Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Март 13, 2024
Abstract
Background
Breast
cancer
ranks
first
among
malignant
tumors,
of
which
triple-negative
breast
(TNBC)
is
characterized
by
its
highly
invasive
behavior
and
the
worst
prognosis.
Timely
diagnosis
precise
treatment
TNBC
are
substantially
challenging.
Abnormal
tumor
vessels
play
a
crucial
role
in
progression
treatment.
Nitric
oxide
(NO)
regulates
angiogenesis
maintains
vascular
homeostasis,
while
effective
NO
delivery
can
normalize
vasculature.
Accordingly,
we
have
proposed
here
microenvironment
remodeling
strategy
based
on
NO-induced
vessel
normalization
extracellular
matrix
collagen
degradation
with
multimodality
imaging-guided
nanoparticles
against
called
DNMF/PLGA.
Results
Nanoparticles
were
synthesized
using
chemotherapeutic
agent
doxorubicin
(DOX),
donor
L-arginine
(L-Arg),
ultrasmall
spinel
ferrites
(MnFe
2
O
4
),
poly
(lactic-co-glycolic
acid)
(PLGA)
shell.
Nanoparticle
distribution
was
accurately
monitored
real-time
through
enhanced
magnetic
resonance
imaging
photoacoustic
imaging.
Near-infrared
irradiation
cells
revealed
that
MnFe
catalyzes
production
large
amount
reactive
oxygen
species
(ROS)
from
H
,
resulting
cascade
catalysis
L-Arg
to
trigger
presence
ROS.
In
addition,
DOX
activates
niacinamide
adenine
dinucleotide
phosphate
oxidase
generate
supply
.
The
generated
improves
endothelial
cell
integrity
pericellular
contractility
promote
induces
activation
endogenous
metalloproteinases
(mainly
MMP-1
MMP-2)
so
as
extravascular
degradation,
thereby
providing
an
auxiliary
mechanism
for
efficient
nanoparticle
penetration.
Moreover,
effect
photothermal
served
chemo-hyperthermia
synergistic
therapy
TNBC.
Conclusion
two
therapeutic
mechanisms,
along
mechanism,
perfectly
combined
enhance
effects.
Briefly,
image-guided
provide
reliable
potential
application
fight
Graphical
Coordination Chemistry Reviews,
Год журнала:
2024,
Номер
508, С. 215754 - 215754
Опубликована: Март 12, 2024
The
science
of
nanotechnology
has
been
proposed
as
a
factor
main
change
in
the
field
cancer
diagnosis
and
treatment.
challenges
common
clinical
treatment
breast
can
be
dominate
by
proof
targeting
cells
nanoscale
drug
delivery
system.
Due
to
specific
properties
nanoparticles
such
biocompatibility,
minimum
toxicity,
excellent
stability,
multifunctional
encapsulations
therapeutic
agents,
increased
permeability
retention
effect,
selective
targeting,
they
apply
for
therapy.
Multidrug
resistance
many
chemotherapy
drugs
is
one
conventional
that
overcome
nanoparticles.
However,
vivo
vitro
studies
limited
this
field,
number
approved
nano
formulation
not
significantly
over
years.
Successful
translation
nanomedicines
arduous
requiring
considerable
preclinical
tests.
Two-dimensional
(2D)
monolayer
cell
cultures
animal
models,
which
are
routinely
used
research
discovery/screening
seem
inadequate.
To
address
challenge,
biomimetic
three-dimensional
(3D)
tumor
models
like
spheroids,
organoids,
scaffolds/hydrogels,
bioprinted,
microfluidic
chips
have
established
using
engineering
approach.
Taking
physiopathology
microenvironment
into
account,
potential
enhance
disease
modeling
drug/nanomedicine
screening.
development
3D
comprised
patient's
own
cancer,
stromal,
immune
exploited
promising
platform
provide
personalized
Pharmaceuticals,
Год журнала:
2024,
Номер
17(12), С. 1711 - 1711
Опубликована: Дек. 18, 2024
Nanotechnology
has
revolutionised
biomedical
research,
offering
innovative
healthcare
solutions.
Plant-based
nanotechnology
is
emerging
as
a
sustainable
alternative,
minimising
environmental
impacts
and
enhancing
therapeutic
effectiveness.
This
paper
explores
the
potential
of
plant-derived
nanoparticles
(PNPs)
in
medicine,
highlighting
their
biocompatibility,
multifunctionality,
eco-friendliness.
PNPs,
synthesised
through
green
methods,
have
demonstrated
promising
applications
drug
delivery,
cancer
therapy,
antimicrobial
treatments,
tissue
regeneration.
