Journal of Translational Medicine,
Год журнала:
2022,
Номер
20(1)
Опубликована: Март 22, 2022
Abstract
Background
The
phagocytosis
checkpoints
of
CD47/SIRPα,
PD1/PDL1,
CD24/SIGLEC10,
and
MHC/LILRB1
have
shown
inhibited
macrophages
in
distinct
tumors.
However,
their
therapeutic
significance
remain
largely
unknown
intrahepatic
cholangiocarcinoma
(ICC)
patients.
Methods
We
analyzed
sequencing
data
from
the
Cancer
Genome
Atlas
(TCGA)
identified
differently
expressed
genes
between
tumors
para‐tumors.
Then,
we
investigated
expression
CD68,
SIRPα,
PD1,
SIGLEC10
by
IHC
81
ICC
patients,
clinical
these
markers
with
different
risk
factors
was
also
measured.
Results
Tumor
infiltration
immune
cells
analysis
TCGA
revealed
that
significantly
increased.
Further
showed
M0
were
higher
M2
lower
compared
paracancerous
tissues,
while
there
no
significant
difference
M1
macrophages.
then
examined
some
markers,
found
(iNOS,
TNF,
IL12A,
B)
increased,
(ARG1
CD206)
decreased
ICCs
tissues.
Furthermore,
increased
significantly,
but
LILRB1
did
not.
patients
IHC,
which
a
similar
pattern
to
emerged
data.
Upon
analyzing
correlation
progression
high
PD1
are
correlated
poor
among
shows
correlation.
More
SIRPα
+
or
TAMs
observed
tumor
tissues
HBV
infections
non‐HBV‐infected
Multivariate
indicated
independent
indicators
patient
prognosis.
Conclusion
Hyperactivated
CD47/SIRPα
PD1/PD‐L1
signals
CD68
negative
prognostic
for
after
resection.
anti-CD47
combination
anti-PD1
CD47/PD1
bispecific
antibody
(BsAb)
may
represent
promising
treatments
ICC.
studies
required
future
confirmed
our
findings.
Journal of Nanobiotechnology,
Год журнала:
2022,
Номер
20(1)
Опубликована: Дек. 27, 2022
Abstract
Synthetic
nanoparticles
with
surface
bioconjugation
are
promising
platforms
for
targeted
therapy,
but
their
simple
biological
functionalization
is
still
a
challenging
task
against
the
complex
intercellular
environment.
Once
synthetic
enter
body,
they
phagocytosed
by
immune
cells
system.
Recently,
cell
membrane
camouflage
strategy
has
emerged
as
novel
therapeutic
tactic
to
overcome
these
issues
utilizing
fundamental
properties
of
natural
cells.
Macrophage,
type
system
cells,
plays
critical
roles
in
various
diseases,
including
cancer,
atherosclerosis,
rheumatoid
arthritis,
infection
and
inflammation,
due
recognition
engulfment
function
removing
substances
pathogens.
Macrophage
membranes
inherit
protein
profiles
biointerfacing
source
Therefore,
macrophage
cloaking
can
protect
from
phagocytosis
Meanwhile,
make
use
correspondence
accurately
recognize
antigens
target
inflamed
tissue
or
tumor
sites.
In
this
review,
we
have
summarized
advances
fabrication,
characterization
homing
capacity
cancers,
cardiovascular
central
nervous
microbial
infections.
Although
membrane-camouflaged
currently
fetal
stage
development,
there
huge
potential
challenge
explore
conversion
mode
clinic.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 10, 2024
Macrophages
are
crucial
cells
in
the
human
body's
innate
immunity
and
engaged
a
variety
of
non-inflammatory
reactions.
can
develop
into
two
kinds
when
stimulated
by
distinct
internal
environments:
pro-inflammatory
M1-like
macrophages
anti-inflammatory
M2-type
macrophages.
During
inflammation,
activated
alternatively,
maintaining
reasonably
steady
ratio
is
critical
for
homeostasis
Pharmaceutics,
Год журнала:
2023,
Номер
15(8), С. 2042 - 2042
Опубликована: Июль 29, 2023
Exosome-based
drug
delivery
is
emerging
as
a
promising
field
with
the
potential
to
revolutionize
therapeutic
interventions.
Exosomes,
which
are
small
extracellular
vesicles
released
by
various
cell
types,
have
attracted
significant
attention
due
their
unique
properties
and
natural
ability
transport
bioactive
molecules.
These
nano-sized
vesicles,
ranging
in
size
from
30
150
nm,
can
effectively
variety
of
cargoes,
including
proteins,
nucleic
acids,
lipids.
Compared
traditional
systems,
exosomes
exhibit
biocompatibility,
low
immunogenicity,
reduced
toxicity.
In
addition,
be
designed
tailored
improve
targeting
efficiency,
cargo
loading
capacity,
stability,
paving
way
for
personalized
medicine
precision
therapy.
