New‐onset autoimmune phenomena post‐COVID‐19 vaccination

Immunology, Год журнала: 2021, Номер 165(4), С. 386 - 401

Опубликована: Дек. 27, 2021

Abstract Coronavirus disease 2019 (COVID‐19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has led to an unprecedented setback for global economy and health. Vaccination is one of the most effective interventions substantially reduce death due SARS‐CoV‐2 infection. programmes are being rolled out globally, but these vaccines have been approved without extensive studies on their side‐effects efficacy. Recently, new‐onset autoimmune phenomena after COVID‐19 vaccination reported increasingly (e.g. immune thrombotic thrombocytopenia, liver diseases, Guillain–Barré syndrome, IgA nephropathy, rheumatoid arthritis systemic lupus erythematosus). Molecular mimicry, production particular autoantibodies role certain vaccine adjuvants seem be substantial contributors phenomena. However, whether association between manifestations coincidental or causal remains elucidated. Here, we summarize emerging evidence about occurring in response vaccines. Although information pertaining risk as a consequence controversial, merely propose our current understanding associated with vaccine. In fact, do not aim disavow overwhelming benefits mass preventing morbidity mortality. These reports could help guide clinical assessment management vaccination.

Язык: Английский

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Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line

Current Issues in Molecular Biology, Год журнала: 2022, Номер 44(3), С. 1115 - 1126

Опубликована: Фев. 25, 2022

Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 injection. Furthermore, a recent study SARS-CoV-2 RNA can be reverse-transcribed integrated into genome human cells. In this study, we investigated effect on liver cell line Huh7 vitro. cells were exposed to quantitative PCR was performed extracted from We detected high levels changes gene expression long interspersed nuclear element-1 (LINE-1), which is an endogenous reverse transcriptase. Immunohistochemistry using antibody binding LINE-1 open reading frame-1 RNA-binding protein (ORFp1) treated with indicated increased nucleus distribution LINE-1. genomic DNA amplified sequence unique BNT162b2. Our results indicate fast up-take Huh7, leading distribution. also show transcribed intracellularly as 6 h upon exposure.

Язык: Английский

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Cardiac complications following mRNA COVID‐19 vaccines: A systematic review of case reports and case series

Reviews in Medical Virology, Год журнала: 2021, Номер 32(4)

Опубликована: Дек. 17, 2021

Abstract There have been several local and systemic adverse events associated with mRNA COVID‐19 vaccines. Pericarditis, myocarditis myocardial infarction are examples of cardiac complications related to these In this article, we conducted a systematic review case reports series identify the clinical profile, investigations, management reported post‐mRNA We systematically searched PubMed, Scopus, Web Science, Google Scholar, as well medRxiv preprint server, terms including: ‘SARS‐CoV‐2’, ‘COVID‐19’, ‘messenger RNA vaccine*’, ‘mRNA‐1273 vaccine’, ‘BNT162 ‘myocarditis’, ‘pericarditis’, ‘stroke’ ‘Myocardial Ischemia’ up 25 September 2021. Studies were excluded if they not or series, cases from non‐mRNA Case included that investigated potential The JBI checklist was used assess quality data synthesis using qualitative methodology called narrative synthesis. Sixty‐nine studies, including 43 26 included. Myocarditis/myopericarditis pericarditis most common among 243 complications, post vaccination. Males median age 21 years had highest frequency myocarditis. Almost three quarters (74.4%) received BNT162b2 vaccine 87.7% second dose vaccine. Chest pain (96.1%) fever (38.2%) presentations. CK‐MB, troponin, NT‐proBNP elevated in 100%, 99.5% 78.3% subjects, respectively. ST‐segment abnormality electrocardiogram feature. Cardiac magnetic resonance imaging, which is gold‐standard approach for diagnosing myocarditis, abnormal all patients diagnosed Non‐steroidal anti‐inflammatory drugs prescribed medication Apart inflammatory conditions, some rare Takotsubo cardiomyopathy, infarction, non‐obstructive coronary arteries, isolated tachycardia also following immunisation acknowledge only reviewing studies one limitation our study. found commonly event vaccines, presented chest rise biomarkers. Further large‐scale observational recommended.

Язык: Английский

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Autoimmune and autoinflammatory conditions after COVID-19 vaccination. New case reports and updated literature review

Journal of Autoimmunity, Год журнала: 2022, Номер 132, С. 102898 - 102898

Опубликована: Авг. 24, 2022

Язык: Английский

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Ocular Complications Following Vaccination for COVID-19: A One-Year Retrospective

Vaccines, Год журнала: 2022, Номер 10(2), С. 342 - 342

Опубликована: Фев. 21, 2022

Vaccination efforts as a mitigation strategy in the corona virus disease 2019 (COVID-19) pandemic are fully underway. A vital component of understanding optimal clinical use these vaccines is thorough investigation adverse events following vaccination. To date, some limited reports and reviews have discussed ocular COVID-19 vaccination, but systematic review detailing with manifestations courses well proposed mechanisms has yet to be published. This comprehensive one-year into vaccination against meant furnish sound for ophthalmologists primary care physicians based on existing body data. We discuss categorized one following: eyelid, orbit, uveitis, retina, vascular, neuro-ophthalmology, motility disorders, other.

