Nanoscale Advances, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Recent focus on sustainable nanoparticle synthesis highlights bioinspired nano-antimicrobials advantages over chemically synthesized counterparts. This study pioneers the green of porphyrinic nanocubes, demonstrating potent antibacterial activity through sono-photodynamic inactivation. approach holds promise in combating antibiotic resistance.
Язык: Английский
Advanced Functional Materials, Год журнала: 2024, Номер 34(40)
Опубликована: Июль 3, 2024
Abstract Sonodynamic therapy (SDT), as a promising non‐invasive therapeutic modality combining ultrasound (US) and sonosensitizers to produce cytotoxic reactive oxygen species (ROS) for treating deep‐seated tumors, has received increasing attention in recent years. Porphyrins are multifunctional organic materials, which can be excited both by light US ROS possess various fascinating features, including controllable synthetic processes, excellent biodegradability, low cytotoxicity without or US. Nevertheless, their poor water solubility, skin‐photosensitive toxicity, insufficient target specificity hinder clinical applications sonosensitizer. Although the issue may improved using nanoparticle carriers, SDT efficacy enhanced with other modalities, such combination makes it more confusing about true mechanism of SDT. This review will focus on following points: 1) Why porphyrin‐based considered most sonosensitizer SDT? 2) Recent progress development sonosensitizers. 3) What new insight been gained years? 4) The trend designing efficient existing challenges. Finally, future perspective practical based discussed.
Язык: Английский
Процитировано
14
Inorganic Chemistry Communications, Год журнала: 2024, Номер 163, С. 112352 - 112352
Опубликована: Март 28, 2024
Язык: Английский
Процитировано
4
Advanced Sensor and Energy Materials, Год журнала: 2024, Номер 3(4), С. 100123 - 100123
Опубликована: Авг. 28, 2024
Язык: Английский
Процитировано
4
Advanced Optical Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 25, 2025
Abstract Pure organic stimuli‐responsive phosphorescent materials with multi‐color afterglows, good reversibility, and ease manipulation are highly appealing for dynamic anti‐counterfeiting applications, but remain challenging to achieve. In this work, a soft organogel is rationally designed by introducing functional carbonyl (benzoyl or acetyl) units into dibenzofuran skeleton promote the intersystem crossing (ISC), screening potential organogelators through predicting self‐assembly process aid of all‐atom molecular simulation (AMDS). AMDS indicates that gelator candidates ( DBF‐Me DBF‐Ph ) can self‐assemble in mixture DMSO/H 2 O balanced π‐π intermolecular interactions between neighboring molecules, thus promoting gelation. Notably, fiber gel exhibits yellow afterglow at room temperature (298 K) lifetime 235.1 ms, which be switched off 358 K restored after cooling temperature. Furthermore, turn green 208 blue 77 K, due slight change conformation packing as revealed analysis temperature‐dependent single crystal structures. This single‐component gel, capable achieving color‐tunable “on‐off”‐switchable response, offers significant developing ultralong RTP multi‐level features.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Процитировано
0
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142645 - 142645
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Essays in Biochemistry, Год журнала: 2025, Номер 69(02)
Опубликована: Апрель 10, 2025
Metal ions are essential elements in biological processes and immune homeostasis. They can regulate cancer cell death through multiple distinct molecular pathways stimulate cells implicated antitumor responses, suggesting opportunities to design novel metal ion-based therapies. However, their small size high charge density result poor target uptake, uncontrolled biodistribution, rapid clearance from the body, reducing therapeutic efficacy increasing potential off-target toxicity. coordination polymer nanoparticles (MCP NPs) nanoscale networks composed of organic ligands linked via noncovalent interactions. MCP NPs offer a promising nanoplatform for reshaping into more drug-like formulations, improving vivo pharmacological performance index therapy applications. This review provides comprehensive overview inherent functions therapy, showcasing examples NP systems designed preclinical applications where drug delivery principles play critical role enhancing outcomes. versatile ion engineering approaches using selected ions, various ligands, functional payloads, enabling on-demand nano-drug designs that significantly improve reduce side effects effective therapy.
Язык: Английский
Процитировано
0
Aggregate, Год журнала: 2025, Номер unknown
Опубликована: Апрель 11, 2025
ABSTRACT Sonodynamic therapy (SDT) is an innovative cancer modality that harnesses the energy of ultrasound to activate sonosensitizers for producing reactive oxygen species (ROS), culminating in eradication tumor cells. Compared with photodynamic therapy, SDT has capacity penetrate deeply into biological tissues, thereby holding significant promise addressing situated or surgically inaccessible tumors. The effectiveness greatly dependent on characteristics sonosensitizers, and unlike inorganic organic offer a more controlled synthesis process have excellent biocompatibility. This review presents meticulous undertaking categorize elucidate their mechanisms action therapeutic effects context SDT. Design strategies are also summarized, we emphasize critical role nanotechnology localization, imaging, multimodal synergistic offering approach achieving precise targeting. In addition, impact delineated when integrated other oncological modalities, such as photothermal enhance efficacy. Finally, discusses challenges future perspectives advancement clinical within realm oncology.
Язык: Английский
Процитировано
0
Materials Today Chemistry, Год журнала: 2025, Номер 45, С. 102702 - 102702
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Acta Chimica Sinica, Год журнала: 2024, Номер 82(4), С. 443 - 443
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
1