Опубликована: Янв. 1, 2025
Язык: Английский
Advanced Drug Delivery Reviews, Год журнала: 2023, Номер 201, С. 115049 - 115049
Опубликована: Авг. 12, 2023
Mesoporous silica nanoparticles (MSNs) have attracted the attention of chemists, who developed numerous systems for encapsulation a plethora molecules, allowing use mesoporous biomedical applications. MSNs been extensively studied their in nanomedicine, applications such as drug delivery, diagnosis, and bioimaging, demonstrating significant vivo efficacy different preclinical models. Nevertheless, transition into clinical trials, it is imperative to understand characteristics that make effective safe. The biosafety properties are greatly influenced by physicochemical particle shape, size, surface modification, framework. In this review, we compile most relevant recent progress literature up present analyzing contributions on biodistribution, biodegradability, clearance MSNs. Furthermore, ongoing trials potential challenges related administration materials advanced therapeutics discussed. This approach aims provide solid overview state-of-the-art field encourage translation clinic.
Язык: Английский
Процитировано
98
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2529 - 2529
Опубликована: Фев. 21, 2024
Glioblastoma (GB) stands out as the most prevalent and lethal form of brain cancer. Although great efforts have been made by clinicians researchers, no significant improvement in survival has achieved since Stupp protocol became standard care (SOC) 2005. Despite multimodality treatments, recurrence is almost universal with rates under 2 years after diagnosis. Here, we discuss recent progress our understanding GB pathophysiology, particular, importance glioma stem cells (GSCs), tumor microenvironment conditions, epigenetic mechanisms involved growth, aggressiveness recurrence. The discussion on therapeutic strategies first covers SOC treatment targeted therapies that shown to interfere different signaling pathways (pRB/CDK4/RB1/P16
Язык: Английский
Процитировано
63
European Journal of Pharmacology, Год журнала: 2025, Номер unknown, С. 177300 - 177300
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
3
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101457 - 101457
Опубликована: Янв. 5, 2025
Central nervous system (CNS) diseases are a major cause of disability and death worldwide. Due to the blood-brain barrier (BBB), drug delivery for CNS is extremely challenging. Nano-delivery systems can overcome limitations BBB deliver drugs CNS, improve ability target brain provide potential therapeutic methods diseases. At same time, choice different (bypassing or crossing BBB) further optimize effect nano-drug system. This article reviews nano-delivery way enters brain. Different kinds nanoparticles were discussed in depth.
Язык: Английский
Процитировано
1
Cancer Letters, Год журнала: 2025, Номер unknown, С. 217522 - 217522
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown
Опубликована: Март 19, 2025
Iron oxide (e.g., Fe3O4 or γ-Fe2O3) nanoparticles are promising candidates for a variety of biomedical applications ranging from magnetic hyperthermia therapy to drug delivery and biodetection due their superparamagnetism, nontoxicity, biodegradability. While particles small size (below critical size, ∼20 nm) display superparamagnetic behavior at room temperature, these tend penetrate highly sensitive areas the body such as blood–brain barrier, leading undesired effects. In addition, possess high probability retention, which can lead genotoxicity biochemical toxicity. Increasing particle is means addressing problems but also suppresses superparamagnetism. We have overcome this limit by synthesizing unique polycrystalline iron composed multiple nanocrystals 10 15 nm while tuning 160 400 nm. These so-called superparticles preserve characteristics exhibit excellent responses. The specific absorption rates exceed 250 W/g (HAC = 800 Oe, f 310 kHz) low concentration 0.5 mg/mL, indicating capability in cancer treatment with minimum dose. Our study underscores potential size-tunable properties advanced sensing technologies.
Язык: Английский
Процитировано
1
Journal of Materials Chemistry B, Год журнала: 2024, Номер 12(7), С. 1677 - 1705
Опубликована: Янв. 1, 2024
Nanocarriers loaded with anticancer agents strategically intervene to block cell signaling pathways in glioblastoma.
Язык: Английский
Процитировано
8
International Journal of Pharmaceutics, Год журнала: 2024, Номер 666, С. 124800 - 124800
Опубликована: Окт. 5, 2024
Язык: Английский
Процитировано
7
Bioactive Materials, Год журнала: 2023, Номер 33, С. 396 - 423
Опубликована: Ноя. 27, 2023
Glioblastoma (GBM) is an aggressive malignancy of the central nervous system (CNS) that remains incurable despite multitude improvements in cancer therapeutics. The conventional chemo and radiotherapy post-surgery have only been able to improve prognosis slightly; however, development resistance and/or tumor recurrence almost inevitable. There a pressing need for adjuvant molecular therapies can successfully efficiently block progression. During last few decades, non-coding RNAs (ncRNAs) emerged as key players regulating various hallmarks including GBM. levels many ncRNAs are dysregulated cancer, ectopic modulation their by delivering antagonists or overexpression constructs could serve attractive option therapy. therapeutic potential several types ncRNAs, miRNAs, lncRNAs, circRNAs, has validated both vitro vivo models However, delivery these RNA-based therapeutics highly challenging, especially tumors brain blood-brain barrier (BBB) poses major obstacle, among others. Also, since RNA extremely fragile nature, careful considerations must be met while designing agent. In this review we shed light on how ncRNA therapy overcome limitations its predecessor with emphasis smart nanomaterials aide safe targeted nucleic acids treat Additionally, critical gaps currently exist successful transition from viral non-viral vector systems identified. Finally, provided perspective future directions, pathways, target areas achieving rapid clinical translation of, macromolecular advance effective treatment GBM other related diseases.
Язык: Английский
Процитировано
15
Pharmaceutics, Год журнала: 2023, Номер 15(5), С. 1362 - 1362
Опубликована: Апрель 28, 2023
Lactoferrin (Lf)—a glycoprotein of the transferrin family—has been investigated as a promising molecule with diverse applications, including infection inhibition, anti-inflammation, antioxidant properties and immune modulation. Along that, Lf was found to inhibit growth cancerous tumors. Owing unique such iron-binding positive charge, could interrupt cancer cell membrane or influence apoptosis pathway. In addition, being common mammalian excretion, offers is in terms targeting delivery diagnosis cancer. Recently, nanotechnology significantly enhanced therapeutic index natural glycoproteins Lf. Therefore, context this review, understanding summarized followed by different strategies nano-preparation, inorganic nanoparticles, lipid-based nanoparticles polymer-based management. At end study, potential future applications are discussed pave way for translating into actual usage.
Язык: Английский
Процитировано
14