Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications

Journal of Controlled Release, Год журнала: 2022, Номер 353, С. 1127 - 1149

Опубликована: Дек. 26, 2022

Язык: Английский

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Macrophage cell membrane-based nanoparticles: a new promising biomimetic platform for targeted delivery and treatment

Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)

Опубликована: Дек. 27, 2022

Abstract Synthetic nanoparticles with surface bioconjugation are promising platforms for targeted therapy, but their simple biological functionalization is still a challenging task against the complex intercellular environment. Once synthetic enter body, they phagocytosed by immune cells system. Recently, cell membrane camouflage strategy has emerged as novel therapeutic tactic to overcome these issues utilizing fundamental properties of natural cells. Macrophage, type system cells, plays critical roles in various diseases, including cancer, atherosclerosis, rheumatoid arthritis, infection and inflammation, due recognition engulfment function removing substances pathogens. Macrophage membranes inherit protein profiles biointerfacing source Therefore, macrophage cloaking can protect from phagocytosis Meanwhile, make use correspondence accurately recognize antigens target inflamed tissue or tumor sites. In this review, we have summarized advances fabrication, characterization homing capacity cancers, cardiovascular central nervous microbial infections. Although membrane-camouflaged currently fetal stage development, there huge potential challenge explore conversion mode clinic.

Язык: Английский

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Macrophage polarization: an important role in inflammatory diseases

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Апрель 10, 2024

Macrophages are crucial cells in the human body's innate immunity and engaged a variety of non-inflammatory reactions. can develop into two kinds when stimulated by distinct internal environments: pro-inflammatory M1-like macrophages anti-inflammatory M2-type macrophages. During inflammation, activated alternatively, maintaining reasonably steady ratio is critical for homeostasis

Язык: Английский

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Exosome-Based Drug Delivery: Translation from Bench to Clinic

Pharmaceutics, Год журнала: 2023, Номер 15(8), С. 2042 - 2042

Опубликована: Июль 29, 2023

Exosome-based drug delivery is emerging as a promising field with the potential to revolutionize therapeutic interventions. Exosomes, which are small extracellular vesicles released by various cell types, have attracted significant attention due their unique properties and natural ability transport bioactive molecules. These nano-sized vesicles, ranging in size from 30 150 nm, can effectively variety of cargoes, including proteins, nucleic acids, lipids. Compared traditional systems, exosomes exhibit biocompatibility, low immunogenicity, reduced toxicity. In addition, be designed tailored improve targeting efficiency, cargo loading capacity, stability, paving way for personalized medicine precision therapy. However, despite exosome-based delivery, its clinical application remains challenging limitations exosome isolation purification, efficiency insufficient targeted rapid elimination circulation. This comprehensive review focuses on transition bench clinic, highlighting key aspects, such structure biogenesis, methods, surface engineering techniques, applications. It also discusses challenges prospects this field.

Язык: Английский

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Controlling the biodistribution and clearance of nanomedicines

Nature Reviews Bioengineering, Год журнала: 2023, Номер 2(3), С. 214 - 232

Опубликована: Дек. 20, 2023

Язык: Английский

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Macrophage: Key player in the pathogenesis of autoimmune diseases

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Фев. 14, 2023

The macrophage is an essential part of the innate immune system and also serves as bridge between immunity adaptive response. As initiator executor response, plays important role in various physiological processes such tolerance, fibrosis, inflammatory angiogenesis phagocytosis apoptotic cells. Consequently, dysfunction a vital cause occurrence development autoimmune diseases. In this review, we mainly discuss functions macrophages diseases, especially systemic lupus erythematosus (SLE), rheumatic arthritis (RA), sclerosis (SSc) type 1 diabetes (T1D), providing references for treatment prevention

Язык: Английский

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Melatonin Engineering M2 Macrophage‐Derived Exosomes Mediate Endoplasmic Reticulum Stress and Immune Reprogramming for Periodontitis Therapy

Advanced Science, Год журнала: 2023, Номер 10(27)

