Investigation of the Relationship between Inflammatory Factors CRP, IL-6 and IL-1â and Major Depressive Disorder: A Hospital Based, Case-Control Study DOI Creative Commons
Ather Muneer, Furqan Ahmad,

Mariam Tariq

и другие.

ANNALS OF ABBASI SHAHEED HOSPITAL AND KARACHI MEDICAL & DENTAL COLLEGE, Год журнала: 2024, Номер 29(2), С. 143 - 151

Опубликована: Май 30, 2024

Objective: The present study aims to investigate the relationship of these factors and major depres- sive disorder in a sample patients presenting psychiatry department teaching hospital private medical college Islamabad, Pakistan. Methods: Using convenience sampling total 50 participants were included which comprised 25 with depressive (MDD) matched healthy controls (HC). severity depression was determined help Hamilton Rating Scale for Depres- sion (HRSD) while demographic details collected pro- forma. pro-inflammatory markers (CRP, IL-6 IL-1â) measured serum by taking peripheral venous samples from both cases controls. Statistical analysis performed using SPSS, version 22. Results: Patients MDD had significantly higher levels as com- pared In HC cytokines not raised any significant degree, consistently acute episodes (two t test 2-tailed significance d” 0.01). Conclusion: This showed that sensitive indicators inflammation local pa- tients MDD. Our lends support inflammatory hypothesis depression, so there is further need this avenue. manner it would be possible discover much needed biomarkers, opening new paths more effective therapeutics recalcitrant disorder.

Язык: Английский

Estrogen-immuno-neuromodulation disorders in menopausal depression DOI Creative Commons

Yuling Zhang,

Xiying Tan,

Chaozhi Tang

и другие.

Journal of Neuroinflammation, Год журнала: 2024, Номер 21(1)

Опубликована: Июнь 19, 2024

Abstract A significant decrease in estrogen levels puts menopausal women at high risk for major depression, which remains difficult to cure despite its relatively clear etiology. With the discovery of abnormally elevated inflammation depressed women, immune imbalance has become a novel focus study depression. In this paper, we examined characteristics and possible mechanisms caused by decreased during menopause found that deficiency disrupted homeostasis, especially inflammatory cytokines through ERα/ERβ/GPER-associated NLRP3/NF-κB signaling pathways. We also analyzed destruction blood-brain barrier, dysfunction neurotransmitters, blockade BDNF synthesis, attenuation neuroplasticity cytokine activity, investigated estrogen-immuno-neuromodulation disorders Current research suggests drugs targeting molecules are promising restoring homeostasis system may play positive role intervention treatment

Язык: Английский

Процитировано

9
Protective effect of melatonin against metabolic disorders and neuropsychiatric injuries in type 2 diabetes mellitus mice DOI
Xinran Gao,

Huaizhi Sun,

Yadong Wei

и другие.

Phytomedicine, Год журнала: 2024, Номер 131, С. 155805 - 155805

Опубликована: Июнь 4, 2024

Язык: Английский

Процитировано

8
Assessing causality between chronic obstructive pulmonary disease with depression: A bidirectional Mendelian randomization study DOI Creative Commons
Ang Liu,

Ping-Yang Hong,

Bin Su

и другие.

Journal of Affective Disorders, Год журнала: 2024, Номер 351, С. 782 - 789

Опубликована: Фев. 8, 2024

Our investigation utilized a two-sample Mendelian randomization approach to explore the ambiguous bidirectional relationship between Chronic Obstructive Pulmonary Disease (COPD) and depression, furthering insights from existing observational studies. In this study, we conducted using genome-wide association studies (GWAS) datasets. We initially analyzed depression data Psychiatric Genomics Consortium UK Biobank (n = 500,199), alongside COPD FinnGen 329,552). The second phase involved comparing 372,472) with 361,194). analysis employs various methods guarantee comprehensive rigorous investigation. initial analytic utilizing inverse variance weighted (IVW) method, does not significantly contribute incidence of (IVW odds ratio (OR) 0.989, 95 % confidence interval (CI) 0.895 1.092, P 0.824). Conversely, suggested statistically significant where may precipitate development COPD, notable increase in risk OR 1.421, CI 1.149 1.756, 0.001). Subsequent validation through second-step reinforced hypothesis that elevates likelihood onset 1.002, 1.0003 1.0046, 0.028). analysis, determined escalate depression. our suggests elevate developing COPD. This insight underscores importance enhancing prevention, screening, treatment strategies for individuals

Язык: Английский

Процитировано

6
Mediating effects of gastroesophageal reflux disease and smoking behavior on the relationship between depression and chronic obstructive pulmonary disease: Trans-ethnic Mendelian randomization study DOI

Zewen Cheng,

Jian Wu,

C. F. Xu

и другие.

