Journal of Nanotechnology,
Год журнала:
2025,
Номер
2025(1)
Опубликована: Янв. 1, 2025
Using
carbon‐based
nanoparticles,
such
as
diamond,
graphite,
fullerene,
and
nanotubes,
has
increased
their
research
possible
strategies
for
drug
delivery
to
control
diseases,
especially
cancer.
However,
because
these
materials,
when
interacting
with
the
living
environment,
release
substances
that
are
capable
of
inducing
cell
death
by
themselves,
it
is
vital
importance
analyze
type
particle
can
induce.
Although
there
different
efforts
describe
kind
nanoparticles
used
treat
diseases
cancer,
no
paper
explains
mechanisms
induced
nanoparticle
systems.
Therefore,
this
attempts
gain
cutting‐edge
information
on
using
nanopolymorphisms
mechanism
particles
produce.
In
conclusion,
carbon
interact
directly
membranes,
causing
physical
damage
disturbing
integrity
membrane.
This
alteration
mainly
lead
necrosis
or
apoptosis.
The
definition
a
predominant
each
depends
dose‐dependent
manner.
Primarily,
concentrations
cytotoxicity
were
100–500
μg/mL.
several
studies
analyzed,
was
only
find
nanodiamonds
proved
not
be
cytotoxic.
Pharmaceutics,
Год журнала:
2023,
Номер
15(9), С. 2286 - 2286
Опубликована: Сен. 6, 2023
Graphene-based
nanomaterials
(GBNMs),
specifically
graphene
oxide
(GO)
and
reduced
(rGO),
have
shown
great
potential
in
cancer
therapy
owing
to
their
physicochemical
properties.
As
GO
rGO
strongly
absorb
light
the
near-infrared
(NIR)
region,
they
are
useful
photothermal
(PTT)
for
treatment.
However,
despite
structural
similarities
of
rGO,
exhibit
different
influences
on
anticancer
treatment
due
capacities.
In
this
review,
various
characterization
techniques
used
compare
features
first
outlined.
Then,
a
comprehensive
summary
discussion
applicability
GBNMs
context
PTT
diverse
types
presented.
This
includes
integration
with
secondary
therapeutic
strategies,
particular
focus
capacity
achieved
through
irradiation
parameters
modifications
implemented.
Furthermore,
dedicated
section
is
devoted
studies
hybrid
magnetic-GBNMs.
Finally,
challenges
prospects
associated
utilization
GBNM
PTT,
primary
emphasis
clinical
translation,
addressed.
Journal of Materials Research and Technology,
Год журнала:
2023,
Номер
28, С. 2671 - 2698
Опубликована: Дек. 16, 2023
Graphene
is
a
promising
candidate
for
use
as
cushioning/filler
material
in
composites
due
to
its
extraordinary
mechanical
and
thermal
properties.
When
added
composite
materials,
graphene
can
improve
the
composite's
overall
strength,
durability,
impact
resistance.
One
of
primary
benefits
using
materials
high
strength-to-weight
ratio.
one
most
robust
known
man,
when
it
significantly
increase
their
strength
without
adding
much
weight.
Another
benefit
conductivity.
dissipate
heat
quickly
efficiently,
which
be
advantageous
applications
where
management
critical,
such
electronics
aerospace.
The
addition
reduce
amount
energy
transferred
during
impact,
reducing
risk
damage
or
failure
material.
In
properties,
highly
chemically
resistant,
making
ideal
harsh
environments.
It
also
relatively
inexpensive
compared
other
high-performance
an
attractive
option
large-scale
industrial
applications.
Overall,
has
potential
revolutionize
by
providing
high-strength,
lightweight,
thermally
conductive
that
durability
performance
diverse
range
Various
application
field
been
elaborated
this
review
work.
Toxics,
Год журнала:
2024,
Номер
12(1), С. 82 - 82
Опубликована: Янв. 18, 2024
Graphene-based
nanomaterials
(GBNs)
consist
of
a
single
or
few
layers
graphene
sheets
modified
including
pristine
graphene,
nanosheets
(GNS),
oxide
(GO),
reduced
(rGO),
as
well
with
various
functional
groups
chemicals
(e.g.,
hydroxyl,
carboxyl,
and
polyethylene
glycol),
which
are
frequently
used
in
industrial
biomedical
applications
owing
to
their
exceptional
physicochemical
properties.
