Animals,
Год журнала:
2021,
Номер
11(8), С. 2473 - 2473
Опубликована: Авг. 23, 2021
Due
to
its
large
surface
area,
the
skin
is
susceptible
various
injuries,
possibly
accompanied
by
entrance
of
infective
agents
into
body.
Commensal
organisms
that
constitute
microbiota
play
important
roles
in
orchestration
cutaneous
homeostasis
and
immune
competence.
The
opportunistic
pathogen
Staphylococcus
aureus
present
as
part
normal
biota
mucous
membranes
both
humans
animals,
but
can
cause
disease
when
it
invades
body
either
due
trauma
or
because
impaired
response
host.
Colonization
livestock
S.
a
precursor
for
majority
bacterial
infections,
which
range
from
boils
sepsis,
with
best-characterized
being
bovine
mastitis.
Antibiotic
treatment
these
infections
contribute
promotion
resistant
strains
even
multidrug
resistance.
development
antibiotic
resistance
currently
available
antibiotics
worldwide
problem.
Considering
increasing
ability
bacteria
effectively
resist
antibacterial
agents,
reduce
consumption
preserve
effectiveness
future.
Plants
are
recognized
sources
bioactive
substances,
including
activity
towards
clinically
microorganisms.
This
review
provides
an
overview
current
knowledge
on
major
groups
phytochemicals
their
modes
action.
It
also
list
known
used
plant
species
aimed
at
treating
preventing
livestock.
Pharmaceutics,
Год журнала:
2025,
Номер
17(2), С. 229 - 229
Опубликована: Фев. 10, 2025
Skin
disorders
are
the
fourth
most
common
cause
of
all
diseases,
which
affect
nearly
one-third
world’s
population.
Topical
drug
delivery
can
be
effective
in
treating
a
range
skin
disorders,
including
microbial
infections,
cancer,
dermatitis,
burn
injury,
wounds,
and
psoriasis.
Bioadhesive
nanoparticles
(BNPs)
serve
as
an
efficient
topical
system
they
dual
purposes
bioadhesives
nanocarriers,
mediate
targeted
delivery,
prolong
retention
time,
deepen
penetration
through
layers.
There
is
increasing
demand
for
BNP-based
applications
medicine
because
their
various
advantages,
biodegradability,
flexibility,
biocompatibility,
enhanced
adhesive
strength.
A
number
BNPs
have
already
been
developed
evaluated
potential
systems.
In
addition,
studies
carried
out
to
evaluate
treatment
atopic
irritant
contact
psoriasis,
severe
injuries.
This
review
article
timely
unique,
it
provides
extensive
unique
summary
recent
advances
wide-ranging
disorders.
Moreover,
this
also
useful
discussion
on
bioadhesion
mechanism
biopolymers
that
used
prepare
BNPs.
Advances in Colloid and Interface Science,
Год журнала:
2023,
Номер
321, С. 103002 - 103002
Опубликована: Сен. 27, 2023
Wound
healing
primarily
involves
preventing
severe
infections,
accelerating
healing,
and
reducing
pain
scarring.
Therefore,
the
multifunctional
application
of
lipid-based
nanoparticles
(LBNs)
has
received
considerable
attention
in
drug
discovery
due
to
their
solid
or
liquid
lipid
core,
which
increases
ability
provide
prolonged
release,
reduce
treatment
costs,
improve
patient
compliance.
LBNs
have
also
been
used
medical
cosmetic
practices
formulated
for
various
products
based
on
skin
type,
disease
conditions,
administration
product
efficiency,
stability,
toxicity;
therefore,
understanding
interaction
with
biological
systems
is
very
important.
it
necessary
perform
an
in-depth
analysis
results
from
a
comprehensive
characterization
process
produce
delivery
desired
properties.
This
review
will
detailed
information
different
types
LBNs,
formulation
methods,
characterisation,
antimicrobial
activity,
wound
models
(both
vitro
vivo
studies).
Also,
clinical
commercial
applications
are
summarized.
International Journal of Surgery,
Год журнала:
2023,
Номер
109(8), С. 2365 - 2377
Опубликована: Май 9, 2023
Wounds
represent
various
significant
health
concerns
for
patients
and
also
contribute
major
costs
to
healthcare
systems.