Опубликована: Июль 14, 2023

Periodontitis is a chronic infectious disease caused by bacterial irritation. As an essential component of the host immunity, macrophages are highly plastic and play crucial role in inflammatory response. An appropriate timely transition from proinflammatory (M1) to anti-inflammatory (M2) indispensable for treating periodontitis. M2 macrophage-derived exosomes (M2-exos) can actively target sites modulate immune microenvironments, M2-exos effectively treat Excessive endoplasmic reticulum stress (ER stress) unfolded protein response (UPR) destructive pathological characteristics during periodontal bone loss. Although melatonin has antioxidant effects, studies focusing on ER modulation remain limited. This study fabricates engineered loading with (Mel@M2-exos) result, drive macrophage reprogramming M1 type, which resolves inflammation accelerated healing. Melatonin released Mel@M2-exos rescues osteogenic cementogenic differentiation capacity human ligament cells (hPDLCs) reducing excessive UPR. Injectable gelatin methacryloyl (GelMA) hydrogels sustained-release accelerate regeneration rats ligation-induced Taken together, engineering promising candidates tissue regeneration.

Язык: Английский

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Regulatory Mechanism of M1/M2 Macrophage Polarization in the Development of Autoimmune Diseases

Mediators of Inflammation, Год журнала: 2023, Номер 2023, С. 1 - 20

Опубликована: Июнь 8, 2023

Macrophages are innate immune cells in the organism and can be found almost tissues organs. They highly plastic heterogeneous participate response, thereby playing a crucial role maintaining homeostasis of body. It is well known that undifferentiated macrophages polarize into classically activated (M1 macrophages) alternatively (M2 under different microenvironmental conditions. The directions macrophage polarization regulated by series factors, including interferon, lipopolysaccharide, interleukin, noncoding RNAs. To elucidate various autoimmune diseases, we searched literature on with PubMed database. Search terms as follows: macrophages, polarization, signaling pathways, RNA, inflammation, systemic lupus erythematosus, rheumatoid arthritis, nephritis, Sjogren’s syndrome, Guillain-Barré multiple sclerosis. In present study, summarize common diseases. addition, also features recent advances particular focus immunotherapeutic potential diseases potentially effective therapeutic targets.

Язык: Английский

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M2 Macrophage Hybrid Membrane‐Camouflaged Targeted Biomimetic Nanosomes to Reprogram Inflammatory Microenvironment for Enhanced Enzyme‐Thermo‐Immunotherapy

Advanced Materials, Год журнала: 2023, Номер 35(39)

Опубликована: Июнь 20, 2023

Excessive inflammatory reactions caused by uric acid deposition are the key factor leading to gout. However, clinical medications cannot simultaneously remove and eliminate inflammation. An M2 macrophage-erythrocyte hybrid membrane-camouflaged biomimetic nanosized liposome (USM[H]L) is engineered deliver targeted self-cascading bienzymes immunomodulators reprogram microenvironment in gouty rats. The cell-membrane-coating endow nanosomes with good immune escape lysosomal achieve long circulation time intracellular retention times. After being uptaken cells, synergistic enzyme-thermo-immunotherapies achieved: uricase nanozyme degraded hydrogen peroxide, respectively; improved catalytic abilities of each other; produced photothermal effects; methotrexate has immunomodulatory anti-inflammatory effects. levels markedly decrease, ankle swelling claw curling effectively alleviated. cytokines ROS while cytokine increase. Proinflammatory M1 macrophages reprogrammed phenotype. Notably, IgG IgM USM[H]L-treated rats decrease substantially, uricase-treated show high immunogenicity. Proteomic analysis that there 898 downregulated 725 upregulated differentially expressed proteins protein-protein interaction network indicates signaling pathways include spliceosome, ribosome, purine metabolism, etc.

Язык: Английский

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Bone‐Targeted Exosomes: Strategies and Applications

Advanced Healthcare Materials, Год журнала: 2023, Номер 12(18)

Опубликована: Март 7, 2023

Abstract As the global population ages, bone‐related diseases have increasingly become a major social problem threatening human health. Exosomes, as natural cell products, been used to treat due their superior biocompatibility, biological barrier penetration, and therapeutic effects. Moreover, modified exosomes exhibit strong bone‐targeting capabilities that may improve efficacy avoid systemic side effects, demonstrating promising translational potential. However, review of bone‐targeted is still lacking. Thus, recently developed for applications in this are focused. The biogenesis regulatory functions exosomes, constructive strategies bone‐targeting, effects introduced. By summarizing developments challenges It striven shed light on selection exosome different bone highlight potential future clinical orthopedics.

Язык: Английский

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