An AIE-Based Theranostic Nanoplatform for Enhanced Colorectal Cancer Therapy: Real-Time Tumor-Tracking and Chemical-Enhanced Photodynamic Therapy DOI
Jiaqi Feng, Xiang Tian,

Ruige Cao

et al.

Published: Jan. 1, 2023

The combination of diagnostic and therapeutic agents in the form theranostic platforms is receiving increasing attention to enhance tumor efficacy. However, traditional systems relying on simultaneous encapsulation, embedding or conjugation various onto nanocarriers always require intricate synthetic process. Herein, a supramolecular drug-drug self-delivery nanosystem (DSDN) based newly developed aggregation-induced emission (AIE) photosensitizer (CBTM) an anti-tumor tyroservaltide (YSV) was constructed integrate near-infrared (NIR) fluorescence, photodynamic, chemotherapeutic effects. Transmission electron microscopy (TEM) dynamic light scattering (DLS) confirmed that YSV CBTM could co-assemble into YSV/CBTM nanoparticles via π-π stacking hydrogen bonding, with regular round-shape morphology homogeneous size. Inspiringly, entered CT26 cells high NIR fluorescence emission, allowing preoperative diagnosis. Meanwhile, as-prepared efficiently produce reactive oxygen species (ROS) under irradiation for effective photodynamic ablation cells. More importantly, peptide drug not only improve availability CBTM, but also serve as toxic adjuvant therapy (PDT) efficacy CBTM. Thereafter, most tumors were thoroughly ablated by combining PDT chemotherapy (CT) maximal killing colorectal tissues. Regarding advantages nanosystem, we believe this strategy significantly potentiate survival cancer mice maximizing efficacy, offer prospective insights advanced applications.

Language: Английский

Recent Applications of PLGA in Drug Delivery Systems DOI Open Access
Jie Yang,

Huiying Zeng,

Yusheng Luo

et al.

Polymers, Journal Year: 2024, Volume and Issue: 16(18), P. 2606 - 2606

Published: Sept. 14, 2024

Poly(lactic-co-glycolic acid) (PLGA) is a widely used biodegradable and biocompatible copolymer in drug delivery systems (DDSs). In this article, we highlight the critical physicochemical properties of PLGA, including its molecular weight, intrinsic viscosity, monomer ratio, blockiness, end caps, that significantly influence release profiles degradation times. This review also covers extensive literature on application PLGA delivering small-molecule drugs, proteins, peptides, antibiotics, antiviral drugs. Furthermore, discuss role PLGA-based DDSs treating various diseases, cancer, neurological disorders, pain, inflammation. The incorporation drugs into nanoparticles microspheres has been shown to enhance their therapeutic efficacy, reduce toxicity, improve patient compliance. Overall, holds great promise for advancement treatment management multiple chronic conditions.

Language: Английский

Citations

22
Microbe-material hybrids for therapeutic applications DOI
Meng Chen, Lili Xia, Chenyao Wu

et al.

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(16), P. 8306 - 8378

Published: Jan. 1, 2024

As natural living substances, microorganisms have emerged as useful resources in medicine for creating microbe-material hybrids ranging from nano to macro dimensions. The engineering of microbe-involved nanomedicine capitalizes on the distinctive physiological attributes microbes, particularly their intrinsic "living" properties such hypoxia tendency and oxygen production capabilities. Exploiting these remarkable characteristics combination with other functional materials or molecules enables synergistic enhancements that hold tremendous promise improved drug delivery, site-specific therapy, enhanced monitoring treatment outcomes, presenting substantial opportunities amplifying efficacy disease treatments. This comprehensive review outlines microbial derivatives used biomedicine specific advantages therapeutic application. In addition, we delineate fundamental strategies mechanisms employed constructing hybrids. diverse biomedical applications constructed hybrids, encompassing bioimaging, anti-tumor, anti-bacteria, anti-inflammation diseases therapy are exhaustively illustrated. We also discuss current challenges prospects associated clinical translation hybrid platforms. Therefore, unique versatility potential exhibited by position them promising candidates development next-generation biomaterials theranostic functionalities.

Language: Английский

Citations

7
Coated Bacteria: Advanced Living Materials for Microbial Therapy DOI Creative Commons
Zhenping Cao, Jinyao Liu

Accounts of Materials Research, Journal Year: 2024, Volume and Issue: 5(7), P. 872 - 883