Wound
healing
comprises
of
overlapped
coordinated
steps
such
as
homeostasis,
inflammation,
proliferation,
remodeling.
In
response
the
failure
many
strategies
in
delivering
intended
results
including
wound
closure,
fluid
loss
control,
exhibiting
properties
durability,
targeted
delivery,
accelerated
action,
along
with
histocompatibility,
numerous
nanotechnological
advances
have
been
introduced.
To
understand
magnitude
therapy,
this
systematic
updated
review
discussing
effectiveness
nanoemulsions
has
undertaken.
This
portrays
mechanisms
associated
healing,
factors
delayed
technologies
utilized
treat
wounds
effectively.
While
are
available,
attracted
tremendous
attention
scientists
globally
research
therapy
due
their
long-term
thermodynamic
stability
bioavailability.
Nanoemulsions
not
only
aid
tissue
repair,
but
considered
an
excellent
delivery
system
synthetic
natural
actives.
Nanotechnology
provides
several
pivotal
benefits
improved
skin
permeation,
controlled
release,
stimulation
fibroblast
cell
proliferation.
The
role
preparation
techniques
highlighted
special
emphasis
on
mechanistic
insights.
article
illustrates
recent
advancements
utilization
treatment.
An
adequate
literature
search
conducted
using
keywords
‘Nanoemulsions
healing’,
‘Wound
nanoemulsions’,
‘Herbal
actives
therapy’,
‘Natural
oils
treatment’
etc.,
from
PubMed,
Science
Direct,
Google
Scholar
databases.
Referred
original
publications
English
language
accessed
till
April
2022
included,
whereas
nonEnglish
papers,
unpublished
data,
nonoriginal
papers
were
excluded
study.
Pharmaceutics,
Год журнала:
2024,
Номер
16(10), С. 1333 - 1333
Опубликована: Окт. 17, 2024
Nanoemulsions
(NEs)
are
submicron-sized
heterogeneous
biphasic
liquid
systems
stabilized
by
surfactants.
They
physically
transparent
or
translucent,
optically
isotropic,
and
kinetically
stable,
with
droplet
sizes
ranging
from
20
to
500
nm.
Their
unique
properties,
such
as
high
surface
area,
small
size,
enhanced
bioavailability,
excellent
physical
stability,
rapid
digestibility,
make
them
ideal
for
encapsulating
various
active
substances.
This
review
focuses
on
recent
advancements,
future
prospects,
challenges
in
the
field
of
NEs,
particularly
oral,
parenteral,
ophthalmic
delivery.
It
also
discusses
clinical
trials
patents.
Different
types
vitro
vivo
NE
characterization
techniques
summarized.
High-energy
low-energy
preparation
methods
briefly
described
diagrams.
Formulation
considerations
commonly
used
excipients
ocular,
drug
delivery
presented.
The
emphasizes
need
new
functional
improve
permeation
large
molecular
weight
unstable
proteins,
oligonucleotides,
hydrophilic
drugs
advance
rapidly.
Bioengineering,
Год журнала:
2024,
Номер
11(2), С. 168 - 168
Опубликована: Фев. 9, 2024
Treatment
of
chronic
wounds
is
challenging,
and
the
development
different
formulations
based
on
insulin
has
shown
efficacy
due
to
their
ability
regulate
oxidative
stress
inflammatory
reactions.
The
formulation
with
polysaccharides
in
biohybrid
hydrogel
systems
advantage
synergistically
combining
bioactivity
protein
biocompatibility
properties
polysaccharides.
In
this
study,
a
containing
insulin,
chitosan,
hydroxypropyl
methyl
cellulose
(Chi/HPMC/Ins)
was
prepared
characterized
by
FTIR,
thermogravimetric,
gel
point
analyses.
vitro
cell
viability
migration
potential
Chi/HPMC/Ins
were
evaluated
human
keratinocyte
cells
(HaCat)
MTT
wound
scratch
assay.
applied
excisional
full-thickness
diabetic
mice
for
twenty
days
vivo
studies.
Cell
studies
indicated
no
cytotoxicity
hydrogel.
Moreover,
promoted
faster
gap
closure
vivo,
treated
resulted
closure,
formation
more
organized
granulation
tissue,
hair
follicle
regeneration.
These
results
suggest
that
hydrogels
might
promote
healing
could
be
new
dressing
healing.
