Acta Biomaterialia, Год журнала: 2024, Номер 187, С. 328 - 339
Опубликована: Авг. 23, 2024
Язык: Английский
Biomaterials, Год журнала: 2023, Номер 303, С. 122391 - 122391
Опубликована: Ноя. 15, 2023
Язык: Английский
Процитировано
39
Advanced Materials, Год журнала: 2024, Номер unknown
Опубликована: Окт. 6, 2024
Abstract Ferroptosis nano‐inducers have drawn considerable attention in the treatment of malignant tumors. However, low intratumoral hydrogen peroxide level and complex biological barriers hinder ability nanomedicines to generate sufficient reactive oxygen species (ROS) achieve tumor penetration. Here a near‐infrared (NIR)‐driven ROS self‐supplying nanomotor is successfully designed for synergistic chemodynamic therapy (CDT) photothermal (PTT). Janus created by asymmetrical modification polydopamine (PDA) with zinc (ZnO 2 ) subsequent ferrous ion (Fe 2+ chelation via polyphenol groups from PDA, here refer as ZnO @PDA‐Fe (Z@P‐F). capable slowly releasing (H O into an acidic microenvironment (TME) providing ingredients Fenton reaction necessary ferroptosis. Upon NIR laser irradiation, loaded Fe released thermal gradient simultaneously formed owing asymmetric PDA coating, thus endowing self‐thermophoresis based enhanced diffusion lysosomal escape Therefore, release ions ), self‐supplied H , nanomotors actuation further improve CDT/PTT efficacy, showing great potential active therapy.
Язык: Английский
Процитировано
16
Small, Год журнала: 2024, Номер 20(11)
Опубликована: Янв. 10, 2024
Abstract Over the past decades, development of nanoparticles (NPs) to increase efficiency clinical treatments has been subject intense research. Yet, most NPs have reported possess low efficacy as their actuation is hindered by biological barriers. For instance, synovial fluid (SF) present in joints mainly composed hyaluronic acid (HA). These viscous media pose a challenge for many applications nanomedicine, passive tend become trapped complex networks, which reduces ability reach target location. This problem can be addressed using active (nanomotors, NMs) that are self‐propelled enzymatic reactions, although enzyme‐powered NMs, capable navigating these environments, remains considerable challenge. Here, synergistic effects two NMs troops, namely hyaluronidase (HyaNMs, Troop 1) and urease (UrNMs, 2) demonstrated. 1 interacts with SF reducing its viscosity, thus allowing 2 swim more easily through SF. Through collective motion, increases diffusion macromolecules. results pave way widespread use e.g., treating joint injuries improving therapeutic effectiveness compared traditional methods.
Язык: Английский
Процитировано
14
ACS Applied Materials & Interfaces, Год журнала: 2024, Номер 16(15), С. 18252 - 18267
Опубликована: Апрель 6, 2024
Nitric oxide (NO) intervenes, that is, a potential treatment strategy, and has attracted wide attention in the field of tumor therapy. However, therapeutic effect NO is still poor, due to its short half-life instability. Therapeutic concentration ranges should be delivered target tissue sites, cell, even subcellular organelles control generation. Mitochondria have been considered major cancer therapy for their essential roles cell metabolism apoptosis. In this study, mesoporous silicon-coated gold nanorods encapsulated with mitochondria targeted thermosensitive lipid layer (AuNR@MSN-lipid-DOX) served as carrier load prodrug (BNN6) build near-infrared-triggered synergetic photothermal NO-chemotherapy platform (AuNR@MSN(BNN6)-lipid-DOX). The core AuNR@MSN exhibited excellent conversion capability high loading efficiency terms BNN6, reaching value 220 mg/g (w/w), which achieved precise release NO. outer biocompatible layer, comprising phospholipid DPPC mitochondrial-targeted DSPE-PEG2000-DOX, guided whole nanoparticle 4T1 cells observed through confocal microscopy. mitochondria, nanoparticles increased local temperature over 42 °C under NIR irradiation, from BNN6 detected by probe DSPE-PEG2000-DOX significantly inhibited vitro vivo (PTT)–NO therapy–chemotherapy modes. built NIR-triggered combination nanoplatform can serve strategy multimodal collaboration.
Язык: Английский
Процитировано
10
Acta Biomaterialia, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1
Journal of Colloid and Interface Science, Год журнала: 2024, Номер 662, С. 857 - 869
Опубликована: Фев. 11, 2024
Язык: Английский
Процитировано
9
Advanced Materials, Год журнала: 2024, Номер 36(32)
Опубликована: Май 31, 2024
Photothermal immunotherapy has shown great promise in the treatment of tumor metastasis. However, thermal resistance cells substantially compromises effect photothermal immunotherapy. Herein, a high-performance organic pyroelectric nanoplatform,
Язык: Английский
Процитировано
7
Nanoscale, Год журнала: 2023, Номер 15(46), С. 18550 - 18570
Опубликована: Янв. 1, 2023
This review provides inspiration and promotes the clinical application of light-driven micro/nanomotors in biomedical field.
Язык: Английский
Процитировано
13
Journal of Colloid and Interface Science, Год журнала: 2023, Номер 657, С. 799 - 810
Опубликована: Дек. 6, 2023
Язык: Английский
Процитировано
12
Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 244, С. 114179 - 114179
Опубликована: Авг. 28, 2024
Язык: Английский
Процитировано
5