Given
the
widespread
production
extensive
application
GBNs,
they
can
be
disseminated
wide
range
environmental
mediums,
such
air,
water,
food,
soil.
GBNs
enter
human
body
through
routes
inhalation,
ingestion,
dermal
penetration,
injection,
implantation
applications,
majority
tend
accumulate
respiratory
system.
inhaled
substantially
deposited
tract
may
impair
lung
defenses
clearance,
resulting
formation
granulomas
pulmonary
fibrosis.
However,
specific
toxicity
system
caused
by
different
influencing
factors,
underlying
mechanisms
remain
relatively
scarce.
This
review
summarizes
recent
advances
exposure,
metabolism,
potential
mechanisms,
current
limitations,
future
perspectives
Nanomaterials,
Год журнала:
2024,
Номер
14(2), С. 186 - 186
Опубликована: Янв. 13, 2024
Cancer
is
a
severe
disease
that,
in
2022,
caused
more
than
9.89
million
deaths
worldwide.
One
worrisome
type
of
cancer
bone
cancer,
such
as
osteosarcoma
and
Ewing
tumors,
which
occur
frequently
infants.
This
study
shows
an
active
interest
the
use
graphene
oxide
its
derivatives
therapy
against
cancer.
We
present
systematic
review
analyzing
current
state
art
related
to
GO
treating
osteosarcoma,
through
evaluating
existing
literature.
In
this
sense,
studies
focused
on
GO-based
nanomaterials
for
potential
applications
were
reviewed,
has
revealed
that
there
excellent
trend
toward
nanomaterials,
based
their
thermal
anti-cancer
activities,
treatment
various
therapeutic
approaches.
However,
research
needed
develop
highly
efficient
localized
therapies.
It
suggested,
therefore,
photodynamic
therapy,
photothermal
nanocarriers
should
be
considered
non-invasive,
specific,
alternatives
osteosarcoma.
These
options
promising
approaches
enhance
effectiveness
while
also
seeking
reduce
side
effects
minimize
damage
surrounding
healthy
tissues.
The
bibliometric
analysis
photochemical
treatments
reduced
from
January
2004
December
2022
extracted
948
documents
with
search
strategy,
mainly
papers,
conference
demonstrating
high-impact
field
supported
by
need
selective
central
countries
leading
are
United
States,
Iran,
Italy,
Germany,
China,
South
Korea,
Australia,
strong
collaborations
At
same
time,
most-cited
papers
published
journals
impact
factors
6.0
(2021),
290
citations.
Additionally,
most
topic
high
factor
journals,
according
performed,
field.
In
this
study,
the
synthesis,
characterization,
density
functional
theory
calculations
(DFT),
and
effect
of
polyethylenimine
(PEI)-functionalized
nitrogen-doped
graphene
quantum
dots
(PEI
N-GQDs)
their
palladium
metal
nanoparticles
nanocomposites
(PdNPs/PEI
on
cancer
cells
were
extensively
investigated.
The
focus
also
includes
investigating
cytotoxic
apoptotic
effects
ovarian
cells,
which
pose
a
serious
risk
to
women's
health
have
high
death
rates
from
delayed
diagnosis,
inadequate
response
treatment,
decreased
survival.
Graphene
differentially
effective
against
cell
lines.
particular,
smaller
particle
size
morphology
PdNPs/PEI
N-GQDs
compared
with
PEI
probably
enhance
activity
through
highly
improved
uptake
by
cells.
These
findings
emphasize
importance
in
composite
drugs
for
efficient
treatment.
DFT
results
revealed
that
Pd-containing
nanocomposite,
highest
occupied
molecular
orbital–lowest
unoccupied
orbital
gap,
exhibited
higher
reactivity
anticancer
human
line,
OVCAR-3.
Significantly,
application
initiated
apoptosis,
offering
valuable
insights
into
intricate
interplay
between
nanomaterials
biology.
