Recent advances in the potential effects of natural products from traditional Chinese medicine against respiratory diseases targeting ferroptosis DOI Creative Commons
Tian Chen, Lu Ding,

Meiru Zhao

и другие.

Chinese Medicine, Год журнала: 2024, Номер 19(1)

Опубликована: Март 22, 2024

Abstract Respiratory diseases, marked by structural changes in the airways and lung tissues, can lead to reduced respiratory function and, severe cases, failure. The side effects of current treatments, such as hormone therapy, drugs, radiotherapy, highlight need for new therapeutic strategies. Traditional Chinese Medicine (TCM) offers a promising alternative, leveraging its ability target multiple pathways mechanisms. Active compounds from herbs other natural sources exhibit anti-inflammatory, antioxidant, antitumor, immunomodulatory effects, making them valuable preventing treating conditions. Ferroptosis, unique form programmed cell death (PCD) distinct apoptosis, necrosis, others, has emerged key area interest. However, comprehensive reviews on how products influence ferroptosis diseases are lacking. This review will explore potential mechanisms TCM modulating like acute injury (ALI), asthma, pulmonary fibrosis (PF), chronic obstructive disease (COPD), ischemia–reperfusion (LIRI), hypertension (PH), cancer, aiming provide insights research clinical application health.

Язык: Английский

Molecular mechanisms of ferroptosis and relevance to inflammation DOI Open Access

Liyan Deng,

Shasha He,

Nuoqing Guo

и другие.

Inflammation Research, Год журнала: 2022, Номер 72(2), С. 281 - 299

Опубликована: Дек. 19, 2022

Язык: Английский

Процитировано

153
Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects DOI Creative Commons

Qin Ru,

Yusheng Li,

Lin Chen

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Окт. 14, 2024

Iron, an essential mineral in the body, is involved numerous physiological processes, making maintenance of iron homeostasis crucial for overall health. Both overload and deficiency can cause various disorders human diseases. Ferroptosis, a form cell death dependent on iron, characterized by extensive peroxidation lipids. Unlike other kinds classical unprogrammed death, ferroptosis primarily linked to disruptions metabolism, lipid peroxidation, antioxidant system imbalance. Ferroptosis regulated through transcription, translation, post-translational modifications, which affect cellular sensitivity ferroptosis. Over past decade or so, diseases have been as part their etiology, including cancers, metabolic disorders, autoimmune diseases, central nervous cardiovascular musculoskeletal Ferroptosis-related proteins become attractive targets many major that are currently incurable, some regulators shown therapeutic effects clinical trials although further validation potential needed. Therefore, in-depth analysis its molecular mechanisms may offer additional strategies prevention treatment. In this review, we discuss significance contribution etiology development along with evidence supporting targeting approach. Importantly, evaluate recent promising interventions, providing guidance future targeted treatment therapies against

Язык: Английский

Процитировано

81
The mechanism of ferroptosis and its related diseases DOI Creative Commons
Shijian Feng, Dan Tang, Yichang Wang

и другие.

Molecular Biomedicine, Год журнала: 2023, Номер 4(1)

Опубликована: Окт. 16, 2023

Abstract Ferroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation lipid peroxides, provides novel avenue for delving into intersection metabolism, oxidative stress, and disease pathology. We have witnessed mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, traumatic tissue injuries. By unraveling intricate underpinnings molecular machinery, contributors, signaling conduits, regulatory networks governing researchers aim bridge gap between intricacies this unique mode multifaceted implications health disease. In light rapidly advancing landscape ferroptosis research, we present comprehensive review aiming at extensive in origins progress human diseases. This concludes careful analysis potential treatment approaches carefully designed either inhibit or promote ferroptosis. Additionally, succinctly summarized therapeutic targets compounds that hold promise targeting within various facet underscores burgeoning possibilities manipulating as strategy. summary, enriched insights both investigators practitioners, while fostering an elevated comprehension latent translational utilities. revealing basic processes investigating possibilities, crucial resource scientists medical aiding deep understanding effects situations.

