Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

Journal of Hematology & Oncology, Год журнала: 2022, Номер 15(1)

Опубликована: Сен. 12, 2022

Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving therapeutic potential various agents and bioactive molecules through enhanced permeability retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective tumor cells utilizing cell surface-specific receptors, vasculature antigens high accuracy affinity. Additionally, stimuli-responsive nanoplatforms also been as a promising strategy against tumors, these maintain their stealth feature under conditions, but upon homing cancerous lesions or microenvironment, are responsive release cargoes. In this review, we comprehensively summarize field active number studies context emerging nanoplatform development, discuss how knowledge contribute further improvements clinical practice.

Язык: Английский

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Development of Nanocarrier-Based Radionuclide and Photothermal Therapy in Combination with Chemotherapy in Melanoma Cancer Treatment

ACS Applied Materials & Interfaces, Год журнала: 2023, Номер 15(10), С. 13460 - 13471

Опубликована: Март 3, 2023

Conventional cancer therapy methods have serious drawbacks that are related to the nonspecific action of anticancer drugs leads high toxicity on normal cells and increases risk recurrence. The therapeutic effect can be significantly enhanced when various treatment modalities implemented. Here, we demonstrate radio- photothermal (PTT) delivered through nanocarriers (gold nanorods, Au NRs) in combination with chemotherapy a melanoma results complete tumor inhibition compared single therapy. synthesized effectively labeled 188Re radionuclide radiolabeling efficiency (94-98%) radiochemical stability (>95%) appropriate for Further, 188Re-Au NRs, mediating conversion laser radiation into heat, were intratumorally injected PTT was applied. Upon irradiation near-infrared laser, dual achieved. Additionally, 188Re-labeled NRs paclitaxel (PTX) has improved (188Re-labeled irradiation, PTX) monoregime. Thus, this local triple-combination step toward clinical translation use treatment.

Язык: Английский

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The antioxidant and anticancer activity of Quercus coccifera plant leaves extracts

Saudi Journal of Biological Sciences, Год журнала: 2024, Номер 31(5), С. 103979 - 103979

Опубликована: Март 11, 2024

Quercus species are one of the medicinal plants that commonly used in treatment different diseases. coccifera (Q. coccifera) is part which grow Jordan and traditional folklore medicine. The aim this study to confirm ability leaves extracts exert anticancer activity. In study, an extraction method dried-leaves using polarity solvents was used. Extracts were pre-evaluated for antioxidant activities while active measure half maximal effective concentration (EC50) against 2,2-Diphenyl-1-picrylhydrazyl (DPPH), Half-maximal inhibitory (IC50) cancer cells. Methanol, boiled microwaved water had greater than 80 % activity, strongest more 99 %, extract. Similarly, pre-evaluation treatments cell lines indicated a strong biological activity 70 from previously mentioned extracts, highest 90 all lines. EC50 DPPH obtained by 0.009 mg/ml lower positive control quercetin. same manner, lung, breast, prostate highly affected with IC50 14.1, 7.2, 25.1 µg/ml, respectively, selectivity index (SI) 4.71. Q. show promising be source new therapeutics.

Язык: Английский

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Novel bio-carriers for radionuclide delivery in cancer radiotherapy

Coordination Chemistry Reviews, Год журнала: 2025, Номер 533, С. 216557 - 216557

Опубликована: Фев. 26, 2025

Язык: Английский

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Tannic acid-iron(III) complex functionalized porous calcium carbonate as pesticide carrier for pH-controlled release

Journal of environmental chemical engineering, Год журнала: 2023, Номер 11(3), С. 110124 - 110124

Опубликована: Май 12, 2023

Язык: Английский

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Calcium carbonate nanoparticles tumor delivery for combined chemo-photodynamic therapy: Comparison of local and systemic administration

Journal of Controlled Release, Год журнала: 2023, Номер 359, С. 400 - 414

Опубликована: Июнь 16, 2023

Язык: Английский

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Asiatic acid cyclodextrin inclusion micro-cocrystal for insoluble drug delivery and acute lung injury therapy enhancement

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Март 17, 2024

Abstract Background Acute lung injury (ALI) is a fatal respiratory disease caused by overreactive immune reactions (e.g., SARS-CoV-2 infection), with high mortality rate. Its treatment often compromised inefficient drug delivery barriers and insufficient potency of the currently used drugs. Therefore, developing highly effective lung-targeted strategy pressing clinical need. Results In this study, micro-sized inclusion cocrystal asiatic acid/γ-cyclodextrin (AA/γCD, stoichiometry molar ratio 2:3 mean size 1.8 μm) was prepared for ALI treatment. The dissolution behavior AA/γCD cocrystals followed “spring-and-hover” model, which meaned that could dissolve from in an complex form, thereby promoting significantly improved water solubility (nine times higher than free AA). This made cyclodextrin-based solid form enhanced absorption efficiency. biodistribution experiments demonstrated accumulated predominantly (C max = 50 µg/g) after systemic administration due to micron size-mediated passive targeting effect. group showed anti-inflammatory therapeutic effect, as evidenced reduced levels pro-inflammatory cytokines bronchoalveolar lavage fluids (BALF). Histological examination confirmed effectively inhibited inflammation reactions. Conclusion were successfully delivered into lungs pulmonary had significant effect on ALI. Graphic abstract

