An in silico insight on inhibitory potential of short-chain PFHxA and PFHxS against endogenous antioxidant enzymes DOI Creative Commons
Prem Rajak, Abhratanu Ganguly,

Sukhendu Dey

и другие.

Sustainable Horizons, Год журнала: 2024, Номер 12, С. 100116 - 100116

Опубликована: Июнь 28, 2024

Per- and polyfluoroalkyl substances (PFAS) are a large group of synthetic chemicals that globally used in various commercial products like cloths, carpets, cookware, firefighting foams, cosmetics, electronic products, etc. Inappropriate disposal these consumer could lead to environmental contamination with PFAS. Nowadays short-chain PFAS substituting the long chain due their short half-life. However, multiple studies have suggested such as Perfluorohexanoic acid (PFHxA) Perfluorohexanesulfonic (PFHxS) modulate antioxidant enzyme activities, induce Reactive Oxygen Species production, contribute oxidative stress organisms. Notably, experimental set-ups aiming investigate mode action compounds on antioxidants entirely lacking. Hence present study, ligand-docking approach was adopted potential intermolecular interactions between major Glutathione peroxidase-4, reductase, S-Transferase, Catalase, Superoxide dismutase-1. Three-dimensional structures proteins were processed docked individually PFHxA PFHxS using AutoDock vina.. Results indicated significant binding affinities Interestingly, non-covalent H-bonds, van der Waals, CH bonds, halogen alkyl/pi-alkyl apparent at protein-ligand interface. Hence, results suggest both may potentially interact endogenous this outcome can be detrimental redox homeostasis living

Язык: Английский

Lithium-ion battery recycling: a source of per- and polyfluoroalkyl substances (PFAS) to the environment? DOI Creative Commons
Amanda Rensmo, Eleni Savvidou, Ian T. Cousins

и другие.

Environmental Science Processes & Impacts, Год журнала: 2023, Номер 25(6), С. 1015 - 1030

Опубликована: Янв. 1, 2023

Recycling of lithium-ion batteries (LIBs) is a rapidly growing industry, which vital to address the increasing demand for metals, and achieve sustainable circular economy. Relatively little information known about environmental risks posed by LIB recycling, in particular with regards emission persistent (in)organic fluorinated chemicals. Here we present an overview on use substances - per- polyfluoroalkyl (PFAS) state-of-the-art LIBs, along recycling conditions may lead their formation and/or release environment. Both organic inorganic are widely reported components, including electrodes binder, electrolyte (and additives), separator. Among most common LiPF6 (an salt), polymeric PFAS polyvinylidene fluoride (used as electrode binder separator). Currently process involves pyrometallurgy, operates at high temperatures (up 1600 °C), sufficient mineralization. However, hydrometallurgy, increasingly popular alternative approach, under milder (<600 could favor incomplete degradation substances. This supported wide range detected bench-scale experiments. Overall, this review highlights need further investigate emissions during suggests that substitution PFAS-based materials (i.e. manufacturing), or alternatively post-treatments changes be required avoid

Язык: Английский

Процитировано

49
Overview of Per- and Polyfluoroalkyl Substances (PFAS), Their Applications, Sources, and Potential Impacts on Human Health DOI Creative Commons
Zunaira Habib,

Minkyung Song,

Sadaf Ikram

и другие.

Pollutants, Год журнала: 2024, Номер 4(1), С. 136 - 152

Опубликована: Март 6, 2024

Per- and polyfluoroalkyl substances (PFAS) belong to a group of synthetic compounds that have recently raised concerns about human health environmental quality due their great prevalence, degradation resistance, potential toxicity. This review focuses on the applications PFAS effects health. Specific emphasis has been laid (i) application/use PFAS, (ii) sources distribution in diverse compartments, (iii) impact Significant humans are associated with exposure i.e., immunotoxicity, thyroid kidney disorders, cancer, etc. Conclusions obtained from studies demonstrate inadequate evidence should not be used justify delaying risk reduction steps for alternatives. can determined different matrices using both traditional analytical approaches, liquid chromatography coupled mass spectrometry (LC-MS/MS) semi-quantitative passive sampling, advanced methods colorimetric, spectrofluorimetric, electrochemical detection. Traditional costly broadly available, while emerging, cost-effective less sensitive unable meet regulatory limits. There is still significant number performed fully comprehend real contamination by PFAS.

