Multifunctional Porphyrin‐Based Sonosensitizers for Sonodynamic Therapy

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(40)

Published: July 3, 2024

Abstract Sonodynamic therapy (SDT), as a promising non‐invasive therapeutic modality combining ultrasound (US) and sonosensitizers to produce cytotoxic reactive oxygen species (ROS) for treating deep‐seated tumors, has received increasing attention in recent years. Porphyrins are multifunctional organic materials, which can be excited both by light US ROS possess various fascinating features, including controllable synthetic processes, excellent biodegradability, low cytotoxicity without or US. Nevertheless, their poor water solubility, skin‐photosensitive toxicity, insufficient target specificity hinder clinical applications sonosensitizer. Although the issue may improved using nanoparticle carriers, SDT efficacy enhanced with other modalities, such combination makes it more confusing about true mechanism of SDT. This review will focus on following points: 1) Why porphyrin‐based considered most sonosensitizer SDT? 2) Recent progress development sonosensitizers. 3) What new insight been gained years? 4) The trend designing efficient existing challenges. Finally, future perspective practical based discussed.

Language: Английский

---

Porphyrin-based nanoarchitectures in sensing: Characterization, and applications in detecting gases, biomolecules, and environmental contaminants

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 163, P. 112352 - 112352

Published: March 28, 2024

Language: Английский

---

Porphyrin-based metal-organic frameworks for cancer theranostics

Advanced Sensor and Energy Materials, Journal Year: 2024, Volume and Issue: 3(4), P. 100123 - 100123

Published: Aug. 28, 2024

Language: Английский

---

From Hard Crystal to Soft Fiber: Thermochromic Color‐Tunable and “On‐Off”‐Switchable Afterglow of Single‐Component Ultralong RTP Organogel

Advanced Optical Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 25, 2025

Abstract Pure organic stimuli‐responsive phosphorescent materials with multi‐color afterglows, good reversibility, and ease manipulation are highly appealing for dynamic anti‐counterfeiting applications, but remain challenging to achieve. In this work, a soft organogel is rationally designed by introducing functional carbonyl (benzoyl or acetyl) units into dibenzofuran skeleton promote the intersystem crossing (ISC), screening potential organogelators through predicting self‐assembly process aid of all‐atom molecular simulation (AMDS). AMDS indicates that gelator candidates ( DBF‐Me DBF‐Ph ) can self‐assemble in mixture DMSO/H 2 O balanced π‐π intermolecular interactions between neighboring molecules, thus promoting gelation. Notably, fiber gel exhibits yellow afterglow at room temperature (298 K) lifetime 235.1 ms, which be switched off 358 K restored after cooling temperature. Furthermore, turn green 208 blue 77 K, due slight change conformation packing as revealed analysis temperature‐dependent single crystal structures. This single‐component gel, capable achieving color‐tunable “on‐off”‐switchable response, offers significant developing ultralong RTP multi‐level features.

Language: Английский

---

Manganese-Based Nanosystems: Advancing MRI and Multimodal Imaging Agents

Published: Jan. 1, 2025

---

Porphyrin-based covalent organic framework with NIR absorption: Preparation, hyaluronic acid modification, and cascading a hypoxia-sensitive drug for synergistic therapy of cancer phototherapy/chemotherapy

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142645 - 142645

Published: March 1, 2025

Language: Английский

---

Metal coordination polymer nanoparticles for cancer therapy

Essays in Biochemistry, Journal Year: 2025, Volume and Issue: 69(02)

Published: April 10, 2025

Metal ions are essential elements in biological processes and immune homeostasis. They can regulate cancer cell death through multiple distinct molecular pathways stimulate cells implicated antitumor responses, suggesting opportunities to design novel metal ion-based therapies. However, their small size high charge density result poor target uptake, uncontrolled biodistribution, rapid clearance from the body, reducing therapeutic efficacy increasing potential off-target toxicity. coordination polymer nanoparticles (MCP NPs) nanoscale networks composed of organic ligands linked via noncovalent interactions. MCP NPs offer a promising nanoplatform for reshaping into more drug-like formulations, improving vivo pharmacological performance index therapy applications. This review provides comprehensive overview inherent functions therapy, showcasing examples NP systems designed preclinical applications where drug delivery principles play critical role enhancing outcomes. versatile ion engineering approaches using selected ions, various ligands, functional payloads, enabling on-demand nano-drug designs that significantly improve reduce side effects effective therapy.

Language: Английский

---

Development and Application of Organic Sonosensitizers in Cancer Therapy

Aggregate, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

ABSTRACT Sonodynamic therapy (SDT) is an innovative cancer modality that harnesses the energy of ultrasound to activate sonosensitizers for producing reactive oxygen species (ROS), culminating in eradication tumor cells. Compared with photodynamic therapy, SDT has capacity penetrate deeply into biological tissues, thereby holding significant promise addressing situated or surgically inaccessible tumors. The effectiveness greatly dependent on characteristics sonosensitizers, and unlike inorganic organic offer a more controlled synthesis process have excellent biocompatibility. This review presents meticulous undertaking categorize elucidate their mechanisms action therapeutic effects context SDT. Design strategies are also summarized, we emphasize critical role nanotechnology localization, imaging, multimodal synergistic offering approach achieving precise targeting. In addition, impact delineated when integrated other oncological modalities, such as photothermal enhance efficacy. Finally, discusses challenges future perspectives advancement clinical within realm oncology.

Language: Английский

---

Metal-based nanomedicine systems for the diagnosis and treatment of colorectal cancer: Current advances and future perspectives

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 45, P. 102702 - 102702

Published: April 1, 2025

Language: Английский

---

Design and Synthesis of Nanoscale Zr-Porphyrin IX Framework for Synergistic Photodynamic and Sonodynamic Therapy of Tumors

Acta Chimica Sinica, Journal Year: 2024, Volume and Issue: 82(4), P. 443 - 443

Published: Jan. 1, 2024

Language: Английский

---