Psoriasis
is
a
multifactorial
immune-mediated
inflammatory
disease.
Its
pathogenesis
involves
abnormal
accumulation
of
neutrophils
and
T-cell-related
abnormalities.
Pyroptosis
type
regulated
cell
death
associated
with
innate
immunity,
but
its
role
in
psoriasis
unclear.
In
this
study,
we
found
that
gasdermin
D
(GSDMD
)
higher
human
psoriatic
skin
than
normal
skin,
imiquimod-induced
psoriasis-like
mouse
the
expression
Gsdmd
was
most
significantly
altered
Il1b
also
mainly
expressed
neutrophils.
Immunohistochemical
staining
serial
sections
lesions
from
patients
healthy
control
showed
GSDMD
lesion,
especially
deficiency
mitigates
inflammation
mice.
contributes
to
inflammation,
while
depletion
attenuates
development
reduces
release
cytokines.
We
neutrophil
pyroptosis
involved
which
provides
new
insights
into
treatment
by
targeting
pyroptosis.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Авг. 1, 2024
NETosis,
a
regulated
form
of
neutrophil
death,
is
crucial
for
host
defense
against
pathogens.
However,
the
release
extracellular
traps
(NETs)
during
NETosis
can
have
detrimental
effects
on
surrounding
tissues
and
contribute
to
pro-inflammatory
response,
in
addition
their
role
controlling
microbes.
Although
it
well-established
that
IL-23-Th17
axis
plays
key
pathogenesis
psoriasis,
emerging
evidence
suggests
as
an
autoinflammatory
disease,
also
associated
with
NETosis.
The
purpose
this
review
provide
comprehensive
understanding
mechanisms
underlying
psoriasis.
It
will
cover
topics
such
formation
NETs,
immune
cells
involved
potential
biomarkers
prognostic/predicting
factors
By
analyzing
intricate
relationship
between
aims
identify
novel
possibilities
targeting
treatment
Experimental Dermatology,
Год журнала:
2024,
Номер
33(7)
Опубликована: Июль 1, 2024
Autoimmune
skin
disease
is
a
kind
of
heterogeneous
with
complicated
pathogenesis.
Many
factors
such
as
genetic,
infectious,
environmental
and
even
psychological
may
interact
together
to
trigger
synergistic
effect
for
the
development
abnormal
innate
adaptive
immune
responses.
Although
exact
mechanisms
remain
unclear,
recent
evidence
suggests
that
pyroptosis
plays
pivotal
role
in
autoimmune
disease.
The
feature
first
formation
pores
cellular
membranes,
then
cell
rupture
release
intracellular
substances
pro-inflammatory
cytokines,
interleukin-1
beta
(IL-1β)
IL-18.
This
hyperactive
inflammatory
programmed
death
damages
homeostasis
system
advances
autoimmunity.
review
briefly
summarises
molecular
regulatory
pyrin
domain-containing
protein
3
(NLRP3)
inflammasome
gasdermin
family,
well
pyroptosis,
highlights
latest
progress
disease,
including
systemic
lupus
erythematosus,
psoriasis,
atopic
dermatitis
scleroderma
attempts
identify
its
potential
advantages
therapeutic
target
or
prognostic
biomarker
these
diseases.
Immunity Inflammation and Disease,
Год журнала:
2024,
Номер
12(7)
Опубликована: Июль 1, 2024
Abstract
Background
Psoriasis
refers
to
a
highly
prevalent
and
immunologically
mediated
dermatosis
with
considerable
deterioration
in
life
quality.
Wogonin,
sort
of
flavonoid,
has
been
mentioned
elicit
protective
activities
skin
diseases.
However,
whether
Wogonin
is
implicated
the
treatment
psoriasis
its
specific
mechanisms
are
not
fully
understood.
Aim
The
present
work
attempted
elaborate
role
during
process
concentrate
on
associated
action
mechanism.
Methods
Cell
counting
kit‐8
(CCK‐8)
method
was
initially
applied
assay
viability
human
keratinocyte
HaCaT
cells
treated
by
varying
concentrations
Wogonin.
To
mimic
vitro,
were
exposed
M5
cytokines.
CCK‐8
5‐Ethynyl‐2′‐deoxyuridine
assays
adopted
for
measurement
cell
proliferation.
Inflammatory
levels
examined
enzyme‐linked
immunosorbent
assay.
Immunofluorescence
staining
tested
nucleotide‐binding
oligomerization
domain
(NOD)‐like
receptor
family
pyrin
containing
3
(NLRP3)
Caspase‐1
expressions.
Western
blot
protein
expressions
proliferation‐,
inflammation‐,
pyroptosis‐associated
factors,
NLRP3.
Results
antagonized
proliferation,
inflammatory
response,
NLRP3/caspase‐1/Gasdermin‐D
(GSDMD)‐mediated
pyroptosis
M5‐challenged
cells.
Besides,
NLRP3
elevation
partially
abrogated
effects
M5‐induced
NLRP3/caspase‐1/GSDMD‐mediated
Conclusion
In
word,
might
exert
anti‐proliferation,
anti‐inflammatory
anti‐pyroptosis
model
blockade
NLRP3/Caspase‐1/GSDMD
pathway
be
recognized
as
potential
mechanism
underlying
psoriasis,
suggesting
prospective
anti‐psoriasis
drug.