Язык: Английский

Процитировано

20
Characterization of per- and polyfluoroalkyl substances (PFASs) in Chinese river and lake sediments DOI
Roberto Xavier Supe Tulcan, Christian Miguel Huarez Yarlequé, Xiaoxia Lü

и другие.

Journal of Hazardous Materials, Год журнала: 2025, Номер 489, С. 137680 - 137680

Опубликована: Фев. 20, 2025

Язык: Английский

Процитировано

2
PFAS in municipal solid waste landfills: Sources, leachate composition, chemical transformations, and future challenges DOI Creative Commons
Ethan S. Coffin, Donald M. Reeves, Daniel P. Cassidy

и другие.

Current Opinion in Environmental Science & Health, Год журнала: 2022, Номер 31, С. 100418 - 100418

Опубликована: Ноя. 29, 2022

Язык: Английский

Процитировано

48
The decomposition and emission factors of a wide range of PFAS in diverse, contaminated organic waste fractions undergoing dry pyrolysis DOI Creative Commons
Erlend Sørmo, Gabriela Castro, Michel Hubert

и другие.

Journal of Hazardous Materials, Год журнала: 2023, Номер 454, С. 131447 - 131447

Опубликована: Апрель 18, 2023

Current treatment options for organic waste contaminated with per- and polyfluoroalkyl substances (PFAS) are generally limited to incineration, composting or landfilling, all resulting in emissions. Dry pyrolysis is a promising emerging alternative these practices, but there uncertainty related the fate of PFAS during this process. The present work first developed robust method determination complex matrices, such as sewage sludge biochar. Then, mass balance was established 56 different full-scale (2–10 kg biochar hr-1, 500–800 °C) sludges, food reject, garden timber. were found wastes (56–3651 ng g-1), resulted ≥ 96.9% removal. Residual (0.1–3.4 g-1) detected biochars obtained at temperatures up 750 °C dominated by long chain PFAS. Emitted loads ranged from 0.01 3.1 mg tonne-1 produced short Emissions made < 3% total PFAS-mass wastes. Remaining uncertainties mainly presence thermal degradation products flue gas condensation oils.

Язык: Английский

Процитировано

42
Firefighters’ exposure to per-and polyfluoroalkyl substances (PFAS) as an occupational hazard: A review DOI Creative Commons
Nur‐Us‐Shafa Mazumder,

Md. Tanjim Hossain,

Fatema Tuj Jahura

и другие.

Frontiers in Materials, Год журнала: 2023, Номер 10

Опубликована: Март 23, 2023

The term “firefighter” and “cancer” have become so intertwined in the past decade that they are now nearly inseparable. Occupational exposure of firefighters to carcinogenic chemicals may increase their risk developing different types cancer. PFAS one major classes exposed as occupational hazard. Elevated levels been observed firefighters’ blood serum recent studies. Possible sources include turnout gear, aqueous film-forming foam, air dust at both fire scene station. Preliminary discussion on includes definition, classification, chemical structure. review is then followed by identifying encounter an structural properties used identified sources, degradation, pathways reviewed. elevated level how this might associate with increased cancer discussed. Our shows a significant amount gear migration untreated layers, itself be potential source exposure. from foams (AFFF), air, stations already established sources. Studies suggest higher compared general population. This suggests hazard could for firefighters.

Язык: Английский

Процитировано

35
Per- and polyfluorinated alkyl substances (PFAS) in Pennsylvania surface waters: A statewide assessment, associated sources, and land-use relations DOI Creative Commons
Sara E. Breitmeyer, Amy M. Williams, Joseph W. Duris

и другие.

