Dyspnea in Post-Acute COVID-19: A Multi-Parametric Cardiopulmonary Evaluation DOI Open Access
Antonella Cecchetto, Gabriella Guarnieri,

G Torreggiani

и другие.

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(14), С. 4658 - 4658

Опубликована: Июль 13, 2023

Post-acute COVID-19 is characterized by the persistence of dyspnea, but pathophysiology unclear. We evaluated prevalence dyspnea during follow-up and factors at admission associated with persistence. After five months from discharge, 225 consecutive patients hospitalized for moderate to severe pneumonia were assessed clinically laboratory tests, echocardiography, six-minute walking test (6MWT), pulmonary function tests. Fifty-one reported persistent dyspnea. C-reactive protein (p = 0.025, OR 1.01 (95% CI 1.00-1.02)) admission, longer duration hospitalization 0.005, 1.05 1.01-1.10)) higher body mass index 0.001, 1.15 1.06-1.28)) independent predictors Absolute drop in SpO2 6MWT 1.37 1.13-1.69)), right ventricular (RV) global longitudinal strain 0.016, 1.12 1.02-1.25)) RV strain/systolic artery pressure ratio 0.034, 0.14 0.02-0.86)) independently post-acute In conclusion, present many after pneumonia. While index, are desaturation 6MWT, echocardiographic dysfunction this symptom period.

Язык: Английский

Risk Factors Associated With Post−COVID-19 Condition DOI Open Access
Vasiliki Tsampasian, Hussein Elghazaly,

R. Chattopadhyay

и другие.

JAMA Internal Medicine, Год журнала: 2023, Номер 183(6), С. 566 - 566

Опубликована: Март 23, 2023

Post-COVID-19 condition (PCC) is a complex heterogeneous disorder that has affected the lives of millions people globally. Identification potential risk factors to better understand who at developing PCC important because it would allow for early and appropriate clinical support.To evaluate demographic characteristics comorbidities have been found be associated with an increased PCC.Medline Embase databases were systematically searched from inception December 5, 2022.The meta-analysis included all published studies investigated and/or predictors in adult (≥18 years) patients.Odds ratios (ORs) each factor pooled selected studies. For factor, random-effects model was used compare between individuals without factor. Data analyses performed 2022, February 10, 2023.The patient age; sex; body mass index, calculated as weight kilograms divided by height meters squared; smoking status; comorbidities, including anxiety depression, asthma, chronic kidney disease, obstructive pulmonary diabetes, immunosuppression, ischemic heart disease; previous hospitalization or ICU (intensive care unit) admission COVID-19; vaccination against COVID-19.The initial search yielded 5334 records which 255 articles underwent full-text evaluation, identified 41 total 860 783 patients included. The findings showed female sex (OR, 1.56; 95% CI, 1.41-1.73), age 1.21; 1.11-1.33), high BMI 1.15; 1.08-1.23), 1.10; 1.07-1.13) PCC. In addition, presence 2.48; 1.97-3.13 OR, 2.37; 2.18-2.56, respectively). Patients had vaccinated COVID-19 2 doses significantly lower compared not 0.57; 0.43-0.76).This systematic review demonstrated certain (eg, sex), severe PCC, whereas protective role sequelae. These may enable understanding develop provide additional evidence benefits vaccination.PROSPERO Identifier: CRD42022381002.

Язык: Английский

Процитировано

532
Long COVID: a review and proposed visualization of the complexity of long COVID DOI Creative Commons
Rubeshan Perumal, Letitia Shunmugam, Kogieleum Naidoo

и другие.

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Апрель 20, 2023

Post-Acute Sequelae of Severe Acute Respiratory Syndrome Coronavirus - 2 (SARS-CoV-2) infection, or Long COVID, is a prevailing second pandemic with nearly 100 million affected individuals globally and counting. We propose visual description the complexity COVID its pathogenesis that can be used by researchers, clinicians, public health officials to guide global effort toward an improved understanding eventual mechanism-based provision care afflicted patients. The proposed visualization framework for should evidence-based, dynamic, modular, systems-level approach condition. Furthermore, further research such could establish strength relationships between pre-existing conditions (or risk factors), biological mechanisms, resulting clinical phenotypes outcomes COVID. Notwithstanding significant contribution disparities in access social determinants have on disease course long our model focuses primarily mechanisms. Accordingly, sets out scientific, clinical, efforts better understand abrogate burden imposed

Язык: Английский

Процитировано

64
Cardiovascular disease as part of Long COVID: a systematic review DOI
Vasiliki Tsampasian, Maria Bäck, Marco Bernardi

и другие.

European Journal of Preventive Cardiology, Год журнала: 2024, Номер unknown

Опубликована: Фев. 20, 2024

Long COVID syndrome has had a major impact on million patients' lives worldwide. The cardiovascular system is an important aspect of this multifaceted disease that may manifest in many ways. We have hereby performed narrative review order to identify the extent manifestations syndrome.

Язык: Английский

Процитировано

20
Chronic inflammation in post-acute sequelae of COVID-19 modulates gut microbiome: a review of literature on COVID-19 sequelae and gut dysbiosis DOI Creative Commons
Najeeha Talat Iqbal,

Hana Khan,

Aqsa Khalid

и другие.

Molecular Medicine, Год журнала: 2025, Номер 31(1)

Опубликована: Янв. 23, 2025

Язык: Английский

Процитировано

3
Risk of long covid in patients with pre-existing chronic respiratory diseases: a systematic review and meta-analysis DOI Creative Commons
Paul Terry, R. Eric Heidel, Alexandria Quesenberry

и другие.

