Journal of Health and Rehabilitation Research,
Год журнала:
2024,
Номер
4(1), С. 1701 - 1705
Опубликована: Март 31, 2024
Background:
Flavonoids
are
recognized
for
their
extensive
health
benefits,
including
antioxidant,
anti-inflammatory,
antimicrobial,
and
neuroprotective
effects.
Traditional
methods
flavonoid
extraction,
often
dependent
on
toxic
solvents
high
energy
inputs,
have
prompted
the
exploration
of
more
sustainable
efficient
extraction
techniques.
This
movement
aligns
with
global
shift
towards
greener
methodologies
that
promise
to
enhance
purity
yield
these
vital
phytochemicals
therapeutic
purposes.
Objective:
In
this
hypothesis-driven
study,
we
aimed
evaluate
effectiveness
advanced
green
technologies—microwave-assisted
(MAE),
supercritical
fluid
(SFE),
ultrasound-assisted
(UAE)—for
isolating
flavonoids
from
botanical
sources.
A
secondary
objective
was
assess
antioxidant
capabilities
extracted
flavonoids,
thereby
linking
efficiency
process
bioactivity
compounds.
Methods:
The
study
utilized
MAE,
SFE,
UAE
extract
a
predetermined
plant
source,
optimizing
parameters
each
method
maximize
activity.
quantitatively
measured
in
mg
per
gram
dry
material,
while
capacity
evaluated
using
DPPH
(2,2-diphenyl-1-picrylhydrazyl)
assay,
focusing
percentage
radical
scavenging
Results:
Our
findings
indicated
MAE
most
method,
producing
120
mg/g
an
85%
SFE
followed,
yields
100
90
mg/g,
capacities
80%
75%
activity,
respectively.
These
results
not
only
supported
our
hypothesis
techniques
could
outperform
traditional
extracting
but
also
highlighted
as
superior
technique
terms
both
efficacy.
Conclusion:
validates
potential
technologies,
particularly
microwave-assisted
effective
alternatives
conventional
methods.
By
extracts,
technologies
pave
way
significant
advancements
pharmaceutical
nutraceutical
industries,
fostering
deeper
understanding
utilization
wellness.
The Veterinary Journal,
Год журнала:
2025,
Номер
unknown, С. 106358 - 106358
Опубликована: Апрель 1, 2025
Antimicrobial
resistance
is
a
growing
global
concern,
prompting
for
antibiotic
alternatives
in
animal
production.
Seaweed,
abundant
bioactive
compounds
with
anti-inflammatory
properties,
offers
natural
substitute
to
synthetic
compounds.
Considering
this,
the
objective
of
present
study
was
evaluate
bioactivity
three
seaweeds
1:1
combination
Ascophyllum
nodosum,
Palmaria
palmata,
and
Ulva
lactuca.
Initially,
polyphenol,
flavonoid,
total
phlorotannin
content
seaweed
species
were
assessed
through
colorimetric
assays.
Subsequently,
first
evaluated
an
inhibition
protein
precipitation
assay
then
confirmed
vitro
gene
expression
assays
LPS-stimulated
porcine
alveolar
macrophages
(PAMs).
The
evaluation
molecules
revealed
high
TPC
(1487.67±40.39
1763.57±69.01mg
TAE/100mg
sample,
respectively),
as
well
TFC
(95.68±3.62
126.09±7.34mg
CE/100mg
sample)
TPhC
(0.167±0.02
0.23±0.01mg
PGE/100mg)
AN
UL,
respectively.
inhibiting
disclosed
that
extracts
combining
two
algae
(ANUL,
ANPP,
PPUL)
more
effective
than
effect
exhibited
by
each
single
extract.
assessment
significant
down-regulation
IL-1β
TNF-α
extracts.
In
contrast,
TGF-β
showed
increasing
trend.
These
findings,
along
confirmation
molecules,
highlight
algae's
potential,
making
them
suitable
antibiotics
disease
prevention
livestock
sector.
Therefore,
future
research
should
explore
specific
validate
their
efficacy
vivo
confirm
potential
use
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(15), С. 8419 - 8419
Опубликована: Авг. 1, 2024
Cardiovascular
diseases
(CVDs)
are
responsible
for
significant
mortality
rates
globally
that
have
been
raised
due
to
the
limitation
of
available
treatments
and
prevalence
CVDs.
The
innovative
research
identification
potential
preventives
CVDs
essential
alleviate
global
deaths
complications.
marine
environment
is
a
rich
source
bioactive
substances
provides
unique
chemical
arsenal
against
numerous
ailments
its
unrivaled
biodiversity.
Marine
polyphenolic
compounds
(MPCs)
because
their
structural
variety
biologically
activity.