Their
unique
properties,
such
high
surface
area
bioactive
components,
enable
improved
targeting,
controlled
release,
reducing
side
effects
treatment
efficacy.
Additionally,
compounds’
inherent
antioxidant
retained
within
platinum
(PNPs),
present
opportunities
for
combating
resistance
promoting
wound
healing.
Despite
potential,
challenges
remain
standardising
PNP
synthesis,
ensuring
consistency,
scaling
up
production
industrial
applications.
review
emphasises
need
further
research
on
toxicity,
regulatory
frameworks
to
fully
harness
capabilities
clinical
commercial
represents
promising,
greener
alternative
advancing
solutions,
aligning
with
global
sustainability
goals.
Journal of Controlled Release,
Год журнала:
2024,
Номер
372, С. 751 - 777
Опубликована: Июль 4, 2024
Despite
significant
advances,
cancer
remains
a
leading
global
cause
of
death.
Current
therapies
often
fail
due
to
incomplete
tumor
removal
and
nonspecific
targeting,
spurring
interest
in
alternative
treatments.
Hyperthermia,
which
uses
elevated
temperatures
kill
cells
or
boost
their
sensitivity
radio/chemotherapy,
has
emerged
as
promising
alternative.
Recent
advancements
employ
nanoparticles
(NPs)
heat
mediators
for
selective
cell
destruction,
minimizing
damage
healthy
tissues.
This
approach,
known
NP
hyperthermia,
falls
into
two
categories:
photothermal
(PTT)
magnetothermal
(MTT).
PTT
utilizes
NPs
that
convert
light
heat,
while
MTT
magnetic
activated
by
alternating
fields
(AMF),
both
achieving
localized
damage.
These
methods
offer
advantages
like
precise
minimal
invasiveness,
reduced
systemic
toxicity.
However,
the
efficacy
hyperthermia
depends
on
many
factors,
particular,
properties,
microenvironment
(TME),
TME-NP
interactions.
Optimizing
this
treatment
requires
accurate
monitoring
strategies,
such
nanothermometry
biologically
relevant
screening
models
can
better
mimic
physiological
features
human
body.
review
explores
state-of-the-art
NP-mediated
discussing
available
nanomaterials,
strengths
weaknesses,
characterization
methods,
future
directions.
Our
particular
focus
lies
preclinical
techniques,
providing
an
updated
perspective
relevance
journey
towards
clinical
trials.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Март 13, 2024
Abstract
Background
Breast
cancer
ranks
first
among
malignant
tumors,
of
which
triple-negative
breast
(TNBC)
is
characterized
by
its
highly
invasive
behavior
and
the
worst
prognosis.
Timely
diagnosis
precise
treatment
TNBC
are
substantially
challenging.
Abnormal
tumor
vessels
play
a
crucial
role
in
progression
treatment.
Nitric
oxide
(NO)
regulates
angiogenesis
maintains
vascular
homeostasis,
while
effective
NO
delivery
can
normalize
vasculature.
Accordingly,
we
have
proposed
here
microenvironment
remodeling
strategy
based
on
NO-induced
vessel
normalization
extracellular
matrix
collagen
degradation
with
multimodality
imaging-guided
nanoparticles
against
called
DNMF/PLGA.
Results
Nanoparticles
were
synthesized
using
chemotherapeutic
agent
doxorubicin
(DOX),
donor
L-arginine
(L-Arg),
ultrasmall
spinel
ferrites
(MnFe
2
O
4
),
poly
(lactic-co-glycolic
acid)
(PLGA)
shell.
Nanoparticle
distribution
was
accurately
monitored
real-time
through
enhanced
magnetic
resonance
imaging
photoacoustic
imaging.
Near-infrared
irradiation
cells
revealed
that
MnFe
catalyzes
production
large
amount
reactive
oxygen
species
(ROS)
from
H
,
resulting
cascade
catalysis
L-Arg
to
trigger
presence
ROS.
In
addition,
DOX
activates
niacinamide
adenine
dinucleotide
phosphate
oxidase
generate
supply
.
The
generated
improves
endothelial
cell
integrity
pericellular
contractility
promote
induces
activation
endogenous
metalloproteinases
(mainly
MMP-1
MMP-2)
so
as
extravascular
degradation,
thereby
providing
an
auxiliary
mechanism
for
efficient
nanoparticle
penetration.
Moreover,
effect
photothermal
served
chemo-hyperthermia
synergistic
therapy
TNBC.
Conclusion
two
therapeutic
mechanisms,
along
mechanism,
perfectly
combined
enhance
effects.
Briefly,
image-guided
provide
reliable
potential
application
fight
Graphical