However,
despite
exosome-based
delivery,
its
clinical
application
remains
challenging
limitations
exosome
isolation
purification,
efficiency
insufficient
targeted
rapid
elimination
circulation.
This
comprehensive
review
focuses
on
transition
bench
clinic,
highlighting
key
aspects,
such
structure
biogenesis,
methods,
surface
engineering
techniques,
applications.
It
also
discusses
challenges
prospects
this
field.
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Фев. 14, 2023
The
macrophage
is
an
essential
part
of
the
innate
immune
system
and
also
serves
as
bridge
between
immunity
adaptive
response.
As
initiator
executor
response,
plays
important
role
in
various
physiological
processes
such
tolerance,
fibrosis,
inflammatory
angiogenesis
phagocytosis
apoptotic
cells.
Consequently,
dysfunction
a
vital
cause
occurrence
development
autoimmune
diseases.
In
this
review,
we
mainly
discuss
functions
macrophages
diseases,
especially
systemic
lupus
erythematosus
(SLE),
rheumatic
arthritis
(RA),
sclerosis
(SSc)
type
1
diabetes
(T1D),
providing
references
for
treatment
prevention
Periodontitis
is
a
chronic
infectious
disease
caused
by
bacterial
irritation.
As
an
essential
component
of
the
host
immunity,
macrophages
are
highly
plastic
and
play
crucial
role
in
inflammatory
response.
An
appropriate
timely
transition
from
proinflammatory
(M1)
to
anti-inflammatory
(M2)
indispensable
for
treating
periodontitis.
M2
macrophage-derived
exosomes
(M2-exos)
can
actively
target
sites
modulate
immune
microenvironments,
M2-exos
effectively
treat
Excessive
endoplasmic
reticulum
stress
(ER
stress)
unfolded
protein
response
(UPR)
destructive
pathological
characteristics
during
periodontal
bone
loss.
Although
melatonin
has
antioxidant
effects,
studies
focusing
on
ER
modulation
remain
limited.
This
study
fabricates
engineered
loading
with
(Mel@M2-exos)
result,
drive
macrophage
reprogramming
M1
type,
which
resolves
inflammation
accelerated
healing.
Melatonin
released
Mel@M2-exos
rescues
osteogenic
cementogenic
differentiation
capacity
human
ligament
cells
(hPDLCs)
reducing
excessive
UPR.
Injectable
gelatin
methacryloyl
(GelMA)
hydrogels
sustained-release
accelerate
regeneration
rats
ligation-induced
Taken
together,
engineering
promising
candidates
tissue
regeneration.
Mediators of Inflammation,
Год журнала:
2023,
Номер
2023, С. 1 - 20
Опубликована: Июнь 8, 2023
Macrophages
are
innate
immune
cells
in
the
organism
and
can
be
found
almost
tissues
organs.
They
highly
plastic
heterogeneous
participate
response,
thereby
playing
a
crucial
role
maintaining
homeostasis
of
body.
It
is
well
known
that
undifferentiated
macrophages
polarize
into
classically
activated
(M1
macrophages)
alternatively
(M2
under
different
microenvironmental
conditions.
The
directions
macrophage
polarization
regulated
by
series
factors,
including
interferon,
lipopolysaccharide,
interleukin,
noncoding
RNAs.
To
elucidate
various
autoimmune
diseases,
we
searched
literature
on
with
PubMed
database.
Search
terms
as
follows:
macrophages,
polarization,
signaling
pathways,
RNA,
inflammation,
systemic
lupus
erythematosus,
rheumatoid
arthritis,
nephritis,
Sjogren’s
syndrome,
Guillain-Barré
multiple
sclerosis.
In
present
study,
summarize
common
diseases.
addition,
also
features
recent
advances
particular
focus
immunotherapeutic
potential
diseases
potentially
effective
therapeutic
targets.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
12(18)
Опубликована: Март 7, 2023
Abstract
As
the
global
population
ages,
bone‐related
diseases
have
increasingly
become
a
major
social
problem
threatening
human
health.
Exosomes,
as
natural
cell
products,
been
used
to
treat
due
their
superior
biocompatibility,
biological
barrier
penetration,
and
therapeutic
effects.
Moreover,
modified
exosomes
exhibit
strong
bone‐targeting
capabilities
that
may
improve
efficacy
avoid
systemic
side
effects,
demonstrating
promising
translational
potential.
However,
review
of
bone‐targeted
is
still
lacking.
Thus,
recently
developed
for
applications
in
this
are
focused.
The
biogenesis
regulatory
functions
exosomes,
constructive
strategies
bone‐targeting,
effects
introduced.
By
summarizing
developments
challenges
It
striven
shed
light
on
selection
exosome
different
bone
highlight
potential
future
clinical
orthopedics.