Nrf2-mediated anti-inflammatory polarization of macrophages as therapeutic targets for osteoarthritis

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Авг. 12, 2022

Macrophages are the most abundant immune cells within synovial joints, and also main innate effector triggering initial inflammatory responses in pathological process of osteoarthritis (OA). The transition macrophages between pro-inflammatory anti-inflammatory phenotypes can play a key role building intra-articular microenvironment. cascade induced by TNF-α, IL-1β, IL-6 is closely related to M1 macrophages, resulting production pro-chondrolytic mediators. However, IL-10, IL1RA, CCL-18, IGF, TGF M2 leading protection cartilage promoted regeneration. inhibition NF-κB signaling pathway central OA treatment via controlling while nuclear factor erythroid 2-related 2 (Nrf2) appears not attract widespread attention field. Nrf2 transcription encoding large number antioxidant enzymes. activation have effects, which complex crosstalk with pathway. inhibit polarization promote through potential transductions including TGF-β/SMAD, TLR/NF-κB, JAK/STAT pathways, regulation or cooperation Notch, NLRP3, PI3K/Akt, MAPK signaling. And expression heme oxygenase-1 (HO-1) negative for be mechanisms promotion. Furthermore, candidates activating phenotype reviewed this work, such as itaconate fumarate derivatives, curcumin, quercetin, melatonin, mesenchymal stem cells, low-intensity pulsed ultrasound.

Язык: Английский

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Extracellular vesicles in the pathogenesis and treatment of acute lung injury

Military Medical Research, Год журнала: 2022, Номер 9(1)

Опубликована: Ноя. 1, 2022

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common life-threatening diseases associated with severe inflammation. Both have high mortality rates, despite decades of research on clinical ALI/ARDS, there no effective therapeutic strategies. Disruption alveolar-capillary barrier integrity or activation inflammatory responses leads to inflammation injury. Recently, studies the role extracellular vesicles (EVs) in regulating normal pathophysiologic cell activities, including responses, attracted attention. Injured dysfunctional cells often secrete EVs into serum bronchoalveolar lavage fluid altered cargoes, which can be used diagnose predict development ALI/ARDS. secreted by mesenchymal stem also attenuate reactions dysfunction preserve restore function, thereby promote proliferation tissue regeneration. This review focuses roles pathogenesis pulmonary inflammation, particularly

Язык: Английский

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Exosomes derived from induced cardiopulmonary progenitor cells alleviate acute lung injury in mice

Acta Pharmacologica Sinica, Год журнала: 2024, Номер 45(8), С. 1644 - 1659

Опубликована: Апрель 8, 2024

Язык: Английский

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Mesenchymal stem cell exosomes as nanotherapeutics for dry age-related macular degeneration

Journal of Controlled Release, Год журнала: 2023, Номер 357, С. 356 - 370

Опубликована: Апрель 10, 2023

Язык: Английский

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Research progress of extracellular vesicles and exosomes derived from mesenchymal stem cells in the treatment of oxidative stress-related diseases

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Авг. 14, 2023

There is growing evidence that mesenchymal stem cell-derived extracellular vesicles and exosomes can significantly improve the curative effect of oxidative stress-related diseases. Mesenchymal cell (MSC-EVs MSC-Exos) are rich in bioactive molecules have many biological regulatory functions. In this review, we describe how MSC-EVs MSC-Exos reduce related markers stress inflammation various systemic diseases, molecular mechanism treating apoptosis vascular injury induced by stress. The results a large number experimental studies shown both local administration effectively inhibit response diseases promote survival regeneration damaged parenchymal cells. mRNA miRNAs most important disease treatment, which apoptosis, necrosis lung, heart, kidney, liver, bone, skin other cells, their survive regenerate.

Язык: Английский

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Multitargeted Immunomodulatory Therapy for Viral Myocarditis by Engineered Extracellular Vesicles

ACS Nano, Год журнала: 2024, Номер 18(4), С. 2782 - 2799

Опубликована: Янв. 17, 2024

Immune regulation therapies are considered promising for treating classically activated macrophage (M1)-driven viral myocarditis (VM). Alternatively, (M2)-derived extracellular vesicles (M2 EVs) have great immunomodulatory potential owing to their ability reprogram macrophages, but therapeutic efficacy is hampered by insufficient targeting capacity in vivo. Therefore, we developed cardiac-targeting peptide (CTP) and platelet membrane (PM)-engineered M2 EVs enriched with inflammatory protein-II (vMIP-II), termed CTP/PM-M2 EVsvMIP-II-Lamp2b, improve the delivery of "cargo" heart tissues. In a mouse model VM, intravenously injected EVsvMIP-II-Lamp2b could be carried into myocardium via CTP, PM, vMIP-II. microenvironment, macrophages differentiated from circulating monocytes residing showed enhanced endocytosis rates EVsvMIP-II-Lamp2b. Subsequently, successfully released functional cytosol, which facilitated reprogramming M1 reparative macrophages. vMIP-II not only helps increase also collaborates regulate microenvironment downregulate levels multiple chemokine receptors. Finally, cardiac immune was protectively regulated achieve repair. Taken together, our findings suggest that CTP-and-PM-engineered represent an effective means VM show promise clinical applications.

