SSRN Electronic Journal, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Ageing Research Reviews, Год журнала: 2023, Номер 89, С. 101981 - 101981
Опубликована: Июнь 10, 2023
Язык: Английский
Процитировано
49
Bioactive Materials, Год журнала: 2024, Номер 36, С. 126 - 156
Опубликована: Март 2, 2024
Small extracellular vesicles (sEVs) are known to be secreted by a vast majority of cells. These sEVs, specifically exosomes, induce specific cell-to-cell interactions and can activate signaling pathways in recipient cells through fusion or interaction. nanovesicles possess several desirable properties, making them ideal for regenerative medicine nanomedicine applications. properties include exceptional stability, biocompatibility, wide biodistribution, minimal immunogenicity. However, the practical utilization particularly clinical settings at large scale, is hindered expensive procedures required their isolation, limited circulation lifetime, suboptimal targeting capacity. Despite these challenges, sEVs have demonstrated remarkable ability accommodate various cargoes found extensive applications biomedical sciences. To overcome limitations broaden potential applications, researchers should strive deepen understanding current loading, characterization techniques. Additionally, acquiring fundamental knowledge about origins employing state-of-the-art methodologies expand research scope. This review provides comprehensive overview exosome-based strategies diverse domains, encompassing cancer therapy, immunotherapy, biomarker Furthermore, we emphasize immense exosomes medicine.
Язык: Английский
Процитировано
35
Small, Год журнала: 2024, Номер 20(26)
Опубликована: Янв. 12, 2024
Abstract Although bioactive compounds (BCs) have many important functions, their applications are greatly limited due to own defects. The development of nanocarriers (NCs) technology has gradually overcome the defects BCs. NCs equally as BCs some extent. Self‐assembly (SA) methods build advantages than chemical methods, and SA significant impact on structure function NCs. However, relationship among mechanism, structure, not been given enough attention. Therefore, from perspective bottom‐up building concept SA‐structure‐function is emphasized promote SA‐based First, conditions forces for occurring introduced, then basis molecular mechanism protein, polysaccharide, lipid summarized. Then, varieties structures formed based introduced in detail. Finally, facing how be well solved by also elaborated. This review attempts describe great significance constructing artificial deliver aspects SA‐structure‐function, so wide application
Язык: Английский
Процитировано
22
European journal of medical research, Год журнала: 2023, Номер 28(1)
Опубликована: Авг. 25, 2023
Abstract Fisetin, a natural flavonoid, possesses numerous biological activities that have been extensively studied in various diseases. When it comes to cancer, fisetin exhibits range of effects, such as suppressing cell growth, triggering programmed death, reducing the formation new blood vessels, protecting against oxidative stress, and inhibiting migration. Moreover, has ability enhance effectiveness chemotherapy. The anticancer properties can be attributed diverse array molecules signaling pathways, including vascular endothelial growth factor (VEGF), mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-κB), PI3K/Akt/mTOR, Nrf2/HO-1. Consequently, holds promise therapeutic agent for treatment. In this review, we place emphasis on functions molecular targets therapy.
Язык: Английский
Процитировано
26
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Март 23, 2023
Cancer causes significant mortality and morbidity worldwide, but existing pharmacological treatments are greatly limited by the inherent heterogeneity of cancer as a disease, well unsatisfactory efficacy specificity therapeutic drugs. Biopharmaceutical barriers such low permeability poor water solubility, along with absence active targeting capabilities, often result in suboptimal clinical results. The difficulty successfully reaching destroying tumor cells is also compounded undesirable impacts on healthy tissue, including off-target effects high toxicity, which further impair ability to effectively manage disease optimize patient outcomes. However, last few decades, development nanotherapeutics has allowed for use rational design order maximize success. Advances fabrication nano-sized delivery systems, coupled variety surface engineering strategies promote customization, have resulted promising approaches targeted, site-specific drug fewer unwanted better efficacy. These nano systems been able overcome some challenges conventional related pharmacokinetics, biodistribution, target specificity. In particular, lipid-based nanosystems extensively explored due their biocompatibility, versatility, adaptability. Lipid-based treatment varied diverse, liposomal therapeutics, lipidic nanoemulsions, solid lipid nanoparticles, nanostructured carriers, lipid-polymer nanohybrids, supramolecular nanolipidic structures. This review aims provide an overview diverse formulations lipid-engineered current field, researchers attempt translate these from bench clinic.