BMJ Open Respiratory Research, Год журнала: 2025, Номер 12(1), С. e002528 - e002528

Опубликована: Янв. 1, 2025

Background An estimated 10–30% of people with COVID-19 experience debilitating long-term symptoms or long covid. Underlying health conditions associated chronic inflammation may increase the risk Methods We conducted a systematic review and meta-analysis to examine whether covid was altered by pre-existing asthma obstructive pulmonary disease (COPD) in adults. identified studies searching PubMed Embase databases from inception 13 September 2024. excluded that focused on children defined only terms respiratory symptoms. used random-effects, restricted maximum likelihood models analyse data pooled 51 studies, which included 43 analyses 30 COPD. The bias assessed using ROBINS-E table. Results found 41% increased odds (95% CI 1.29 1.54); COPD 32% 1.16 1.51). Pre-existing asthma, but not COPD, covid-associated fatigue. observed heterogeneity results related hospitalisation status. Potential confounding inconsistent measurement exposure outcome variables were among limitations. Conclusions Our findings support hypothesis covid, including fatigue outcomes patients asthma. Because targets tract, these inflammatory lower tract could provide mechanistic clues common pathway for development sequelae

Язык: Английский

Процитировано

3
Long COVID: Clinical Framing, Biomarkers, and Therapeutic Approaches DOI Open Access
Valeria Conti, Graziamaria Corbi, Francesco Sabbatino

и другие.

Journal of Personalized Medicine, Год журнала: 2023, Номер 13(2), С. 334 - 334

Опубликована: Фев. 15, 2023

More than two years after the onset of COVID-19 pandemic, healthcare providers are facing an emergency within emergency, so-called long COVID or post-COVID-19 syndrome (PCS). Patients diagnosed with PCS develop extended range persistent symptoms and/or complications from COVID-19. The risk factors and clinical manifestations many various. Advanced age, sex/gender, pre-existing conditions certainly influence pathogenesis course this syndrome. However, absence precise diagnostic prognostic biomarkers may further complicate management patients. This review aimed to summarize recent evidence on influencing PCS, possible biomarkers, therapeutic approaches. Older patients recovered approximately one month earlier younger patients, higher rates symptoms. Fatigue during acute phase appears be important factor for symptom persistence. Female sex, older active smoking associated a developing PCS. incidence cognitive decline death in controls. Complementary alternative medicine improvement symptoms, particularly fatigue. heterogeneous nature post-COVID complexity who often polytreated due concomitant conditions, suggest holistic integrated approach provide useful guidance treatment overall COVID.

Язык: Английский

Процитировано

33
Identification and diagnosis of long COVID-19: A scoping review DOI Creative Commons
Sujata Srikanth,

J. Boulos,

Tristan Dover

и другие.

Progress in Biophysics and Molecular Biology, Год журнала: 2023, Номер 182, С. 1 - 7

Опубликована: Май 12, 2023

Язык: Английский

Процитировано

31
Post-acute sequelae of SARS-CoV-2 infection (Long COVID) in older adults DOI
Samantha Russell,

Karen Parker,

Andrea Lehoczki

и другие.

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Июнь 14, 2024

Язык: Английский

Процитировано

12
A randomized open-label clinical trial on the effect of Amantadine on post Covid 19 fatigue DOI Creative Commons

Ali Amini Harandi,

Hossein Pakdaman,

Aida Medghalchi

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Янв. 16, 2024

Abstract Many COVID-19 survivors experience lingering post-COVID-19 symptoms, notably chronic fatigue persisting for months after the acute phase. Despite its prevalence, limited research has explored effective treatments fatigue. This randomized controlled clinical trial assessed impact of Amantadine on patients with The intervention group received two weeks, while control no treatment. Fatigue levels were using Visual Analog Scale (VAFS) and Severity (FSS) questionnaires before trial. At study's onset, VAFS mean scores 7.90 ± 0.60 in 7.34 0.58 ( P -value = 0.087). After dropped to 3.37 0.44, significantly lower than group's 5.97 0.29 < 0.001). Similarly, FSS at trial's commencement 53.10 5.96 50.38 4.88 0.053). end, decreased 28.40 2.42, markedly 42.59 1.50 In this study, we report safety, tolerability, substantial fatigue-relieving effects demonstrates a statistically significant reduction levels, suggesting Amantadine's potential as an treatment persistent condition.

Язык: Английский

Процитировано

10
Mechanisms of long COVID: An updated review DOI Creative Commons
Yan Liu, Xiaoying Gu, Haibo Li

и другие.

Chinese Medical Journal - Pulmonary and Critical Care Medicine, Год журнала: 2023, Номер 1(4), С. 231 - 240

Опубликована: Дек. 1, 2023

The coronavirus disease 2019 (COVID-19) pandemic has been ongoing for more than 3 years, with an enormous impact on global health and economies. In some patients, symptoms signs may remain after recovery from severe acute respiratory syndrome 2 (SARS-CoV-2) infection, which cannot be explained by alternate diagnosis; this condition defined as long COVID. Long COVID exist in patients both mild is prevalent infection different SARS-CoV-2 variants. most common include fatigue, dyspnea, other involving multiple organs. Vaccination results lower rates of To date, the mechanisms unclear. narrative review, we summarized clinical presentations current evidence regarding pathogenesis

Язык: Английский

Процитировано

21