Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Авг. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Язык: Английский

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Cell-derived nanomaterials for biomedical applications

Science and Technology of Advanced Materials, Год журнала: 2024, Номер 25(1)

Опубликована: Фев. 7, 2024

The ever-growing use of nature-derived materials creates exciting opportunities for novel development in various therapeutic biomedical applications. Living cells, serving as the foundation nanoarchitectonics, exhibit remarkable capabilities that enable bioinspired and biomimetic systems, which will be explored this review. To understand development, we first revisited anatomy cells to explore characteristics building blocks life is relevant. Interestingly, animal have amazing due inherent functionalities each specialized cell type. Notably, versatility membranes allows red blood neutrophils' cloak inorganic nanoparticles would naturally eliminated by immune system. This underscores how facilitate interactions with surroundings through recognition, targeting, signalling, exchange, cargo attachment. functionality membrane-coated can tailored improved strategically engineering membrane, selecting from a variety known distinct properties. On other hand, plant synthesizing nanoparticles. They play role synthesis metal, carbon-based, polymer nanoparticles, used applications such antimicrobials or antioxidants. One versatile components found photosynthetic system, particularly thylakoid, pigment chlorophyll. While there are challenges consistently these derived nature, exploration begins unveil endless possibilities nanoarchitectonics research.

Язык: Английский

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Overview of phytosomes in treating cancer: Advancement, challenges, and future outlook

Heliyon, Год журнала: 2023, Номер 9(6), С. e16561 - e16561

Опубликована: Май 24, 2023

One of the major causes death on globe is cancer. It has remained a significant obstacle for current therapies and not yet been effectively treated. Conventional treatment strategies available cancer such as surgery, chemotherapy, radiation therapy etc. have severe adverse effects. The use herbal active constituents in tremendous potential to increase effectiveness conventional therapy. Natural plant components reported strong vitro pharmacological activity but narrow vivo absorption. In order their bioavailability absorption get around drawbacks negative effects traditional extracts, Phytosomes are one growing nanotechnologies that can be used improve miscibility bioactive phytoconstituents lipid-rich barriers overcome poor bioavailability. Many novel drug delivery carriers employed targeted phytoconstituent at site action. well-known biocompatible nanocarriers solubility permeability phytopharmaceuticals among various systems (NDDS). This review mainly focused well approaches Nano carrier therapies. Also comprising summary most recent research development phytosomes better Additionally provides information about formulation, characterization technique mechanism release from phytosome. Some made phytosome which shown proven anticancer also studied. Finally, challenges future perspective related discussed.

Язык: Английский

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Vincristine-based nanoformulations: a preclinical and clinical studies overview

Drug Delivery and Translational Research, Год журнала: 2023, Номер 14(1), С. 1 - 16

Опубликована: Авг. 8, 2023

Abstract Vincristine (VCR) is a chemotherapeutic agent obtained from natural alkaloid plant source Catharanthus roseus. VCR has been significantly useful in treatments of lung cancer, lymphocyte-based leukaemia, glioblastomas and acute myeloid leukaemia. attaches to tubulin fibrils prevents filament polymerization that permanently led mitosis inhibition cancer cells. Clinically, administered patients multidrug combination reduce adverse drug effects potential blockage bone marrow due prescribed monotherapy. However, possesses low tissue affinity at higher dose often irreversible neurotoxicity. Conventional injectables are successfully used clinics, but lack controlled release, non-specific biodistribution consequent off-target side still major challenges. Currently, nanotechnological delivery systems being explored for improvement pharmacokinetic profile tumour-specific targeting. Various nanomedicine formulations such as liposomes, lipid nanoparticles, polymeric nanocarriers have studied under various vitro vivo models. In this review, we summarised the role VCR, evaluated mechanism action, pharmacokinetics challenges associated with delivery. Moreover, application effect on anticancer efficacy preclinical clinical setting also discussed. Graphical

Язык: Английский

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Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines

Journal of Nanobiotechnology, Год журнала: 2023, Номер 21(1)

Опубликована: Ноя. 29, 2023

Abstract Traditional Chinese Medicines (TCMs) have been used for centuries the treatment and management of various diseases. However, their effective delivery to targeted sites may be a major challenge due poor water solubility, low bioavailability, potential toxicity. Nanocarriers, such as liposomes, polymeric nanoparticles, inorganic nanoparticles organic/inorganic nanohybrids based on active constituents from TCMs extensively studied promising strategy improve achieve higher therapeutic effect with fewer side effects compared conventional formulations. This review summarizes recent advances in nanocarrier-based systems types TCMs, including terpenoids, polyphenols, alkaloids, flavonoids, quinones, different natural sources. covers design preparation nanocarriers, characterization, vitro/vivo evaluations. Additionally, this highlights challenges opportunities field suggests future directions research. Nanocarrier-based shown great improving efficacy serve comprehensive resource researchers field. Graphical abstract

Язык: Английский

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Lipid-engineered nanotherapeutics for cancer management

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Март 23, 2023

Cancer causes significant mortality and morbidity worldwide, but existing pharmacological treatments are greatly limited by the inherent heterogeneity of cancer as a disease, well unsatisfactory efficacy specificity therapeutic drugs. Biopharmaceutical barriers such low permeability poor water solubility, along with absence active targeting capabilities, often result in suboptimal clinical results. The difficulty successfully reaching destroying tumor cells is also compounded undesirable impacts on healthy tissue, including off-target effects high toxicity, which further impair ability to effectively manage disease optimize patient outcomes. However, last few decades, development nanotherapeutics has allowed for use rational design order maximize success. Advances fabrication nano-sized delivery systems, coupled variety surface engineering strategies promote customization, have resulted promising approaches targeted, site-specific drug fewer unwanted better efficacy. These nano systems been able overcome some challenges conventional related pharmacokinetics, biodistribution, target specificity. In particular, lipid-based nanosystems extensively explored due their biocompatibility, versatility, adaptability. Lipid-based treatment varied diverse, liposomal therapeutics, lipidic nanoemulsions, solid lipid nanoparticles, nanostructured carriers, lipid-polymer nanohybrids, supramolecular nanolipidic structures. This review aims provide an overview diverse formulations lipid-engineered current field, researchers attempt translate these from bench clinic.

Язык: Английский

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Cisplatin and oleanolic acid Co-loaded pH-sensitive CaCO₃nanoparticles for synergistic chemotherapy

RSC Advances, Год журнала: 2022, Номер 12(23), С. 14808 - 14818

Опубликована: Янв. 1, 2022

Despite being one of the most potent anticancer agents, cisplatin (CDDP) clinical usage is limited owing to acquired resistance and severe adverse effects including nephrotoxicity.

Язык: Английский

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Supramolecular self-assembled peptide-engineered nanofibers: A propitious proposition for cancer therapy

International Journal of Biological Macromolecules, Год журнала: 2023, Номер 256, С. 128452 - 128452

Опубликована: Дек. 1, 2023

Язык: Английский

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Harnessing Nanotechnology for Idarubicin Delivery in Cancer Therapy: Current Approaches and Future Perspectives

BioNanoScience, Год журнала: 2024, Номер 14(4), С. 4108 - 4130

Опубликована: Апрель 11, 2024

Язык: Английский

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Recent advances in the development of multifunctional lipid-based nanoparticles for co-delivery, combination treatment strategies, and theranostics in breast and lung cancer

Journal of Drug Delivery Science and Technology, Год журнала: 2022, Номер 71, С. 103300 - 103300

Опубликована: Март 31, 2022

Язык: Английский

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