Molecular Medicine,
Год журнала:
2025,
Номер
31(1)
Опубликована: Май 22, 2025
Abstract
Psoriasis
is
a
significant
global
health
challenge
due
to
limited
treatment
efficacy.
Paris
saponin
VII
(PSVII)
shows
anti-inflammatory
and
anti-proliferative
potential
but
its
role
in
psoriasis
unclear.
In
this
study,
PSVII
was
identified
from
library
of
natural
compounds
as
therapeutic
candidate
for
psoriasis.
murine
model,
reduced
skin
lesion
severity,
epidermal
thickness,
inflammatory
factor
expression,
preliminaryly
indicating
properties.
vitro,
inhibited
HaCaT
cell
hyperproliferation,
regulated
the
cycle,
induced
apoptosis,
modulated
reactive
oxygen
species
(ROS).
Bioinformatics
analyses
suggested
that
signal
transducer
activator
transcription
3
(STAT3),
cysteine
aspartate
specific
protease
1
(Caspase-1),
process
pyroptosis
are
likely
targets
mechanisms
action.
could
reduce
mortality
psoriatic
cells
lowered
expression
levels
NLR
Family
Pyrin
Domain
Containing
(NLRP3),
Caspase-1,
Gasdermin
D
(GSDMD),
Interleukins
(IL)-18,
IL-1β,
underscoring
modulating
within
these
cells.
Mechanistically,
may
suppress
STAT3/nuclear
kappa
B
(NFκB)
signaling
pathway.
Consequently,
plays
management.
modulate
pyroptotic
death
by
targeting
STAT3/NFκB
cascade,
leading
effects,
thereby
ameliorating
symptoms.
Expert Opinion on Therapeutic Targets,
Год журнала:
2024,
Номер
28(7), С. 587 - 600
Опубликована: Июль 2, 2024
Psoriasis
is
a
chronic
immune-mediated
skin
condition
with
several
types
of
manifestation,
including
psoriatic
arthritis.
In
recent
years,
studies
have
demonstrated
multiple
molecules
and
mechanisms
that
play
important
roles
in
the
pathophysiology
psoriasis.
Studies
been
conducted
to
determine
role
adipokines,
bioactive
peptides
secreted
by
adipose
tissue,
pathogenesis
inflammatory
diseases.
These
shown
adipokines
are
dysregulated
psoriasis
their
abnormal
expression
profile
could
contribute
observed
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 11, 2024
Abstract
Psoriasis
is
a
multifactorial
immune-mediated
inflammatory
disease.
Its
pathogenesis
involves
abnormal
accumulation
of
neutrophils
and
T-cell
related
abnormalities.
Pyroptosis
type
regulated
cell
death
associated
with
innate
immunity,
but
its
role
in
psoriasis
unclear.
In
this
study,
we
found
that
gasdermin
D
(Gsdmd)
higher
human
psoriatic
skin
than
normal
skin,
imiquimod-induced
psoriasis-like
mouse
the
expression
Gsdmd
was
most
significantly
altered
Il1b
also
mainly
expressed
neutrophils.
Immunohistochemical
staining
serial
sections
lesions
from
patients
healthy
control
showed
GSDMD
lesion,
especially
deficiency
mitigates
inflammation
mice.
contributes
to
inflammation,
while
depletion
attenuates
development
reduces
release
cytokines.
We
neutrophil
pyroptosis
involved
which
provides
new
insights
into
treatment
by
targeting
pyroptosis.
Psoriasis
is
a
multifactorial
immune-mediated
inflammatory
disease.
Its
pathogenesis
involves
abnormal
accumulation
of
neutrophils
and
T-cell
related
abnormalities.
Pyroptosis
type
regulated
cell
death
associated
with
innate
immunity,
but
its
role
in
psoriasis
unclear.
In
this
study,
we
found
that
gasdermin
D
(Gsdmd)
higher
human
psoriatic
skin
than
normal
skin,
imiquimod-induced
psoriasis-like
mouse
the
expression
Gsdmd
was
most
significantly
altered
Il1b
also
mainly
expressed
neutrophils.
Immunohistochemical
staining
serial
sections
lesions
from
patients
healthy
control
showed
GSDMD
lesion,
especially
deficiency
mitigates
inflammation
mice.
contributes
to
inflammation,
while
depletion
attenuates
development
reduces
release
cytokines.
We
neutrophil
pyroptosis
involved
which
provides
new
insights
into
treatment
by
targeting
pyroptosis.
Psoriasis
is
a
multifactorial
immune-mediated
inflammatory
disease.
Its
pathogenesis
involves
abnormal
accumulation
of
neutrophils
and
T-cell
related
abnormalities.
Pyroptosis
type
regulated
cell
death
associated
with
innate
immunity,
but
its
role
in
psoriasis
unclear.
In
this
study,
we
found
that
gasdermin
D
(Gsdmd)
higher
human
psoriatic
skin
than
normal
skin,
imiquimod-induced
psoriasis-like
mouse
the
expression
Gsdmd
was
most
significantly
altered
Il1b
also
mainly
expressed
neutrophils.
Immunohistochemical
staining
serial
sections
lesions
from
patients
healthy
control
showed
GSDMD
lesion,
especially
deficiency
mitigates
inflammation
mice.
contributes
to
inflammation,
while
depletion
attenuates
development
reduces
release
cytokines.
We
neutrophil
pyroptosis
involved
which
provides
new
insights
into
treatment
by
targeting
pyroptosis.
