The
combination
of
diagnostic
and
therapeutic
agents
in
the
form
theranostic
platforms
is
receiving
increasing
attention
to
enhance
tumor
efficacy.
However,
traditional
systems
relying
on
simultaneous
encapsulation,
embedding
or
conjugation
various
onto
nanocarriers
always
require
intricate
synthetic
process.
Herein,
a
supramolecular
drug-drug
self-delivery
nanosystem
(DSDN)
based
newly
developed
aggregation-induced
emission
(AIE)
photosensitizer
(CBTM)
an
anti-tumor
tyroservaltide
(YSV)
was
constructed
integrate
near-infrared
(NIR)
fluorescence,
photodynamic,
chemotherapeutic
effects.
Transmission
electron
microscopy
(TEM)
dynamic
light
scattering
(DLS)
confirmed
that
YSV
CBTM
could
co-assemble
into
YSV/CBTM
nanoparticles
via
π-π
stacking
hydrogen
bonding,
with
regular
round-shape
morphology
homogeneous
size.
Inspiringly,
entered
CT26
cells
high
NIR
fluorescence
emission,
allowing
preoperative
diagnosis.
Meanwhile,
as-prepared
efficiently
produce
reactive
oxygen
species
(ROS)
under
irradiation
for
effective
photodynamic
ablation
cells.
More
importantly,
peptide
drug
not
only
improve
availability
CBTM,
but
also
serve
as
toxic
adjuvant
therapy
(PDT)
efficacy
CBTM.
Thereafter,
most
tumors
were
thoroughly
ablated
by
combining
PDT
chemotherapy
(CT)
maximal
killing
colorectal
tissues.
Regarding
advantages
nanosystem,
we
believe
this
strategy
significantly
potentiate
survival
cancer
mice
maximizing
efficacy,
offer
prospective
insights
advanced
applications.
Polymers,
Год журнала:
2024,
Номер
16(18), С. 2606 - 2606
Опубликована: Сен. 14, 2024
Poly(lactic-co-glycolic
acid)
(PLGA)
is
a
widely
used
biodegradable
and
biocompatible
copolymer
in
drug
delivery
systems
(DDSs).
In
this
article,
we
highlight
the
critical
physicochemical
properties
of
PLGA,
including
its
molecular
weight,
intrinsic
viscosity,
monomer
ratio,
blockiness,
end
caps,
that
significantly
influence
release
profiles
degradation
times.
This
review
also
covers
extensive
literature
on
application
PLGA
delivering
small-molecule
drugs,
proteins,
peptides,
antibiotics,
antiviral
drugs.
Furthermore,
discuss
role
PLGA-based
DDSs
treating
various
diseases,
cancer,
neurological
disorders,
pain,
inflammation.
The
incorporation
drugs
into
nanoparticles
microspheres
has
been
shown
to
enhance
their
therapeutic
efficacy,
reduce
toxicity,
improve
patient
compliance.
Overall,
holds
great
promise
for
advancement
treatment
management
multiple
chronic
conditions.
Chemical Society Reviews,
Год журнала:
2024,
Номер
53(16), С. 8306 - 8378
Опубликована: Янв. 1, 2024
As
natural
living
substances,
microorganisms
have
emerged
as
useful
resources
in
medicine
for
creating
microbe-material
hybrids
ranging
from
nano
to
macro
dimensions.
The
engineering
of
microbe-involved
nanomedicine
capitalizes
on
the
distinctive
physiological
attributes
microbes,
particularly
their
intrinsic
"living"
properties
such
hypoxia
tendency
and
oxygen
production
capabilities.
Exploiting
these
remarkable
characteristics
combination
with
other
functional
materials
or
molecules
enables
synergistic
enhancements
that
hold
tremendous
promise
improved
drug
delivery,
site-specific
therapy,
enhanced
monitoring
treatment
outcomes,
presenting
substantial
opportunities
amplifying
efficacy
disease
treatments.
This
comprehensive
review
outlines
microbial
derivatives
used
biomedicine
specific
advantages
therapeutic
application.
In
addition,
we
delineate
fundamental
strategies
mechanisms
employed
constructing
hybrids.
diverse
biomedical
applications
constructed
hybrids,
encompassing
bioimaging,
anti-tumor,
anti-bacteria,
anti-inflammation
diseases
therapy
are
exhaustively
illustrated.
We
also
discuss
current
challenges
prospects
associated
clinical
translation
hybrid
platforms.
Therefore,
unique
versatility
potential
exhibited
by
position
them
promising
candidates
development
next-generation
biomaterials
theranostic
functionalities.
Accounts of Materials Research,
Год журнала:
2024,
Номер
5(7), С. 872 - 883
Опубликована: Июнь 24, 2024
ConspectusLiving
materials
represent
an
emerging
and
innovative
concept
at
the
forefronts
of
science
due
to
distinctive
living
characteristics.
Living
organisms,
such
as
microorganisms,
plant
cells,
mammalian
have
been
used
major
elements
for
fabrication
materials.