Язык: Английский

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Advances in nanomaterial-targeted treatment of acute lung injury after burns

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июнь 18, 2024

Abstract Acute lung injury ( ALI ) is a common complication in patients with severe burns and has complex pathogenesis high morbidity mortality rates. A variety of drugs have been identified the clinic for treatment ALI, but they toxic side effects caused by easy degradation body distribution throughout body. In recent years, as understanding mechanism underlying improved, scholars developed new nanomaterials that can be safely effectively targeted ALI. Most these methods involve such lipids, organic polymers, peptides, extracellular vesicles or cell membranes, inorganic nanoparticles other nanomaterials, which are to reach tissues perform their functions through active targeting passive targeting, process involves cells organelles. this review, first, mechanisms pathophysiological features occurrence after burn reviewed, potential therapeutic targets summarized, existing classified, possible problems challenges discussed provide reference development

Язык: Английский

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Next-generation treatments: Immunotherapy and advanced therapies for COVID-19

Heliyon, Год журнала: 2024, Номер 10(5), С. e26423 - e26423

Опубликована: Фев. 19, 2024

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in 2019 following prior outbreaks of coronaviruses like SARS and MERS recent decades, underscoring their high potential infectivity humans. Insights from previous have played a significant role developing effective strategies to mitigate the global impact SARS-CoV-2. As January 7, 2024, there been 774,075,242 confirmed cases worldwide. To date, 13.59 billion vaccine doses administered, 7,012,986 documented fatalities (https://www.who.int/)Despite progress addressing rapid evolution SARS-CoV-2 challenges human defenses, presenting ongoing challenges. emergence new lineages, shaped mutation recombination processes, has led successive waves infections. This scenario reveals need for next-generation vaccines as crucial requirement ensuring protection against demand calls formulations that trigger robust adaptive immune response without leading inflammation linked with infection.Key mutations detected Spike protein, critical target neutralizing antibodies design —specifically within Receptor Binding Domain region Omicron variant lineages (B.1.1.529), currently dominant worldwide, intensified concerns due association immunity evasion vaccinations infections.As world deals this evolving threat, narrative extends realm emerging variants, each displaying implications remain largely misunderstood. Notably, JN.1 lineage is gaining prevalence, early findings suggest it stands among immune-evading characteristic attributed its L455S. Moreover, detrimental consequences novel bear particularly on immunocompromised individuals older adults. Immunocompromised face such suboptimal responses vaccines, rendering them more susceptible disease. Similarly, adults an increased risk disease presence comorbid conditions, find themselves at heightened vulnerability develop Thus, recognizing these intricate factors effectively tailoring public health protect vulnerable populations. In context, review aims describe, analyze, discuss current treatments encompassing immunotherapeutic approaches advanced therapies complements will offer solutions counter disadvantages existing options. Preliminary outcomes show virus address immunomodulatory associated COVID-19. Furthermore, capacity promote tissue repair demonstrated, which can be noteworthy who stand actors landscape possess broader potential, offering wide range variants enhancing ability constant virus. are projected treatment alternatives managing Chronic Post-COVID-19 syndromeand long-term complications.

Язык: Английский

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Regulation of the Nrf2/HO-1 axis by mesenchymal stem cells-derived extracellular vesicles: implications for disease treatment

Frontiers in Cell and Developmental Biology, Год журнала: 2024, Номер 12

Опубликована: Июнь 10, 2024

This comprehensive review inspects the therapeutic potential of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) across multiple organ systems. Examining their impact on integumentary, respiratory, cardiovascular, urinary, and skeletal systems, study highlights versatility MSC-EVs in addressing diverse medical conditions. Key pathways, such as Nrf2/HO-1, consistently emerge central mediators antioxidative anti-inflammatory effects. From expediting diabetic wound healing to mitigating oxidative stress-induced skin injuries, alleviating acute lung even offering solutions for conditions like myocardial infarction renal ischemia-reperfusion injury, demonstrate promising efficacy. Their adaptability different administration routes identifying specific factors opens avenues innovative regenerative strategies. positions candidates future clinical applications, providing a overview medicine.

Язык: Английский

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Innate and adaptive immune response in SARS-CoV-2 infection-Current perspectives

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Ноя. 22, 2022

Coronavirus disease 2019 (COVID-19) has been a global pandemic, caused by novel coronavirus strain with strong infectivity, severe acute respiratory syndrome 2 (SARS-CoV-2). With the in-depth research, close relationship between COVID-19 and immune system dug out. During infection, macrophages, dendritic cells, natural killer CD8 + T Th1, Th17, Tfh cells effector B are all involved in anti-SARS-CoV-2 responses, however, dysfunctional responses will ultimately lead to excessive inflammation, lung injury, even other organ failure. Thus, detailed understanding of pertinent response during provide insights predicting outcomes developing appropriate therapeutic approaches. In this review, we mainly clarify role target-vaccine development treatment.

Язык: Английский

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