Allergology International,
Год журнала:
2021,
Номер
71(1), С. 3 - 13
Опубликована: Дек. 13, 2021
Atopic
dermatitis
(AD)
is
the
most
common
chronic
skin
inflammatory
disease,
with
a
profound
impact
on
patients'
quality
of
life.
AD
varies
considerably
in
clinical
course,
age
onset
and
degree
to
which
it
accompanied
by
allergic
non-allergic
comorbidities.
Skin
barrier
impairment
both
lesional
nonlesional
now
recognized
as
critical
often
early
feature
AD.
This
may
be
explained
number
abnormalities
identified
within
stratum
corneum
granulosum
layers
epidermis.
The
goal
this
review
provide
an
overview
key
defects
AD,
starting
historical
perspective.
We
will
also
highlight
some
commonly
used
methods
characterize
quantify
function.
There
ample
opportunity
for
further
investigative
work
we
call
out
throughout
review.
These
include:
quantifying
relative
individual
epidermal
putting
more
holistic
view
physiological
measures
function,
well
determining
whether
these
barrier-specific
endotypes
predict
phenotypes
(e.g.
onset,
natural
history,
comorbidities,
response
therapies,
etc).
Mechanistic
studies
new
(and
development)
therapies
that
specifically
target
immune
pathways,
Staphylococcus
aureus
abundance
and/or
help
us
understand
dynamic
crosstalk
between
compartments
their
importance
Signal Transduction and Targeted Therapy,
Год журнала:
2023,
Номер
8(1)
Опубликована: Март 24, 2023
Abstract
Allergic
diseases
such
as
allergic
rhinitis
(AR),
asthma
(AAS),
atopic
dermatitis
(AD),
food
allergy
(FA),
and
eczema
are
systemic
caused
by
an
impaired
immune
system.
Accompanied
high
recurrence
rates,
the
steadily
rising
incidence
rates
of
these
attracting
increasing
attention.
The
pathogenesis
is
complex
involves
many
factors,
including
maternal-fetal
environment,
living
genetics,
epigenetics,
body’s
status.
exhibits
a
marked
heterogeneity,
with
phenotype
endotype
defining
visible
features
associated
molecular
mechanisms,
respectively.
With
rapid
development
immunology,
biology,
biotechnology,
new
biological
drugs
have
been
designed
for
treatment
diseases,
anti-immunoglobulin
E
(IgE),
anti-interleukin
(IL)-5,
anti-thymic
stromal
lymphopoietin
(TSLP)/IL-4,
to
control
symptoms.
For
doctors
scientists,
it
becoming
more
important
understand
influencing
pathogenesis,
progress
diseases.
This
review
aimed
assess
epidemiology,
therapeutic
interventions
AR,
AAS,
AD,
FA.
We
hope
help
scientists
systematically.
Nutrients,
Год журнала:
2021,
Номер
13(5), С. 1638 - 1638
Опубликована: Май 13, 2021
Adverse
food
reactions
include
immune-mediated
allergies
and
non-immune-mediated
intolerances.
However,
this
distinction
the
involvement
of
different
pathogenetic
mechanisms
are
often
confused.
Furthermore,
there
is
a
discrepancy
between
perceived
vs.
actual
prevalence
non-immune
to
that
extremely
common.
The
risk
an
inappropriate
approach
their
correct
identification
can
lead
diets
with
severe
nutritional
deficiencies.
This
narrative
review
provides
outline
pathophysiologic
clinical
features
immune
adverse
food-along
general
diagnostic
therapeutic
strategies.
Special
emphasis
placed
on
specific
concerns
for
each
these
conditions
from
combined
point
view
gastroenterology
immunology,
in
attempt
offer
useful
tool
practicing
physicians
discriminating
diverging
disease
entities
planning
management.
We
conclude
dietary
control
both
immune-
food-induced
diseases
might
minimize
gaps
patients,
thus
helping
improve
quality
life
reduce
economic
costs
Mucosal Immunology,
Год журнала:
2022,
Номер
15(5), С. 908 - 926
Опубликована: Июнь 7, 2022
Barrier
integrity
is
central
to
the
maintenance
of
healthy
immunological
homeostasis.
Impaired
skin
barrier
function
linked
with
enhanced
allergen
sensitization
and
development
diseases
such
as
atopic
dermatitis
(AD),
which
can
precede
other
allergic
disorders,
for
example,
food
allergies
asthma.