Further,
MPCs
well-reported
valuable
biological
activities,
such
as
anti-inflammatory,
cardioprotective,
antioxidant,
demonstrating
encouraging
results
in
preventing
treating
Therefore,
investigation
structure-activity
relationship
(SAR)
between
insights
reveal
how
components
these
affect
effectiveness.
comprehending
this
correlation
advancing
medications
nutraceuticals
sourced
from
sources,
which
could
transform
strategy
cardiovascular
diseases.
study
comprehensive
analysis
existing
by
emphasizing
role
CVD
evaluating
SAR
with
challenges
future
directions.
Applied Sciences,
Год журнала:
2024,
Номер
14(18), С. 8255 - 8255
Опубликована: Сен. 13, 2024
Marine-derived
nutrients
and
bioactive
compounds
may
offer
a
myriad
of
biological
benefits,
such
as
anticancer
anti-inflammatory
properties,
technological
potential,
enhancing
food
quality
additives.
Their
role
in
the
sustainable
development
technology
is
fundamental,
especially
advancing
knowledge
functional
foods
related
technologies.
Algae
are
considered
one
major
sources
marine-derived
ingredients
subject
several
recent
studies.
Despite
their
translation
marine
ingredients’
potential
into
marine-based
competitiveness
industry
faces
hurdles
extraction
process
operational
systems
scale-up
that
needs
to
tackle.
The
complexity
matrices
with
diverse
solubilities
adds
processes
lead
low
yields
or
bioactivity
loss.
Contaminants,
like
heavy
metals
pesticide
residues
organisms,
require
rigorous
purification
for
product
safety.
use
biorefinery
production,
particularly
cascade
processes,
offers
zero-waste
solutions,
contributing
blue
economy
aligning
UN
sustainability
goals.
Sustainability
assessment
tools
critical
evaluating
production’s
environmental,
social,
economic
impacts.
A
continued
exploration
collaboration
essential
future,
fostering
innovation
create
resilient,
equitable,
eco-friendly
system.
Background
The
marine
environment,
with
its
rich
biodiversity
and
nutrient-dense
ecosystems,
offers
immense
potential
for
discovering
novel
pharmaceutical
products.
Plants,
Год журнала:
2024,
Номер
13(15), С. 2148 - 2148
Опубликована: Авг. 2, 2024
Few
researches
have
explored
the
production
of
pharmaceuticals
from
aquatic
plants.
Therefore,
this
study
explored,
for
first
time,
phytochemical
composition
and
bioactivities
ten
Aquatic
plant
shoots
various
Nile
River
canals
were
collected,
dried,
ground
aqueous
extract
preparation.
Phytochemical
antioxidant
capacity
assessed
using
DPPH
assays.
Extracts
tested
antiparasitic,
antibacterial,
anti-biofilm,
anticancer
activities
through
standard
in
vitro
assays,
measuring
IC50
values,
evaluating
mechanisms
action,
including
cell
viability
high-content
screening
The
results
showed
that
plants
rich
pharmaceutical
compounds.
these
extracts
exceeded
vitamin
C.
promising
antiparasitic
activity
against
pathogens
like
Opisthorchis
viverrini
Plasmodium
falciparum,
with
values
between
0.7
2.5
µg/mL.
They
also
demonstrated
low
MICs
pathogenic
bacteria,
causing
DNA
damage,
increased
plasma
membrane
permeability,
90%
biofilm
inhibition.
In
terms
activity,
effective
a
panel
cancer
lines,
Ludwigia
stolonifera
exhibiting
highest
efficacy.
Its
ranged
0.5
µg/mL
pancreatic,
esophageal,
colon
cells
to
1.5
gastric
cells.
Overall,
all
below
6
µg/mL,
showing
significant
apoptotic
nuclear
intensity,
mitochondrial
cytochrome
c
release,
outperforming
doxorubicin.
This
highlights
potential
as
sources
new,
safe,
drugs
strong
properties.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2024,
Номер
unknown, С. 1 - 16
Опубликована: Сен. 3, 2024
Pyropia
spp.
seaweeds
are
delicious
and
nutritious
red
algae
widely
consumed
for
a
long
history.
However,
due
to
the
non-digestibility
of
cell
wall
components
by
human
intestinal
tract,
bioaccessibility
intracellular
bioactive
compounds
is
low.
The
current
industrial
processing
food
drying
roasting
cannot
break
down
wall;
however,
studies
indicate
that
fermentation
food-derived
microorganisms
an
efficient
method
solve
this
problem.
This
paper
reviews
research
on
spp.,
including
manufacturing
process,
alterations
in
chemical
composition,
flavor
properties,
bioactivities,
mechanisms.
Furthermore,
limitations
opportunities
developing
explored.
Studies
demonstrated
key
metabolites
fermented
were
degraded
polysaccharides,
released
phenolic
flavonoids,
formed
amino
acids,
which
possessed
bioactivities
such
as
antioxidant,
anti-glycation,
anti-diabetic,
lipid
metabolism
regulation
beneficial
health.
increased
implied
promoted
components.
Notably,
positively
contributed
safety
food.
In
conclusion,
benefits
nutrition,
flavor,
bioactivity,
suggest
technology
has
promising
future
application
industry.