Язык: Английский
Процитировано
24
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Янв. 10, 2025
Immunotherapy is a cutting-edge approach that leverages sophisticated technology to target tumor-specific antibodies and modulate the immune system eradicate cancer enhance patients' quality of life. Bioinformatics genetic science advancements have made it possible diagnose treat patients using immunotherapy technology. However, current immunotherapies against limited clinical benefits due cancer-associated antigens, which often fail interact with cells exhibit insufficient therapeutic targeting unintended side effects. To surmount this challenge, nanoparticle systems emerged as potential strategy for transporting immunotherapeutic agents activating combat tumors. Consequently, process potentially generates an antigen-specific T response effectively suppresses growth. Furthermore, nanoplatforms high specificity, efficacy, diagnostic potential, imaging capabilities, making them promising tools treatment. informative paper delves into various available immunotherapies, including CAR therapy checkpoint blockade, cytokines, vaccines, monoclonal antibodies. concept theragnostic nanotechnology, integrates diagnostics more personalized treatment therapy. Additionally, covers different nanocarrier systems, marketed products, trials, regulatory considerations, future prospects immunotherapy.
Язык: Английский
Процитировано
2
Ultrasonics Sonochemistry, Год журнала: 2023, Номер 97, С. 106451 - 106451
Опубликована: Май 20, 2023
Ultrasonically-induced nanoemulsions have been widely investigated for the development of functional food, cosmetics, and pharmaceuticals due to ideal droplet sizes (DS), low polydispersity index (PDI), superior physical stability. However, a series frequently-used ultrasonic set-ups mainly suffered from energy efficiency caused by large acoustic impedance consumption, subordinately confronted with throughput, complicated fabrication complex structure weak cavitation. Herein, we employed typical microreactor (USMR) that ensured high-efficient input generated intense cavitation behavior efficient breakage droplets continuous production unified oil-in-water (O/W) in single cycle without any pre-emulsification treatment. The emulsification was optimized tuning formula indexes, technological parameters, numerical analysis using Response Surface Methodology (RSM), followed comparison traditional probe. USMR exhibited easy scale-up remarkable uniformity mode. In addition, concurrent uniform high throughput could also be achieved larger power. Based on RSM analysis, DS PDI 96.4 nm 0.195 were observed under optimal conditions, respectively, well consistent predicted values. Impressively, spherical morphology stability, which held 45 days at 4℃ 25℃. results present work may provide paradigm preparation nanomaterials based novel tools.
Язык: Английский
Процитировано
20
Pharmaceutics, Год журнала: 2024, Номер 16(11), С. 1376 - 1376
Опубликована: Окт. 26, 2024
Oils and lipids help make water-insoluble drugs soluble by dispersing them in an aqueous medium with the of a surfactant enabling their absorption across gut barrier. The emergence microemulsions (thermodynamically stable), nanoemulsions (kinetically self-emulsifying drug delivery systems added unique characteristics that suitable for prolonged storage controlled release. In 1990s, solid-phase were introduced to reduce leakage from nanoparticles prolong Manipulating structure emulsions solid lipid has enabled multifunctional loading therapeutic macromolecules such as proteins, nucleic acid, vaccines, etc. Phospholipids surfactants well-defined polar head carbon chain have been used prepare bilayer vesicles known liposomes niosomes, respectively. increasing knowledge targeting ligands external factors gain control over pharmacokinetics ever-increasing number synthetic are expected vesicular preferred choice encapsulation targeted agents. This review discusses different oil-based nanoparticulate drugs. salient features each system highlighted, special emphasis is given studies compare them.
Язык: Английский
Процитировано
9
Chemical Communications, Год журнала: 2024, Номер 60(93), С. 13641 - 13652
Опубликована: Янв. 1, 2024
Hypoxia limits the phototherapeutic efficacy of porphyrin-based nMOFs; loading with hypoxia-activated drug TPZ enhances combined PDT and chemotherapy effects.
Язык: Английский
Процитировано
7
International Journal of Pharmaceutics, Год журнала: 2024, Номер 667, С. 124944 - 124944
Опубликована: Ноя. 10, 2024
Язык: Английский
Процитировано
7