Язык: Английский

Процитировано

70
Polystyrene nanoplastics lead to ferroptosis in the lungs DOI Creative Commons
Yuhao Wu, Junke Wang,

Tianxin Zhao

и другие.

Journal of Advanced Research, Год журнала: 2023, Номер 56, С. 31 - 41

Опубликована: Март 17, 2023

It has been shown that polystyrene nanoplastic (PS-NP) exposure induces toxicity in the lungs. This study aims to provide foundational evidence corroborate ferroptosis and abnormal HIF-1α activity are main factors contributing pulmonary dysfunction induced by PS-NP exposure. Fifty male female C57BL/6 mice were exposed distilled water or 100 nm 200 PS-NPs via intratracheal instillation for 7 consecutive days. Hematoxylin eosin (H&E) Masson trichrome staining performed observe histomorphological changes To clarify mechanisms of PS-NP-induced lung injury, we used μg/ml, μg/ml 400 treat human bronchial epithelial cell line BEAS-2B 24 h. RNA sequencing (RNA-seq) cells was following The levels glutathione, malondialdehyde, ferrous iron (Fe2+), reactive oxygen species (ROS) measured. expression ferroptotic proteins detected tissues Western blotting. blotting, immunohistochemistry, immunofluorescence evaluate HIF-1α/HO-1 signaling pathway activity. H&E revealed substantial perivascular lymphocytic inflammation a bronchiolocentric pattern, demonstrated critical collagen deposits lungs after RNA-seq differentially expressed genes PS-NP-exposed enriched lipid metabolism ion binding processes. After exposure, Fe2+, ROS increased, but glutathione level decreased. altered significantly. These results verified led injury through ferroptosis. Finally, discovered played an important role regulating injury. caused activating pathway, eventually

Язык: Английский

Процитировано

62
Ferroptosis inhibitors: past, present and future DOI Creative Commons
Lei Zhang, Yi Luo, Yang Xiang

и другие.

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Май 23, 2024

Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed mechanisms its formation continue to explore effective inhibitors in disease. Recent studies shown correlation between pathological neurodegenerative diseases, as well diseases involving tissue or organ damage. Acting on ferroptosis-related targets may provide new strategies for treatment ferroptosis-mediated diseases. This article specifically describes metabolic pathways summarizes reported action natural synthetic small molecule their efficacy The paper also treatments such gene therapy, nanotechnology, summarises challenges encountered clinical translation inhibitors. Finally, relationship other modes discussed, hopefully paving way future drug design discovery.

Язык: Английский

Процитировано

23
Targeting Ferroptosis as a Promising Therapeutic Strategy for Ischemia-Reperfusion Injury DOI Creative Commons
Yihang Pan, Xueke Wang, Xiwang Liu

и другие.

Antioxidants, Год журнала: 2022, Номер 11(11), С. 2196 - 2196

Опубликована: Ноя. 6, 2022

Ischemia-reperfusion (I/R) injury is a major challenge in perioperative medicine that contributes to pathological damage various conditions, including ischemic stroke, myocardial infarction, acute lung injury, liver transplantation, kidney and hemorrhagic shock. I/R often irreversible, current treatments for are limited. Ferroptosis, type of regulated cell death characterized by the iron-dependent accumulation lipid hydroperoxides, has been implicated multiple diseases, injury. Emerging evidence suggests ferroptosis can serve as therapeutic target alleviate pharmacological strategies targeting have developed models. Here, we systematically summarize recent advances research on provide comprehensive analysis ferroptosis-regulated genes investigated context I/R, well applications regulators, insights into developing this devastating disease.

Язык: Английский

Процитировано

71
SIRT1-mediated p53 deacetylation inhibits ferroptosis and alleviates heat stress-induced lung epithelial cells injury DOI Creative Commons
Hui Chen, Xiaoping Lin,

Xiao‐Hong Yi

и другие.

