Expert Opinion on Drug Delivery,
Journal Year:
2024,
Volume and Issue:
21(4), P. 553 - 572
Published: April 2, 2024
Intranasal
administration
is
an
effective
drug
delivery
routes
in
modern
pharmaceutics.
However,
unlike
other
vivo
biological
barriers,
the
nasal
mucosal
barrier
characterized
by
high
turnover
and
selective
permeability,
hindering
diffusion
of
both
particulate
systems
molecules.
The
fate
administrated
nanomedicines
often
significantly
affected
nano-biointeractions.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(4), P. 1313 - 1313
Published: April 21, 2023
Chitosan,
a
biocompatible
and
biodegradable
polysaccharide
derived
from
chitin,
has
surfaced
as
material
of
promise
for
drug
delivery
biomedical
applications.
Different
chitin
chitosan
extraction
techniques
can
produce
materials
with
unique
properties,
which
be
further
modified
to
enhance
their
bioactivities.
Chitosan-based
systems
have
been
developed
various
routes
administration,
including
oral,
ophthalmic,
transdermal,
nasal,
vaginal,
allowing
targeted
sustained
release
drugs.
Additionally,
used
in
numerous
applications,
such
bone
regeneration,
cartilage
tissue
cardiac
corneal
periodontal
wound
healing.
Moreover,
also
utilized
gene
delivery,
bioimaging,
vaccination,
cosmeceutical
Modified
derivatives
improve
biocompatibility
resulting
innovative
promising
potentials
This
article
summarizes
the
recent
findings
on
its
application
science.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(4), P. 1963 - 1963
Published: Feb. 18, 2023
Chitosan-based
nanoparticles
(chitosan-based
nanocomposites;
chitosan
nanoparticles;
ChNPs)
are
promising
materials
that
receiving
a
lot
of
attention
in
the
last
decades.
ChNPs
have
great
potential
as
nanocarriers.
They
able
to
encapsulate
drugs
well
active
compounds
and
deliver
them
specific
place
body
providing
controlled
release.
In
article,
an
overview
has
been
made
most
frequently
used
preparation
methods,
developed
applications
medicine.
The
presentation
important
information
concerning
ChNPs,
especially
chitosan’s
properties
drug
delivery
systems
(DDS),
method
NPs
production
was
quoted.
Additionally,
specification
classification
NPs’
morphological
features
determined
their
application
together
with
methods
attaching
NPs.
latest
scientific
reports
DDS
using
administered
orally,
through
eye,
on
skin
transdermally
were
taken
into
account.
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(11), P. 4683 - 4716
Published: Sept. 2, 2024
About
40%
of
approved
drugs
and
nearly
90%
drug
candidates
are
poorly
water-soluble
drugs.
Low
solubility
reduces
the
drugability.
Effectively
improving
bioavailability
is
a
critical
issue
that
needs
to
be
urgently
addressed
in
development
application.
This
review
briefly
introduces
conventional
solubilization
techniques
such
as
solubilizers,
hydrotropes,
cosolvents,
prodrugs,
salt
modification,
micronization,
cyclodextrin
inclusion,
solid
dispersions,
details
crystallization
strategies,
ionic
liquids,
polymer-based,
lipid-based,
inorganic-based
carriers
bioavailability.
Some
most
commonly
used
carrier
materials
for
presented.
Several
using
summarized.
Furthermore,
this
summarizes
mechanism
each
technique,
reviews
latest
research
advances
challenges,
evaluates
potential
clinical
translation.
could
guide
selection
approach,
dosage
form,
administration
route
Moreover,
we
discuss
several
promising
attracting
increasing
attention
worldwide.
Polymers,
Journal Year:
2024,
Volume and Issue:
16(4), P. 510 - 510
Published: Feb. 13, 2024
Efficient
drug
delivery
remains
a
critical
challenge
for
treating
neurodegenerative
diseases,
such
as
Alzheimer’s
disease
(AD).
Using
innovative
nanomaterials,
delivering
current
medications
like
acetylcholinesterase
inhibitors
to
the
brain
through
intranasal
route
is
promising
strategy
managing
AD.
Here,
we
developed
unique
combinational
system
based
on
N,N,N-trimethyl
chitosan
nanoparticles
(NPs).
These
NPs
encapsulate
rivastigmine,
most
potent
inhibitor,
along
with
insulin,
complementary
therapeutic
agent.
The
spherical
exhibited
zeta
potential
of
17.6
mV,
size
187.00
nm,
and
polydispersity
index
(PDI)
0.29.
Our
findings
demonstrate
significantly
improved
transport
efficiency
sheep
nasal
mucosa
using
compared
solutions.
efficiencies
73.3%
rivastigmine
96.9%
surpassing
solutions,
which
showed
52%
21%
insulin
ex
vivo.
results
highlight
new
approach
enhancing
efficiency.
mucoadhesive
offer
novel
simultaneous
cerebral
could
prove
helpful
in
developing
effective
treatments
AD
other
conditions.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 10, 2024
The
recent
decade
has
witnessed
a
remarkable
surge
in
the
field
of
nanoparticles,
from
their
synthesis,
characterization,
and
functionalization
to
diverse
applications.
At
nanoscale,
these
particles
exhibit
distinct
physicochemical
properties
compared
bulk
counterparts,
enabling
multitude
applications
spanning
energy,
catalysis,
environmental
remediation,
biomedicine,
beyond.
This
review
focuses
on
specific
nanoparticle
categories,
including
magnetic,
gold,
silver,
quantum
dots
(QDs),
as
well
hybrid
variants,
specifically
tailored
for
biomedical
A
comprehensive
comparison
prevalent
chemical,
physical,
biological
synthesis
methods
are
presented.
To
enhance
biocompatibility
colloidal
stability,
facilitate
surface
modification
cargo/agent
loading,
surfaces
coated
with
different
synthetic
polymers
very
recently,
cell
membrane
coatings.
utilization
polymer-
or
membrane-coated
nanoparticles
opens
wide
variety
such
magnetic
resonance
imaging
(MRI),
hyperthermia,
photothermia,
sample
enrichment,
bioassays,
drug
delivery,
etc.
With
this
review,
goal
is
provide
toolbox
insights
into
polymer
applications,
while
also
addressing
challenges
involved
translating
laboratory
benchtops
vitro
vivo
Furthermore,
perspectives
future
trends
developments
rapidly
evolving
domain
provided.