Given
favorable
features
including
reproductivity,
genetic
modifiability,
adaptability,
cultivability,
bacteria
received
increasing
attention
development
engineered
Particularly,
owing
inherent
abilities
target
colonize
specific
in
vivo
sites,
activate
immune
responses,
inhibit
pathogens,
play
key
roles
maintaining
human
health
currently
widely
exploited
preparation
therapeutic
agents.
However,
caused
by
innate
immunogenicity,
metabolic
activity,
movability,
use
bacteria-based
applications
often
suffers
from
poor
biosafety
insufficient
bioavailability,
inevitably
resulting
low
treatment
efficacy.
In
order
address
these
challenges,
extensive
efforts
invested
designing
engineering
various
advanced
generate
superior
agents
using
modification
surface
decoration.In
this
Account,
we
summarize
recent
advances
our
group
with
a
focus
on
coating
material
microbial
therapy.
First,
present
brief
introduction
existing
nature
that
possess
characteristics
reproduction,
biosynthesis,
self-healing,
self-organization,
self-adaption,
environment
responsiveness,
particular
emphasis
advantages
composed
Second,
elaborate
current
challenges
then
showcase
strategies
prepare
bacterial
therapeutics
individual
bacteria.
Three
types
are
included
Account:
(1)
physical
strategy
coat
eukaryotic
cell
membranes
red
blood
cells
yeast
mechanical
extrusion;
(2)
chemical
wrap
synthetic
coatings
interfacial
self-assembly
mineralization;
(3)
biological
encapsulate
self-secreted
biofilms
apoptosis
bodies
through
external
stimulations.
We
highlight
coated
can
be
endowed
wide
range
coating-derived
exogenous
functions
enumerate
their
appealing
reduced
clearance,
increased
improved
safety,
preferential
colonization
vivo.
Third,
shift
potential
treating
diseases,
especially
different
cancer
intestinal
inflammations.
Lastly,
discuss
remaining
need
addressed
further
clinic
practice
outlooks
preparing
next-generation
well
future
bench
bedside
translation.
anticipate
Account
offer
valuable
insights
generation
therapy
encourage
ideas
new
initiatives
expand
preventing
diseases.
ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 17, 2025
IgA
nephropathy
(IgAN)
is
a
primary
glomerulonephritis
mediated
by
autoimmunity,
characterized
an
abnormal
increase
and
the
deposition
of
in
glomeruli.
In
recent
years,
most
studies
have
emphasized
crucial
role
gut-kidney
axis
pathogenesis
nephropathy,
ileal
Peyer
patches
intestinal
mucosal
immune
system
are
main
site
for
production.
Therefore,
this
study,
hydroxychloroquine
(HCQ)
dexamethasone
(DXM)
were
used
as
model
drugs,
yeast
cell
wall
(YCW)-coated
oleic
acid-grafted
chitosan
(CSO)
was
carrier
to
construct
oral
drug
delivery
HCQ/DXM@CSO@YCW.
This
achieves
targeted
through
(YCW),
reduces
production,
synergistically
regulates
inflammatory
pathological
environment.
The
had
good
gastrointestinal
stability
biocompatibility.
vitro
experiments
shown
uptake
ability
dendritic
cells
macrophages,
showed
that
YCW
has
targeting
properties.
vivo
pharmacodynamic
HCQ/DXM@CSO@YCW
could
significantly
reduce
serum
levels
renal
tissue
IgAN
mice,
well
IL-6,
TNF-α,
TGF-β
tissue,
improving
morphology
tissue.
DXM/HCQ@CSO@YCW
administration
provided
new
platform
immunotherapy
nephropathy.
ACS Biomaterials Science & Engineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 15, 2025
Living
Therapeutic
Materials
represent
a
promising
technology
to
tackle
therapeutic
problems
that
classical
materials
cannot
address.
Despite
the
advancements
on
new
functions
of
these
devices,
applications,
and
fabrication
methods,
preclinical
evaluation
is
still
very
limited
challenges
appear
when
incorporating
living
devices
in
contact
with
host.
This
critical
bottleneck
path
translation
clinic.
Therefore,
we
have
compiled
literature
Materials,
focus
microorganism-based
materials,
summarized
investigations
carried
out
assess
their
biocompatibility,
safety,
efficacy.
We
split
three
parts:
vitro,
ex
vivo,
vivo
assessments,
where
describe
common
practices
remaining
challenges.
Therapeutic Delivery,
Год журнала:
2023,
Номер
14(7), С. 459 - 472
Опубликована: Июль 1, 2023
The
currently
available
formulations
provided
non-targeted
treatment
of
colon
cancer,
the
deadliest
cancer
variant.
Due
to
biopharmaceutical
hindrances,
majority
drugs
are
unable
reach
target
site.
Polylactic-co-glycolic
acid
(PLGA)
is
one
versatile
polymers
in
treatment,
diagnostics
and
theranostics.
unique
mechanism
surface
modifications
PLGA
properties
has
been
a
keen
interest
be
used
different
nanoparticles
for
improving
attributes.
ongoing
use
these
smart
nano-carriers
allowed
targeted
delivery
several
active
components
on
wide
scale.
main
goal
this
review
compile
information
PLGA-based
nanocarriers
which
possess
desirable
drug
applications,
including
biocompatibility,
biodegradability
tunable
drug-release
kinetics.
