Lanthanide-Doped ZnO Nanoparticles: Unraveling Their Role in Cytotoxicity, Antioxidant Capacity, and Nanotoxicology

Antioxidants, Год журнала: 2024, Номер 13(2), С. 213 - 213

Опубликована: Фев. 8, 2024

This study used a sonochemical synthesis method to prepare (La, Sm)-doped ZnO nanoparticles (NPs). The effect of incorporating these lanthanide elements on the structural, optical, and morphological properties ZnO-NPs was analyzed. cytotoxicity reactive oxygen species (ROS) generation capacity were evaluated against breast (MCF7) colon (HT29) cancer cell lines. Their antioxidant activity analyzed using DPPH assay, their toxicity towards Artemia salina nauplii also evaluated. results revealed that treatment with NPs resulted in death 10.559–42.546% 18.230–38.643% MCF7 HT29 cells, respectively. attributed ability downregulate ROS formation within two lines dose-dependent manner. In inhibited free radicals at IC50 values ranging from 3.898 126.948 μg/mL. Against A. nauplii, synthesized did not cause nor induce changes tested concentrations. A series machine learning (ML) models predict biological performance ZnO-NPs. Among designed ML models, gradient boosting model greatest mean absolute error (MAE) (MAE 9.027, R2 = 0.86). data generated this work provide innovative insights into influence La Sm structural arrangement chemical features ZnO-NPs, together cytotoxicity, activity, vivo toxicity.

Язык: Английский

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“Multi‐in‐One” Yolk‐Shell Structured Nanoplatform Inducing Pyroptosis and Antitumor Immune Response Through Cascade Reactions

Small, Год журнала: 2024, Номер 20(30)

Опубликована: Фев. 25, 2024

Abstract Pyroptosis, a new mode of regulatory cell death, holds promising prospect in tumor therapy. The occurrence pyroptosis can trigger the release damage‐associated molecular patterns (DAMPs) and activate antitumor immune response. Moreover, enhancing intracellular reactive oxygen species (ROS) generation effectively induce pyroptosis. Herein, an integrated nanoplatform (hCZAG) based on zeolitic imidazolate framework‐8 (ZIF‐8) with Cu 2+ Zn as active nodes glucose oxidase (GOx) loading is constructed to evoke GOx elevate hydrogen peroxide (H 2 O ) levels regulate unfavorable microenvironment (TME). be reduced + by endogenous overexpressed GSH both exert Fenton‐like activity promote ROS amplify oxidative stress. In addition, accumulation leads aggregation lipoylated dihydrolipoamide S‐acetyltransferase (DLAT), thus resulting cuproptosis. Notably, outburst induced hCZAG activates Caspase‐1 proteins, cleavage gasdermin D (GSDMD), induces Pyroptosis further elicits adaptive response, leading immunogenic death (ICD). This study provides effective strategies for triggering pyroptosis‐mediated immunotherapy achieving improved therapeutic effects.

Язык: Английский

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Supramolecular assembly of Polydopamine@Fe nanoparticles with near-infrared light-accelerated cascade catalysis applied for synergistic photothermal-enhanced chemodynamic therapy

Journal of Colloid and Interface Science, Год журнала: 2024, Номер 676, С. 626 - 635

Опубликована: Июль 14, 2024

Язык: Английский

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Tumor Microenvironment‐Activatable Metal‐Phenolic Nanoformulations for Ultrasound‐Boosted Ferroptosis through Triple Regulatory Pathways

Advanced Functional Materials, Год журнала: 2024, Номер 34(44)

Опубликована: Июль 16, 2024

Abstract Despite its effectiveness in exterminating tumor cells, ferroptosis is seriously hampered by the high expression of antioxidant glutathione (GSH) and inadequacy endogenous H 2 O tumors. Herein, metal‐phenolic nanoformulations (FNCP NFs) composed sonosensitizer Chlorin e6 (Ce6), phenolic GSH consumer naphthazarin, Fe 3+ , followed modification PEG2000, are strategically designed fabricated for ultrasound‐boosted cells through triple regulatory pathways. The carrier‐free FNCP NFs can rapidly dissociate under microenvironment response with assistance ultrasound, releasing 2+ Ce6, naphthazarin. Ce6 capable producing singlet oxygen ( 1 ) hydroxyl radicals · OH) ultrasound‐activated sonodynamic therapy Fenton reaction‐mediated chemodynamic (CDT), respectively, which not only induce apoptotic cell death but also lead to effective accumulation lipid peroxidation (LPO), resulting ferroptosis. Meanwhile, released naphthazarin self‐cycling valence alternations /Fe promote significant decrease intracellular contents, further inducing inactivation peroxidase 4 (GPX4) up‐regulation LPO levels, eventually realizing synergistically enhanced This facile feasible design versatile offers a new strategy effectively improving efficiency multimodal cancer therapies.

