Skin barrier defects in atopic dermatitis: From old idea to new opportunity DOI Creative Commons
Takeshi Yoshida, Lisa A. Beck, Anna De Benedetto

et al.

Allergology International, Journal Year: 2021, Volume and Issue: 71(1), P. 3 - 13

Published: Dec. 13, 2021

Atopic dermatitis (AD) is the most common chronic skin inflammatory disease, with a profound impact on patients' quality of life. AD varies considerably in clinical course, age onset and degree to which it accompanied by allergic non-allergic comorbidities. Skin barrier impairment both lesional nonlesional now recognized as critical often early feature AD. This may be explained number abnormalities identified within stratum corneum granulosum layers epidermis. The goal this review provide an overview key defects AD, starting historical perspective. We will also highlight some commonly used methods characterize quantify function. There ample opportunity for further investigative work we call out throughout review. These include: quantifying relative individual epidermal putting more holistic view physiological measures function, well determining whether these barrier-specific endotypes predict phenotypes (e.g. onset, natural history, comorbidities, response therapies, etc). Mechanistic studies new (and development) therapies that specifically target immune pathways, Staphylococcus aureus abundance and/or help us understand dynamic crosstalk between compartments their importance

Language: Английский

Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies DOI Open Access
Milton Pividori, Nathan Schoettler, Dan L. Nicolae

et al.

The Lancet Respiratory Medicine, Journal Year: 2019, Volume and Issue: 7(6), P. 509 - 522

Published: April 27, 2019

Language: Английский

Citations

297
Pathogenesis of allergic diseases and implications for therapeutic interventions DOI Creative Commons
Ji Wang, Yumei Zhou, Honglei Zhang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: March 24, 2023

Abstract Allergic diseases such as allergic rhinitis (AR), asthma (AAS), atopic dermatitis (AD), food allergy (FA), and eczema are systemic caused by an impaired immune system. Accompanied high recurrence rates, the steadily rising incidence rates of these attracting increasing attention. The pathogenesis is complex involves many factors, including maternal-fetal environment, living genetics, epigenetics, body’s status. exhibits a marked heterogeneity, with phenotype endotype defining visible features associated molecular mechanisms, respectively. With rapid development immunology, biology, biotechnology, new biological drugs have been designed for treatment diseases, anti-immunoglobulin E (IgE), anti-interleukin (IL)-5, anti-thymic stromal lymphopoietin (TSLP)/IL-4, to control symptoms. For doctors scientists, it becoming more important understand influencing pathogenesis, progress diseases. This review aimed assess epidemiology, therapeutic interventions AR, AAS, AD, FA. We hope help scientists systematically.

Language: Английский

Citations

143
Type 2 Inflammation Contributes to Skin Barrier Dysfunction in Atopic Dermatitis DOI
Lisa A. Beck, Michael J. Cork, Masayuki Amagai

et al.

JID Innovations, Journal Year: 2022, Volume and Issue: 2(5), P. 100131 - 100131

Published: April 26, 2022

Language: Английский

Citations

141
Food Allergy and Intolerance: A Narrative Review on Nutritional Concerns DOI Open Access
Domenico Gargano,

Ramapraba Appanna,

Antonella Santonicola

et al.

Nutrients, Journal Year: 2021, Volume and Issue: 13(5), P. 1638 - 1638

Published: May 13, 2021

Adverse food reactions include immune-mediated allergies and non-immune-mediated intolerances. However, this distinction the involvement of different pathogenetic mechanisms are often confused. Furthermore, there is a discrepancy between perceived vs. actual prevalence non-immune to that extremely common. The risk an inappropriate approach their correct identification can lead diets with severe nutritional deficiencies. This narrative review provides outline pathophysiologic clinical features immune adverse food-along general diagnostic therapeutic strategies. Special emphasis placed on specific concerns for each these conditions from combined point view gastroenterology immunology, in attempt offer useful tool practicing physicians discriminating diverging disease entities planning management. We conclude dietary control both immune- food-induced diseases might minimize gaps patients, thus helping improve quality life reduce economic costs

Language: Английский

Citations

109
Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation DOI Creative Commons
Aurélien Trompette,

Julie Pernot,

Olaf Perdijk

et al.

Mucosal Immunology, Journal Year: 2022, Volume and Issue: 15(5), P. 908 - 926

Published: June 7, 2022

Barrier integrity is central to the maintenance of healthy immunological homeostasis. Impaired skin barrier function linked with enhanced allergen sensitization and development diseases such as atopic dermatitis (AD), which can precede other allergic disorders, for example, food allergies asthma. Epidemiological evidence indicates that children suffering from have lower levels dietary fibre-derived short-chain fatty acids (SCFA). Using an experimental model AD-like inflammation, we report a fermentable fibre-rich diet alleviates systemic disease severity. The gut-skin axis underpins this phenomenon through SCFA production, particularly butyrate, strengthens by altering mitochondrial metabolism epidermal keratinocytes production key structural components. Our results demonstrate fibre improve integrity, ultimately limiting early development.The Graphical Abstract was designed using Servier Medical Art images ( https://smart.servier.com ).

