Layer-by-layer self-assembly coatings on strontium titanate nanotubes with antimicrobial and anti-inflammatory properties to prevent implant-related infections

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 244, P. 114183 - 114183

Published: Aug. 28, 2024

Language: Английский

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Substrate curvature influences cytoskeletal rearrangement and modulates macrophage phenotype

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Inflammation is a vital immune response, tightly orchestrated through both biochemical and biophysical cues. Dysregulated inflammation contributes to chronic diseases, highlighting the need for novel therapies that modulate responses with minimal side effects. While several pathways of are well understood, influence physical properties such as substrate curvature on cell behavior remains underexplored. This study investigates how impacts macrophage cytoskeletal dynamics, gene expression, immunophenotype mechanosensitive pathways. Gelatin-based microgels tunable surface curvatures were fabricated via water-in-oil emulsification crosslinked genipin. Microgels sorted into three size ranges, yielding high (40-50 µm), intermediate (150-250 low (350-400 µm) profiles. Macrophages seeded onto these microgels, dynamics examined using confocal microscopy, SEM, actin-specific staining. Gene expression pro- anti-inflammatory markers was quantified qPCR. The role actin polymerization assessed Latrunculin-A (Lat-A) treatment. adhered effectively high- low-curvature displaying curvature-dependent morphological changes. Confocal imaging revealed macrophages exhibited significantly higher F-actin density than those high-curvature microgels. Correspondingly, qPCR analysis showed upregulation pro-inflammatory (e.g., Tnf, Nos2) in conditions, while Arg1) elevated conditions. Lat-A treatment reduced modulated patterns, confirming regulation phenotype. These findings demonstrate influences by modulating associated immunophenotypic actin-mediated transcriptional By controlling curvature, therapeutic biomaterials may direct responses, offering new avenue treating inflammatory diseases. mechanobiological approach presents promising strategy precision immunomodulation regenerative medicine.

Language: Английский

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Carboxymethyl chitosan/oxidized hyaluronic acid hydrogel-encapsulated hucMSC-derived exosomes for enhanced hepatic regeneration and post-hepatectomy applications

Carbohydrate Polymers, Journal Year: 2025, Volume and Issue: 353, P. 123248 - 123248

Published: Jan. 13, 2025

Language: Английский

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Synergistic anti-oxidative/anti-inflammatory treatment for acute lung injury with selenium based chlorogenic acid nanoparticles through modulating Mapk8ip1/MAPK and Itga2b/PI3k-AKT axis

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 23, 2025

Language: Английский

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Octyl succinic anhydride-modified chitosan/oxidized sodium alginate Schiff base hydrogel loaded with terbinafine hydrochloride: pH-responsive, self-repairing, antifungal properties

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 301, P. 140431 - 140431

Published: Jan. 28, 2025

Language: Английский

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Recent advances in hyaluronic acid-based hydrogels for diabetic wound healing

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140797 - 140797

Published: Feb. 7, 2025

Language: Английский

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Zn-DHM nanozymes regulate metabolic and immune homeostasis for early diabetic wound therapy

Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 63 - 84

Published: March 6, 2025

Language: Английский

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Ti₃C₂T_x MXene‐Decorated 3D‐Printed Ceramic Scaffolds for Enhancing Osteogenesis by Spatiotemporally Orchestrating Inflammatory and Bone Repair Responses

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 8, 2024

Abstract Inflammatory responses play a central role in coordinating biomaterial‐mediated tissue regeneration. However, precise modulation of dynamic variations microenvironmental inflammation post‐implantation remains challenging. In this study, the traditional β‐tricalcium phosphate‐based scaffold is remodeled via ultrathin MXene‐Ti 3 C 2 decoration and Zn 2+ /Sr ion‐substitution, endowing with excellent reactive oxygen species‐scavenging ability, near‐infrared responsivity, enhanced mechanical properties. The induction mild hyperthermia around implant periodic irradiation facilitates spatiotemporal regulation inflammatory cytokines secreted by spectrum macrophage phenotypes. process initially amplifies pro‐inflammatory response, then accelerates M1‐to‐M2 polarization transition, yielding satisfactory pattern osteo‐immunomodulation during natural bone healing process. Later, sustained release ions gradual degradation 3D maintains favorable reparative M2‐dominated immunological microenvironment that supports new mineralization. Precise temporal immunoregulation intelligent enhances regeneration rat cranial defect model. This strategy paves way for application materials to guide toward outcome, making clinical treatment more predictable durable. findings also demonstrate irradiation‐derived promising method immunomodulation.

Language: Английский

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Glucose and pH dual-responsive hydrogels with antibacterial, reactive oxygen species scavenging, and angiogenesis properties for promoting the healing of infected diabetic foot ulcers

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

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Enhanced diabetic foot ulcer treatment with a chitosan-based thermosensitive hydrogel loaded self-assembled multi-functional nanoparticles for antibacterial and angiogenic effects

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 347, P. 122740 - 122740

Published: Sept. 12, 2024

Language: Английский

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