Published: June 24, 2024

ConspectusLiving materials represent an emerging and innovative concept at the forefronts of science due to distinctive living characteristics. Living organisms, such as microorganisms, plant cells, mammalian have been used major elements for fabrication materials. Given favorable features including reproductivity, genetic modifiability, adaptability, cultivability, bacteria received increasing attention development engineered Particularly, owing inherent abilities target colonize specific in vivo sites, activate immune responses, inhibit pathogens, play key roles maintaining human health currently widely exploited preparation therapeutic agents. However, caused by innate immunogenicity, metabolic activity, movability, use bacteria-based applications often suffers from poor biosafety insufficient bioavailability, inevitably resulting low treatment efficacy. In order address these challenges, extensive efforts invested designing engineering various advanced generate superior agents using modification surface decoration.In this Account, we summarize recent advances our group with a focus on coating material microbial therapy. First, present brief introduction existing nature that possess characteristics reproduction, biosynthesis, self-healing, self-organization, self-adaption, environment responsiveness, particular emphasis advantages composed Second, elaborate current challenges then showcase strategies prepare bacterial therapeutics individual bacteria. Three types are included Account: (1) physical strategy coat eukaryotic cell membranes red blood cells yeast mechanical extrusion; (2) chemical wrap synthetic coatings interfacial self-assembly mineralization; (3) biological encapsulate self-secreted biofilms apoptosis bodies through external stimulations. We highlight coated can be endowed wide range coating-derived exogenous functions enumerate their appealing reduced clearance, increased improved safety, preferential colonization vivo. Third, shift potential treating diseases, especially different cancer intestinal inflammations. Lastly, discuss remaining need addressed further clinic practice outlooks preparing next-generation well future bench bedside translation. anticipate Account offer valuable insights generation therapy encourage ideas new initiatives expand preventing diseases.

Language: Английский

Citations

4
Yeast Cell Wall-Mediated Ileal Targeted Delivery System for IgA Nepharopathy Therapy DOI

Chaoying Tian,

Mei Yan,

Jialing Guo

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

IgA nephropathy (IgAN) is a primary glomerulonephritis mediated by autoimmunity, characterized an abnormal increase and the deposition of in glomeruli. In recent years, most studies have emphasized crucial role gut-kidney axis pathogenesis nephropathy, ileal Peyer patches intestinal mucosal immune system are main site for production. Therefore, this study, hydroxychloroquine (HCQ) dexamethasone (DXM) were used as model drugs, yeast cell wall (YCW)-coated oleic acid-grafted chitosan (CSO) was carrier to construct oral drug delivery HCQ/DXM@CSO@YCW. This achieves targeted through (YCW), reduces production, synergistically regulates inflammatory pathological environment. The had good gastrointestinal stability biocompatibility. vitro experiments shown uptake ability dendritic cells macrophages, showed that YCW has targeting properties. vivo pharmacodynamic HCQ/DXM@CSO@YCW could significantly reduce serum levels renal tissue IgAN mice, well IL-6, TNF-α, TGF-β tissue, improving morphology tissue. DXM/HCQ@CSO@YCW administration provided new platform immunotherapy nephropathy.

Language: Английский

Citations

0
Preparation and gastrointestinal delivery performance of Malus baccata (Linn.) polyphenols loaded nanoparticles based on yeast membranes DOI

Qing Song Yao Qing Song Yao,

Huipeng Zhu,

Lu Wang

et al.

Food Research International, Journal Year: 2025, Volume and Issue: 207, P. 116129 - 116129

Published: March 2, 2025

Language: Английский

Citations

0
Preclinical Assessment of Living Therapeutic Materials: State-of-Art and Challenges DOI Creative Commons

Krupansh Desai,

Joëlle Mekontso,

Ketaki Deshpande

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Living Therapeutic Materials represent a promising technology to tackle therapeutic problems that classical materials cannot address. Despite the advancements on new functions of these devices, applications, and fabrication methods, preclinical evaluation is still very limited challenges appear when incorporating living devices in contact with host. This critical bottleneck path translation clinic. Therefore, we have compiled literature Materials, focus microorganism-based materials, summarized investigations carried out assess their biocompatibility, safety, efficacy. We split three parts: vitro, ex vivo, vivo assessments, where describe common practices remaining challenges.

Language: Английский

Citations

0
An AIE-based theranostic nanoplatform for enhanced colorectal cancer therapy: Real-time tumor-tracking and chemical-enhanced photodynamic therapy DOI
Jiaqi Feng, Xiang Tian,

Ruige Cao

et al.

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 35(12), P. 109657 - 109657

Published: Feb. 20, 2024

Language: Английский

Citations

3
Preparation and characterization of PLGA nano-drug delivery system co-loaded with tranilast/gallium phytate for stent coating DOI

Kai-chao Wen,

Z.W. Li,

Ji-heng Liu

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 97, P. 105812 - 105812

Published: May 24, 2024

Language: Английский

Citations

2
Carbohydrate polymer-based nanoparticles with cell membrane camouflage for cancer therapy: A review DOI

Haijia Hou,

Xuejian Liu, Jun Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 289, P. 138620 - 138620

Published: Dec. 13, 2024

Language: Английский

Citations

1
A short appraisal of polylactic-co-glycolic acid based polymer nanotechnology for colon cancer: recent advances and literature evidences DOI
Abhinav Vashishat,

Amrinder Singh,

Balak Das Kurmi

et al.

Therapeutic Delivery, Journal Year: 2023, Volume and Issue: 14(7), P. 459 - 472

Published: July 1, 2023

The currently available formulations provided non-targeted treatment of colon cancer, the deadliest cancer variant. Due to biopharmaceutical hindrances, majority drugs are unable reach target site. Polylactic-co-glycolic acid (PLGA) is one versatile polymers in treatment, diagnostics and theranostics. unique mechanism surface modifications PLGA properties has been a keen interest be used different nanoparticles for improving attributes. ongoing use these smart nano-carriers allowed targeted delivery several active components on wide scale. main goal this review compile information PLGA-based nanocarriers which possess desirable drug applications, including biocompatibility, biodegradability tunable drug-release kinetics.

Language: Английский

Citations

2