Potential lifetime effects caused by cellular uptake of nanoplastics: A review

Environmental Pollution, Год журнала: 2023, Номер 329, С. 121668 - 121668

Опубликована: Апрель 20, 2023

Язык: Английский

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The role of HIF-1α/HO-1 pathway in hippocampal neuronal ferroptosis in epilepsy

iScience, Год журнала: 2023, Номер 26(11), С. 108098 - 108098

Опубликована: Сен. 29, 2023

Epilepsy, a common central nervous system disorder, remains an enigma in pathogenesis. Emerging consensus designates hippocampal neuronal injury as cornerstone for epileptogenic foci, pivotal epileptic genesis and progression. Ferroptosis, regulated cell death modality hinging on iron, catalyzes lipid reactive oxygen species formation through iron membrane polyunsaturated fatty acid interplay, culminating oxidative death. This research investigates the role of hypoxia-inducible factor (HIF)-1α/heme oxygenase (HO)-1 neuron ferroptosis during epilepsy. Untargeted metabolomics exposes metabolite discrepancies between epilepsy patients healthy individuals, unveiling escalated stress, heightened bilirubin, augmented metabolism blood. Enrichment analyses unveil active HIF-1 pathway pathogenesis, reinforced by HIF-1α signaling perturbations DisGeNET database. PTZ-kindled mice model confirms increased ferroptotic markers, HIF-1α, HO-1 Study implicates HIF-1α/HO-1 potentially regulates ferroptosis, metabolism, thereby promoting propagation

Язык: Английский

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Particulate Matter Induces Oxidative Stress and Ferroptosis in Human Lung Epithelial Cells

Toxics, Год журнала: 2024, Номер 12(2), С. 161 - 161

Опубликована: Фев. 19, 2024

Numerous toxicological studies have highlighted the association between urban particulate matter (PM) and increased respiratory infections lung diseases. The adverse impact on lungs is directly linked to complex composition of matter, initiating reactive oxygen species (ROS) production consequent lipid peroxidation. Excessive ROS, particularly within mitochondria, can destroy subcellular organelles through various pathways. In this study, we confirmed induction ferroptosis, an iron-dependent cell death, upon exposure PM using RT-qPCR signaling pathway analysis. We used KRISS CRM 109-02-004, certified reference material for analysis produced by Korea Research Institute Standards Science (KRISS). To validate that ferroptosis causes endothelial toxicity, assessed intracellular mitochondrial potential, ROS overproduction, peroxidation, specific biomarkers. Following PM, a significant increase in generation decrease potential were observed. Furthermore, it induced hallmarks including accumulation loss antioxidant defenses, cellular iron accumulation. addition, occurrence oxidative stress as key feature was expression levels markers such NQO1, CYP1B1, FTH1, SOD2, NRF. Finally, observed, xCT/SLC7A11, TRIM16, HMOX-1, FTL, CHAC1, GPX4. This provides evidence elevated induce stress, which ultimately triggers ferroptosis. conclusion, our results show CRM, induces production, leading subsequent These suggest may offer strategies treatment

Язык: Английский

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HO-1 activation contributes to cadmium-induced ferroptosis in renal tubular epithelial cells via increasing the labile iron pool and promoting mitochondrial ROS generation

Chemico-Biological Interactions, Год журнала: 2024, Номер 399, С. 111152 - 111152

Опубликована: Июль 16, 2024

Язык: Английский

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Maternal exposure to nanopolystyrene induces neurotoxicity in offspring through P53-mediated ferritinophagy and ferroptosis in the rat hippocampus

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Окт. 23, 2024

There are increasing concerns regarding the rapid expansion of polystyrene nanoplastics (PS-NPs), which could impact human health. Previous studies have shown that can be transferred from mothers to offspring through placenta and breast milk, resulting in cognitive deficits offspring. However, neurotoxic effects maternal exposure on its mechanisms remain unclear. In this study, PS-NPs (50 nm) were gavaged female rats throughout gestation lactation establish an model study neurotoxicity behavioral changes caused by Neonatal rat hippocampal neuronal cells used investigate pathways NPs induce neurodevelopmental toxicity rats, using iron inhibitors, autophagy reactive oxygen species (ROS) scroungers, P53 NCOA4 inhibitors. We found low dosages cause ferroptosis hippocampus offspring, a decline cognitive, learning, memory abilities induced NOCA4-mediated ferritinophagy promoted inciting ROS production activate P53-mediated ferritinophagy. Furthermore, levels antioxidant factors glutathione peroxidase 4 (GPX4) (GSH), responsible for ferroptosis, reduced. summary, revealed consumption during damage Our results serve as basis further research into

Язык: Английский

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Esketamine alleviates ferroptosis-mediated acute lung injury by modulating the HIF-1α/HO-1 pathway

International Immunopharmacology, Год журнала: 2024, Номер 142, С. 113065 - 113065

Опубликована: Сен. 7, 2024

Язык: Английский

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Metabolomics reveals that PS-NPs promote lung injury by regulating prostaglandin B1 through the cGAS-STING pathway

Chemosphere, Год журнала: 2023, Номер 342, С. 140108 - 140108

Опубликована: Сен. 13, 2023

Язык: Английский

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Foodborne and airborne polyethersulfone nanoplastics respectively induce liver and lung injury in mice: Comparison with microplastics

Environment International, Год журнала: 2023, Номер 183, С. 108350 - 108350

Опубликована: Ноя. 25, 2023

Micro/nanoplastics (MNP) are ubiquitous in the environment and multiple living organisms. The toxicity of some common types MNP, e.g., polyethersulfone (PES) remains poorly understood. Multi-omics approaches were used this study to determine effects foodborne airborne PES MNP on liver lung, respectively. Foodborne capable inducing gut microbial dysbiosis, serum metabolic disruption, transcriptomic dysregulation, affecting antioxidant activity function, resulting injury. As for they found induce nasal lung transcriptome disturbance, cause disrupted NP respectively greater than MP, which could be associated with differences between MP exposures. relevant results suggest that disrupt "gut microbiota-gut-liver" axis hepatic injury, while affect "airborne microbiota-lung" findings benefit diagnoses injury induced by as well proper use human environment.

Язык: Английский

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Nasal instillation of polystyrene nanoplastics induce lung injury via mitochondrial DNA release and activation of the cyclic GMP-AMP synthase-stimulator of interferon genes-signaling cascade

The Science of The Total Environment, Год журнала: 2024, Номер 948, С. 174674 - 174674

Опубликована: Июль 11, 2024

Язык: Английский

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XueBiJing injection improves the symptoms of sepsis-induced acute lung injury by mitigating oxidative stress and ferroptosis

Journal of Ethnopharmacology, Год журнала: 2024, Номер 337, С. 118732 - 118732

Опубликована: Авг. 23, 2024

Язык: Английский

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