Expert Opinion on Drug Delivery, Год журнала: 2024, Номер 21(4), С. 553 - 572
Опубликована: Апрель 2, 2024
Intranasal administration is an effective drug delivery routes in modern pharmaceutics. However, unlike other vivo biological barriers, the nasal mucosal barrier characterized by high turnover and selective permeability, hindering diffusion of both particulate systems molecules. The fate administrated nanomedicines often significantly affected nano-biointeractions.
Язык: Английский
Pharmaceutics, Год журнала: 2023, Номер 15(4), С. 1313 - 1313
Опубликована: Апрель 21, 2023
Chitosan, a biocompatible and biodegradable polysaccharide derived from chitin, has surfaced as material of promise for drug delivery biomedical applications. Different chitin chitosan extraction techniques can produce materials with unique properties, which be further modified to enhance their bioactivities. Chitosan-based systems have been developed various routes administration, including oral, ophthalmic, transdermal, nasal, vaginal, allowing targeted sustained release drugs. Additionally, used in numerous applications, such bone regeneration, cartilage tissue cardiac corneal periodontal wound healing. Moreover, also utilized gene delivery, bioimaging, vaccination, cosmeceutical Modified derivatives improve biocompatibility resulting innovative promising potentials This article summarizes the recent findings on its application science.
Язык: Английский
Процитировано
262
Molecules, Год журнала: 2023, Номер 28(4), С. 1963 - 1963
Опубликована: Фев. 18, 2023
Chitosan-based nanoparticles (chitosan-based nanocomposites; chitosan nanoparticles; ChNPs) are promising materials that receiving a lot of attention in the last decades. ChNPs have great potential as nanocarriers. They able to encapsulate drugs well active compounds and deliver them specific place body providing controlled release. In article, an overview has been made most frequently used preparation methods, developed applications medicine. The presentation important information concerning ChNPs, especially chitosan’s properties drug delivery systems (DDS), method NPs production was quoted. Additionally, specification classification NPs’ morphological features determined their application together with methods attaching NPs. latest scientific reports DDS using administered orally, through eye, on skin transdermally were taken into account.
Язык: Английский
Процитировано
191
Carbohydrate Research, Год журнала: 2024, Номер 542, С. 109199 - 109199
Опубликована: Июнь 27, 2024
Язык: Английский
Процитировано
39
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 273, С. 132916 - 132916
Опубликована: Июнь 5, 2024
Язык: Английский
Процитировано
19
International Journal of Pharmaceutics, Год журнала: 2025, Номер 672, С. 125319 - 125319
Опубликована: Фев. 5, 2025
Язык: Английский
Процитировано
2
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 251, С. 126390 - 126390
Опубликована: Авг. 16, 2023
Язык: Английский
Процитировано
34
International Journal of Biological Macromolecules, Год журнала: 2023, Номер 245, С. 125554 - 125554
Опубликована: Июнь 24, 2023
Язык: Английский
Процитировано
26
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 14(11), С. 4683 - 4716
Опубликована: Сен. 2, 2024
About 40% of approved drugs and nearly 90% drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving bioavailability is a critical issue that needs to be urgently addressed in development application. This review briefly introduces conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, details crystallization strategies, ionic liquids, polymer-based, lipid-based, inorganic-based carriers bioavailability. Some most commonly used carrier materials for presented. Several using summarized. Furthermore, this summarizes mechanism each technique, reviews latest research advances challenges, evaluates potential clinical translation. could guide selection approach, dosage form, administration route Moreover, we discuss several promising attracting increasing attention worldwide.
Язык: Английский
Процитировано
14
Polymers, Год журнала: 2024, Номер 16(4), С. 510 - 510
Опубликована: Фев. 13, 2024
Efficient drug delivery remains a critical challenge for treating neurodegenerative diseases, such as Alzheimer’s disease (AD). Using innovative nanomaterials, delivering current medications like acetylcholinesterase inhibitors to the brain through intranasal route is promising strategy managing AD. Here, we developed unique combinational system based on N,N,N-trimethyl chitosan nanoparticles (NPs). These NPs encapsulate rivastigmine, most potent inhibitor, along with insulin, complementary therapeutic agent. The spherical exhibited zeta potential of 17.6 mV, size 187.00 nm, and polydispersity index (PDI) 0.29. Our findings demonstrate significantly improved transport efficiency sheep nasal mucosa using compared solutions. efficiencies 73.3% rivastigmine 96.9% surpassing solutions, which showed 52% 21% insulin ex vivo. results highlight new approach enhancing efficiency. mucoadhesive offer novel simultaneous cerebral could prove helpful in developing effective treatments AD other conditions.
Язык: Английский
Процитировано
13
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Июнь 10, 2024
The recent decade has witnessed a remarkable surge in the field of nanoparticles, from their synthesis, characterization, and functionalization to diverse applications. At nanoscale, these particles exhibit distinct physicochemical properties compared bulk counterparts, enabling multitude applications spanning energy, catalysis, environmental remediation, biomedicine, beyond. This review focuses on specific nanoparticle categories, including magnetic, gold, silver, quantum dots (QDs), as well hybrid variants, specifically tailored for biomedical A comprehensive comparison prevalent chemical, physical, biological synthesis methods are presented. To enhance biocompatibility colloidal stability, facilitate surface modification cargo/agent loading, surfaces coated with different synthetic polymers very recently, cell membrane coatings. utilization polymer- or membrane-coated nanoparticles opens wide variety such magnetic resonance imaging (MRI), hyperthermia, photothermia, sample enrichment, bioassays, drug delivery, etc. With this review, goal is provide toolbox insights into polymer applications, while also addressing challenges involved translating laboratory benchtops vitro vivo Furthermore, perspectives future trends developments rapidly evolving domain provided.
Язык: Английский
Процитировано
13