The Science of The Total Environment, Год журнала: 2023, Номер 888, С. 164161 - 164161

Опубликована: Май 15, 2023

The objectives of this study are to identify per- and polyfluoroalkyl substances (PFAS) in Pennsylvania surface waters, corresponding associations with potential sources PFAS contamination (PSOC) other parameters, compare raw water concentrations human ecological benchmarks. Surface samples from 161 streams were collected September 2019 analyzed for 33 target chemistry. Land use physical attributes upstream catchments geospatial counts PSOC local summarized. hydrologic yield the sum (∑PFAS) each stream was computed by normalizing site's load drainage area catchment. Utilizing conditional inference tree analysis, percentage development (>7.58 %) identified as a primary driver ∑PFAS yields. When removed yields closely related chemistry associated landscape alteration (e.g., or agricultural cropland), such total nitrogen, chloride, ammonia, but also count pollution control facilities (agricultural, industrial, stormwater, and/or municipal waste abatement facilities). In oil gas regions, combined sewage outfalls. Sites surrounded ≥2 electronic manufacturing had elevated (median = 241 ng/s/km2). Study results critical guide future research, regulatory policy, best practices that will mitigate contamination, communication health risks exposure waters.

Язык: Английский

Процитировано

28
A critical review of perfluoroalkyl and polyfluoroalkyl substances (PFAS) landfill disposal in the United States DOI
Thabet Tolaymat, Nicole M. Robey, Max J. Krause

и другие.

The Science of The Total Environment, Год журнала: 2023, Номер 905, С. 167185 - 167185

Опубликована: Сен. 19, 2023

Язык: Английский

Процитировано

28
The association between per- and polyfluoroalkyl substances (PFASs) and brain, esophageal, melanomatous skin, prostate, and lung cancer using the 2003–2018 US National Health and Nutrition Examination Survey (NHANES) datasets DOI Creative Commons
Jinyoung Moon, Yongseok Mun

Heliyon, Год журнала: 2024, Номер 10(2), С. e24337 - e24337

Опубликована: Янв. 1, 2024

IntroductionThe purpose of this study was to use the US National Health and Nutrition Examination Survey (NHANES) datasets examine potential relationships between four per- polyfluoroalkyl substance (PFAS) exposures each type cancer, specifically perfluorooctanoic acid (PFOA), perfluorooctane sulfonic (PFOS), perfluorohexane (PFHxS), perfluorononanoic (PFNA).MethodsA logistic regression analysis performed. A directed acyclic graph plotted adjust for confounders.ResultsThe odds ratio (OR) brain cancer a one-unit increase in ln (PFHxS) 8.16 (95 % confidence interval [CI] 2.98–68.89). The OR esophageal one unit (PFOA) (PFOS) 5.10 CI 1.18–17.34) 3.97 1.24–11.42), respectively. melanoma 1.65 1.07–2.58) 1.55 1.07–2.25), prostate (PFNA) 1.21 1.00–1.48) 1.27 1.00–1.62), lung 2.62 1.24–5.83) 2.38 1.00–5.52), respectively.DiscussionConsidering that brain, esophageal, melanomatous skin cancers have not been targets epidemiologic studies regarding PFAS exposure, future could target these as outcomes interest.

Язык: Английский

Процитировано

15
Forever Chemicals, Per-and Polyfluoroalkyl Substances (PFAS), in Lubrication DOI Creative Commons
Darrius Dias,

Jake Bons,

Abhishek Kumar

и другие.

Lubricants, Год журнала: 2024, Номер 12(4), С. 114 - 114

Опубликована: Март 29, 2024

Per- and polyfluoroalkyl substances (PFAS), also known as forever chemicals, exhibit exceptional chemical stability resistance to environmental degradation thanks their strong C-F bonds nonpolar nature. However, widespread use persistence have a devastating impact on the environment. This review examines roles of PFAS in tribological applications, specifically lubricants lubricating systems. article focuses conventional advanced lubricants, including ionic liquids (ILs) modern automotive vehicles. The objective this paper is provide comprehensive overview adverse impacts whilst acknowledging outstanding performance surface coatings, composite materials, additives oils greases. pathways through which are introduced into environment via systems such seals O-rings identified, alongside subsequent dispersion routes interfaces across they interact. Furthermore, we examine toxicological implications exposure terrestrial aquatic life forms, plants, animals, humans, along with ecological consequences bioaccumulation biomagnification trophic levels ecosystems. ends potential remediation strategies for use, treatment technologies, biodegradation, recovery recycling methods, search more environmentally benign alternatives.

Язык: Английский

Процитировано

13