Language: Английский

Citations

102
Dupilumab significantly improves skin barrier function in patients with moderate‐to‐severe atopic dermatitis DOI
Evgeny Berdyshev, Elena Goleva, Robert Bissonnette

et al.

Allergy, Journal Year: 2022, Volume and Issue: 77(11), P. 3388 - 3397

Published: July 11, 2022

Abstract Background Atopic dermatitis (AD) is characterized by abnormal skin lipids that are largely driven hyperactivated type 2 immune responses. The antibody to the α‐subunit of interleukin (IL)‐4 receptor, dupilumab, was recently approved treat AD and demonstrated strong efficacy. However, role dupilumab therapy in regulation barrier structure function has not been fully explored. Methods We have evaluated content transepidermal water loss (TEWL) lesional non‐lesional adults adolescents with moderate‐to‐severe over course 16‐week treatment compared those values matched healthy volunteers. Results Dupilumab provided a significant decrease TEWL lesions, lowering it almost levels seen subjects. Blocking IL‐4/IL‐13 signaling normalized lipid composition (decreased ceramides non‐hydroxy fatty acids C18‐sphingosine increased level esterified omega‐hydroxy acid‐containing ceramides) ceramide chain length as well stratum corneum patients. Partial changes for these parameters were already observed after weeks, full response achieved 8 weeks treatment. Conclusions Inhibition allows restoration patients AD.

Language: Английский

Citations

74
Stratum corneum lipid and cytokine biomarkers at age 2 months predict the future onset of atopic dermatitis DOI

E. Berdyshev,

Jihyun Kim, Byung Eui Kim

et al.

Journal of Allergy and Clinical Immunology, Journal Year: 2023, Volume and Issue: 151(5), P. 1307 - 1316

Published: Feb. 23, 2023

Language: Английский

Citations

48
Skin as the target for allergy prevention and treatment DOI Creative Commons
Andreina Marques‐Mejias, Irene Bartha, Christina E. Ciaccio

et al.

Annals of Allergy Asthma & Immunology, Journal Year: 2024, Volume and Issue: 133(2), P. 133 - 143

Published: Jan. 21, 2024

Language: Английский

Citations

18
Involvement and repair of epithelial barrier dysfunction in allergic diseases DOI Creative Commons
Hui-Fei Lu,

Yi-Chi Zhou,

Litao Yang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 1, 2024

The epithelial barrier serves as a critical defense mechanism separating the human body from external environment, fulfilling both physical and immune functions. This plays pivotal role in shielding environmental risk factors such allergens, pathogens, pollutants. However, since 19th century, escalating threats posed by pollution, global warming, heightened usage of industrial chemical products, alterations biodiversity have contributed to noteworthy surge allergic disease incidences. Notably, diseases frequently exhibit dysfunction barrier. proposed hypothesis introduces novel avenue for prevention treatment diseases. Despite increased attention development, numerous questions persist regarding mechanisms underlying disruption normal function. Consequently, this review aims provide comprehensive overview barrier’s diseases, encompassing influencing factors, assessment techniques, repair methodologies. By doing so, it seeks present innovative strategies

Language: Английский

Citations

17
Basics and recent advances in the pathophysiology of atopic dermatitis DOI
Takeshi Nakahara, Makiko Kido‐Nakahara, Gaku Tsuji

et al.

The Journal of Dermatology, Journal Year: 2020, Volume and Issue: 48(2), P. 130 - 139

Published: Oct. 29, 2020

Abstract Atopic dermatitis is a common, chronic inflammatory skin disease that characterized by barrier dysfunction, inflammation and intense itch. Although the exact mechanisms behind its pathogenesis remain unclear, it evident complex interplay among itch are critical in development, progression chronicity. Abnormalities filaggrin, intercellular lipids tight junctions induce barrier‐disrupted skin, which produces thymic stromal lymphopoietin, interleukin (IL)‐25 IL‐33; these turn promote type 2 immune deviation. This then downregulates expression of filaggrin keratinocytes exacerbates epidermal dysfunction. Furthermore, various mediators/pruritogens produced during this process can act directly on sensory nerves cause In review, we summarize basics recent advances our understanding pathophysiology atopic focusing three aspects:

Language: Английский

Citations

101