Язык: Английский

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Aromaticity Tuning of Heavy-Atom-Free Photosensitizers for Singlet Fission-Enhanced Immunogenic Photodynamic Oncotherapy

Nano Letters, Год журнала: 2024, Номер 24(24), С. 7524 - 7533

Опубликована: Июнь 10, 2024

The quantum yield of reactive oxygen species is central importance for the development organic photosensitizers and photodynamic therapy (PDT). A common molecular design approach optimizing involves incorporation heavy atoms into their backbones. However, this raises concerns regarding heightened dark cytotoxicity a shortened triplet-state lifetime. Herein, we demonstrate heavy-atom-free (HAF) photosensitizer strategy founded on singlet fission (SF) mechanism cancer PDT. Through "single-atom surgery" to deleting in pyrazino[2,3-

Язык: Английский

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Transformable Tumor Microenvironment‐Responsive Oxygen Vacancy‐Rich MnO₂@Hydroxyapatite Nanospheres for Highly Efficient Cancer Sonodynamic Immunotherapy

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Фев. 17, 2025

Despite the promise of sonodynamic therapy (SDT)-mediated immunotherapy, anticancer efficacy current sonosensitizers is greatly limited by immunosuppressive tumor microenvironment (TME) and their inability to selectively respond it. Herein, oxygen vacancy-rich MnO2@hydroxyapatite (Ca10(PO4)6(OH)2) core-shell nanospheres (denoted as Ov-MO@CPO) an advanced TME-responsive sonosensitizer for immunotherapy demonstrated. The Ov-MO@CPO maintains its structural integrity under neutral conditions but dissolves pH-sensitive hydroxyapatite shell acidic TME release active MnO2 core, which reinvigorates H2O2 consumption hypoxia alleviation due catalase-like activity. Furthermore, introduced vacancies optimize electronic structure Ov-MO@CPO, with states near Fermi level higher d-band center. It results in accelerated electron-hole pair separation lower catalytic energy barriers boost ultrasound (US)-initiated ROS production. These multimodal synergistic effects effectively reverse microenvironment, inhibiting growth metastasis 4T1 tumor-bearing mice. No evident toxic are observed normal mouse tissues. Additionally, when combined immune checkpoint inhibitor, Ov-MO@CPO-mediated SDT further improves effectiveness immunotherapy. This work affords a new avenue developing TME-dependent SDT-mediated

Язык: Английский

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Nanomedicine-mediated regulated cell death in cancer immunotherapy

Journal of Controlled Release, Год журнала: 2023, Номер 364, С. 174 - 194

Опубликована: Окт. 27, 2023

Язык: Английский

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Intelligent Biomaterialomics: Molecular Design, Manufacturing, and Biomedical Applications

Advanced Materials, Год журнала: 2023, Номер 36(22)

Опубликована: Июль 25, 2023

Abstract Materialomics integrates experiment, theory, and computation in a high‐throughput manner, has changed the paradigm for research development of new functional materials. Recently, with rapid characterization machine‐learning technologies, establishment biomaterialomics that tackles complex physiological behaviors become accessible. Breakthroughs clinical translation nanoparticle‐based therapeutics vaccines have been observed. Herein, recent advances biomaterials, including polymers, lipid‐like materials, peptides/proteins, discovered through screening or machine learning‐assisted methods, are summarized. The molecular design structure‐diversified libraries; characterization, screening, preparation; and, their applications drug delivery discussed detail. Furthermore, prospects main challenges future highlighted.

Язык: Английский

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Rapid Screening of Microalgae as Potential Sources of Natural Antioxidants

Foods, Год журнала: 2023, Номер 12(14), С. 2652 - 2652

Опубликована: Июль 10, 2023

In order to rapidly screen microalgae species as feedstocks for antioxidants, extracts were obtained from 16 strains (under 11 genera, 7 classes) using two methods: a one-step extraction with ethanol/water and three-step fractionating procedure hexane, ethylacetate, water successively. Measuring the total phenol content (TPC), carotenoid (TCC), antioxidant activity of extracts, indicating TPC TCC, played an important role in determining microalgae. A weighted scoring system was used evaluate activity, scores microalgal samples methods calculated same system. Among investigated microalgae, Euglena gracilis SCSIO-46781 had highest score, contributing high followed by Arthrospira platensis SCSIO-44012, Nannochloropsis sp. SCSIO-45224, Phaeodactylum tricornutum SCSIO-45120, SCSIO-45006, respectively. Additionally, above-mentioned five are currently being applied commercial production, this could be effective not only screening but also species/strains strong adaptation environmental stress, which is critical trait their cultivation.

Язык: Английский

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A Triple‐Responsive Polymeric Prodrug Nanoplatform with Extracellular ROS Consumption and Intracellular H₂O₂ Self‐Generation for Imaging‐Guided Tumor Chemo‐Ferroptosis‐Immunotherapy

Advanced Healthcare Materials, Год журнала: 2024, Номер 13(16)

Опубликована: Фев. 7, 2024

Abstract High reactive oxygen species (ROS) levels in tumor microenvironment (TME) impair both immunogenic cell death (ICD) efficacy and T activity. Furthermore, escapes immunosurveillance via programmed death‐1/programmed ligand‐1 (PD‐L1) signal, the insufficient intracellular hydrogen peroxide weakens ferroptosis efficacy. To tackle above issues, a glutathione (GSH)/ROS/pH triple‐responsive prodrug nanomedicine that encapsulates Fe 2 O 3 nanoparticle electrostatic interaction is constructed for magnetic resonance imaging (MRI)‐guided multi‐mode theranostics with chemotherapy/ferroptosis/immunotherapy. The diselenide bond consumes ROS TME to increase cells ICD efficacy, cleavage of which facilitates PD‐L1 antagonist D peptide release block immune checkpoint. After internalization, released acidic endosome MRI simultaneously lipid peroxides generation ferroptosis. Doxorubicin cleaved from polymers condition high GSH level accompanied by ICD, potentiates NADPH oxidase mediated H self‐generation. In vivo results indicate nanoplatform strengthens induces cytotoxic lymphocytes proliferation, inhibits 4T1 regression metastasis, prolongs survival median. all, new strategy proposed strengthening activity cascade as well checkpoint blockade effective immunotherapy.

Язык: Английский

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