Язык: Английский

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Exploiting the layer-by-layer nanoarchitectonics for the fabrication of polymer capsules: A toolbox to provide multifunctional properties to target complex pathologies

Advances in Colloid and Interface Science, Год журнала: 2022, Номер 304, С. 102680 - 102680

Опубликована: Апрель 17, 2022

Polymer capsules fabricated via the layer-by-layer (LbL) approach have attracted a great deal of attention for biomedical applications thanks to their tunable architecture. Compared alternative methods, in which precise control over final properties systems is usually limited, intrinsic versatility LbL allows functionalization all constituents polymeric following relatively simple protocols. In fact, can be adjusted from inner cavity outer layer through shell, resulting therapeutic, diagnostic, or theranostic (i.e., combination therapeutic and diagnostic) agents that adapted particular characteristics patient face challenges encountered complex pathologies. The industry demands novel biomaterials capable targeting several mechanisms and/or cellular pathways simultaneously while being tracked by minimally invasive techniques, thus highlighting need shift monofunctional multifunctional polymer capsules. present review, those strategies permit advanced are accordingly introduced. Each capsule cavity, multilayer membrane layer) thoroughly analyzed overview toward fabrication presented. Special emphasis given potential these capsules, including examples performed vitro vivo validation studies. Finally, process future perspective safe translation into clinic summarized.

Язык: Английский

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Designing of Polymeric Nanoparticles for Enhanced Breast Cancer Therapy: Combining Paclitaxel, Boric Acid and Tannic Acid for Controlled Drug Delivery

ChemistrySelect, Год журнала: 2024, Номер 9(7)

Опубликована: Фев. 12, 2024

Abstract This study introduces an innovative approach to enhance breast cancer treatment by combining Boric Acid (BA) and Tannic (TA) with Paclitaxel (PTX) within gelatin/sodium alginate (Gel/NaAlg) nanoparticles, resulting in a synergistic combination therapy. The methodology involved integrating PTX, TA, BA into the polymeric framework using emulsion cross‐linking method. nanoparticles underwent rigorous characterization, confirming their suitability as controlled release platform. Techniques such Scanning Electron Microscope (SEM), Differential Calorimetry (DSC), X‐ray Diffractometry (XRD), Fourier Transform Infrared Spectroscopy (FTIR) were employed for thorough analysis. synthesized demonstrated size below 204 nm, extensive analyses confirmed structural integrity composition. Notably, Gel/NaAlg/PTX/BA/TA exhibited superior drug kinetics compared other formulations, offering promising strategy of hydrophobic drugs like PTX. Entrapment efficiency ranged from 49.84 % 63.38 %, loading capacities spanned 49.81 61.42 μg/mg. pioneers novel therapy incorporating TA PTX‐loaded Gel/NaAlg nanoparticlesThese findings emphasize importance continued exploration delivery systems more effective interventions.

Язык: Английский

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Macrophage In Vitro and In Vivo Tracking via Anchored Microcapsules

ACS Applied Materials & Interfaces, Год журнала: 2022, Номер 14(46), С. 51579 - 51592

Опубликована: Ноя. 11, 2022

A new promising trend in personalized medicine is the use of autologous cells (macrophages or stem cells) for cell-based therapy and also as a "Trojan horse" targeted delivery drug carrier. The natural ability macrophages chemotaxis allows them to deliver cargo damaged area, significantly reducing side effects on healthy organ tissues. Therefore, it important develop tools track their behavior organism. While labeled containers can serve anchored tags imaging vivo, they affect properties functions macrophages. This work demonstrates that 3 μm sized capsules based biocompatible polyelectrolytes fluorescently with both Cy7 RITC dyes do not cell functionalization vitro, such viability, proliferation, movement transformed monocyte/macrophage-like (RAW 264.7) primary bone marrow derived (BMDM) at maximal loading five per cell. In addition, allowed fluorescent detection ex vivo loaded 24 h after tail vein injection visualization microcapsule-laden using confocal microscopy. We have delivered about 62.5% injected BMDM containing 12.5 million 3.75 μg high-molecular-weight (0.3 pg/capsule) liver. Our results demonstrate polyelectrolyte microcapsules be used safe macrophage loading, allowing tracking delivery, which will facilitate development macrophage-based protocols.

Язык: Английский

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