International Journal of Hyperthermia, Год журнала: 2022, Номер 39(1), С. 977 - 986

Опубликована: Июль 19, 2022

Acute lung injury (ALI) is a common complication of heat stroke (HS) and direct cause death. However, the mechanism underlying ALI following HS remains unclear.To investigate whether ferroptosis involved in HS-ALI. We established model mice mouse epithelial-2 cells (MLE-2). The severity was measured by H&E staining, wet-to-dry weight ratio, Transmission electron microscopy. Potential markers Fe2+, malondialdehyde (MDA), hydroxynonenal (4-HNE) lipid peroxidation were detected. percentages cell death viability induced assessed LDH CCK8 assays. SLC7A11, ACSL4, GPX4, SIRT1, p53, p53 K382 acetylation levels Western blot.The administration inhibitor ferrostatin-1(Fer-1) could significantly ameliorate injury, inhibiting MDA 4-HNE, ameliorating HS-induced increased decreased SLC7A11 suggesting vivo vitro. Moreover, SIRT1 expression decreased, MLE-2 cells. Activation improve epithelial caused ang Besides, activation reduce levels, that prevent via acetylation.These findings substantiate vital role SIRT1/p53 axis mediating HS-ALI, targeting may represent novel therapeutic strategy to during HS.

Язык: Английский

Процитировано

60
Ferroptosis Regulated by Hypoxia in Cells DOI Creative Commons
Xiangnan Zheng,

Yuqiong Liang,

Cen Zhang

и другие.

Cells, Год журнала: 2023, Номер 12(7), С. 1050 - 1050

Опубликована: Март 30, 2023

Ferroptosis is an oxidative damage-related, iron-dependent regulated cell death with intracellular lipid peroxide accumulation, which associated many physiological and pathological processes. It exhibits unique features that are morphologically, biochemically, immunologically distinct from other forms. by iron metabolism, anti-oxidant defense systems, as well various signal pathways. Hypoxia, found in a group of conditions, can affect multiple cellular functions activation the hypoxia-inducible factor (HIF) signaling mechanisms. Emerging evidence demonstrated hypoxia regulates ferroptosis certain types conditions. In this review, we summarize basic mechanisms regulations hypoxia, regulation may contribute to numerous diseases therapies.

Язык: Английский

Процитировано

36
Exploring the molecular mechanisms of isoliquiritin extraction using choline chloride-citric acid deep eutectic solvents DOI
Yi Hu, Zhuxian Wang,

Peiyi Liang

и другие.

Sustainable Chemistry and Pharmacy, Год журнала: 2023, Номер 33, С. 101099 - 101099

Опубликована: Май 2, 2023

Язык: Английский

Процитировано

25
The ACSL4 Network Regulates Cell Death and Autophagy in Diseases DOI Creative Commons
Fangquan Chen, Rui Kang, Jiao Liu

и другие.

Biology, Год журнала: 2023, Номер 12(6), С. 864 - 864

Опубликована: Июнь 15, 2023

Lipid metabolism, cell death, and autophagy are interconnected processes in cells. Dysregulation of lipid metabolism can lead to such as via ferroptosis apoptosis, while lipids also play a crucial role the regulation autophagosome formation. An increased autophagic response not only promotes survival but causes death depending on context, especially when selectively degrading antioxidant proteins or organelles that promote ferroptosis. ACSL4 is an enzyme catalyzes formation long-chain acyl-CoA molecules, which important intermediates biosynthesis various types lipids. found many tissues particularly abundant brain, liver, adipose tissue. linked variety diseases, including cancer, neurodegenerative disorders, cardiovascular disease, acute kidney injury, metabolic disorders (such obesity non-alcoholic fatty liver disease). In this review, we introduce structure, function, ACSL4; discuss its ferroptosis, autophagy; summarize pathological function; explore potential implications targeting treatment diseases.

Язык: Английский

Процитировано

24