Non-invasive CT imaging biomarker to predict immunotherapy response in gastric cancer: a multicenter study

Journal for ImmunoTherapy of Cancer, Год журнала: 2023, Номер 11(11), С. e007807 - e007807

Опубликована: Ноя. 1, 2023

Background Despite remarkable benefits have been provided by immune checkpoint inhibitors in gastric cancer (GC), predictions of treatment response and prognosis remain unsatisfactory, making identifying biomarkers desirable. The aim this study was to develop validate a CT imaging biomarker predict the immunotherapy patients with GC investigate associated infiltration patterns. Methods This retrospective included 294 who received anti-PD-1/PD-L1 from three independent medical centers between January 2017 April 2022. A radiomics score (RS) developed intratumoral peritumoral features on pretreatment images immunotherapy-related progression-free survival (irPFS). performance RS evaluated area under time-dependent receiver operating characteristic curve (AUC). Multivariable Cox regression analysis performed construct predictive nomogram irPFS. C-index used determine nomogram. Bulk RNA sequencing tumors 42 Cancer Genome Atlas RS-associated Results Overall, 89 (median age, 57 years (IQR 48–66 years); 171 males) had an objective immunotherapy. 13 that yielded AUCs 12-month irPFS 0.787, 0.810 0.785 training, internal validation, external validation 1 cohorts, respectively, AUC 24-month 0.805 2 cohort. Patients low longer each cohort (p<0.05). analyses showed is prognostic factor integrated clinical characteristics improved predicting irPFS, 0.687–0.778 training cohorts. M1 macrophage infiltration. Conclusion findings suggest non-invasive can effectively outcomes innate signaling, which serve as potential tool for individual decisions.

Язык: Английский

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Magnesium Ions Promote the Induction of Immunosuppressive Bone Microenvironment and Bone Repair through HIF‐1α‐TGF‐β Axis in Dendritic Cells

Small, Год журнала: 2024, Номер 20(33)

Опубликована: Апрель 25, 2024

The effect of immunoinflammation on bone repair during the recovery process defects needs to be further explored. It is reported that Mg

Язык: Английский

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Expanding the Therapeutic World of Tryptophan Metabolism

Circulation, Год журнала: 2022, Номер 145(24), С. 1799 - 1802

Опубликована: Июнь 13, 2022

Язык: Английский

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Comprehensive single-cell analysis of triple-negative breast cancer based on cDC1 immune-related genes: prognostic model construction and immunotherapy potential

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 19, 2025

Язык: Английский

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Mechanisms of indoleamine 2,3-dioxygenase (IDO)-mediated immunosuppression

Elsevier eBooks, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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