Protective effect of melatonin on imidacloprid-induced pyroptosis and ferroptosis by mediating peptidoglycan in the gut of the common carp (Cyprinus carpio)

Pesticide Biochemistry and Physiology, Год журнала: 2024, Номер 202, С. 105935 - 105935

Опубликована: Апрель 28, 2024

Язык: Английский

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Melatonin alleviates LPS-induced depression-like behavior in mice by inhibiting ferroptosis by regulating RNA methylation-mediated SIRT6/Nrf2/HO-1 pathway

European Journal of Nutrition, Год журнала: 2024, Номер unknown

Опубликована: Сен. 19, 2024

Язык: Английский

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Ferroptosis: A new insight for treatment of acute kidney injury

Frontiers in Pharmacology, Год журнала: 2022, Номер 13

Опубликована: Ноя. 17, 2022

Acute kidney injury (AKI), one of the most prevalent clinical diseases with a high incidence rate worldwide, is characterized by rapid deterioration renal function and further triggers accumulation metabolic waste toxins, leading to complications dysfunction other organs. Multiple pathogenic factors, such as rhabdomyolysis, infection, nephrotoxic medications, ischemia-reperfusion injury, contribute onset progression AKI. However, detailed mechanism remains unclear. Ferroptosis, recently identified nonapoptotic cell death, iron-dependent caused lipid peroxide in cells. A variety studies have demonstrated that ferroptosis plays significant role AKI development, contrast forms apoptosis, necroptosis, pyroptosis. In this review, we systemically summarized definition, primary biochemical mechanisms, key regulators associated pharmacological research progress We discussed its therapeutic potential for prevention AKI, hope providing useful reference basic studies.

Язык: Английский

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Therapeutic Effects of Melatonin in the Regulation of Ferroptosis: A Review of Current Evidence

Current Drug Targets, Год журнала: 2024, Номер 25(8), С. 543 - 557

Опубликована: Май 6, 2024

Ferroptosis is implicated in the pathogenesis of multiple diseases, including neurodegenerative cardiovascular kidney pathologies, ischemia-reperfusion injury, and cancer. The current review article highlights involvement ferroptosis traumatic brain acute damage, ethanol-induced liver PM2.5-induced lung injury. Melatonin, a molecule produced by pineal gland many other organs, well known for its anti- aging, anti-inflammatory, anticancer properties used treatment different diseases. Melatonin's ability to activate anti-ferroptosis pathways sirtuin (SIRT)6/p- nuclear factor erythroid 2-related 2 (Nrf2), Nrf2/ antioxidant responsive element (ARE)/ heme oxygenase (HO-1)/SLC7A11/glutathione peroxidase (GPX4)/ prostaglandin-endoperoxide synthase (PTGS2), extracellular signal-regulated kinase (ERK)/Nrf2, ferroportin (FPN), Hippo/ Yes-associated protein (YAP), Phosphoinositide 3-kinase (PI3K)/ B (AKT)/ mammalian target rapamycin (mTOR) SIRT6/ receptor coactivator 4 (NCOA4)/ ferritin heavy chain 1 (FTH1) signaling suggests that it could serve as valuable therapeutic agent preventing cell death associated with various Further research needed fully understand precise mechanisms which melatonin regulates potential target.

Язык: Английский

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Asiatic acid ameliorates doxorubicin-induced cardiotoxicity by promoting FPN-mediated iron export and inhibiting ferroptosis

Acta Pharmacologica Sinica, Год журнала: 2024, Номер unknown

Опубликована: Авг. 14, 2024

Язык: Английский

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