Epidemiological
evidence
indicates
that
children
suffering
from
have
lower
levels
dietary
fibre-derived
short-chain
fatty
acids
(SCFA).
Using
an
experimental
model
AD-like
inflammation,
we
report
a
fermentable
fibre-rich
diet
alleviates
systemic
disease
severity.
The
gut-skin
axis
underpins
this
phenomenon
through
SCFA
production,
particularly
butyrate,
strengthens
by
altering
mitochondrial
metabolism
epidermal
keratinocytes
production
key
structural
components.
Our
results
demonstrate
fibre
improve
integrity,
ultimately
limiting
early
development.The
Graphical
Abstract
was
designed
using
Servier
Medical
Art
images
(
https://smart.servier.com
).
Allergy,
Год журнала:
2022,
Номер
77(11), С. 3388 - 3397
Опубликована: Июль 11, 2022
Abstract
Background
Atopic
dermatitis
(AD)
is
characterized
by
abnormal
skin
lipids
that
are
largely
driven
hyperactivated
type
2
immune
responses.
The
antibody
to
the
α‐subunit
of
interleukin
(IL)‐4
receptor,
dupilumab,
was
recently
approved
treat
AD
and
demonstrated
strong
efficacy.
However,
role
dupilumab
therapy
in
regulation
barrier
structure
function
has
not
been
fully
explored.
Methods
We
have
evaluated
content
transepidermal
water
loss
(TEWL)
lesional
non‐lesional
adults
adolescents
with
moderate‐to‐severe
over
course
16‐week
treatment
compared
those
values
matched
healthy
volunteers.
Results
Dupilumab
provided
a
significant
decrease
TEWL
lesions,
lowering
it
almost
levels
seen
subjects.
Blocking
IL‐4/IL‐13
signaling
normalized
lipid
composition
(decreased
ceramides
non‐hydroxy
fatty
acids
C18‐sphingosine
increased
level
esterified
omega‐hydroxy
acid‐containing
ceramides)
ceramide
chain
length
as
well
stratum
corneum
patients.
Partial
changes
for
these
parameters
were
already
observed
after
weeks,
full
response
achieved
8
weeks
treatment.
Conclusions
Inhibition
allows
restoration
patients
AD.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Фев. 1, 2024
The
epithelial
barrier
serves
as
a
critical
defense
mechanism
separating
the
human
body
from
external
environment,
fulfilling
both
physical
and
immune
functions.
This
plays
pivotal
role
in
shielding
environmental
risk
factors
such
allergens,
pathogens,
pollutants.
However,
since
19th
century,
escalating
threats
posed
by
pollution,
global
warming,
heightened
usage
of
industrial
chemical
products,
alterations
biodiversity
have
contributed
to
noteworthy
surge
allergic
disease
incidences.
Notably,
diseases
frequently
exhibit
dysfunction
barrier.
proposed
hypothesis
introduces
novel
avenue
for
prevention
treatment
diseases.
Despite
increased
attention
development,
numerous
questions
persist
regarding
mechanisms
underlying
disruption
normal
function.
Consequently,
this
review
aims
provide
comprehensive
overview
barrier’s
diseases,
encompassing
influencing
factors,
assessment
techniques,
repair
methodologies.
By
doing
so,
it
seeks
present
innovative
strategies
The Journal of Dermatology,
Год журнала:
2020,
Номер
48(2), С. 130 - 139
Опубликована: Окт. 29, 2020
Abstract
Atopic
dermatitis
is
a
common,
chronic
inflammatory
skin
disease
that
characterized
by
barrier
dysfunction,
inflammation
and
intense
itch.
Although
the
exact
mechanisms
behind
its
pathogenesis
remain
unclear,
it
evident
complex
interplay
among
itch
are
critical
in
development,
progression
chronicity.
Abnormalities
filaggrin,
intercellular
lipids
tight
junctions
induce
barrier‐disrupted
skin,
which
produces
thymic
stromal
lymphopoietin,
interleukin
(IL)‐25
IL‐33;
these
turn
promote
type
2
immune
deviation.
This
then
downregulates
expression
of
filaggrin
keratinocytes
exacerbates
epidermal
dysfunction.
Furthermore,
various
mediators/pruritogens
produced
during
this
process
can
act
directly
on
sensory
nerves
cause
In
review,
we
summarize
basics
recent
advances
our
understanding
pathophysiology
atopic
focusing
three
aspects:
