Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders

Neuronal Signaling, Год журнала: 2023, Номер 7(4)

Опубликована: Окт. 27, 2023

Abstract Emotion dysregulation (ED) describes a difficulty with the modulation of which emotions are felt, as well when and how these experienced or expressed. It is focal overarching symptom in many severe prevalent neuropsychiatric diseases, including bipolar disorders (BD), attention deficit/hyperactivity disorder (ADHD), borderline personality (BPD). In all disorders, ED can manifest through symptoms depression, anxiety, affective lability. Considering symptomatic similarities between BD, ADHD, BPD, transdiagnostic approach promising lens investigation. Mounting evidence supports role peripheral inflammatory markers stress multifactorial aetiology physiopathology BPD. Of note, neural circuits that regulate appear particularly vulnerable to insults inflammation, impact neuroimmune milieu central nervous system. Thus far, few studies have examined link inflammation To our knowledge, no specific work has provided critical comparison results from disorders. fill this gap literature, we review known associations mechanisms linking general, clinically, BD. Our narrative begins an examination routes followed by discussion disorder-specific accounting for methodological limitations relevant confounding factors. Finally, critically discuss both correspondences discrepancies comment on potential vulnerability therapeutic interventions.

Язык: Английский

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Shared and unique characteristics of metabolic syndrome in psychotic disorders: a review

Frontiers in Psychiatry, Год журнала: 2024, Номер 15

Опубликована: Март 4, 2024

Introduction People with psychosis spectrum disorders (PSD) face an elevated risk of metabolic syndrome (MetS), which may reduce their life expectancy by nearly 20%. Pinpointing the shared and specific characteristics clinical implications MetS in PSD is crucial for designing interventions to this risk, but up-to-date review on across lacking. Methods This narrative fills gap examining literature both distinct transdiagnostically, i.e., traditional categorical diagnoses, a focus psychiatric cardio-metabolic management. Results We discuss common PSD, as well factors contributing development patients, including unhealthy lifestyle factors, genetic predisposition, pro-inflammatory state, drugs consumption, antipsychotic medication, psychotic symptoms. highlight importance early identification management existing gaps literature, instance screening younger patients. compare hypotheses-generating associations different concluding reviewing recommendations challenges screening, monitoring, managing PSD. Conclusion Early are mitigate long-term toll Interventions should healthy appropriate pharmacological behavioral interventions. Further translational research needed develop targeted personalized treatment approaches vulnerable population, aiming at improving physical health overall well-being.

Язык: Английский

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Applications of Mendelian randomization in psychiatry: a comprehensive systematic review

Psychiatric Genetics, Год журнала: 2022, Номер 32(6), С. 199 - 213

Опубликована: Окт. 20, 2022

Psychiatric diseases exact a heavy socioeconomic toll, and it is particularly difficult to identify their risk factors causative mechanisms due multifactorial nature, the limited physiopathological insight, many confounding factors, potential reverse causality between psychiatric diseases. These characteristics make Mendelian randomization (MR) precious tool for studying these disorders. MR an analytical method that employs genetic variants linked certain factor, assess if observational association factor health outcome compatible with causal relationship. We report first systematic review of all existing applications findings in disorders, aiming at facilitating identification may be common different diseases, paving way transdiagnostic studies psychiatry, which are currently lacking. searched Web Knowledge, Scopus, Pubmed databases (until 3 May 2022) articles on psychiatry. The protocol was preregistered PROSPERO (CRD42021285647). included methodological details results from 50 articles, mainly schizophrenia, major depression, autism spectrum bipolar disorder. While this shows how can offer unique opportunities unraveling links etiological elements specific transdiagnostically, some flaws literature limit reliability probably underlie heterogeneity. highlight perspectives recommendations future works

Язык: Английский

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Celecoxib for Mood Disorders: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(10), С. 3497 - 3497

Опубликована: Май 16, 2023

The effects of celecoxib on a broad spectrum mood disorders and inflammatory parameters have not yet been comprehensively evaluated. aim this study was to systematically summarize the available knowledge topic. Data from both preclinical clinical studies were analyzed, considering efficacy safety in treatment disorders, as well correlation with effect treatment. Forty-four included. We found evidence supporting antidepressant dose 400 mg/day used for 6 weeks an add-on major depression (SMD = −1.12 [95%Cl: −1.71,−0.52], p 0.0002) mania −0.82 [95% CI:−1.62,−0.01], 0.05). above dosage sole also confirmed depressed patients somatic comorbidity −1.35 CI:−1.95,−0.75], < 0.0001). no conclusive effectiveness bipolar depression. Celecoxib at mg/d up 12 appeared be safe disorders. Although association between response has studies, trials. Further are needed evaluate depression, long-term evaluating recurrent involving treatment-resistant populations, assessing markers.

Язык: Английский

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HERV-W upregulation expression in bipolar disorder and schizophrenia: unraveling potential links to systemic immune/inflammation status

Retrovirology, Год журнала: 2024, Номер 21(1)

Опубликована: Апрель 21, 2024

Abstract Background Bipolar disorder (BD) and schizophrenia (SZ) are the two main mental disorders with unknown etiology that significantly impact individuals’ quality of life. The potential pro-inflammatory role in their pathogenesis is postulated Human Endogenous Retrovirus W (HERV-W) an emerging candidate to modulate this pathogenic finding. HERVs, ancient retroviruses human genome, may play roles inflammation disease pathogenesis. Despite HERVs’ involvement autoimmune diseases, influence on remains underexplored. Therefore, aim study was assess level HERV-W-env expression systemic inflammatory profile through concentration IL-2, IL-4, IL-6, IL-10, TNF-α INF-γ cytokines BD SZ patients. Results All participants showed expression, but its higher patients ( p < 0.01) than control. When separated, individuals exhibited HERV-W control group 0.01). Higher serum levels IL-10 were found = 0.0001 0.001, respectively) 0.01, group, while decreased IFN-γ IL-2 as compared controls 0.05) 0.05), respectively. TNF-α/IL-4 TNF-α/IL-10 ratios, lower IFN-γ/IL-10 observed controls. Significant negative correlation between r =-0.47 well positive correlations or ratios 0.48 0.05 0.46 0.05, Conclusion These findings suggest not only a link both SZ, also possible status

Язык: Английский

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Dynamic functional hippocampal markers of residual depressive symptoms in euthymic bipolar disorder

Brain and Behavior, Год журнала: 2023, Номер 13(6)

Опубликована: Апрель 16, 2023

Bipolar disorder (BD) is a severe, chronic, affective characterized by recurrent switching between mood states, psychomotor and cognitive symptoms, which can linger in euthymic states as residual symptoms. Hippocampal alterations may play key role the neural processing of BD However, its dynamic functional connectivity (dFC) remains unclear. Therefore, present study explores hippocampal dFC relation to symptoms.We assessed hippocampus-based coactivation patterns (CAPs) on resting-state fMRI data 25 patients age- sex-matched healthy controls (HC).Bilateral with somatomotor networks (SMN) was reduced BD, compared HC, while at same time left hippocampus midcingulo-insular salience system (SN) higher BD. Correlational analysis CAPs clinical scores revealed that bilateral default-like network (DMN) correlated depression Furthermore, pathological hyperconnectivity default mode SMN frontoparietal (FPN) modulated BD.Overall, we observed large-scale brain associated decreased flexibility control, detection, emotion Additionally, provides new insights architecture underlying self-centered perspective environment patients. markers improve treatment, follow-up disabling depressive symptoms particular.

Язык: Английский

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Hippocampal temporal dynamics and spatial heterogeneity unveil vulnerability markers in the offspring of bipolar patients

Bipolar Disorders, Год журнала: 2024, Номер unknown

Опубликована: Авг. 12, 2024

Bipolar disorder (BD) is a highly heritable characterized by emotion dysregulation and recurrent oscillations between mood states. Despite the proven efficacy of early interventions, vulnerability markers in high-risk individuals are still lacking. BD patients present structural alterations hippocampus, pivotal hub regulation networks composed multiple subregions with different projections. However, hippocampal dynamic functional connectivity (dFC) remains unclear. We aim to investigate whether dFC subdivisions differentiates patients, offspring (BDoff), healthy controls (HC); it correlates symptoms differently these groups.

Язык: Английский

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Brain‐derived subgroups of bipolar II depression associate with inflammation and choroid plexus morphology

Psychiatry and Clinical Neurosciences, Год журнала: 2023, Номер 77(11), С. 613 - 621

Опубликована: Авг. 19, 2023

Elevated inflammation and larger choroid plexus (ChP) volume has been previously identified in mood disorders. Connections between inflammation, ChP, clinical symptoms bipolar II depression (BDII-D) are unclear. Data-driven clustering based on neuroanatomical phenotypes may help to elucidate neurobiological associations BDII-D.Inflammatory cytokines, symptoms, features were assessed 150 BDII-D patients. Sixty-eight cortical surface area (SA) 19 subcortical volumes extracted using FreeSurfer. The ChP was segmented manually 3D Slicer. Regularized canonical correlation analysis used identify significantly correlated components SA (excluding the ChP), followed by k-means define brain-derived subgroups of BDII-D. Low-grade derived averaging standardized z scores interleukin (IL)-6, IL-1β, tumor necrosis factor-α (TNF-α), which computed create a composite z-value score. Partial Pearson correlations multiple comparison correction conducted explore volume.Subgroup I demonstrated smaller SA, higher compared with subgroup II. Greater associated low-grade (mean r = 0.289, q 0.003), CRP 0.249, 0.007), IL-6 (left 0.200, 0.03), TNF-α (right 0.226, 0.01), while greater IL-1β severe depressive (r 0.218, 0.045).Neuroanatomically-derived differed their levels volume. These findings suggest an important role elevated peripheral

Язык: Английский

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Limbic-Sensorimotor Tug of War for the Hippocampus: Dynamic Functional Connectivity as a Transdiagnostic Vulnerability Marker in Offspring of Emotion Dysregulation Patients

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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White matter hyperintensities in bipolar disorder: systematic review and meta-analysis

Frontiers in Psychiatry, Год журнала: 2024, Номер 15

Опубликована: Янв. 26, 2024

Background White matter hyperintensities are lesions of presumed vascular origin associated with Cerebral small vessel disease. WMH common findings that and increased risk cognitive impairment dementia. A higher prevalence has been also reported in patients bipolar disorder (BD), although the evidence is conflicting. Objective To compare adults BD, found healthy controls. Methods We searched Embase, Medline/PubMed, references cited articles retrieved on May 20, 2023. included case-control studies compared adult BD controls, using T2-weighted magnetic resonance imaging. performed a meta-analysis random-effects method based inverse-variance approach. Findings 22 reporting data 1313 people. The overall rate was 46.5% 28% controls (pooled Odds Ratio 2.89, 95% CI 1.76; 4.75). moderate heterogeneity across (I 2 = 0.49). Publication bias not significant. Interpretation have burden than Main limitations were impossibility analyzing gender differences type, between studies, non-representative samples, lack control for major confounders search two electronic databases. Systematic review registration https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023428464

Язык: Английский

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