Язык: Английский

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COVID-19 vaccine and autoimmunity. A new case of autoimmune hepatitis and review of the literature

Journal of Translational Autoimmunity, Год журнала: 2022, Номер 5, С. 100140 - 100140

Опубликована: Янв. 1, 2022

Autoimmunity following COVID-19 vaccination has been reported. Herein, a 79-year-old man with clinical and immunological features of autoimmune hepatitis type 1 after ChAdOx1 nCoV-19 is presented. Clinical manifestations rapidly remitted the instauration immunomodulatory management. This case, together comprehensive review literature, illustrates association between vaccines development conditions.

Язык: Английский

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Autoimmune inflammatory rheumatic diseases post-COVID‐19 vaccination

International Immunopharmacology, Год журнала: 2022, Номер 110, С. 109061 - 109061

Опубликована: Июль 15, 2022

Язык: Английский

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Safety of COVID-19 vaccines in multiple sclerosis: A systematic review and meta-analysis

Multiple Sclerosis Journal, Год журнала: 2023, Номер 29(4-5), С. 585 - 594

Опубликована: Фев. 1, 2023

Background Data are sparse regarding the safety of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines in patients with multiple sclerosis (MS). Objective To estimate (1) pooled proportion MS experiencing relapse among vaccine recipients; (2) rate transient neurological worsening, adverse events, and serious events; (3) previous outcomes interest for different SARS-CoV-2 types. Methods Systematic review meta-analysis pharmacovigilance registries observational studies. Results Nineteen studies comprising 14,755 who received 23,088 doses COVID-19 were included. Mean age was 43.3 years (95% confidence interval (CI): 40–46.6); relapsing-remitting, secondary-progressive, primary-progressive clinically isolated diagnosed 82.6% CI: 73.9–89.8), 12.6% 6.3–20.8), 6.7% 4.2–9.9), 2.9% 1–5.9) cases, respectively. The at a mean time 20 days 12–28.2) from vaccination 1.9% 1.3%–2.6%; I = 78%), risk being independent type administered SARS-CoV-2-vaccine ( p subgroup differences 0.7 messenger RNA (mRNA), inactivated virus, adenovector-based vaccines). After vaccination, worsening observed 4.8% 2.3%–8.1%) patients. Adverse events reported 52.8% 46.7%–58.8%) 0.1% 0%–0.2%) vaccinations, Conclusion does not appear to increase MS. Weighted against risks SARS-CoV-2-related complications exacerbations, these data provide compelling pro-vaccination arguments

Язык: Английский

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COVID-19 Vaccination and the Rate of Immune and Autoimmune Adverse Events Following Immunization: Insights From a Narrative Literature Review

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Июль 5, 2022

Despite their proven efficacy and huge contribution to the health of humankind, vaccines continue be a source concern for some individuals around world. Vaccinations against COVID-19 increased number distressed people intensified distrust, particularly as pandemic was still emerging populations were encouraged vaccinated under various slogans like "back normal life" "stop coronavirus", goals which are achieved. As fear vaccination-related adverse events following immunization (AEFIs) is main reason vaccine hesitancy, we reviewed immune autoimmune AEFIs in particular, though very rare, most worrisome aspect vaccines. Among others, commonly administered include neurological ones such Guillain-Barre syndrome, transverse myelitis, Bell's palsy, well myocarditis. In addition, newly introduced notion related vaccines, "vaccine-induced thrombotic thrombocytopenia/vaccine-induced prothrombotic thrombocytopenia" (VITT/VIPITT)", importance well. Overviewing recent medical literature while focusing on major AEFIs, demonstrating rate occurrence, presenting cases reported, link specific type represented aim our work. this narrative review, illustrate different types current use, associated with focus 3 (BNT162b2, mRNA-1273, ChAdOx1). While extremely low, addressing issue manner, opinion, best strategy coping hesitancy.

Язык: Английский

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Multisystem Inflammatory Syndrome in an Adult after COVID-19 Vaccination: a Case Report and Literature Review

Journal of Korean Medical Science, Год журнала: 2021, Номер 36(45)

Опубликована: Янв. 1, 2021

As the number of people vaccinated increases, who complain adverse reactions continue to occur. We experienced a case characterized by low blood pressure, persistent fever, edema due increased systemic vascular permeability, and inflammation confirmed image laboratory examinations after ChAdOx1 coronavirus disease 2019 (COVID-19) vaccination. The diagnostic criteria for multisystem inflammatory syndrome (MIS) in adults are known as fever 3 days or more adults, 2 mucocutaneous/gastrointestinal/neurologic symptoms, elevation markers, clinical/imaging diagnosis heart failure. A 67-year-old man was medicated hypertension diabetes admitted complaining maculopapular rash, diarrhea, headache, chills, dizziness 6 first vaccination nCoV-19 Korea. COVID-19 test negative but with leukocytosis, skin pulmonary edema, markers. His lab findings clinical course were consistent those MIS He methylprednisolone 1 mg/kg diuretics recovered rapidly. discharged weeks cure at outpatient clinic. report an

Язык: Английский

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