Gels,
Год журнала:
2025,
Номер
11(3), С. 163 - 163
Опубликована: Фев. 24, 2025
The
objective
of
this
work
was
to
investigate
the
use
nanocrystalline
cellulose
(NCC)
as
a
drug-delivery
excipient
for
buccal
films.
Gel-like
dispersions
were
created
by
blending
either
gel
or
powder
NCC
(gNCC
pNCC)
with
natural
polymers
(alginate,
pectin,
chitosan)
in
water,
glycerol
serving
plasticiser.
Ibuprofen
(IBU)
an
active
pharmaceutical
ingredient
(API)
dissolved
self-microemulsifying
drug
delivery
system
(SMEDDS)
improve
its
solubility
prior
addition
gel-like
dispersions.
Dispersions
dried,
and
resulting
films
cut
3
cm
×
1.5
size,
appropriate
delivery.
Rheological
measurements
revealed
that
shorter,
thinner,
less
crystalline
nanocellulose
fibres
are
more
favourable
stronger
properties.
While
overall,
weaker
structure
film
casting
also
resulted
shorter
disintegration
time,
not
case
NCC–chitosan
films;
here,
low
chitosan
neutral
media
proved
be
main
obstacle.
Nevertheless,
prolonged
did
impact
dissolution
IBU,
these
exhibited
fastest
rate,
followed
NCC–pectin
NCC–alginate.
Furthermore,
properties
significantly
influenced
behaviour
formulations,
gNCC
favouring
faster
IBU
release
due
formation
casting.
Pharmaceutics,
Год журнала:
2022,
Номер
14(6), С. 1152 - 1152
Опубликована: Май 28, 2022
The
ideal
drug
delivery
system
has
a
bioavailability
comparable
to
parenteral
dosage
forms
but
is
as
convenient
and
easy
use
for
the
patient
oral
solid
forms.
In
recent
years,
there
been
increased
interest
in
transdermal
(TDD)
non-invasive
approach
that
generally
regarded
being
administer
more
vulnerable
age
groups,
such
paediatric
geriatric
patients,
while
avoiding
certain
concerns
arise
from
due
poor
absorbability
metabolism
concerns.
However,
despite
its
many
merits,
TDD
remains
restricted
select
few
drugs.
physiology
of
skin
poses
barrier
against
feasible
drugs,
limiting
applicability
only
those
drugs
possess
physicochemical
properties
allowing
them
be
successfully
delivered
transdermally.
Several
techniques
have
developed
enhance
permeability
Both
chemical
(e.g.,
thermal
mechanical)
passive
(vesicle,
nanoparticle,
nanoemulsion,
dispersion,
nanocrystal)
investigated
substances
across
skin.
Furthermore,
hybrid
approaches
combining
penetration
enhancement
technologies
with
physical
are
intensively
researched
improve
permeation
substances.
This
review
aims
summarize
trends
discuss
merits
drawbacks
various
chemical,
physical,
currently
improving
Nature Reviews Bioengineering,
Год журнала:
2023,
Номер
1(3), С. 208 - 225
Опубликована: Фев. 2, 2023
Oral
administration
is
a
widespread
and
convenient
drug
delivery
approach.
However,
oral
can
be
affected
by
the
complex
digestive
tract
environment,
including
irregular
tissue
morphology,
presence
of
enzymes,
mucus
mucosal
barriers,
spatiotemporal
variance
in
physiological
parameters.
These
obstacles
prevent
many
therapeutics.
To
overcome
these
challenges,
devices
designed
with
bioinspired
compositions,
structures
or
functions
to
make
more
drugs
available
for
administration.
Various
have
been
developed
harnessing
biological
materials
living
microorganisms,
imitating
functions.
In
this
Review,
we
discuss
design
modification
devices,
examining
engineering
strategies
target
specific
tissues
applications.
We
highlight
how
key
bottlenecks
addressed
through
designs,
concluding
an
outlook
on
remaining
challenges
towards
clinical
translation
devices.
commonly
used
strategy
deliver
harsh
environment
prevents
negatively
affect
efficacy.
This
Review
discusses
microorganisms
into
that
associated
delivery.
Pharmaceutics,
Год журнала:
2024,
Номер
16(5), С. 626 - 626
Опубликована: Май 7, 2024
In
this
study,
we
focused
on
innovative
approaches
to
improve
drug
administration
in
oral
pathology,
especially
by
transmucosal
and
transdermal
pathways.
These
improvements
refer
the
type
of
microneedles
used
(proposing
needles
saw),
use
certain
enhancers
such
as
essential
oils
(which,
besides
amplifier
action,
also
have
intrinsic
actions
health),
associations
active
substances
with
synergistic
well
copolymeric
membranes,
cemented
directly
tooth.
