Low serum albumin: A neglected predictor in patients with cardiovascular disease

European Journal of Internal Medicine, Год журнала: 2022, Номер 102, С. 24 - 39

Опубликована: Май 7, 2022

Язык: Английский

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Novel perspective into the interaction behavior study of the cyanidin with human serum albumin-holo transferrin complex: Spectroscopic, calorimetric and molecular modeling approaches

Journal of Molecular Liquids, Год журнала: 2022, Номер 356, С. 119042 - 119042

Опубликована: Март 30, 2022

Язык: Английский

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Predictive value of serum albumin levels on cancer survival: a prospective cohort study

Frontiers in Oncology, Год журнала: 2024, Номер 14

Опубликована: Март 4, 2024

Background Serum albumin levels and cancer mortality are closely related, yet large-sample studies encompassing a broad spectrum of types lacking. Methods This study encompassed patients diagnosed with across the continuous 10 cycles NHANES surveys from 1999 to 2018. The population was stratified into two groups based on median (≤ 4.2g/dL > 4.2 g/dL) or aggressiveness (well-survived cancers poorly-survived cancers). Survival rates were estimated using Kaplan-Meier method. Cox proportional hazards model employed evaluate association between serum mortality. Restricted cubic spline (RCS) analysis conducted assess nonlinear relationship risk Results curves demonstrated that ≤ g/dL exhibited lower survival compared those g/dL, irrespective aggressiveness. Following adjustment for confounders, decreased associated an elevated all [all cancers, HR (95%CI) = 2.03(1.73, 2.37); well survived 1.78(1.38, 2.32); poorly 1.99(1.64, 2.42)]. RCS analyses revealed stable negative in groups, regardless confounder adjustment. Conclusion Low predict higher Furthermore, observed

Язык: Английский

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Cytotoxic pyrrole-based gold(III) chelates target human topoisomerase II as dual-mode inhibitors and interact with human serum albumin

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер unknown, С. 117330 - 117330

Опубликована: Янв. 1, 2025

Язык: Английский

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Serum Albumin for Magnetic Nanoparticles Coating

Magnetochemistry, Год журнала: 2022, Номер 8(2), С. 13 - 13

Опубликована: Янв. 20, 2022

Magnetic nanoparticles (MNPs) have great potential in biochemistry and medical science. In particular, iron oxide demonstrated a promising effect various biomedical applications due to their high magnetic properties, large surface area, stability, easy functionalization. However, colloidal biocompatibility, toxicity of MNPs physiological environments are crucial for vivo application. this context, many research articles focused on the possible procedures coating improve physic-chemical biological properties. This review highlights one viable fabrication strategy biocompatible using human serum albumin (HSA). HSA is mainly transport protein with functions fundamental processes. As it most abundant plasma proteins, not single drug blood passes without its strength test. It influences pharmacokinetics, biodistribution different drug-delivery systems by binding or forming corona surface. The development albumin-based carriers gaining increasing importance targeted delivery cancer therapy. Considering this, highly candidate theranostics area can provide prolonged circulation, possibly resolve drug-resistance problem.

Язык: Английский

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Molecular docking approach on the binding stability of derivatives of phenolic acids (DPAs) with Human Serum Albumin (HSA): Hydrogen-bonding versus hydrophobic interactions or combined influences?

JCIS Open, Год журнала: 2023, Номер 12, С. 100096 - 100096

Опубликована: Сен. 21, 2023

Molecular docking (Mol.Doc) techniques were employed to ascertain the binding affinity and energetics of hydroxy derivatives benzoic cinnamic acids extract from Psidium guajava L. with Human Serum Albumin (HSA). Caffeic acid (CA), Ferullic (FA), Sinapic (SA), Syringic (SyA) Vanillic (VA) are phenolic (DPA) in studies which acts as guest molecule. Docking various feasible conformers DPA HSA (host) was explored these categorized based on score is correlated energy (BE) stability depends upon molecular interactions. Among acids, SA-HSA complex energetically more favorable BE order formation DPA-HSA follows SA > FA = CA VA SyA, though SyA structurally similar each other, likewise exhibit a structure. The molecule domains several Hydrogen-bonding (HB) interaction governs host-guest established. Interestingly, presence multiple hydrophobic interactions (pi-pi, pi-alkyl, pi-cation or anion, pi-sigma pi-amide) competes over HB resulting decrease BE. We report that an excellent site selective site-specific ligand prefers dock Sudlow II comprising sub IIIA IIIB respectively. However, all other do not behave neither nor specific such they prefer reside both III (non-Sudlow site) HSA. authenticate well amino moieties act donor acceptor sites apart further establish has least probable I (warfarin site), whereas domain most preferred favoured among domains.

Язык: Английский

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A Comprehensive Multispectroscopic and Computational Analysis of the Interaction between Plant-Based Antiplasmodial Compounds and Bovine Serum Albumin

ACS Omega, Год журнала: 2024, Номер 9(5), С. 5576 - 5591

Опубликована: Янв. 28, 2024

This study was conducted to explore the interaction between two plant-based antiplasmodial compounds, gartanin and friedelin, bovine serum albumin (BSA). The objectives aimed elucidate binding characteristics, structural changes, thermodynamic parameters associated with interaction. Various methods were used including UV–vis, fluorescence, circular dichroism spectroscopy, supported by molecular docking dynamics simulation. results showed a concentration-dependent compounds BSA, revealing changes in protein conformation stability. obtained that plant products bound BSA through static quenching moderate affinity (104 M–1) BSA. Thermodynamic transitions calculated from spectroscopic revealed hydrogen bond van der Waals forces caused partial conformational alteration secondary structure of as α-helical content decreased an increase β sheets, random coils, other structures. Computational analysis provided insights into sites affinities. enhances our understanding interactions antiplamodial plants, supporting research choosing, designing, optimizing molecules for biomedical applications focus on selectively targeting their sites.

Язык: Английский

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Applications of Raman spectroscopy in clinical medicine

Food Frontiers, Год журнала: 2024, Номер 5(2), С. 392 - 419

Опубликована: Янв. 10, 2024

Abstract Raman spectroscopy is a nondestructive and highly effective technique for analyzing biological tissues diagnosing diseases by providing detailed spectral information about the specific molecular structures of substances. Its efficacy in these applications has been widely recognized, making it powerful tool field. This article presents comprehensive overview latest developments its wide‐ranging diagnosis critical diseases, such as cancer, infections, neurodegenerative predicting surgical outcomes. It highlights significant contributions areas, shedding light on potential valuable diagnostic tool. delves into advancements biomedical sciences, with focus state‐of‐the‐art techniques surface‐enhanced spectroscopy, resonance tip‐enhanced spectroscopy. These have shown great various within The explores their use ex vivo medical diagnosis, covering topics sample collection, data processing, successful establishment correlations between spectra biochemical diseases. Furthermore, discusses limitations current research offers insights future directions further exploration field sciences.

Язык: Английский

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A review of recent advances in drug loading, mathematical modeling and applications of hydrogel drug delivery systems

Journal of Materials Science, Год журнала: 2024, Номер 59(32), С. 15077 - 15116

Опубликована: Авг. 1, 2024

Язык: Английский

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Nanoplastics alter the conformation and activity of human serum albumin

NanoImpact, Год журнала: 2022, Номер 27, С. 100412 - 100412

Опубликована: Июль 1, 2022

Язык: Английский

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