, AR common in China. primarily caused by abnormal regulation immune system. Its pathophysiological mechanism involves series cells and mediators, including cytokines. The present review summarizes China complex AR. Additionally, host allergen contact, signal transduction, cell activation, cytokine release, inflammatory reactions are described according their sequence occurrence. Keywords: rhinitis, response, immunoglobulin E, histamine, inflammation

Язык: Английский

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Quercetin a promising functional food additive against allergic Diseases: A comprehensive and mechanistic review

Journal of Functional Foods, Год журнала: 2024, Номер 116, С. 106152 - 106152

Опубликована: Апрель 5, 2024

The crucial roles of innate and acquired immunity in the pathogenesis allergic diseases have been well highlighted based on molecular mechanisms. Thus, modulation unregulated unabated inflammatory responses is a therapeutic strategy diseases. One most important natural compounds with high immune anti-inflammation potency quercetin, found various fruits vegetables, namely onions, shallots, apples, berry crops. Therefore, this study, we reviewed influences quercetin against conditions, including asthma, rhinitis, atopic dermatitis, conjunctivitis, anaphylaxis. Scientific databases, PubMed, Scopus, Web Sciences, EMBASE, were searched English until March 2024. Quercetin's beneficial effects attributed to its anti-cancer, anti-viral, anti-oxidant, anti-inflammatory activities, also decrease pro-inflammatory cytokines, leukotrienes production, inhibition histamine release, suppression interleukin IL-4 production. It can reduce production antigen-specific IgE antibodies improve Th1/Th2 balance. These qualities be used as treat According findings these investigations, may influence allergy illnesses.

Язык: Английский

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Immunomodulatory effect of PLGA-encapsulated mesenchymal stem cells-derived exosomes for the treatment of allergic rhinitis

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Июль 8, 2024

Introduction Allergic rhinitis (AR) is an upper airway inflammatory disease of the nasal mucosa. Conventional treatments such as symptomatic pharmacotherapy and allergen-specific immunotherapy have considerable limitations drawbacks. As emerging therapy with regenerative potential immunomodulatory effect, mesenchymal stem cell-derived exosomes (MSC-Exos) recently been trialed for treatment various autoimmune diseases. Methods In order to achieve sustained protected release MSC-Exos intranasal administration, we fabricated Poly(lactic-co-glycolic acid) (PLGA) micro nanoparticles-encapsulated (PLGA-Exos) using mechanical double emulsion local AR. Preclinical in vivo imaging, ELISA, qPCR, flow cytometry, immunohistochemical staining, multiomics sequencing were used phenotypic mechanistic evaluation therapeutic effect PLGA-Exos vitro . Results The results showed that our PLGA platform could efficiently encapsulate a manner. At protein level, upregulated IL-2, IL-10 IFN-γ, downregulated IL-4, IL-17 antigen-specific IgE ovalbumin (OVA)-induced AR mice. cellular reduced Th2 cells, increased Tregs, reestablished Th1/Th2 balance. tissue significantly attenuated infiltration immune cells (e.g., eosinophils goblet cells) Finally, analysis discovered several signaling cascades, e.g., peroxisome proliferator-activated receptor (PPAR) pathway glycolysis pathway, might mechanistically support PLGA-Exos. Discussion For first time, present biomaterial-facilitated delivery system novel promising strategy treatment.

Язык: Английский

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Overcoming barriers to intranasal corticosteroid use in patients with uncontrolled allergic rhinitis

Integrated Pharmacy Research and Practice, Год журнала: 2017, Номер Volume 6, С. 109 - 119

Опубликована: Май 1, 2017

Abstract: Patients suffering from allergic rhinitis often attempt to self-manage their ­symptoms and may seek advice pharmacists about nonprescription product choices. Several drug classes, both prescription over-the-counter (OTC), are available, including intranasal corticosteroids (INCSs); oral, intranasal, ocular antihistamines; leukotriene antagonists; topical systemic decongestants, as well immunotherapies. Selection of the optimal treatment approach depends on temporal pattern, frequency, severity symptoms patient's age. Nasal congestion is typically most bothersome symptom, although rhinorrhea, postnasal drip, also problematic. Together, these adversely impact quality life, work productivity, sleep quality, ability perform daily activities, particularly when uncontrolled. Practice guidelines recognize that INCSs effective medications for controlling symptoms, nasal congestion. Available INCS products have comparable safety efficacy profiles, but they differ in formulation characteristics sensory attributes. barriers can impede use INCSs, concerns safety, misperceptions regarding loss response frequent use, undesirable sensations associated with administration. Given increasing number available OTC, help allay by discussing expectations, recommending favorable characteristics, reviewing proper technique administration selected product. These steps foster a collaborative relationship between patient pharmacist rhinitis. Keywords: allergy, sprays, medications, counseling, pharmacy practice

Язык: Английский

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Allergic rhinitis, allergic contact dermatitis and disease comorbidity belong to separate entities with distinct composition of T-cell subsets, cytokines, immunoglobulins and autoantibodies

Allergy Asthma and Clinical Immunology, Год журнала: 2022, Номер 18(1)

Опубликована: Фев. 11, 2022

Allergic rhinitis (AR) and allergic contact dermatitis (ACD) are prevalent diseases have significant impacts on patients' daily life. Despite many studies AR or ACD been conducted separately, little is known about the immune responses in patients of combined with interplay between ACD. Our study compared various aspects elements or/and ACD, aiming to characterize AR, ACD.A total 57 diagnosed 28 healthy volunteers were included. further divided into seasonal (SAR) perennial (PAR). All subjects' blood samples taken assess concentration immunoglobulins, complement C3, C4, autoantibodies cytokines serum by immunoturbidimetry, ELISA Luminex200 platform. Peripheral mononuclear cells (PBMCs) subjected analysis lymphocyte subpopulations flow cytometry.It indicated that disease caused elevated levels IgE, IgA, IgG, IgG4, as well IL-4, IL-15, IL-8 IL-6 serum. possessed a decreased CD4/CD8 ratio an increased proportion memory CD4 + T-cell subset, skewed Th2 response enhanced CD8 activation. Compared sole condition, presented significantly subset prone autoimmune disorders autoantibodies. The only least affected those other conditions. Additionally, exhibited different cytokine profiles proportions subsets.In this study, we illuminated respective characteristics Meanwhile, discovered PAR SAR compartments. It suggested these conditions belong entities. Characterizing detailed changes would help develop proper treatments targeting particular diseases.

Язык: Английский

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