We
propose
a
review
principles
release
at
level
mucosa
main
systems
pathology.
Controlled
failure
applicable
pathology
include
following:
fast
dissolving
films,
mucoadhesive
tablets,
hydrogels,
intraoral
composite
wafers,
smart
drugs.
The
novelty
elements
brought
paper
possibilities
optimizing
localized
delivery
system
osteoarthritis
temporomandibular
joint,
neuropathic
pain,
cancer,
periodontitis,
pericoronitis,
maintaining
health.
would
like
mention
possibility
incorporating
natural
products
into
controlled
paying
special
attention
oils.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 25, 2024
The
development
of
human
papillomavirus
(HPV)
vaccines
has
made
substantive
progress,
as
represented
by
the
approval
five
prophylactic
since
2006.
Generally,
deployment
HPV
is
effective
in
preventing
newly
acquired
infections
and
incidences
HPV-related
malignancies.
However,
there
still
a
long
way
to
go
regarding
prevention
all
eradication
established
infections,
well
subsequent
progression
cancer.
Optimizing
incorporating
L1
proteins
from
more
subtypes,
exploring
adjuvants
that
reinforce
cellular
immune
responses
eradicate
HPV-infected
cells,
developing
therapeutic
used
either
alone
or
combination
with
other
cancer
modalities
might
bring
about
new
era
getting
closer
vision
get
rid
infection
related
diseases.
Herein,
we
summarize
strategies
for
vaccines,
both
therapeutic,
an
emphasis
on
selection
antigens
adjuvants,
implications
vaccine
efficacy
based
preclinical
studies
clinical
trials.
Additionally,
outline
current
cutting-edge
insights
formulation
strategies,
dosing
schedules,
age
expansion
among
recipients,
which
play
important
roles
addressing
barriers
uptake,
such
hesitancy
availability.
Cell Biochemistry and Function,
Год журнала:
2025,
Номер
43(2)
Опубликована: Янв. 28, 2025
ABSTRACT
The
present
study
aimed
to
optimize
a
mouth‐dissolving
film
(MDF)
made
from
Pongamia
pinnata
stem
bark
extract
increase
patient
compliance
and
accelerate
oral
disease
therapy.
Several
extracts
were
prepared,
karanjin
was
used
as
an
herbal
marker
for
the
extracts.
ethanolic
showed
maximum
yield
(12.10%
±
0.09%)
cytotoxic
activity
against
human
cancer
(KB
3‐1)
embryonic
kidney
cell
lines.
MDF
formulation
focused
on
incorporating
fixed
amount
of
varying
concentrations
HPMC
E5
polymer,
along
with
evaluating
performance
plasticizers
like
PEG
400
propylene
glycol
(PG).
An
optimized
determined
based
disintegration
time,
wetting
folding
endurance.
consisted
film‐forming
PG
superior
plasticizer,
ascorbic
acid
antioxidant,
other
ingredients
contributing
solubility,
dispersion,
sweetening,
appearance.
High‐performance
thin‐layer
chromatography‐mass
spectrometry
analysis
confirmed
higher
levels
in
formulation,
ensuring
its
successful
incorporation
stability.
Taste
masking
evaluations
indicate
favorable
taste
profile
high
potential
compliance.
stability
displayed
no
significant
changes
physical
characteristics
film,
affirming
quality.
In
conclusion,
developed
herbal‐based
presents
promising
drug
delivery
system,
offering
enhanced
compliance,
masking,
holds
great
effective
treatment
management
diseases,
providing
convenience
improved
therapeutic
outcomes.
Pharmaceutics,
Год журнала:
2023,
Номер
15(2), С. 361 - 361
Опубликована: Янв. 20, 2023
Orodispersible
Films
(ODFs)
are
drug
delivery
systems
manufactured
with
a
wide
range
of
methods
on
big
scale
or
for
customized
medicines
and
small-scale
pharmacy.
Both
ODFs
their
fabrication
have
certain
limitations.
Many
pharmaceutical
companies
academic
research
centers
across
the
world
cooperate
in
order
to
cope
these
issues
also
find
new
formulations
array
APIs
what
could
make
work
profitable
them
beneficial
patients
as
well.
The
number
pending
patent
applications
granted
patents
innovative
approaches
makes
progress
manufacturing
unquestionable.
commercially
available
is
still
growing.
However,
some
were
discontinued
no
longer
markets.
This
review
aims
summarize
currently
marketed
those
withdrawn
from
sale
provides
an
insight
into
recently
published
studies
concerning
orodispersible
films,
emphasizing
utilized
APIs.
highlights
attempts
scientific
communities
overcome
ODF’s
