Nanobiotechnological approaches for breast cancer Management: Drug delivery systems and 3D In-Vitro models

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 508, P. 215754 - 215754

Published: March 12, 2024

The science of nanotechnology has been proposed as a factor main change in the field cancer diagnosis and treatment. challenges common clinical treatment breast can be dominate by proof targeting cells nanoscale drug delivery system. Due to specific properties nanoparticles such biocompatibility, minimum toxicity, excellent stability, multifunctional encapsulations therapeutic agents, increased permeability retention effect, selective targeting, they apply for therapy. Multidrug resistance many chemotherapy drugs is one conventional that overcome nanoparticles. However, vivo vitro studies limited this field, number approved nano formulation not significantly over years. Successful translation nanomedicines arduous requiring considerable preclinical tests. Two-dimensional (2D) monolayer cell cultures animal models, which are routinely used research discovery/screening seem inadequate. To address challenge, biomimetic three-dimensional (3D) tumor models like spheroids, organoids, scaffolds/hydrogels, bioprinted, microfluidic chips have established using engineering approach. Taking physiopathology microenvironment into account, potential enhance disease modeling drug/nanomedicine screening. development 3D comprised patient's own cancer, stromal, immune exploited promising platform provide personalized

Language: Английский

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Nanoparticle-mediated thermal Cancer therapies: Strategies to improve clinical translatability

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 372, P. 751 - 777

Published: July 4, 2024

Despite significant advances, cancer remains a leading global cause of death. Current therapies often fail due to incomplete tumor removal and nonspecific targeting, spurring interest in alternative treatments. Hyperthermia, which uses elevated temperatures kill cells or boost their sensitivity radio/chemotherapy, has emerged as promising alternative. Recent advancements employ nanoparticles (NPs) heat mediators for selective cell destruction, minimizing damage healthy tissues. This approach, known NP hyperthermia, falls into two categories: photothermal (PTT) magnetothermal (MTT). PTT utilizes NPs that convert light heat, while MTT magnetic activated by alternating fields (AMF), both achieving localized damage. These methods offer advantages like precise minimal invasiveness, reduced systemic toxicity. However, the efficacy hyperthermia depends on many factors, particular, properties, microenvironment (TME), TME-NP interactions. Optimizing this treatment requires accurate monitoring strategies, such nanothermometry biologically relevant screening models can better mimic physiological features human body. review explores state-of-the-art NP-mediated discussing available nanomaterials, strengths weaknesses, characterization methods, future directions. Our particular focus lies preclinical techniques, providing an updated perspective relevance journey towards clinical trials.

Language: Английский

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Green synthesis of epigallocatechin gallate-ferric complex nanoparticles for photothermal enhanced antibacterial and wound healing

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 171, P. 116175 - 116175

Published: Jan. 23, 2024

Bacterial infections are a significant global health concern, particularly in the context of skin and chronic wounds, which was further exacerbated by emerging antibiotic resistance. Therefore, there urgent needs to develop alternative antibacterial strategies without inducing Photothermal therapy (PTT) is promising approach but usually faces limitations such as need for stable environmental-friendly PTT agents ensuring biocompatibility with living tissues, necessitating ongoing research its clinical advancement. Herein, this study, aim green synthesized agent photothermal enhanced wound healing, we proposed facile one-pot method prepare epigallocatechin gallate-ferric (EGCG-Fe) complex nanoparticles. The obtained nanoparticles showed improved good size distribution stability high reproducibility. More importantly, EGCG-Fe have additional conversion ability can give effect on various pathogens, including Gram-positive Staphylococcus aureus (S. aureus) Gram-negative Escherichia coli (E. coli) strains. also powerful biofilm prevention destruction effects promoted healing mice model. In conclusion, be robust material effective novel light controllable properties applications.

Language: Английский

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Biogenic Copper/Zinc Oxide Nanocomposites from Bixa orellana: Anticancer Effects through ROS Generation and Apoptosis Induction in Cervical Carcinoma

Journal of Cluster Science, Journal Year: 2025, Volume and Issue: 36(2)

Published: Feb. 4, 2025

Language: Английский

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GSH-Responsive Pt-based Nanomotor with Improved Doxorubicin Delivery for Synergistic Osteosarcoma Chemotherapy

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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