Journal of Affective Disorders, Год журнала: 2025, Номер 379, С. 176 - 185

Опубликована: Март 11, 2025

Язык: Английский

Процитировано

0
Melatonin alleviates retinal injury induced by vigabatrin and partially enhances its antiepileptic effects DOI

Meng-Die Ma,

Min Fan, Songlin Xu

и другие.

International Immunopharmacology, Год журнала: 2025, Номер 153, С. 114516 - 114516

Опубликована: Март 29, 2025

Язык: Английский

Процитировано

0
Tet1-mediated 5hmC regulates hippocampal neuroinflammation via wnt signaling as a novel mechanism in obstructive sleep apnoea leads to cognitive deficit DOI Creative Commons

Yaru Kong,

Jie Ji,

Xiaojun Zhan

и другие.

Journal of Neuroinflammation, Год журнала: 2024, Номер 21(1)

Опубликована: Авг. 21, 2024

Obstructive sleep apnoea (OSA) is a sleep-disordered breathing characterized by intermittent hypoxia (IH) that may cause cognitive dysfunction. However, the impact of IH on molecular processes involved in function remains unclear. C57BL / 6 J mice were exposed to either normoxia (control) or for weeks. DNA hydroxymethylation was quantified hydroxymethylated immunoprecipitation (hMeDIP) sequencing. ten-eleven translocation 1 (Tet1) knocked down lentivirus. Specifically, assessed behavioral experiments, pathological features HE staining, hippocampal examined dot blot and immunohistochemical while Wnt signaling pathway its downstream effects studied using qRT-PCR, immunofluorescence Luminex liquid suspension chip analysis. showed changes dysfunction hippocampus. Compared with control group, exhibited global hydroxylmethylation hippocampus, expression three hydroxylmethylases increased significantly. The activated, mRNA 5hmC levels Wnt3a, Ccnd2, Prickle2 significantly up-regulated. Further caused neurogenesis abnormalities neuroinflammatory activation, manifested as IBA1 (a marker microglia), GFAP astrocytes), DCX immature neurons), well range inflammatory cytokines (e.g. TNFa, IL3, IL9, IL17A). After Tet1 down, above indicators return normal. Activation associated induced IH.

Язык: Английский

Процитировано

2
Innate immunity-mediated neuroinflammation promotes the onset and progression of post-stroke depression DOI
Mi Xiao, Yujie Chen, 俊哉 佐々木

и другие.

Experimental Neurology, Год журнала: 2024, Номер 381, С. 114937 - 114937

Опубликована: Авг. 26, 2024

Язык: Английский

Процитировано

2
Melatonin protects HT-22 cells against palmitic acid-induced glucolipid metabolic dysfunction and cell injuries: Involved in the regulation of synaptic plasticity and circadian rhythms DOI Open Access
Xinran Gao,

Huaizhi Sun,

Shengwei Hao

и другие.

Biochemical Pharmacology, Год журнала: 2023, Номер 217, С. 115846 - 115846

Опубликована: Окт. 5, 2023

Язык: Английский

Процитировано

6
Psychedelic 25H-NBOMe attenuates post-sepsis depression in rats DOI

B. Ferri,

Cíntia O. de Novais,

Viviana Carolina Trujillo Rojas

и другие.

Neuroscience Letters, Год журнала: 2024, Номер 834, С. 137845 - 137845

Опубликована: Май 29, 2024

Язык: Английский

Процитировано

1
Investigation of the Relationship between Inflammatory Factors CRP, IL-6 and IL-1â and Major Depressive Disorder: A Hospital Based, Case-Control Study DOI Creative Commons
Ather Muneer, Furqan Ahmad,

Mariam Tariq

и другие.

ANNALS OF ABBASI SHAHEED HOSPITAL AND KARACHI MEDICAL & DENTAL COLLEGE, Год журнала: 2024, Номер 29(2), С. 143 - 151

Опубликована: Май 30, 2024

Objective: The present study aims to investigate the relationship of these factors and major depres- sive disorder in a sample patients presenting psychiatry department teaching hospital private medical college Islamabad, Pakistan. Methods: Using convenience sampling total 50 participants were included which comprised 25 with depressive (MDD) matched healthy controls (HC). severity depression was determined help Hamilton Rating Scale for Depres- sion (HRSD) while demographic details collected pro- forma. pro-inflammatory markers (CRP, IL-6 IL-1â) measured serum by taking peripheral venous samples from both cases controls. Statistical analysis performed using SPSS, version 22. Results: Patients MDD had significantly higher levels as com- pared In HC cytokines not raised any significant degree, consistently acute episodes (two t test 2-tailed significance d” 0.01). Conclusion: This showed that sensitive indicators inflammation local pa- tients MDD. Our lends support inflammatory hypothesis depression, so there is further need this avenue. manner it would be possible discover much needed biomarkers, opening new paths more effective therapeutics recalcitrant disorder.

Язык: Английский

Процитировано

0